• 21207 Citations
  • 75 h-Index
1969 …2021
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Fingerprint Dive into the research topics where Laurence Hurley is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
G-Quadruplexes Medicine & Life Sciences
CC 1065 Medicine & Life Sciences
DNA Medicine & Life Sciences
Anthramycin Medicine & Life Sciences
Telomerase Medicine & Life Sciences
Guanine Chemical Compounds
Pharmaceutical Preparations Medicine & Life Sciences
Anti-Bacterial Agents Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1978 2021

CANCER CENTER SUPPORT GRANT

Davis, T. P., Hersh, E. M., Weinstein, R. S., Miesfeld, R., Miller, T. P., Tsaprailis, G., Lynch, R., Chow, H., Nagle, R. B., Watts, G. S., Thomson, C., Roe, D., Stratton, S. P., Alberts, D. S., Hurley, L., Baker, A. F., Livingston, R. B., Dorr, R. T., Cress, A. E., Briehl, M. M., Mash, E. A., Duffy, J., Jones, S., Leibovitz, A., Meyskens, F., Moon, T., Trent, J., Newkirk, D., Von Hoff, D., Mount, D., Doetschman, T., Liebler, D., Marshall, J., McGovern, K., Grogan, T., Kraft, A., Powis, G., Peng, Y., Gerner, E., Aickin, M., Ritenbaugh, C., Taylor, C., Powell, M. B., Bowden, T., Taetle, R., Salmon, S., Ignatenko, N., Bhattacharyya, A. K., Futscher, B. W., Barton, J. K., Montfort, W. "., Roe, D., Garland, L. L., Doetschman, T. C., Kraft, A., Chow, H. & Ellis, N.

National Institutes of Health

9/1/786/30/21

Project: Research project

Neoplasms
Research
Pharmaceutical Services
Research Personnel
Clinical Trials
Gene Expression
Neoplasms
G-Quadruplexes
Drug Therapy
Pharmaceutical Preparations
G-Quadruplexes
Platelet-Derived Growth Factor beta Receptor
promoter regions
Arteriosclerosis
Pancreatic Neoplasms
G-Quadruplexes
Drug Delivery Systems
Transcriptional Silencer Elements
Ribosomal DNA
Gene Expression

Research Output 1969 2019

  • 21207 Citations
  • 75 h-Index
  • 272 Article
  • 3 Chapter
  • 1 Comment/debate
  • 1 Letter
1 Citation (Scopus)

Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death

Song, J. H., Kang, H. J., Luevano, L. A., Gokhale, V., Wu, K., Pandey, R., Chow, H-H., Hurley, L. & Kraft, A., Aug 15 2019, In : Cell Chemical Biology. 26, 8, p. 1110-1121.e4

Research output: Contribution to journalArticle

G-Quadruplexes
Telomerase
Cell growth
Cell death
Prostatic Neoplasms
3 Citations (Scopus)

HMGB1 binds to the KRAS promoter G-quadruplex: A new player in oncogene transcriptional regulation?

Amato, J., Madanayake, T. W., Iaccarino, N., Novellino, E., Randazzo, A., Hurley, L. & Pagano, B., Jan 1 2018, In : Chemical Communications. 54, 68, p. 9442-9445 4 p.

Research output: Contribution to journalArticle

HMGB1 Protein
Gene expression
Proteins
Communication
1 Citation (Scopus)

Intracellular speciation of gold nanorods alters the conformational dynamics of genomic DNA

Ho, D., Kretzmann, J. A., Norret, M., Toshniwal, P., Veder, J. P., Jiang, H., Guagliardo, P., Munshi, A. M., Chawla, R., Evans, C. W., Clemons, T. D., Nguyen, M., Kretzmann, A. L., Blythe, A. J., Saunders, M., Archer, M., Fitzgerald, M., Keelan, J. A., Bond, C. S., Kilburn, M. R. & 3 others, Hurley, L., Smith, N. M. & Iyer, K. S., Dec 1 2018, In : Nature Nanotechnology. 13, 12, p. 1148-1153 6 p.

Research output: Contribution to journalLetter

Nanorods
Gold
nanorods
DNA
deoxyribonucleic acid
11 Citations (Scopus)

Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X

Weldon, C., Dacanay, J. G., Gokhale, V., Boddupally, P. V. L., Behm-Ansmant, I., Burley, G. A., Branlant, C., Hurley, L., Dominguez, C. & Eperon, I. C., Jan 25 2018, In : Nucleic Acids Research. 46, 2, p. 886-896 11 p.

Research output: Contribution to journalArticle

G-Quadruplexes
RNA Splice Sites
Alternative Splicing
Ligands
RNA Precursors
2 Citations (Scopus)
G-Quadruplexes
Guanine
Circular dichroism spectroscopy
Molecular recognition
Electrophoretic mobility