• 21464 Citations
  • 75 h-Index
1969 …2021
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Fingerprint Dive into the research topics where Laurence Hurley is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
G-Quadruplexes Medicine & Life Sciences
CC 1065 Medicine & Life Sciences
DNA Medicine & Life Sciences
Anthramycin Medicine & Life Sciences
Telomerase Medicine & Life Sciences
Guanine Medicine & Life Sciences
Alkylation Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1978 2021


Davis, T. P., Hersh, E. M., Weinstein, R. S., Miesfeld, R., Miller, T. P., Tsaprailis, G., Lynch, R., Chow, H., Nagle, R. B., Watts, G. S., Thomson, C., Roe, D., Stratton, S. P., Alberts, D. S., Hurley, L., Baker, A. F., Livingston, R. B., Dorr, R. T., Cress, A. E., Briehl, M. M., Mash, E. A., Duffy, J., Jones, S., Leibovitz, A., Meyskens, F., Moon, T., Trent, J., Newkirk, D., Von Hoff, D., Mount, D., Doetschman, T., Liebler, D., Marshall, J., McGovern, K., Grogan, T., Kraft, A., Powis, G., Peng, Y., Gerner, E., Aickin, M., Ritenbaugh, C., Taylor, C., Powell, M. B., Bowden, T., Taetle, R., Salmon, S., Ignatenko, N., Bhattacharyya, A. K., Futscher, B. W., Barton, J. K., Montfort, W. "., Roe, D., Garland, L. L., Doetschman, T. C., Kraft, A., Chow, H. & Ellis, N.

National Institutes of Health


Project: Research project

Pharmaceutical Services
Research Personnel
Clinical Trials
Gene Expression
Drug Therapy
Pharmaceutical Preparations
Platelet-Derived Growth Factor beta Receptor
promoter regions
Pancreatic Neoplasms
Drug Delivery Systems
Transcriptional Silencer Elements
Ribosomal DNA
Gene Expression

Research Output 1969 2019

  • 21464 Citations
  • 75 h-Index
  • 273 Article
  • 3 Chapter
  • 1 Comment/debate
  • 1 Letter
2 Citations (Scopus)

Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death

Song, J. H., Kang, H. J., Luevano, L. A., Gokhale, V., Wu, K., Pandey, R., Chow, H-H., Hurley, L. & Kraft, A., Aug 15 2019, In : Cell Chemical Biology. 26, 8, p. 1110-1121.e4

Research output: Contribution to journalArticle

Cell growth
Cell death
Prostatic Neoplasms
1 Citation (Scopus)

TGF-β-induced fibrotic stress increases G-quadruplex formation in human fibroblasts

Toshniwal, P., Nguyen, M., Guédin, A., Viola, H., Ho, D., Kim, Y., Bhatt, U., Bond, C. S., Hool, L., Hurley, L. H., Mergny, J. L., Fear, M., Wood, F., Iyer, S. K. & Smith, N. M., Nov 1 2019, In : FEBS Letters. 593, 22, p. 3149-3161 13 p.

Research output: Contribution to journalArticle

Medical problems
Genetic Promoter Regions
6 Citations (Scopus)

HMGB1 binds to the KRAS promoter G-quadruplex: A new player in oncogene transcriptional regulation?

Amato, J., Madanayake, T. W., Iaccarino, N., Novellino, E., Randazzo, A., Hurley, L. & Pagano, B., Jan 1 2018, In : Chemical Communications. 54, 68, p. 9442-9445 4 p.

Research output: Contribution to journalArticle

HMGB1 Protein
Gene expression
4 Citations (Scopus)

Intracellular speciation of gold nanorods alters the conformational dynamics of genomic DNA

Ho, D., Kretzmann, J. A., Norret, M., Toshniwal, P., Veder, J. P., Jiang, H., Guagliardo, P., Munshi, A. M., Chawla, R., Evans, C. W., Clemons, T. D., Nguyen, M., Kretzmann, A. L., Blythe, A. J., Saunders, M., Archer, M., Fitzgerald, M., Keelan, J. A., Bond, C. S., Kilburn, M. R. & 3 others, Hurley, L., Smith, N. M. & Iyer, K. S., Dec 1 2018, In : Nature Nanotechnology. 13, 12, p. 1148-1153 6 p.

Research output: Contribution to journalLetter

deoxyribonucleic acid
14 Citations (Scopus)

Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X

Weldon, C., Dacanay, J. G., Gokhale, V., Boddupally, P. V. L., Behm-Ansmant, I., Burley, G. A., Branlant, C., Hurley, L., Dominguez, C. & Eperon, I. C., Jan 25 2018, In : Nucleic Acids Research. 46, 2, p. 886-896 11 p.

Research output: Contribution to journalArticle

RNA Splice Sites
Alternative Splicing
RNA Precursors