• 19973 Citations
  • 74 h-Index
1969 …2021
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  • 3 Similar Profiles
G-Quadruplexes Medicine & Life Sciences
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Telomerase Medicine & Life Sciences
Guanine Chemical Compounds
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DNA Adducts Medicine & Life Sciences

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Projects 1978 2021

CANCER CENTER SUPPORT GRANT

Davis, T. P., Hersh, E. M., Weinstein, R. S., Miesfeld, R., Miller, T. P., Tsaprailis, G., Lynch, R., Chow, H., Nagle, R. B., Watts, G. S., Thomson, C., Roe, D., Stratton, S. P., Alberts, D. S., Hurley, L., Baker, A. F., Livingston, R. B., Dorr, R. T., Cress, A. E., Briehl, M. M., Mash, E. A., Duffy, J., Jones, S., Leibovitz, A., Meyskens, F., Moon, T., Trent, J., Newkirk, D., Von Hoff, D., Mount, D., Doetschman, T., Liebler, D., Marshall, J., McGovern, K., Grogan, T., Kraft, A., Powis, G., Peng, Y., Gerner, E., Aickin, M., Ritenbaugh, C., Taylor, C., Powell, M. B., Bowden, T., Taetle, R., Salmon, S., Ignatenko, N., Bhattacharyya, A. K., Futscher, B. W., Barton, J. K., Montfort, W. "., Roe, D., Garland, L. L., Doetschman, T. C., Kraft, A., Chow, H. & Ellis, N.

National Institutes of Health

9/1/786/30/21

Project: Research projectCenter Core Grants

Neoplasms
Research
Pharmaceutical Services
Research Personnel
Clinical Trials

The Development of Novel Inhibitors of BCL2 Gene Expression as Anticancer Therape

Hurley, L. & Siddiqui-Jain, A.

National Institutes of Health

9/20/142/29/16

Project: Research projectSmall Business Innovation Research Grants (SBIR) - Phase I

Gene Expression
Neoplasms
G-Quadruplexes
Drug Therapy
Pharmaceutical Preparations
G-Quadruplexes
Platelet-Derived Growth Factor beta Receptor
promoter regions
Arteriosclerosis
Pancreatic Neoplasms
G-Quadruplexes
Drug Delivery Systems
Transcriptional Silencer Elements
Ribosomal DNA
Gene Expression

SPORE in Gastrointestinal Cancer

Roe, D., Einspahr, J. G., Bhattacharyya, A. K., Hurley, L., Nelson, M. A., Dragovich, T., Garewal, H. S., Von Hoff, D., Akporiaye, E., Mount, D., Gerner, E., Powis, G., Green, S. B. & Dvorak, K.

National Institutes of Health

9/5/023/31/15

Project: Research projectSpecialized Center

Gastrointestinal Neoplasms
Research
G-Quadruplexes
Drug Delivery Systems
Neoplasms

Research Output 1969 2018

  • 19973 Citations
  • 74 h-Index
  • 270 Article
  • 3 Chapter
  • 1 Comment/debate
4 Citations

Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X

Weldon, C., Dacanay, J. G., Gokhale, V., Boddupally, P. V. L., Behm-Ansmant, I., Burley, G. A., Branlant, C., Hurley, L., Dominguez, C. & Eperon, I. C., Jan 25 2018, In : Nucleic Acids Research. 46, 2, p. 886-896 11 p.

Research output: Contribution to journalArticle

G-Quadruplexes
RNA Splice Sites
Alternative Splicing
Ligands
RNA Precursors
G-Quadruplexes
Platelet-Derived Growth Factor beta Receptor
Guanine
Circular dichroism spectroscopy
Molecular recognition
15 Citations

Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA

Weldon, C., Behm-Ansmant, I., Hurley, L., Burley, G. A., Branlant, C., Eperon, I. C. & Dominguez, C., Jan 1 2017, In : Nature Chemical Biology. 13, 1, p. 18-20 3 p.

Research output: Contribution to journalArticle

G-Quadruplexes
RNA
Biological Phenomena
RNA Precursors
7-deazaguanine
17 Citations

Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression

Kaiser, C. E., Van Ert, N. A., Agrawal, P., Chawla, R., Yang, D. & Hurley, L., Jun 28 2017, In : Journal of the American Chemical Society. 139, 25, p. 8522-8536 15 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein K
G-Quadruplexes
Transcription
Gene expression
Benzophenanthridines
8 Citations

Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma

Liang, W. S., Hendricks, W., Kiefer, J., Schmidt, J., Sekar, S., Carpten, J., Craig, D. W., Adkins, J., Cuyugan, L., Manojlovic, Z., Halperin, R. F., Helland, A., Nasser, S., Legendre, C., Hurley, L., Sivaprakasam, K., Johnson, D. B., Crandall, H., Busam, K. J., Zismann, V. & 6 othersDeluca, V., Lee, J., Sekulic, A., Ariyan, C. E., Sosman, J. & Trent, J., Apr 1 2017, In : Genome Research. 27, 4, p. 524-532 9 p.

Research output: Contribution to journalArticle

Melanoma
Extremities
Skin
Mutation
Solar System