Projects per year
Fingerprint Dive into the research topics where Laurence Hurley is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 3 Similar Profiles
G-Quadruplexes
Medicine & Life Sciences
CC 1065
Medicine & Life Sciences
DNA
Medicine & Life Sciences
Anthramycin
Medicine & Life Sciences
Telomerase
Medicine & Life Sciences
Guanine
Medicine & Life Sciences
Alkylation
Medicine & Life Sciences
Pharmaceutical Preparations
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 1978 2021
CANCER CENTER SUPPORT GRANT
Davis, T. P., Hersh, E. M., Weinstein, R. S., Miesfeld, R., Miller, T. P., Tsaprailis, G., Lynch, R., Chow, H., Nagle, R. B., Watts, G. S., Thomson, C., Roe, D., Stratton, S. P., Alberts, D. S., Hurley, L., Baker, A. F., Livingston, R. B., Dorr, R. T., Cress, A. E., Briehl, M. M., Mash, E. A., Duffy, J., Jones, S., Leibovitz, A., Meyskens, F., Moon, T., Trent, J., Newkirk, D., Von Hoff, D., Mount, D., Doetschman, T., Liebler, D., Marshall, J., McGovern, K., Grogan, T., Kraft, A., Powis, G., Peng, Y., Gerner, E., Aickin, M., Ritenbaugh, C., Taylor, C., Powell, M. B., Bowden, T., Taetle, R., Salmon, S., Ignatenko, N., Bhattacharyya, A. K., Futscher, B. W., Barton, J. K., Montfort, W. "., Roe, D., Garland, L. L., Doetschman, T. C., Kraft, A., Chow, H. & Ellis, N.
9/1/78 → 6/30/21
Project: Research project
Neoplasms
Research
Pharmaceutical Services
Research Personnel
Clinical Trials
The Development of Novel Inhibitors of BCL2 Gene Expression as Anticancer Therape
Siddiqui-Jain, A. & Hurley, L.
9/20/14 → 2/29/16
Project: Research project
Gene Expression
Neoplasms
G-Quadruplexes
Drug Therapy
Pharmaceutical Preparations
G-Quadruplex-Mediated Transcriptional Regulation of PDGFR-??
7/1/10 → 4/30/16
Project: Research project
G-Quadruplexes
Platelet-Derived Growth Factor beta Receptor
promoter regions
Arteriosclerosis
Pancreatic Neoplasms
Establishing a molecular system for drug targeting of transcriptional control
8/1/08 → 7/31/13
Project: Research project
G-Quadruplexes
Drug Delivery Systems
Transcriptional Silencer Elements
Ribosomal DNA
Gene Expression
Research Output 1969 2019
1
Citation
(Scopus)
Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death
Song, J. H., Kang, H. J., Luevano, L. A., Gokhale, V., Wu, K., Pandey, R., Chow, H-H., Hurley, L. & Kraft, A., Aug 15 2019, In : Cell Chemical Biology. 26, 8, p. 1110-1121.e4Research output: Contribution to journal › Article
G-Quadruplexes
Telomerase
Cell growth
Cell death
Prostatic Neoplasms
5
Citations
(Scopus)
HMGB1 binds to the KRAS promoter G-quadruplex: A new player in oncogene transcriptional regulation?
Amato, J., Madanayake, T. W., Iaccarino, N., Novellino, E., Randazzo, A., Hurley, L. & Pagano, B., Jan 1 2018, In : Chemical Communications. 54, 68, p. 9442-9445 4 p.Research output: Contribution to journal › Article
HMGB1 Protein
Gene expression
Proteins
Communication
2
Citations
(Scopus)
Intracellular speciation of gold nanorods alters the conformational dynamics of genomic DNA
Ho, D., Kretzmann, J. A., Norret, M., Toshniwal, P., Veder, J. P., Jiang, H., Guagliardo, P., Munshi, A. M., Chawla, R., Evans, C. W., Clemons, T. D., Nguyen, M., Kretzmann, A. L., Blythe, A. J., Saunders, M., Archer, M., Fitzgerald, M., Keelan, J. A., Bond, C. S., Kilburn, M. R. & 3 others, , Dec 1 2018, In : Nature Nanotechnology. 13, 12, p. 1148-1153 6 p.Research output: Contribution to journal › Letter
Nanorods
Gold
nanorods
DNA
deoxyribonucleic acid
11
Citations
(Scopus)
Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X
Weldon, C., Dacanay, J. G., Gokhale, V., Boddupally, P. V. L., Behm-Ansmant, I., Burley, G. A., Branlant, C., Hurley, L., Dominguez, C. & Eperon, I. C., Jan 25 2018, In : Nucleic Acids Research. 46, 2, p. 886-896 11 p.Research output: Contribution to journal › Article
G-Quadruplexes
RNA Splice Sites
Alternative Splicing
Ligands
RNA Precursors
2
Citations
(Scopus)
The 3′-end region of the human PDGFR-β core promoter nuclease hypersensitive element forms a mixture of two unique end-insertion G-quadruplexes
Onel, B., Carver, M., Agrawal, P., Hurley, L. & Yang, D., Apr 1 2018, In : Biochimica et Biophysica Acta - General Subjects. 1862, 4, p. 846-854 9 p.Research output: Contribution to journal › Article
G-Quadruplexes
Guanine
Circular dichroism spectroscopy
Molecular recognition
Electrophoretic mobility