• 8004 Citations
  • 45 h-Index
19972019

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A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system

Miranda, K. M., Paolocci, N., Katori, T., Thomas, D. D., Ford, E., Bartberger, M. D., Espey, M. G., Kass, D. A., Feelisch, M., Fukuto, J. M. & Wink, D. A., Aug 5 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 16, p. 9196-9201 6 p.

Research output: Contribution to journalArticle

219 Scopus citations

A celebration of inorganic lives: Interview with Peter C. Ford (UC Santa Barbara)

Miranda, K. M., Jan 1 2016, In : Coordination Chemistry Reviews. 306, p. 724-733 10 p.

Research output: Contribution to journalArticle

A chemical perspective on the interplay between NO, reactive oxygen species, and Reactive Nitrogen Oxide Species

Espey, M. G., Miranda, K. M., Thomas, D. D., Xavier, S., Citrin, D., Vitek, M. P. & Wink, D. A., Jan 1 2002, In : Annals of the New York Academy of Sciences. 962, p. 195-206 12 p.

Research output: Contribution to journalArticle

116 Scopus citations

A discussion of the chemistry of oxidative and nitrosative stress in cytotoxicity

Miranda, K. M., Espey, M. G. & Wink, D. A., Apr 30 2000, In : Journal of Inorganic Biochemistry. 79, 1-4, p. 237-240 4 p.

Research output: Contribution to journalArticle

31 Scopus citations

Analysis of the HNO and NO donating properties of alicyclic amine diazeniumdiolates

Bharadwaj, G., Benini, P. G. Z., Basudhar, D., Ramos-Colon, C. N., Johnson, G. M., Larriva, M. M., Keefer, L. K., Andrei, D. & Miranda, K. M., Nov 15 2014, In : Nitric Oxide - Biology and Chemistry. 42, p. 70-78 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite

Miranda, K. M., Espey, M. G. & Wink, D. A., Jan 1 2001, In : Nitric Oxide - Biology and Chemistry. 5, 1, p. 62-71 10 p.

Research output: Contribution to journalArticle

2096 Scopus citations

Bordetella bronchiseptica responses to physiological reactive nitrogen and oxygen stresses

Omsland, A., Miranda, K. M., Friedman, R. L. & Boitano, S., Jul 1 2008, In : FEMS Microbiology Letters. 284, 1, p. 92-101 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Chemotherapeutic potential of diazeniumdiolate-based aspirin prodrugs in breast cancer

Basudhar, D., Cheng, R. C., Bharadwaj, G., Ridnour, L. A., Wink, D. A. & Miranda, K. M., Jun 1 2015, In : Free Radical Biology and Medicine. 83, p. 101-114 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and NO donors: Insights into Listeriocidal activity of oxidative and nitrosative stress

Ogawa, R., Pacelli, R., Espey, M. G., Miranda, K. M., Friedman, N., Kim, S. M., Cox, G., Mitchell, J. B., Wink, D. A. & Russo, A., Feb 1 2001, In : Free Radical Biology and Medicine. 30, 3, p. 268-276 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Comparison of the chemical reactivity of synthetic peroxynitrite with that of the autoxidation products of nitroxyl or its anion

Jorolan, J. H., Buttitta, L. A., Cheah, C. & Miranda, K. M., Apr 2 2015, In : Nitric Oxide - Biology and Chemistry. 44, p. 39-46 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Comparison of the NO and HNO donating properties of diazeniumdiolates: Primary amine adducts release HNO in vivo

Miranda, K. M., Katori, T., Torres De Holding, C. L., Thomas, L., Ridnour, L. A., McLendon, W. J., Cologna, S. M., Dutton, A. S., Champion, H. C., Mancardi, D., Tocchetti, C. G., Saavedra, J. E., Keefer, L. K., Houk, K. N., Fukuto, J. M., Kass, D. A., Paolocci, N. & Wink, D. A., Dec 29 2005, In : Journal of Medicinal Chemistry. 48, 26, p. 8220-8228 9 p.

Research output: Contribution to journalArticle

96 Scopus citations

Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins: A chemical discussion of the differential biological effects of these redox related products of NOS

Miranda, K. M., Nims, R. W., Thomas, D. D., Espey, M. G., Citrin, D., Bartberger, M. D., Paolocci, N., Fukuto, J. M., Feelisch, M. & Wink, D. A., Jan 1 2003, In : Journal of Inorganic Biochemistry. 93, 1-2, p. 52-60 9 p.

Research output: Contribution to journalArticle

105 Scopus citations

Cytotoxicity related to oxidative and nitrosative stress by nitric oxide

Wink, D. A., Miranda, K. M. & Espey, M. G., Jan 1 2001, In : Experimental Biology and Medicine. 226, 7, p. 621-623 3 p.

Research output: Contribution to journalArticle

45 Scopus citations

Design and synthesis of rosiglitazone-ferulic acid-nitric oxide donor trihybrids for improving glucose tolerance

Liu, J., Huang, Z., Ma, W., Peng, S., Li, Y., Miranda, K. M., Tian, J. & Zhang, Y., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 650-665 16 p.

Research output: Contribution to journalArticle

1 Scopus citations
87 Scopus citations

Discriminating formation of HNO from other reactive nitrogen oxide species

Donzelli, S., Espey, M. G., Thomas, D. D., Mancardi, D., Tocchetti, C. G., Ridnour, L. A., Paolocci, N., King, S. B., Miranda, K. M., Lazzarino, G., Fukuto, J. M. & Wink, D. A., Mar 15 2006, In : Free Radical Biology and Medicine. 40, 6, p. 1056-1066 11 p.

Research output: Contribution to journalArticle

77 Scopus citations

Distinction between Nitrosating Mechanisms within Human Cells and Aqueous Solution

Espey, M. G., Miranda, K. M., Thomas, D. D. & Wink, D. A., Aug 10 2001, In : Journal of Biological Chemistry. 276, 32, p. 30085-30091 7 p.

Research output: Contribution to journalArticle

135 Scopus citations

Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class

Andrei, D., Salmon, D. J., Donzelli, S., Wahab, A., Klose, J. R., Citro, M. L., Saavedra, J. E., Wink, D. A., Miranda, K. M. & Keefer, L. K., Nov 24 2010, In : Journal of the American Chemical Society. 132, 46, p. 16526-16532 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Effects of oxidative and nitrosative stress in cytotoxicity

Wink, D. A., Miranda, K. M. & Espey, M. G., Jan 1 2000, In : Seminars in Perinatology. 24, 1, p. 20-23 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Flash photolysis studies of the ruthenium(II) porphyrins RU(P)(NO)(ONO). Multiple pathways involving reactions of intermediates with nitric oxide

Lorković, I. M., Miranda, K. M., Lee, B., Bernhard, S., Schoonover, J. R. & Ford, P. C., Nov 18 1998, In : Journal of the American Chemical Society. 120, 45, p. 11674-11683 10 p.

Research output: Contribution to journalArticle

89 Scopus citations

Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide

Espey, M. G., Thomas, D. D., Miranda, K. M. & Wink, D. A., Aug 20 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 17, p. 11127-11132 6 p.

Research output: Contribution to journalArticle

147 Scopus citations

Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: Effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite

Miranda, K. M., K-i, Y., Espey, M. G., Thomas, D. D., Degraff, W., Mitchell, J. B., Krishna, M. C., Colton, C. A. & Wink, D. A., May 15 2002, In : Archives of Biochemistry and Biophysics. 401, 2, p. 134-144 11 p.

Research output: Contribution to journalArticle

65 Scopus citations

Gene expression profiles of NO- and HNO-donor treated breast cancer cells: Insights into tumor response and resistance pathways

Cheng, R. Y. S., Basudhar, D., Ridnour, L. A., Heinecke, J. L., Kesarwala, A. H., Glynn, S., Switzer, C. H., Ambs, S., Miranda, K. M. & Wink, D. A., Dec 1 2014, In : Nitric Oxide - Biology and Chemistry. 43, p. 17-28 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine

Donzelli, S., Espey, M. G., Flores-Santana, W., Switzer, C. H., Yeh, G. C., Huang, J., Stuehr, D. J., King, S. B., Miranda, K. M. & Wink, D. A., Sep 1 2008, In : Free Radical Biology and Medicine. 45, 5, p. 578-584 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

Glutathione sulfinamide serves as a selective, endogenous biomarker for nitroxyl after exposure to therapeutic levels of donors

Johnson, G. M., Chozinski, T. J., Gallagher, E. S., Aspinwall, C. A. & Miranda, K. M., Nov 2014, In : Free Radical Biology and Medicine. 76, p. 299-307 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems

Thomas, D. D., Miranda, K. M., Espey, M. G., Citrin, D., Jourd'Heuil, D., Paolocci, N., Hewett, S. J., Colton, C. A., Grisham, M. B., Feelisch, M. & Wink, D. A., Jan 1 2002, In : Methods in Enzymology. 359, p. 84-105 22 p.

Research output: Contribution to journalArticle

70 Scopus citations

HNO and NO release from a primary amine-based diazeniumdiolate as a function of pH

Salmon, D. J., De Holding, C. L. T., Thomas, L., Peterson, K. V., Goodman, G. P., Saavedra, J. E., Srinivasan, A., Davies, K. M., Keefer, L. K. & Miranda, K. M., Apr 18 2011, In : Inorganic Chemistry. 50, 8, p. 3262-3270 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Ingress and reactive chemistry of nitroxyl-derived species within human cells

Espey, M. G., Miranda, K. M., Thomas, D. D. & Wink, D. A., Sep 15 2002, In : Free Radical Biology and Medicine. 33, 6, p. 827-834 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

Inhibition of poly(ADP-ribose) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species

Sidorkina, O., Espey, M. G., Miranda, K. M., Wink, D. A. & Laval, J., Dec 1 2003, In : Free Radical Biology and Medicine. 35, 11, p. 1431-1438 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

Inhibitory effects of nitric oxide and nitrosative stress on dopamine- β-hydroxylase

Zhou, X., Espey, M. G., Chen, J. X., Hofseth, L. J., Miranda, K. M., Hussain, S. P., Wink, D. A. & Harris, C. C., Jul 14 2000, In : Journal of Biological Chemistry. 275, 28, p. 21241-21246 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Kinetic feasibility of nitroxyl reduction by physiological reductants and biological implications

Jackson, M. I., Han, T. H., Serbulea, L., Dutton, A., Ford, E., Miranda, K. M., Houk, K. N., Wink, D. A. & Fukuto, J. M., Oct 15 2009, In : Free Radical Biology and Medicine. 47, 8, p. 1130-1139 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Light-triggered and cysteine-mediated nitric oxide release from a biodegradable starch-based film

Roveda, A. C., De Fazio Aguiar, H., Miranda, K. M., Tadini, C. C. & Franco, D. W., Nov 7 2014, In : Journal of Materials Chemistry B. 2, 41, p. 7232-7242 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mechanism of aerobic decomposition of Angeli's salt (Sodium Trioxodinitrate) at physiological pH

Miranda, K. M., Dutton, A. S., Ridnour, L. A., Foreman, C. A., Ford, E., Paolocci, N., Katori, T., Tocchetti, C. G., Mancardi, D., Thomas, D. D., Espey, M. G., Houk, K. N., Fukuto, J. M. & Wink, D. A., Jan 19 2005, In : Journal of the American Chemical Society. 127, 2, p. 722-731 10 p.

Research output: Contribution to journalArticle

85 Scopus citations

Mechanism of pH-dependent decomposition of monoalkylamine diazeniumdiolates to form HNO and NO, deduced from the model compound methylamine diazeniumdiolate, density functional theory, and CBS-QB3 calculations

Dutton, A. S., Suhrada, C. P., Miranda, K. M., Wink, D. A., Fukuto, J. M. & Houk, K. N., Mar 20 2006, In : Inorganic Chemistry. 45, 6, p. 2448-2456 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Mechanisms of cell death governed by the balance between nitrosative and oxidative stress

Espey, M. G., Miranda, K. M., Feelisch, M., Fukuto, J., Grisham, M. B., Vitek, M. P. & Wink, D. A., Jan 1 2000, In : Annals of the New York Academy of Sciences. 899, p. 209-221 13 p.

Research output: Contribution to journalArticle

87 Scopus citations

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

Hofseth, L. J., Saito, S., Perwez Hussain, S., Espey, M. G., Miranda, K. M., Araki, Y., Jhappan, C., Higashimoto, Y., He, P., Linke, S. P., Quezado, M. M., Zurer, I., Rotter, V., Wink, D. A., Appella, E. & Harris, C. C., Jan 7 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 1, p. 143-148 6 p.

Research output: Contribution to journalArticle

275 Scopus citations

Nitrosative capacity of macrophages is dependent on nitric-oxide synthase induction signals

Espey, M. G., Miranda, K. M., Pluta, R. M. & Wink, D. A., Apr 14 2000, In : Journal of Biological Chemistry. 275, 15, p. 11341-11347 7 p.

Research output: Contribution to journalArticle

77 Scopus citations

Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning

Pagliaro, P., Mancardi, D., Rastaldo, R., Penna, C., Gattullo, D., Miranda, K. M., Feelisch, M., Wink, D. A., Kass, D. A. & Paolocci, N., Jan 1 2003, In : Free Radical Biology and Medicine. 34, 1, p. 33-43 11 p.

Research output: Contribution to journalArticle

166 Scopus citations

Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling

Paolocci, N., Saavedra, W. F., Miranda, K. M., Martignani, C., Isoda, T., Hare, J. M., Espey, M. G., Fukuto, J. M., Feelisch, M., Winkt, D. A. & Kass, D. A., Aug 28 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 18, p. 10463-10468 6 p.

Research output: Contribution to journalArticle

238 Scopus citations

Nitroxyl anion regulation of the NMDA receptor

Colton, C. A., Gbadegesin, M., Wink, D. A., Miranda, K. M., Espey, M. G. & Vicini, S., Sep 17 2001, In : Journal of neurochemistry. 78, 5, p. 1126-1134 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Nitroxyl inhibits overt pain-like behavior in mice: Role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway

Staurengo-Ferrari, L., Zarpelon, A. C., Longhi-Balbinot, D. T., Marchesi, M., Cunha, T. M., Alves-Filho, J. C., Cunha, F. Q., Ferreira, S. H., Casagrande, R., Miranda, K. M. & Verri, W. A., Aug 2014, In : Pharmacological Reports. 66, 4, p. 691-698 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: A novel redox paradigm

Wink, D. A., Miranda, K. M., Katori, T., Mancardi, D., Thomas, D. D., Ridnour, L., Espey, M. G., Feelisch, M., Colton, C. A., Fukuto, J. M., Pagliaro, P., Kass, D. A. & Paolocci, N., Dec 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 285, 6 54-6, p. H2264-H2276

Research output: Contribution to journalArticle

92 Scopus citations

Peroxynitrite and myocardial contractility: In vivo versus in vitro effects

Katori, T., Donzelli, S., Tocchetti, C. G., Miranda, K. M., Cormaci, G., Thomas, D. D., Ketner, E. A., Lee, M. J., Mancardi, D., Wink, D. A., Kass, D. A. & Paolocci, N., Nov 15 2006, In : Free Radical Biology and Medicine. 41, 10, p. 1606-1618 13 p.

Research output: Contribution to journalArticle

45 Scopus citations

Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide

Väänänen, A. J., Salmenperä, P., Hukkanen, M., Miranda, K. M., Harjula, A., Rauhala, P. & Kankuri, E., Sep 15 2008, In : Free Radical Biology and Medicine. 45, 6, p. 749-755 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Photochemistry of metal nitrosyl complexes. Delivery of nitric oxide to biological targets

Ford, P. C., Bourassa, J., Miranda, K., Lee, B., Lorkovic, I., Boggs, S., Kudo, S. & Laverman, L., Apr 1998, In : Coordination Chemistry Reviews. 171, 1, p. 185-202 18 p.

Research output: Contribution to journalArticle

258 Scopus citations

Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: Independence from β-adrenergic signaling

Paolocci, N., Katori, T., Champion, H. C., St. John, M. E., Miranda, K. M., Fukuto, J. M., Wink, D. A. & Kass, D. A., Apr 29 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 9, p. 5537-5542 6 p.

Research output: Contribution to journalArticle

261 Scopus citations

Protein nitration is mediated by heme and free metals through Fenton-type chemistry: An alternative to the NO/O2- reaction

Thomas, D. D., Espey, M. G., Vitek, M. P., Miranda, K. M. & Wink, D. A., Oct 1 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 20, p. 12691-12696 6 p.

Research output: Contribution to journalArticle

160 Scopus citations

Reactions of HNO with heme proteins: New routes to HNO-heme complexes and insight into physiological effects

Kumars, M. R., Fukuto, J. M., Miranda, K. M. & Farmer, P. J., Jul 19 2010, In : Inorganic Chemistry. 49, 14, p. 6283-6292 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Signaling and stress: The redox landscape in NOS2 biology

Thomas, D. D., Heinecke, J. L., Ridnour, L. A., Cheng, R. Y., Kesarwala, A. H., Switzer, C. H., McVicar, D. W., Roberts, D. D., Glynn, S., Fukuto, J. M., Wink, D. A. & Miranda, K. M., Jun 2 2015, In : Free Radical Biology and Medicine. 87, p. 204-225 22 p., 12462.

Research output: Contribution to journalArticle

54 Scopus citations

Special issue in honour of Prof. Peter C. Ford

Miranda, K. M., Jan 1 2016, In : Coordination Chemistry Reviews. 306, p. 445-446 2 p.

Research output: Contribution to journalArticle