Kristian Doyle

  • 1333 Citations
  • 14 h-Index
20032019
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Research Output 2003 2019

  • 1333 Citations
  • 14 h-Index
  • 25 Article
  • 2 Chapter
  • 1 Review article
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Article
2003
7 Citations (Scopus)

Working with GFP in the brain

Doyle, K., Simon, R. P., Snyder, A. & Stenzel-Poore, M. P., Mar 1 2003, In : BioTechniques. 34, 3, p. 492-494 3 p.

Research output: Contribution to journalArticle

2005
138 Citations (Scopus)

Neuroprotection by osteopontin in stroke

Meller, R., Stevens, S. L., Minami, M., Cameron, J. A., King, S., Rosenzweig, H., Doyle, K., Lessov, N. S., Simon, R. P. & Stenzel-Poore, M. P., Feb 2005, In : Journal of Cerebral Blood Flow and Metabolism. 25, 2, p. 217-225 9 p.

Research output: Contribution to journalArticle

Osteopontin
Stroke
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Neuroprotective Agents
2007
75 Citations (Scopus)

Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury

Doyle, K., Suchland, K. L., Ciesielski, T. M. P., Lessov, N. S., Grandy, D. K., Scanlan, T. S. & Stenzel-Poore, M. P., Sep 2007, In : Stroke. 38, 9, p. 2569-2576 8 p.

Research output: Contribution to journalArticle

Hypothermia
Thyroxine
Ischemia
Stroke
Wounds and Injuries
2008
504 Citations (Scopus)

Mechanisms of ischemic brain damage

Doyle, K., Simon, R. P. & Stenzel-Poore, M. P., Sep 2008, In : Neuropharmacology. 55, 3, p. 310-318 9 p.

Research output: Contribution to journalArticle

Stroke
Brain
Brain Injuries
Cause of Death
Oxidative Stress
64 Citations (Scopus)

Nasal administration of osteopontin peptide mimetics confers neuroprotection in stroke

Doyle, K., Yang, T., Lessov, N. S., Ciesielski, T. M., Stevens, S. L., Simon, R. P., King, J. S. & Stenzel-Poore, M. P., Jun 30 2008, In : Journal of Cerebral Blood Flow and Metabolism. 28, 6, p. 1235-1248 14 p.

Research output: Contribution to journalArticle

Intranasal Administration
Osteopontin
Stroke
Peptides
Thrombin
2009
39 Citations (Scopus)

A new model of cortical stroke in the rhesus macaque

West, G. A., Golshani, K. J., Doyle, K., Lessov, N. S., Hobbs, T. R., Kohama, S. G., Pike, M. M., Kroenke, C. D., Grafe, M. R., Spector, M. D., Tobar, E. T., Simon, R. P. & Stenzel-Poore, M. P., Jun 2009, In : Journal of Cerebral Blood Flow and Metabolism. 29, 6, p. 1175-1186 12 p.

Research output: Contribution to journalArticle

Macaca mulatta
Anterior Cerebral Artery
Ischemia
Stroke
Neurologic Manifestations
2010
120 Citations (Scopus)

TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke

Doyle, K., Cekanaviciute, E., Mamer, L. E. & Buckwalter, M. S., Oct 11 2010, In : Journal of Neuroinflammation. 7, 62.

Research output: Contribution to journalArticle

Astrocytes
Stroke
Brain
Microglia
Middle Cerebral Artery Infarction
2011
37 Citations (Scopus)

Proof of concept: Pharmacological preconditioning with a Toll-like receptor agonist protects against cerebrovascular injury in a primate model of stroke

Bahjat, F. R., Williams-Karnesky, R. L., Kohama, S. G., West, G. A., Doyle, K., Spector, M. D., Hobbs, T. R. & Stenzel-Poore, M. P., May 2011, In : Journal of Cerebral Blood Flow and Metabolism. 31, 5, p. 1229-1242 14 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Primates
Stroke
Wounds and Injuries
Toll-Like Receptor 9
2012
47 Citations (Scopus)

Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke

Han, J., Pollak, J., Yang, T., Siddiqui, M. R., Doyle, K., Taravosh-Lahn, K., Cekanaviciute, E., Han, A., Goodman, J. Z., Jones, B., Jing, D., Massa, S. M., Longo, F. M. & Buckwalter, M. S., Jul 2012, In : Stroke. 43, 7, p. 1918-1924 7 p.

Research output: Contribution to journalArticle

Stroke
Ligands
Neurogenesis
Brain-Derived Neurotrophic Factor
tropomyosin kinase
14 Citations (Scopus)

Distal hypoxic stroke: A new mouse model of stroke with high throughput, low variability and a quantifiable functional deficit

Doyle, K., Fathali, N., Siddiqui, M. R. & Buckwalter, M. S., May 30 2012, In : Journal of Neuroscience Methods. 207, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Stroke
Circle of Willis
Middle Cerebral Artery Infarction
Middle Cerebral Artery
Motor Cortex
12 Citations (Scopus)

Stratification substantially reduces behavioral variability in the hypoxic-ischemic stroke model

Pollak, J., Doyle, K., Mamer, L., Shamloo, M. & Buckwalter, M. S., Sep 2012, In : Brain and Behavior. 2, 5, p. 698-706 9 p.

Research output: Contribution to journalArticle

Stroke
Gait
Inbred C57BL Mouse
Foot
Drug Therapy
39 Citations (Scopus)

Testing the oxidative stress hypothesis of aging in primate fibroblasts: Is there a correlation between species longevity and cellular ROS production?

Csiszar, A., Podlutsky, A., Podlutskaya, N., Sonntag, W. E., Merlin, S. Z., Philipp, E. E. R., Doyle, K., Davila, A., Recchia, F. A., Ballabh, P., Pinto, J. T. & Ungvari, Z., Aug 2012, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 67 A, 8, p. 841-852 12 p.

Research output: Contribution to journalArticle

Primates
Oxidative Stress
Fibroblasts
Lemur
Reactive Oxygen Species
7 Citations (Scopus)

The double-edged sword of inflammation after stroke: What sharpens each edge?

Doyle, K. & Buckwalter, M. S., Jun 2012, In : Annals of Neurology. 71, 6, p. 729-731 3 p.

Research output: Contribution to journalArticle

CD36 Antigens
Brain Infarction
Intracranial Hemorrhages
Gene Expression Regulation
Hyperlipidemias
2014
73 Citations (Scopus)

Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice

Cekanaviciute, E., Fathali, N., Doyle, K., Williams, A. M., Han, J. & Buckwalter, M. S., 2014, In : GLIA. 62, 8, p. 1227-1240 14 p.

Research output: Contribution to journalArticle

Transforming Growth Factor beta
Stroke
Astrocytes
Up-Regulation
Microglia
2015
86 Citations (Scopus)

B-lymphocyte-mediated delayed cognitive impairment following stroke

Doyle, K., Quach, L. N., Solé, M., Axtell, R. C., Nguyen, T. V. V., Soler-Llavina, G. J., Jurado, S., Han, J., Steinman, L., Longo, F. M., Schneider, J. A., Malenka, R. C. & Buckwalter, M. S., 2015, In : Journal of Neuroscience. 35, 5, p. 2133-2145 13 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Stroke
Dementia
Cognitive Dysfunction
Oligoclonal Bands
4 Citations (Scopus)

Ferumoxytol administration does not alter infarct volume or the inflammatory response to stroke in mice

Doyle, K., Quach, L. N., Arceuil, H. E. D. & Buckwalter, M. S., Jan 1 2015, In : Neuroscience Letters. 584, p. 236-240 5 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Stroke
Iron
Macrophages
Contrast Media
2016
12 Citations (Scopus)

Does B lymphocyte-mediated autoimmunity contribute to post-stroke dementia?

Doyle, K. & Buckwalter, M. S., May 24 2016, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Autoimmunity
Dementia
B-Lymphocytes
Stroke
Regulatory B-Lymphocytes
10 Citations (Scopus)

Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue

Nguyen, T. V. V., Frye, J. B., Zbesko, J. C., Stepanovic, K., Hayes, M., Urzua, A., Serrano, G., Beach, T. G. & Doyle, K., Sep 6 2016, In : Acta neuropathologica communications. 4, 1, 1 p.

Research output: Contribution to journalArticle

Immunoassay
Stroke
Inflammation
Brain
Macrophage Inflammatory Proteins
2017
4 Citations (Scopus)

Bifidobacterium animalis subsp. lactis 420 mitigates the pathological impact of myocardial infarction in the mouse

Danilo, C. A., Constantopoulos, E., McKee, L. A., Chen, H., Regan, J. A., Lipovka, Y., Lahtinen, S., Stenman, L. K., Nguyen, T. V. V., Doyle, K., Slepian, M. J., Khalpey, Z. I. & Konhilas, J., 2017, In : Beneficial microbes. 8, 2, p. 257-269 13 p.

Research output: Contribution to journalArticle

Myocardial Infarction
Probiotics
Anti-Inflammatory Agents
Regulatory T-Lymphocytes
Bifidobacterium animalis
2018
2 Citations (Scopus)

Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia

Nguyen, T. V. V., Hayes, M., Zbesko, J. C., Frye, J. B., Congrove, N. R., Belichenko, N. P., Mckay, B. S., Longo, F. M. & Doyle, K., Sep 24 2018, In : Acta neuropathologica communications. 6, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Myelin Sheath
Amyloid
Dementia
Stroke
Alzheimer Disease
7 Citations (Scopus)

Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts

Zbesko, J. C., Nguyen, T. V. V., Yang, T., Frye, J. B., Hussain, O., Hayes, M., Chung, A., Day, W. A., Stepanovic, K., Krumberger, M., Mona, J., Longo, F. M. & Doyle, K., Apr 1 2018, In : Neurobiology of Disease. 112, p. 63-78 16 p.

Research output: Contribution to journalArticle

Neuroglia
Cicatrix
Stroke
Necrosis
Extracellular Fluid
2 Citations (Scopus)

Gut microbiota contributes to resistance against Pneumococcal Pneumonia in immunodeficient Ragl Mice

Felix, K. M., Jaimez, I. A., Nguyen, T. V. V., Ma, H., Raslan, W. A., Klinger, C. N., Doyle, K. & Wu, H-J. J., Apr 18 2018, In : Frontiers in cellular and infection microbiology. 8, APR, 118.

Research output: Contribution to journalArticle

Pneumococcal Pneumonia
Bacteria
Neutrophils
Lung
Pneumococcal Infections
1 Citation (Scopus)

Liquefaction of the Brain following Stroke Shares a Similar Molecular and Morphological Profile with Atherosclerosis and Mediates Secondary Neurodegeneration in an Osteopontin-Dependent Mechanism

Chung, A. G., Frye, J. B., Zbesko, J. C., Constantopoulos, E., Hayes, M., Figueroa, A. G., Becktel, D. A., Antony Day, W., Konhilas, J., Mckay, B. S., Nguyen, T. V. V. & Doyle, K., Sep 1 2018, In : eNeuro. 5, 5

Research output: Contribution to journalArticle

Osteopontin
Atherosclerosis
Stroke
Brain
Brain Ischemia

Suppressing interferon-γ stimulates microglial responses and repair of microbleeds in the diabetic brain

Taylor, S., Mehina, E., White, E., Reeson, P., Yongblah, K., Doyle, K. & Brown, C. E., Oct 3 2018, In : Journal of Neuroscience. 38, 40, p. 8707-8722 16 p.

Research output: Contribution to journalArticle

Interferons
Brain
Microglia
Type 1 Diabetes Mellitus
Dexamethasone
2019
Blood Vessels
Dementia
Inflammation
Heart Failure
Peptides