• 5196 Citations
  • 33 h-Index
19942019

Research output per year

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Research Output

  • 5196 Citations
  • 33 h-Index
  • 65 Article
  • 8 Review article
  • 3 Comment/debate

[2.2.2]- to [3.2.1]-Bicycle Skeletal Rearrangement Approach to the Gibberellin Family of Natural Products

Smith, B. R. & Njardarson, J. T., May 18 2018, In : Organic Letters. 20, 10, p. 2993-2996 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

A concise ring-expansion route to the compact core of platensimycin

McGrath, N. A., Bartlett, E. S., Sittihan, S. & Njardarson, J. T., Oct 26 2009, In : Angewandte Chemie - International Edition. 48, 45, p. 8543-8546 4 p.

Research output: Contribution to journalArticle

64 Scopus citations

A facile synthesis of α-phosphono esters through methoxycarbonylation of α-phosphono carbanions

Geirsson, J. K. F. & Njardarson, J. T., Nov 28 1994, In : Tetrahedron Letters. 35, 48, p. 9071-9072 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

A graphical journey of innovative organic architectures that have improved our lives

McGrath, N. A., Brichacek, M. & Njardarson, J. T., Dec 1 2010, In : Journal of Chemical Education. 87, 12, p. 1348-1349 2 p.

Research output: Contribution to journalComment/debate

341 Scopus citations

A Mild meta-Selective C–H Alkylation of Catechol Mono-Ethers

Vitaku, E. & Njardarson, J. T., 2016, In : European Journal of Organic Chemistry. 2016, 22, p. 3679-3683 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

An Adler-Becker oxidation approach to vinigrol

Morton, J. G. M., Kwon, L. D., Freeman, J. D. & Njardarson, J. T., Apr 15 2009, In : Tetrahedron Letters. 50, 15, p. 1684-1686 3 p.

Research output: Contribution to journalArticle

25 Scopus citations

Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA approved pharmaceuticals

Vitaku, E., Smith, D. T. & Njardarson, J. T., Dec 26 2014, In : Journal of Medicinal Chemistry. 57, 24, p. 10257-10274 18 p.

Research output: Contribution to journalArticle

1313 Scopus citations

Analysis of US FDA-Approved Drugs Containing Sulfur Atoms

Scott, K. A. & Njardarson, J. T., Feb 1 2018, In : Topics in Current Chemistry. 376, 1, 5.

Research output: Contribution to journalReview article

87 Scopus citations

An efficient oxidative dearomatization-radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products

McGrath, N. A., Binner, J. R., Markopoulos, G., Brichacek, M. & Njardarson, J. T., Jan 7 2011, In : Chemical Communications. 47, 1, p. 209-211 3 p.

Research output: Contribution to journalArticle

25 Scopus citations

An efficient substrate-controlled approach towards hypoestoxide, a member of a family of diterpenoid natural products with an inside-out [9.3.1]bicyclic core

McGrath, N. A., Lee, C. A., Araki, H., Brichacek, M. & Njardarson, J. T., Nov 24 2008, In : Angewandte Chemie - International Edition. 47, 49, p. 9450-9453 4 p.

Research output: Contribution to journalArticle

20 Scopus citations

An expeditious approach toward the total synthesis of CP-263,114

Njardarson, J. T., McDonald, I. M., Spiegel, D. A., Inoue, M. & Wood, J. L., Aug 9 2001, In : Organic Letters. 3, 16, p. 2435-2438 4 p.

Research output: Contribution to journalArticle

49 Scopus citations

An In-pharm-ative educational poster anthology highlighting the therapeutic agents that chronicle our medicinal history

Ilardi, E. A., Vitaku, E. & Njardarson, J. T., Oct 8 2013, In : Journal of Chemical Education. 90, 10, p. 1403-1405 3 p.

Research output: Contribution to journalArticle

28 Scopus citations
2 Scopus citations

Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis

Njardarson, J. T., Biswas, K. & Danishefsky, S. J., Jan 1 2002, In : Chemical Communications. 2, 23, p. 2759-2761 3 p.

Research output: Contribution to journalArticle

47 Scopus citations

Application of phenolic oxidation chemistry in synthesis: Preparation of the BCE ring system of ryanodine

Wood, J. L., Graeber, J. K. & Njardarson, J. T., Nov 3 2003, In : Tetrahedron. 59, 45, p. 8855-8858 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

A scalable rhodium-catalyzed intermolecular aziridination reaction

Smith, D. T. & Njardarson, J. T., Apr 22 2014, In : Angewandte Chemie - International Edition. 53, 17, p. 4278-4280 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

A Survey of the Structures of US FDA Approved Combination Drugs

Das, P., Delost, M. D., Qureshi, M. H., Smith, D. T. & Njardarson, J. T., May 9 2019, In : Journal of Medicinal Chemistry. 62, 9, p. 4265-4311 47 p.

Research output: Contribution to journalReview article

20 Scopus citations
21 Scopus citations

Asymmetric Vinylogous Aza-Darzens Approach to Vinyl Aziridines

Chogii, I., Das, P., Delost, M. D., Crawford, M. N. & Njardarson, J. T., Aug 17 2018, In : Organic Letters. 20, 16, p. 4942-4945 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Base mediated deprotection strategies for trifluoroethyl (TFE) ethers, a new alcohol protecting group

Yang, Q. & Njardarson, J. T., Dec 18 2013, In : Tetrahedron Letters. 54, 51, p. 7080-7082 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

Beyond C, H, O, and N! analysis of the elemental composition of U.S. FDA approved drug architectures

Smith, B. R., Eastman, C. M. & Njardarson, J. T., Dec 11 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 9764-9773 10 p.

Research output: Contribution to journalReview article

98 Scopus citations

Catalytic ring expansion adventures

Njardarson, J. T., Mar 15 2013, In : Synlett. 24, 7, p. 787-803 17 p., ST-2013-A0056-A.

Research output: Contribution to journalArticle

20 Scopus citations

Catalytic ring expansion of vinyl oxetanes: Asymmetric synthesis of dihydropyrans using chiral counterion catalysis

Guo, B., Schwarzwalder, G. & Njardarson, J. T., Jun 4 2012, In : Angewandte Chemie - International Edition. 51, 23, p. 5675-5678 4 p.

Research output: Contribution to journalArticle

50 Scopus citations

Chemistry by design: A web-based educational flashcard for exploring synthetic organic chemistry

Draghici, C. & Njardarson, J. T., Jul 10 2012, In : Journal of Chemical Education. 89, 8, p. 1080-1082 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims

Nagorny, P., Krauss, I., Njardarson, J. T., Perez, L., Gaul, C., Yang, G., Ouerfelli, O. & Danishefsky, S. J., Jul 28 2010, In : Tetrahedron Letters. 51, 30, p. 3873-3875 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

Copper-catalyzed rearrangement of vinyl oxiranes

Batory, L. A., McInnis, C. E. & Njardarson, J. T., Dec 20 2006, In : Journal of the American Chemical Society. 128, 50, p. 16054-16055 2 p.

Research output: Contribution to journalArticle

53 Scopus citations

CP-263,114 synthetic studies. Construction of an isotwistane ring system via rhodium carbenoid C-H insertion

Spiegel, D. A., Njardarson, J. T. & Wood, J. L., Aug 5 2002, In : Tetrahedron. 58, 32, p. 6545-6554 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
68 Scopus citations

Data-mining for sulfur and fluorine: An evaluation of pharmaceuticals to reveal opportunities for drug design and discovery

Ilardi, E. A., Vitaku, E. & Njardarson, J. T., Apr 10 2014, In : Journal of Medicinal Chemistry. 57, 7, p. 2832-2842 11 p.

Research output: Contribution to journalArticle

461 Scopus citations

Dearomatization Approach to 2-Trifluoromethylated Benzofuran and Dihydrobenzofuran Products

Smith, D. T., Vitaku, E. & Njardarson, J. T., Jul 7 2017, In : Organic Letters. 19, 13, p. 3508-3511 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Discovery of Potent Cell Migration Inhibitors through Total Synthesis: Lessons from Structure-Activity Studies of (+)-Migrastatin

Njardarson, J. T., Gaul, C., Shan, D., Huang, X. Y. & Danishefsky, S. J., Feb 4 2004, In : Journal of the American Chemical Society. 126, 4, p. 1038-1040 3 p.

Research output: Contribution to journalArticle

156 Scopus citations

Distinct biological effects of golgicide a derivatives on larval and adult mosquitoes

MacK, D. J., Isoe, J., Miesfeld, R. L. & Njardarson, J. T., Aug 15 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 16, p. 5177-5181 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Double-diels-alder approach to maoecrystal V. unexpected C-C bond-forming fragmentations of the [2.2.2]-bicyclic core

Smith, B. R. & Njardarson, J. T., 2017, In : Organic Letters. 19, 19, p. 5316-5319 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Efficient synthesis of thiopyrans using a sulfur-enabled anionic cascade

Li, F., Calabrese, D., Brichacek, M., Lin, I. & Njardarson, J. T., Feb 20 2012, In : Angewandte Chemie - International Edition. 51, 8, p. 1938-1941 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin

Lecomte, N., Njardarson, J. T., Nagorny, P., Yang, G., Downey, R., Ouerfelli, O., Moore, M. A. S. & Danishefsky, S. J., Sep 13 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 37, p. 15074-15078 5 p.

Research output: Contribution to journalArticle

36 Scopus citations

Evolution of an oxidative dearomatization enabled total synthesis of vinigrol

Yang, Q., Draghici, C., Njardarson, J. T., Li, F., Smith, B. R. & Das, P., Jan 14 2014, In : Organic and Biomolecular Chemistry. 12, 2, p. 330-344 15 p.

Research output: Contribution to journalArticle

26 Scopus citations

Evolution of a synthetic approach to CP-263,114

Njardarson, J. T. & Wood, J. L., Aug 9 2001, In : Organic Letters. 3, 16, p. 2431-2434 4 p.

Research output: Contribution to journalArticle

44 Scopus citations

Formation of fused aromatic architectures via an oxidative dearomatization - Radical cyclization rearomatization approach

Vitaku, E. & Njardarson, J. T., Dec 15 2014, In : Tetrahedron Letters. 56, 23, p. 3550-3552 3 p., 45780.

Research output: Contribution to journalArticle

4 Scopus citations

From Oxiranes to Oligomers: Architectures of US FDA Approved Pharmaceuticals Containing Oxygen Heterocycles

Delost, M. D., Smith, D. T., Anderson, B. J. & Njardarson, J. T., Jun 2 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

33 Scopus citations

Highly concise routes to epothilones: The total synthesis and evaluation of epothilone 490

Biswas, K., Lin, H., Njardarson, J. T., Chappell, M. D., Chou, T. C., Guan, Y., Tong, W. P., He, L., Horwitz, S. B. & Danishefsky, S. J., Aug 21 2002, In : Journal of the American Chemical Society. 124, 33, p. 9825-9832 8 p.

Research output: Contribution to journalArticle

100 Scopus citations

Highly selective copper-catalyzed ring expansion of vinyl thiiranes: Application to synthesis of biotin and the heterocyclic core of plavix

Rogers, E., Araki, H., Batory, L. A., McInnis, C. E. & Njardarson, J. T., Mar 14 2007, In : Journal of the American Chemical Society. 129, 10, p. 2768-2769 2 p.

Research output: Contribution to journalArticle

47 Scopus citations

Intermolecular oxonium ylide mediated synthesis of medium-sized oxacycles

MacK, D. J., Batory, L. A. & Njardarson, J. T., Jan 6 2012, In : Organic Letters. 14, 1, p. 378-381 4 p.

Research output: Contribution to journalArticle

29 Scopus citations

Lewis acid catalyzed [1,3]-sigmatropic rearrangement of vinyl aziridines

Brichacek, M., Lee, D. & Njardarson, J. T., Dec 1 2008, In : Organic Letters. 10, 21, p. 5023-5026 4 p.

Research output: Contribution to journalArticle

64 Scopus citations

Mechanism and the origins of stereospecificity in copper-catalyzed ring expansion of vinyl oxiranes: A traceless dual transition-metal-mediated process

Mustard, T. J. L., MacK, D. J., Njardarson, J. T. & Cheong, P. H. Y., Jan 30 2013, In : Journal of the American Chemical Society. 135, 4, p. 1471-1475 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Metal-free synthesis of fluorinated indoles enabled by oxidative dearomatization

Vitaku, E., Smith, D. T. & Njardarson, J. T., Feb 5 2016, In : Angewandte Chemie - International Edition. 55, 6, p. 2243-2247 5 p.

Research output: Contribution to journalArticle

16 Scopus citations
6 Scopus citations

New Class of Anion-Accelerated Amino-Cope Rearrangements as Gateway to Diverse Chiral Structures

Chogii, I., Das, P., Fell, J. S., Scott, K. A., Crawford, M. N., Houk, K. N. & Njardarson, J. T., Sep 20 2017, In : Journal of the American Chemical Society. 139, 37, p. 13141-13146 6 p.

Research output: Contribution to journalArticle

7 Scopus citations