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  • 3 Similar Profiles
G-Quadruplexes Medicine & Life Sciences
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Telomerase Medicine & Life Sciences
Anti-Bacterial Agents Medicine & Life Sciences
Guanine Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences

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Projects 1978 2021


Davis, T. P., Hersh, E. M., Weinstein, R. S., Miesfeld, R., Miller, T. P., Tsaprailis, G., Lynch, R., Chow, H., Nagle, R. B., Watts, G. S., Thomson, C., Roe, D., Stratton, S. P., Alberts, D. S., Hurley, L., Baker, A. F., Livingston, R. B., Dorr, R. T., Cress, A. E., Briehl, M. M., Mash, E. A., Duffy, J., Jones, S., Leibovitz, A., Meyskens, F., Moon, T., Trent, J., Newkirk, D., Von Hoff, D., Mount, D., Doetschman, T., Liebler, D., Marshall, J., McGovern, K., Grogan, T., Kraft, A., Powis, G., Peng, Y., Gerner, E., Aickin, M., Ritenbaugh, C., Taylor, C., Powell, M. B., Bowden, T., Taetle, R., Salmon, S., Ignatenko, N., Bhattacharyya, A. K., Futscher, B. W., Barton, J. K., Montfort, W. "., Roe, D., Garland, L. L., Doetschman, T. C., Kraft, A., Chow, H. & Ellis, N.

National Institutes of Health


Project: Research projectCenter Core Grants

Pharmaceutical Services
Research Personnel
Clinical Trials

The Development of Novel Inhibitors of BCL2 Gene Expression as Anticancer Therape

Hurley, L. & Siddiqui-Jain, A.

National Institutes of Health


Project: Research projectSmall Business Innovation Research Grants (SBIR) - Phase I

Gene Expression
Drug Therapy
Pharmaceutical Preparations
Platelet-Derived Growth Factor beta Receptor
promoter regions
Pancreatic Neoplasms
Drug Delivery Systems
Transcriptional Silencer Elements
Ribosomal DNA
Gene Expression

SPORE in Gastrointestinal Cancer

Roe, D., Einspahr, J. G., Bhattacharyya, A. K., Hurley, L., Nelson, M. A., Dragovich, T., Garewal, H. S., Von Hoff, D., Akporiaye, E., Mount, D., Gerner, E., Powis, G., Green, S. B. & Dvorak, K.

National Institutes of Health


Project: Research projectSpecialized Center

Gastrointestinal Neoplasms
Drug Delivery Systems

Research Output 1969 2018

  • 19309 Citations
  • 72 h-Index
  • 269 Article
  • 3 Chapter
  • 1 Comment/debate

Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X

Weldon, C., Dacanay, J. G., Gokhale, V., Boddupally, P. V. L., Behm-Ansmant, I., Burley, G. A., Branlant, C., Hurley, L. H., Dominguez, C. & Eperon, I. C. Jan 25 2018 In : Nucleic acids research. 46, 2, p. 886-896 11 p.

Research output: Contribution to journalArticle

RNA Splice Sites
Alternative Splicing
RNA Precursors
9 Citations

Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA

Weldon, C., Behm-Ansmant, I., Hurley, L. H., Burley, G. A., Branlant, C., Eperon, I. C. & Dominguez, C. Jan 1 2017 In : Nature Chemical Biology. 13, 1, p. 18-20 3 p.

Research output: Contribution to journalArticle

Biological Phenomena
RNA Precursors
10 Citations

Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression

Kaiser, C. E., Van Ert, N. A., Agrawal, P., Chawla, R., Yang, D. & Hurley, L. H. Jun 28 2017 In : Journal of the American Chemical Society. 139, 25, p. 8522-8536 15 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein K
Gene expression
4 Citations

Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma

Liang, W. S. , Hendricks, W. , Kiefer, J. , Schmidt, J. , Sekar, S. , Carpten, J. , Craig, D. W. , Adkins, J. , Cuyugan, L. , Manojlovic, Z. , Halperin, R. F. , Helland, A. , Nasser, S. , Legendre, C. , Hurley, L. H. , Sivaprakasam, K. , Johnson, D. B. , Crandall, H. , Busam, K. J. , Zismann, V. & 6 others Deluca, V., Lee, J., Sekulic, A., Ariyan, C. E., Sosman, J. & Trent, J. Apr 1 2017 In : Genome Research. 27, 4, p. 524-532 9 p.

Research output: Contribution to journalArticle

Solar System
2 Citations
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
Drug Delivery Systems