Projects per year
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- 3 Similar Profiles
G-Quadruplexes
Medicine & Life Sciences
CC 1065
Medicine & Life Sciences
DNA
Chemical Compounds
Anthramycin
Medicine & Life Sciences
Telomerase
Medicine & Life Sciences
Guanine
Chemical Compounds
Pharmaceutical Preparations
Medicine & Life Sciences
DNA Adducts
Medicine & Life Sciences
Network
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Projects 1978 2021
CANCER CENTER SUPPORT GRANT
Davis, T. P., Hersh, E. M., Weinstein, R. S., Miesfeld, R., Miller, T. P., Tsaprailis, G., Lynch, R., Chow, H., Nagle, R. B., Watts, G. S., Thomson, C., Roe, D., Stratton, S. P., Alberts, D. S., Hurley, L., Baker, A. F., Livingston, R. B., Dorr, R. T., Cress, A. E., Briehl, M. M., Mash, E. A., Duffy, J., Jones, S., Leibovitz, A., Meyskens, F., Moon, T., Trent, J., Newkirk, D., Von Hoff, D., Mount, D., Doetschman, T., Liebler, D., Marshall, J., McGovern, K., Grogan, T., Kraft, A., Powis, G., Peng, Y., Gerner, E., Aickin, M., Ritenbaugh, C., Taylor, C., Powell, M. B., Bowden, T., Taetle, R., Salmon, S., Ignatenko, N., Bhattacharyya, A. K., Futscher, B. W., Barton, J. K., Montfort, W. "., Roe, D., Garland, L. L., Doetschman, T. C., Kraft, A., Chow, H. & Ellis, N.
9/1/78 → 6/30/21
Project: Research project › Center Core Grants
Neoplasms
Research
Pharmaceutical Services
Research Personnel
Clinical Trials
The Development of Novel Inhibitors of BCL2 Gene Expression as Anticancer Therape
Hurley, L. & Siddiqui-Jain, A.
9/20/14 → 2/29/16
Project: Research project › Small Business Innovation Research Grants (SBIR) - Phase I
Gene Expression
Neoplasms
G-Quadruplexes
Drug Therapy
Pharmaceutical Preparations
G-Quadruplex-Mediated Transcriptional Regulation of PDGFR-??
7/1/10 → 4/30/16
Project: Research project › Research Project
G-Quadruplexes
Platelet-Derived Growth Factor beta Receptor
promoter regions
Arteriosclerosis
Pancreatic Neoplasms
Establishing a molecular system for drug targeting of transcriptional control
8/1/08 → 7/31/13
Project: Research project › Research Project
G-Quadruplexes
Drug Delivery Systems
Transcriptional Silencer Elements
Ribosomal DNA
Gene Expression
SPORE in Gastrointestinal Cancer
Roe, D., Einspahr, J. G., Bhattacharyya, A. K., Hurley, L., Nelson, M. A., Dragovich, T., Garewal, H. S., Von Hoff, D., Akporiaye, E., Mount, D., Gerner, E., Powis, G., Green, S. B. & Dvorak, K.
9/5/02 → 3/31/15
Project: Research project › Specialized Center
Gastrointestinal Neoplasms
Research
G-Quadruplexes
Drug Delivery Systems
Neoplasms
Research Output 1969 2018
4
Citations
Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X
Weldon, C., Dacanay, J. G., Gokhale, V., Boddupally, P. V. L., Behm-Ansmant, I., Burley, G. A., Branlant, C., Hurley, L., Dominguez, C. & Eperon, I. C., Jan 25 2018, In : Nucleic Acids Research. 46, 2, p. 886-896 11 p.Research output: Contribution to journal › Article
G-Quadruplexes
RNA Splice Sites
Alternative Splicing
Ligands
RNA Precursors
The 3′-end region of the human PDGFR-β core promoter nuclease hypersensitive element forms a mixture of two unique end-insertion G-quadruplexes
Onel, B., Carver, M., Agrawal, P., Hurley, L. & Yang, D., Apr 1 2018, In : Biochimica et Biophysica Acta - General Subjects. 1862, 4, p. 846-854 9 p.Research output: Contribution to journal › Article
G-Quadruplexes
Platelet-Derived Growth Factor beta Receptor
Guanine
Circular dichroism spectroscopy
Molecular recognition
15
Citations
Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA
Weldon, C., Behm-Ansmant, I., Hurley, L., Burley, G. A., Branlant, C., Eperon, I. C. & Dominguez, C., Jan 1 2017, In : Nature Chemical Biology. 13, 1, p. 18-20 3 p.Research output: Contribution to journal › Article
G-Quadruplexes
RNA
Biological Phenomena
RNA Precursors
7-deazaguanine
17
Citations
Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression
Kaiser, C. E., Van Ert, N. A., Agrawal, P., Chawla, R., Yang, D. & Hurley, L., Jun 28 2017, In : Journal of the American Chemical Society. 139, 25, p. 8522-8536 15 p.Research output: Contribution to journal › Article
Heterogeneous-Nuclear Ribonucleoprotein K
G-Quadruplexes
Transcription
Gene expression
Benzophenanthridines
8
Citations
Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma
Liang, W. S., Hendricks, W., Kiefer, J., Schmidt, J., Sekar, S., Carpten, J., Craig, D. W., Adkins, J., Cuyugan, L., Manojlovic, Z., Halperin, R. F., Helland, A., Nasser, S., Legendre, C., Hurley, L., Sivaprakasam, K., Johnson, D. B., Crandall, H., Busam, K. J., Zismann, V. & 6 others, Apr 1 2017, In : Genome Research. 27, 4, p. 524-532 9 p.Research output: Contribution to journal › Article
Melanoma
Extremities
Skin
Mutation
Solar System