Lalitha Madhavan

  • 659 Citations
  • 15 h-Index
20032019
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Research Output 2003 2019

  • 659 Citations
  • 15 h-Index
  • 22 Article
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Article
2019
20 Citations (Scopus)

Redox regulation by NRF2 in aging and disease

Schmidlin, C. J., Dodson, M. B., Madhavan, L. & Zhang, D., Jan 1 2019, (Accepted/In press) In : Free Radical Biology and Medicine.

Research output: Contribution to journalArticle

Oxidative stress
Oxidation-Reduction
Oxidative Stress
Aging of materials
Genomic Instability
2018
9 Citations (Scopus)

A Role for Nrf2 Expression in Defining the Aging of Hippocampal Neural Stem Cells

Ray, S., Corenblum, M. J., Anandhan, A., Reed, A., Ortiz, F. O., Zhang, D., Barnes, C. A. & Madhavan, L., Apr 1 2018, In : Cell Transplantation. 27, 4, p. 589-606 18 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem cells
Stem Cells
Aging of materials
Dentate Gyrus
15 Citations (Scopus)

Parkinson's disease skin fibroblasts display signature alterations in growth, redox homeostasis, mitochondrial function, and autophagy

Teves, J. M. Y., Bhargava, V., Kirwan, K. R., Corenblum, M. J., Justiniano, R., Wondrak, G. T., Anandhan, A., Flores, A. J., Schipper, D. A., Khalpey, Z. I., Sligh, J. E., Curiel, C. N., Sherman, S. J. & Madhavan, L., Jan 12 2018, In : Frontiers in Neuroscience. 11, JAN, 737.

Research output: Contribution to journalArticle

Autophagy
Oxidation-Reduction
Parkinson Disease
Homeostasis
Fibroblasts
2017

Small-scale propagation of human iPSCS in serum-free conditions for routine immunocytochemical characterization

Corenblum, M. J. & Madhavan, L., Feb 18 2017, In : Journal of Visualized Experiments. 2017, 120, e55260.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Stem cells
Immunohistochemistry
Serum
Plating
2016
15 Citations (Scopus)

Effects of the iron oxide nanoparticle Molday ION Rhodamine B on the viability and regenerative function of neural stem cells: Relevance to clinical translation

Umashankar, A., Corenblum, M. J., Ray, S., Valdez, M., Yoshimaru, E. S., Trouard, T. P. & Madhavan, L., Apr 27 2016, In : International Journal of Nanomedicine. 11, p. 1731-1748 18 p.

Research output: Contribution to journalArticle

rhodamine B
Neural Stem Cells
Stem cells
Iron oxides
Nanoparticles
26 Citations (Scopus)

Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle-age period

Corenblum, M. J., Ray, S., Remley, Q. W., Long, M., Harder, B., Zhang, D., Barnes, C. A. & Madhavan, L., Aug 1 2016, In : Aging Cell. 15, 4, p. 725-736 12 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem Cells
Regeneration
Lateral Ventricles
Histological Techniques
2015
15 Citations (Scopus)

Chronic amitriptyline treatment attenuates nigrostriatal degeneration and significantly alters trophic support in a rat model of parkinsonism

Paumier, K. L., Sortwell, C. E., Madhavan, L., Terpstra, B., Celano, S. L., Green, J. J., Imus, N. M., Marckini, N., Daley, B., Steece-Collier, K. & Collier, T. J., 2015, In : Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 40, 4, p. 874-883 10 p.

Research output: Contribution to journalArticle

Amitriptyline
Oxidopamine
Brain-Derived Neurotrophic Factor
Parkinsonian Disorders
Antidepressive Agents
6 Citations (Scopus)

Redox-based regulation of neural stem cell function and Nrf2

Madhavan, L., Aug 1 2015, In : Biochemical Society Transactions. 43, p. 627-631 5 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem cells
Oxidation-Reduction
Tissue
Oxidative stress
4 Citations (Scopus)

Sonic hedgehog controls the phenotypic fate and therapeutic efficacy of grafted neural precursor cells in a model of nigrostriatal neurodegeneration

Madhavan, L., Daley, B. F., Davidson, B. L., Boudreau, R. L., Lipton, J. W., Cole-Strauss, A., Steece-Collier, K. & Collier, T. J., Sep 4 2015, In : PLoS One. 10, 9, e0137136.

Research output: Contribution to journalArticle

Glial Cell Line-Derived Neurotrophic Factor
Hedgehogs
Erinaceidae
neurotrophins
neuroglia
1 Citation (Scopus)

Systemic human CD34<sup>+</sup> cells populate the brain and activate host mechanisms to counteract nigrostriatal degeneration

Corenblum, M. J., Flores, A. J., Badowski, M., Harris, D. T. & Madhavan, L., Aug 1 2015, In : Regenerative Medicine. 10, 5, p. 563-577 15 p.

Research output: Contribution to journalArticle

Fetal Blood
Brain
Blood Cells
Blood
Rats
16 Citations (Scopus)

Tricyclic antidepressant treatment evokes regional changes in neurotrophic factors over time within the intact and degenerating nigrostriatal system

Paumier, K. L., Sortwell, C. E., Madhavan, L., Terpstra, B., Daley, B. F. & Collier, T. J., Apr 1 2015, In : Experimental Neurology. 266, p. 11-21 11 p.

Research output: Contribution to journalArticle

Amitriptyline
Tricyclic Antidepressive Agents
Nerve Growth Factors
Glial Cell Line-Derived Neurotrophic Factor
Brain-Derived Neurotrophic Factor
2012
10 Citations (Scopus)

Endogenous neural precursors influence grafted neural stem cells and contribute to neuroprotection in the parkinsonian rat

Madhavan, L., Daley, B. F., Sortwell, C. E. & Collier, T. J., Mar 2012, In : European Journal of Neuroscience. 35, 6, p. 883-895 13 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Cytarabine
Oxidopamine
Transplants
Parkinson Disease
21 Citations (Scopus)

Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model

Gombash, S. E., Lipton, J. W., Collier, T. J., Madhavan, L., Steece-Collier, K., Cole-Strauss, A., Terpstra, B. T., Spieles-Engemann, A. L., Daley, B. F., Wohlgenant, S. L., Thompson, V. B., Manfredsson, F. P., Mandel, R. J. & Sortwell, C. E., Mar 2012, In : Molecular Therapy. 20, 3, p. 544-554 11 p.

Research output: Contribution to journalArticle

Corpus Striatum
Oxidopamine
Dependovirus
Tyrosine 3-Monooxygenase
Neurons
27 Citations (Scopus)

Tricyclic antidepressants delay the need for dopaminergic therapy in early Parkinson's disease

Paumier, K. L., Siderowf, A. D., Auinger, P., Oakes, D., Madhavan, L., Espay, A. J., Revilla, F. J. & Collier, T. J., 2012, In : Movement Disorders. 27, 7, p. 880-887 8 p.

Research output: Contribution to journalArticle

Tricyclic Antidepressive Agents
Antidepressive Agents
Parkinson Disease
Therapeutics
Proportional Hazards Models
2011
112 Citations (Scopus)

Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat

Kordower, J. H., Dodiya, H. B., Kordower, A. M., Terpstra, B., Paumier, K., Madhavan, L., Sortwell, C., Steece-Collier, K. & Collier, T. J., Sep 2011, In : Neurobiology of Disease. 43, 3, p. 552-557 6 p.

Research output: Contribution to journalArticle

alpha-Synuclein
Dopaminergic Neurons
Transplants
Lewy Bodies
Parkinson Disease
2010
27 Citations (Scopus)

A synergistic approach for neural repair: Cell transplantation and induction of endogenous precursor cell activity

Madhavan, L. & Collier, T. J., May 2010, In : Neuropharmacology. 58, 6, p. 835-844 10 p.

Research output: Contribution to journalArticle

Stem Cell Research
Cell Transplantation
Cell- and Tissue-Based Therapy
Stem Cells
Nervous System Diseases
79 Citations (Scopus)

Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss

Spieles-Engemann, A. L., Behbehani, M. M., Collier, T. J., Wohlgenant, S. L., Steece-Collier, K., Paumier, K., Daley, B. F., Gombash, S., Madhavan, L., Mandybur, G. T., Lipton, J. W., Terpstra, B. T. & Sortwell, C. E., Jul 2010, In : Neurobiology of Disease. 39, 1, p. 105-115 11 p.

Research output: Contribution to journalArticle

Subthalamic Nucleus
Dopaminergic Neurons
Substantia Nigra
Parkinson Disease
Oxidopamine
2009
52 Citations (Scopus)

Transplantation of subventricular zone neural precursors induces an endogenous precursor cell response in a rat model of Parkinson's disease

Madhavan, L., Daley, B. F., Paumier, K. I. & Collier, T. J., Jul 1 2009, In : Journal of Comparative Neurology. 515, 1, p. 102-115 14 p.

Research output: Contribution to journalArticle

Lateral Ventricles
Oxidopamine
Parkinson Disease
Transplantation
Tyrosine 3-Monooxygenase
2008
79 Citations (Scopus)

Neural stem/progenitor cells initiate the formation of cellular networks that provide neuroprotection by growth factor-modulated antioxidant expression

Madhavan, L., Ourednik, V. & Ourednik, J., Jan 2008, In : Stem Cells. 26, 1, p. 254-265 12 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Intercellular Signaling Peptides and Proteins
Oxidative Stress
Stem Cells
Antioxidants
2006
60 Citations (Scopus)

Increased "vigilance" of antioxidant mechanisms in neural stem cells potentiates their capability to resist oxidative stress

Madhavan, L., Ourednik, V. & Ourednik, J., 2006, In : Stem Cells. 24, 9, p. 2110-2119 10 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Oxidative Stress
Antioxidants
Glutathione Peroxidase
Reactive Oxygen Species
2005
18 Citations (Scopus)

Grafted neural stem cells shield the host environment from oxidative stress

Madhavan, L., Ourednik, V. & Ourednik, J., 2005, In : Annals of the New York Academy of Sciences. 1049, p. 185-188 4 p.

Research output: Contribution to journalArticle

Oxidative stress
Neural Stem Cells
Stem cells
Oxidative Stress
Neurons
2003
47 Citations (Scopus)

5-Hydroxytryptamine 1A receptor activation protects against N-methyl-D-aspartate-induced apoptotic cell death in striatal and mesencephalic cultures

Madhavan, L., Freed, W. J., Anantharam, V. & Kanthasamy, A. G., Mar 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 304, 3, p. 913-923 11 p.

Research output: Contribution to journalArticle

Corpus Striatum
8-Hydroxy-2-(di-n-propylamino)tetralin
Receptor, Serotonin, 5-HT1A
N-Methylaspartate
Cell Death