• 923 Citations
  • 17 h-Index
19992018
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Research Output 1999 2018

  • 923 Citations
  • 17 h-Index
  • 22 Article
2018
22 Citations (Scopus)

Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition

Tang, H., Babicheva, A., McDermott, K., Gu, Y., Ayon, R. J., Song, S., Wang, Z., Gupta, A., Zhou, T., Sun, X., Dash, S., Wang, Z., Balistrieri, A., Zheng, Q., Cordery, A. G., Desai, A., Rischard, F., Khalpey, Z. I., Wang, J., Black, S. M. & 3 others, Garcia, J. GN., Makino, A. & Yuan, J., Feb 1 2018, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 314, 2, p. L256-L275

Research output: Contribution to journalArticle

Pulmonary Hypertension
Endothelial Cells
Lung
Prolyl Hydroxylases
Smooth Muscle Myocytes
5 Citations (Scopus)

STIM2 (Stromal Interaction Molecule 2)–mediated increase in resting cytosolic free Ca2+ concentration stimulates PASMC proliferation in pulmonary arterial hypertension

Song, S., Carr, S. G., McDermott, K., Rodriguez, M., Babicheva, A., Balistrieri, A., Ayon, R. J., Wang, J., Makino, A. & Yuan, J., Jan 1 2018, In : Hypertension. 71, 3, p. 518-529 12 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Pulmonary Artery
Smooth Muscle Myocytes
Cell Proliferation
NFATC Transcription Factors
2017
6 Citations (Scopus)

Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH

Song, S., Ayon, R. J., Yamamura, A., Yamamura, H., Dash, S., Babicheva, A., Tang, H., Sun, X., Cordery, A. G., Khalpey, Z. I., Black, S. M., Desai, A., Rischard, F., McDermott, K., Garcia, J. GN., Makino, A. & Yuan, J., Mar 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 3, p. L309-L325

Research output: Contribution to journalArticle

Capsaicin
Pulmonary Artery
Smooth Muscle Myocytes
vanilloid receptor subtype 1
Phosphorylation
2 Citations (Scopus)

Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension

Wu, K., Zhang, Q., Wu, X., Lu, W., Tang, H., Liang, Z., Gu, Y., Song, S., Ayon, R. J., Wang, Z., McDermott, K., Balistrieri, A., Wang, C., Black, S. M., Garcia, J. GN., Makino, A., Yuan, J. & Wang, J., Nov 1 2017, In : British Journal of Pharmacology. 174, 22, p. 4155-4172 18 p.

Research output: Contribution to journalArticle

Chloroquine
Vasodilator Agents
Pulmonary Hypertension
Pulmonary Artery
Lung
13 Citations (Scopus)

Inhibition of ciliogenesis promotes Hedgehog signaling, tumorigenesis, and metastasis in breast cancer

Hassounah, N. B., Nunez, M., Fordyce, C., Roe, D., Nagle, R. B., Bunch, T. & McDermott, K., Oct 1 2017, In : Molecular Cancer Research. 15, 10, p. 1421-1430 10 p.

Research output: Contribution to journalArticle

Hedgehogs
Carcinogenesis
Breast Neoplasms
Neoplasm Metastasis
Transforming Growth Factor alpha
2016
31 Citations (Scopus)

ATP promotes cell survival via regulation of cytosolic [Ca2+] and Bcl-2/Bax ratio in lung cancer cells

Song, S., Jacobson, K. N., McDermott, K., Reddy, S. P., Cress, A. E., Tang, H., Dudek, S. M., Black, S. M., Garcia, J. GN., Makino, A. & Yuan, J., Jan 15 2016, In : American Journal of Physiology - Cell Physiology. 310, 2, p. C99-C114

Research output: Contribution to journalArticle

Lung Neoplasms
Cell Survival
Adenosine Triphosphate
bcl-2-Associated X Protein
Tumor Microenvironment
2014
54 Citations (Scopus)

Loss of primary cilia occurs early in breast cancer development

Menzl, I., Lebeau, L., Pandey, R., Hassounah, N. B., Li, F. W., Nagle, R. B., Weihs, K. L. & McDermott, K., 2014, In : Cilia. 3, 1, 7.

Research output: Contribution to journalArticle

Cilia
Breast Neoplasms
Stromal Cells
Neoplasms
Keratin-5
2013
55 Citations (Scopus)

Primary Cilia Are Lost in Preinvasive and Invasive Prostate Cancer

Hassounah, N. B., Nagle, R. B., Saboda, K., Roe, D., Dalkin, B. L. & McDermott, K., Jul 2 2013, In : PLoS One. 8, 7, e68521.

Research output: Contribution to journalArticle

Cilia
prostatic neoplasms
cilia
Prostatic Neoplasms
neoplasms
2012
80 Citations (Scopus)

Molecular pathways: The role of primary cilia in cancer progression and therapeutics with a focus on hedgehog signaling

Hassounah, N. B., Bunch, T. A. & McDermott, K., May 1 2012, In : Clinical Cancer Research. 18, 9, p. 2429-2435 7 p.

Research output: Contribution to journalArticle

Hedgehogs
Cilia
Neoplasms
Therapeutics
HhAntag691
2010
51 Citations (Scopus)

Primary Cilia Regulate Branching Morphogenesis during Mammary Gland Development

McDermott, K., Liu, B. Y., Tlsty, T. D. & Pazour, G. J., Apr 27 2010, In : Current Biology. 20, 8, p. 731-737 7 p.

Research output: Contribution to journalArticle

Cilia
cilia
Human Mammary Glands
Morphogenesis
mammary glands
2009
25 Citations (Scopus)

Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy

Dumont, N., Crawford, Y. G., Sigaroudinia, M., Nagrani, S. S., Wilson, M. B., Buehring, G. C., Turashvili, G., Aparicio, S., Gauthier, M. L., Fordyce, C. A., McDermott, K. & Tlsty, T. D., Dec 8 2009, In : Breast Cancer Research. 11, 6, R87.

Research output: Contribution to journalArticle

Methylation
Breast
Breast Neoplasms
Epithelial Cells
Epigenomics
2008

MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion (Cancer Research (2007) 67, (10222-10229))

Swanson, B. J., McDermott, K., Singh, P. K., Eggers, J. P., Crocker, P. R. & Hollingsworth, M. A., Jan 1 2008, In : Cancer Research. 68, 1, p. 338 1 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Myelin-Associated Glycoprotein
Pancreatic Neoplasms
Research
Neoplasms
2007
59 Citations (Scopus)

MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion

Swanson, B. J., McDermott, K., Singh, P. K., Eggers, J. P., Crocker, P. R. & Hollingsworth, M. A., Nov 1 2007, In : Cancer Research. 67, 21, p. 10222-10229 8 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Myelin-Associated Glycoprotein
Pancreatic Neoplasms
Schwann Cells
Adhesives
2006
97 Citations (Scopus)

p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells.

McDermott, K., Zhang, J., Holst, C. R., Kozakiewicz, B. K., Singla, V. & Tlsty, T. D., Mar 2006, In : PLoS Biology. 4, 3

Research output: Contribution to journalArticle

centrosomes
Centrosome
Genomic Instability
aneuploidy
Aneuploidy
2005
32 Citations (Scopus)

Genetic and epigenetic changes in mammary epithelial cells identify a subpopulation of cells involved in early carcinogenesis

Berman, H., Zhang, J., Crawford, Y. G., Gauthier, M. L., Fordyce, C. A., McDermott, K., Sigaroudinia, M., Kozakiewicz, K. & Tlsty, T. D., 2005, In : Cold Spring Harbor Symposia on Quantitative Biology. 70, p. 317-327 11 p.

Research output: Contribution to journalArticle

Epigenomics
epigenetics
carcinogenesis
breasts
Carcinogenesis
49 Citations (Scopus)

Unbiased selection of localization elements reveals cis-acting determinants of mRNA bud localization in Saccharomyces cerevisiae

Jambhekar, A., McDermott, K., Sorber, K., Shepard, K. A., Vale, R. D., Takizawa, P. A. & DeRisi, J. L., Dec 13 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 50, p. 18005-18010 6 p.

Research output: Contribution to journalArticle

Saccharomyces cerevisiae
RNA
Messenger RNA
Nucleotide Motifs
Proteins
2004
66 Citations (Scopus)

Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis

Tlsty, T. D., Crawford, Y. G., Holst, C. R., Fordyce, C. A., Zhang, J., McDermott, K., Kozakiewicz, K. & Gauthier, M. L., Jul 2004, In : Journal of Mammary Gland Biology and Neoplasia. 9, 3, p. 263-274 12 p.

Research output: Contribution to journalArticle

Epigenomics
Carcinogenesis
Breast
Epithelial Cells
Genomic Instability
2003
31 Citations (Scopus)

The contribution of tandem repeat number to the O-glycosylation of mucins

Scott Silverman, H., Sutton-Smith, M., McDermott, K., Heal, P., Leir, S. H., Morris, H. R., Hollingsworth, M. A., Dell, A. & Harris, A., Apr 1 2003, In : Glycobiology. 13, 4, p. 265-277 13 p.

Research output: Contribution to journalArticle

Glycosylation
Tandem Repeat Sequences
Mucins
Carbohydrates
Mass spectrometry
2001
106 Citations (Scopus)

Identification of MUC1 proteolytic cleavage sites in vivo

Parry, S., Silverman, H. S., McDermott, K., Willis, A., Hollingsworth, M. A. & Harris, A., 2001, In : Biochemical and Biophysical Research Communications. 283, 3, p. 715-720 6 p.

Research output: Contribution to journalArticle

Mucins
Tandem Repeat Sequences
Membranes
Processing
Sequence Homology
34 Citations (Scopus)

In vivo glycosylation of mucin tandem repeats

Silverman, H. S., Parry, S., Sutton-Smith, M., Burdick, M. D., McDermott, K., Reid, C. J., Batra, S. K., Morris, H. R., Hollingsworth, M. A., Dell, A. & Harris, A., 2001, In : Glycobiology. 11, 6, p. 459-471 13 p.

Research output: Contribution to journalArticle

Glycosylation
Tandem Repeat Sequences
Mucins
Tumor-Associated Carbohydrate Antigens
Fast Atom Bombardment Mass Spectrometry
76 Citations (Scopus)

Overexpression of MUC1 reconfigures the binding properties of tumor cells

McDermott, K., Crocker, P. R., Harris, A., Burdick, M. D., Hinoda, Y., Hayashi, T., Imai, K. & Hollingsworth, M. A., Dec 15 2001, In : International Journal of Cancer. 94, 6, p. 783-791 9 p.

Research output: Contribution to journalArticle

E-Selectin
Caco-2 Cells
Neoplasms
L-Selectin
Tandem Repeat Sequences
1999
29 Citations (Scopus)

Phosphorylation of the kinase suppressor of Ras by associated kinases

Volle, D. J., Fulton, J. A., Chaika, O. V., McDermott, K., Huang, H., Steinke, L. A. & Lewis, R. E., Apr 20 1999, In : Biochemistry. 38, 16, p. 5130-5137 8 p.

Research output: Contribution to journalArticle

Phosphorylation
Phosphotransferases
Antigen-Antibody Complex
Phenotype
KSR-1 protein kinase