Keith A Joiner

  • 10165 Citations
  • 55 h-Index
1969 …2020

Research output per year

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Research Output

2003

Host but not parasite cholesterol controls Toxoplasma cell entry by modulating organelle discharge

Coppens, I. & Joiner, K. A., Sep 1 2003, In : Molecular biology of the cell. 14, 9, p. 3804-3820 17 p.

Research output: Contribution to journalArticle

95 Scopus citations

Oxidosqualene cyclase inhibitors as antimicrobial agents

Hinshaw, J. C., Suh, D. Y., Garnier, P., Buckner, F. S., Eastman, R. T., Matsuda, S. P. T., Joubert, B. M., Coppens, I., Joiner, K. A., Merali, S., Nash, T. E. & Prestwich, G. D., Sep 25 2003, In : Journal of Medicinal Chemistry. 46, 20, p. 4240-4243 4 p.

Research output: Contribution to journalArticle

34 Scopus citations

Pleiotropic effect due to targeted depletion of secretory rhoptry protein ROP2 in Toxoplasma gondii

Nakaar, V., Ngô, H. M., Aaronson, E. P., Coppens, I., Stedman, T. T. & Joiner, K. A., Jun 1 2003, In : Journal of Cell Science. 116, 11, p. 2311-2320 10 p.

Research output: Contribution to journalReview article

48 Scopus citations

Toxoplasma gondii Rab6 mediates a retrograde pathway for sorting of constitutively secreted proteins to the Golgi complex

Stedman, T. T., Sussmann, A. R. & Joiner, K. A., Feb 14 2003, In : Journal of Biological Chemistry. 278, 7, p. 5433-5443 11 p.

Research output: Contribution to journalArticle

31 Scopus citations
2002

Golgi biogenesis in Toxoplasma gondii

Pelletier, L., Stern, C. A., Pypaert, M., Sheff, D., Ngô, H. M., Roper, N., He, C. Y., Hu, K., Toomre, D., Coppens, I., Roos, D. S., Joiner, K. A. & Warren, G., Aug 1 2002, In : Nature. 418, 6897, p. 548-552 5 p.

Research output: Contribution to journalArticle

139 Scopus citations

Integrating geriatrics and subspecialty internal medicine: Results of a survey on patient care practices, training, attitudes, and research

Joiner, K. A., Haponik, E. & High, K. P., Feb 15 2002, In : American Journal of Medicine. 112, 3, p. 249-254 6 p.

Research output: Contribution to journalComment/debate

5 Scopus citations

Secretory traffic in the eukaryotic parasite Toxoplasma gondii: Less is more

Joiner, K. A. & Roos, D. S., May 13 2002, In : Journal of Cell Biology. 157, 4, p. 557-563 7 p.

Research output: Contribution to journalShort survey

109 Scopus citations

The cathepsin B of Toxoplasma gondii, toxopain-1, is critical for parasite invasion and rhoptry protein processing

Que, X., Ngô, H., Lawton, J., Gray, M., Liu, Q., Engel, J., Brinen, L., Ghosh, P., Joiner, K. A. & Reed, S. L., Jul 12 2002, In : Journal of Biological Chemistry. 277, 28, p. 25791-25797 7 p.

Research output: Contribution to journalArticle

77 Scopus citations

Toxoplasma gondii Rab5 enhances cholesterol acquisition from host cells

Robibaro, B., Stedman, T. T., Coppens, I., Ngô, H. M., Pypaert, M., Bivona, T., Nam, H. W. & Joiner, K. A., Apr 9 2002, In : Cellular Microbiology. 4, 3, p. 139-152 14 p.

Research output: Contribution to journalArticle

42 Scopus citations
2001

Adequacy of fellowship training: Results of a survey of recently graduated fellows

Joiner, K. A., Dismukes, W. E., Britigan, B. E., Cohen, M. S., Johnson, W. D., Karchmer, A. W., Mandell, G. L. & Stamm, W. E., Feb 1 2001, In : Clinical Infectious Diseases. 32, 2, p. 255-262 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Counterpoint: UNAFs - Perspective and prevention

Quagliarello, V. & Joiner, K., Mar 1 2001, In : Clinical Infectious Diseases. 32, 5, p. 755-756 2 p.

Research output: Contribution to journalShort survey

Endocytosis in different lifestyles of protozoan parasitism: Role in nutrient uptake with special reference to Toxoplasma gondii

Robibaro, B., Hoppe, H. C., Yang, M., Coppens, I., Ngô, H. M., Stedman, T. T., Paprotka, K. & Joiner, K. A., Jan 1 2001, In : International Journal for Parasitology. 31, 12, p. 1343-1353 11 p.

Research output: Contribution to journalReview article

23 Scopus citations

Parasite–host cell interactions in toxoplasmosis: New avenues for intervention?

Coppens, I. & Joiner, K. A., Jan 15 2001, In : Expert Reviews in Molecular Medicine. 3, 2, p. 1-20 20 p.

Research output: Contribution to journalArticle

20 Scopus citations

The Toxoplasma gondii protein ROP2 mediates host organelle association with the parasitophorous vacuole membrane

Sinai, A. P. & Joiner, K. A., Jul 9 2001, In : Journal of Cell Biology. 154, 1, p. 95-108 14 p.

Research output: Contribution to journalArticle

165 Scopus citations

Toxoplasma gondii ADP-ribosylation Factor 1 Mediates Enhanced Release of Constitutively Secreted Dense Granule Proteins

Liendo, A., Stedman, T. T., Ngô, H. M., Chaturvedi, S., Hoppe, H. C. & Joiner, K. A., Jan 25 2001, In : Journal of Biological Chemistry. 276, 21, p. 18272-18281 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2000

Coinfection of fibroblasts with Coxiella burnetti and Toxoplasma gondii: To each their own

Sinai, A. P., Paul, S., Rabinovitch, M., Kaplan, G. & Joiner, K. A., Jun 2000, In : Microbes and Infection. 2, 7, p. 727-736 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
19 Scopus citations

Differential sorting and post-secretory targeting of proteins in parasitic invasion

Ngô, H. M., Hoppe, H. C. & Joiner, K. A., Feb 1 2000, In : Trends in Cell Biology. 10, 2, p. 67-72 6 p.

Research output: Contribution to journalReview article

54 Scopus citations

Functional competence of peritoneal macrophages in murine Lyme borreliosis

Montgomery, R. R., Palmarozza, R. E., Beck, D. S., Ngo, E., Joiner, K. A. & Malawista, S. E., Jan 1 2000, In : Inflammation. 24, 3, p. 277-288 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Protein-targeting determinants in the secretory pathway of apicomplexan parasites

Kaasch, A. J. & Joiner, K. A., Jan 1 2000, In : Current Opinion in Microbiology. 3, 4, p. 422-428 7 p.

Research output: Contribution to journalReview article

14 Scopus citations
9 Scopus citations

Supporting research in departments of internal medicine: Recommendations for NIH

Costa, S. T., Ausiello, D., Joiner, K., Neilson, E. G., Taylor, I. & Wenzel, R., Aug 1 2000, In : American Journal of Medicine. 109, 2, p. 178-180 3 p.

Research output: Contribution to journalComment/debate

2 Scopus citations
38 Scopus citations

Targeting to rhoptry organelles of Toxoplasma gondii involves evolutionarily conserved mechanisms

Hoppe, H. C., Ngo, H. M., Yang, M. & Joiner, K. A., Jan 1 2000, In : Nature Cell Biology. 2, 7, p. 449-456 8 p.

Research output: Contribution to journalArticle

110 Scopus citations

Toxoplasma gondii: Conserved protein machinery in an unusual secretory pathway?

Liendo, A. & Joiner, K. A., Feb 2000, In : Microbes and Infection. 2, 2, p. 137-144 8 p.

Research output: Contribution to journalReview article

7 Scopus citations

Toxoplasma gondii: Are host cell adenosine nucleotides a direct source for purine salvage?

Ngô, H. M., Ngo, E. O., Bzik, D. J. & Joiner, K. A., Jan 1 2000, In : Experimental parasitology. 95, 2, p. 148-153 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Toxoplasma gondii exploits host low-density lipoprotein receptor- mediated endocytosis for cholesterol acquisition

Coppens, I., Sinai, A. P. & Joiner, K. A., Apr 3 2000, In : Journal of Cell Biology. 149, 1, p. 167-180 14 p.

Research output: Contribution to journalArticle

199 Scopus citations

Traffic jams: Protein transport in Plasmodium falciparum

Van Dooren, G. G., Waller, R. F., McFadden, G. I., Joiner, K. A. & Roos, D. S., Oct 1 2000, In : Parasitology Today. 16, 10, p. 421-427 7 p.

Research output: Contribution to journalReview article

55 Scopus citations
1999

Constitutive calcium-independent release of Toxoplasma gondii dense granules occurs through the NSF/SNAP/SNARE/Rab machinery

Chaturvedi, S., Qi, H., Coleman, D., Rodriguez, A., Hanson, P. I., Striepen, B., Roos, D. S. & Joiner, K. A., Jan 22 1999, In : Journal of Biological Chemistry. 274, 4, p. 2424-2431 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

En route to the vacuole. Tracing the secretory pathway of Toxoplasma gondii

Stedman, T. T. & Joiner, K. A., Dec 1 1999, In : Advances in Cellular and Molecular Biology of Membranes and Organelles. 6, C, p. 233-261 29 p.

Research output: Contribution to journalReview article

13 Scopus citations
Open Access
6 Scopus citations

Targeted reduction of nucleoside triphosphate hydrolase by antisense RNA inhibits Toxoplasma gondii proliferation

Nakaar, V., Samuel, B. U., Ngo, E. O. & Joiner, K. A., Feb 19 1999, In : Journal of Biological Chemistry. 274, 8, p. 5083-5087 5 p.

Research output: Contribution to journalArticle

60 Scopus citations

The expression and distribution of dense granule proteins in the enteric (coccidian) forms of Toxoplasma gondii in the small intestine of the cat

Ferguson, D. J. P., Cesbron-Delauw, M. F., Dubremetz, J. F., Sibley, L. D., Joiner, K. A. & Wright, S., Mar 1999, In : Experimental parasitology. 91, 3, p. 203-211 9 p.

Research output: Contribution to journalArticle

44 Scopus citations
1998

Basis for substrate specificity of the Toxoplasma gondii nucleoside triphosphate hydrolase

Nakaar, V., Beckers, C. J. M., Polotsky, V. & Joiner, K. A., Nov 30 1998, In : Molecular and Biochemical Parasitology. 97, 1-2, p. 209-220 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Fellowship training in infectious diseases: A report from the regional and national meetings of infectious diseases division chiefs and program directors

Joiner, K. A., Powderly, W. G., Blaser, M. J., Klempner, M. S., Locksley, R. M., Mandell, G. L., Preheim, L. C., Remington, J. S., Slama, T. G., Steigbigel, N. H. & Bartlett, J. G., May 25 1998, In : Clinical Infectious Diseases. 26, 5, p. 1060-1065 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Induced activation of the Toxoplasma gondii nucleoside triphosphate hydrolase leads to depletion of host cell ATP levels and rapid exit of intracellular parasites from infected cells

Silverman, J. A., Qi, H., Riehl, A., Beckers, C., Nakaar, V. & Joiner, K. A., May 15 1998, In : Journal of Biological Chemistry. 273, 20, p. 12352-12359 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

The parasitophorous vacuole membrane surrounding Plasmodium and Toxoplasma: An unusual compartment in infected cells

Lingelbach, K. & Joiner, K. A., Jul 8 1998, In : Journal of Cell Science. 111, 11, p. 1467-1475 9 p.

Research output: Contribution to journalArticle

212 Scopus citations

The protozoan parasite Toxoplasma gondii targets proteins to dense granules and the vacuolar space using both conserved and unusual mechanisms

Karsten, V., Qi, H., Beckers, C. J. M., Reddy, A., Dubremetz, J. F., Webster, P. & Joiner, K. A., Jun 15 1998, In : Journal of Cell Biology. 141, 6, p. 1323-1333 11 p.

Research output: Contribution to journalArticle

99 Scopus citations

Upstream elements required for expression of nucleoside triphosphate hydrolase genes of Toxoplasma gondii

Nakaar, V., Bermudes, D., Peck, K. R. & Joiner, K. A., May 1 1998, In : Molecular and Biochemical Parasitology. 92, 2, p. 229-239 11 p.

Research output: Contribution to journalArticle

48 Scopus citations
1997

Association of host cell endoplasmic reticulum and mitochondria with the Toxoplasma grondii parasitophorous vacuole membrane: A high affinity interaction

Sinai, A. P., Webster, P. & Joiner, K. A., Oct 25 1997, In : Journal of Cell Science. 110, 17, p. 2117-2128 12 p.

Research output: Contribution to journalArticle

231 Scopus citations
38 Scopus citations

Different fractional domains in the parasitophorous vacuole membrane of Toxoplasma gondii

Samuel, B. U., Qi, H., Ardito, T., Ngo, H., Kashgarian, M. & Joiner, K. A., Dec 1 1997, In : Clinical Infectious Diseases. 25, 2, 1 p.

Research output: Contribution to journalArticle

Erratum: (Journal of Clinical Investigation (April 1997) 99:8 (1814- 1817))

Joiner, K. A., Jan 1 1997, In : Journal of Clinical Investigation. 100, 3, 1 p.

Research output: Contribution to journalComment/debate

Interaction of human mannose-binding protein with Mycobacterium avium

Polotsky, V. Y., Belisle, J. T., Mikusova, K., Ezekowitz, R. A. B. & Joiner, K. A., Jan 1 1997, In : Journal of Infectious Diseases. 175, 5, p. 1159-1168 10 p.

Research output: Contribution to journalArticle

Open Access
71 Scopus citations

Membrane-protein traffic in pathogen-infected cells

Joiner, K. A., Dec 1 1997, In : Journal of Clinical Investigation. 100, 12 SUPPL., p. S25-S27

Research output: Contribution to journalReview article

Membrane-protein traffic in pathogen-infected cells

Joiner, K. A., Apr 15 1997, In : Journal of Clinical Investigation. 99, 8, p. 1814-1817 4 p.

Research output: Contribution to journalReview article

Open Access
20 Scopus citations

Safe haven: The cell biology of nonfusogenic pathogen vacuoles

Sinai, A. P. & Joiner, K. A., Oct 21 1997, In : Annual review of microbiology. 51, p. 415-462 48 p.

Research output: Contribution to journalReview article

185 Scopus citations

Targeting of proteins in the parasitophorous vacuolar space of Toxoplasma gondii

Samuel, B. U., Ngo, H., Qi, H., Dubremetz, J. F. & Joiner, K. A., Dec 1 1997, In : Clinical Infectious Diseases. 25, 2, 1 p.

Research output: Contribution to journalArticle

Targeting the secretory pathway of Toxoplasma gondii

Karsten, V., Qi, H., Beckers, C. J. & Joiner, K. A., Oct 1997, In : Methods: A Companion to Methods in Enzymology. 13, 2, p. 103-111 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

The expression of Toxoplasma proteins in Neospora caninum and the identification of a gene encoding a novel rhoptry protein

Beckers, C. J. M., Wakefield, T. & Joiner, K. A., Nov 1 1997, In : Molecular and Biochemical Parasitology. 89, 2, p. 209-223 15 p.

Research output: Contribution to journalArticle

50 Scopus citations