• 22124 Citations
  • 77 h-Index
1969 …2020

Research output per year

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Research Output

2020

Nucleolin represses transcription of the androgen receptor gene through a G-quadruplex

Miranti, C. K., Moore, S., Kim, Y., Chappeta, V. R., Wu, K., De, B., Gokhale, V., Hurley, L. H. & Reyes-Reyes, E. M., May 12 2020, In : Oncotarget. 11, 19, p. 1758-1776 19 p.

Research output: Contribution to journalArticle

Open Access
2019

In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells

Montoya, J. J., Turnidge, M. A., Wai, D. H., Patel, A. R., Lee, D. W., Gokhale, V., Hurley, L. H., Arceci, R. J., Wetmore, C. & Azorsa, D. O., Dec 27 2019, In : BMC Cancer. 19, 1, 1251.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death

Song, J. H., Kang, H. J., Luevano, L. A., Gokhale, V., Wu, K., Pandey, R., Chow, H-H., Hurley, L. & Kraft, A., Aug 15 2019, In : Cell Chemical Biology. 26, 8, p. 1110-1121.e4

Research output: Contribution to journalArticle

4 Scopus citations

TGF-β-induced fibrotic stress increases G-quadruplex formation in human fibroblasts

Toshniwal, P., Nguyen, M., Guédin, A., Viola, H., Ho, D., Kim, Y., Bhatt, U., Bond, C. S., Hool, L., Hurley, L. H., Mergny, J. L., Fear, M., Wood, F., Iyer, S. K. & Smith, N. M., Nov 1 2019, In : FEBS Letters. 593, 22, p. 3149-3161 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

HMGB1 binds to the KRAS promoter G-quadruplex: A new player in oncogene transcriptional regulation?

Amato, J., Madanayake, T. W., Iaccarino, N., Novellino, E., Randazzo, A., Hurley, L. H. & Pagano, B., Jan 1 2018, In : Chemical Communications. 54, 68, p. 9442-9445 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Intracellular speciation of gold nanorods alters the conformational dynamics of genomic DNA

Ho, D., Kretzmann, J. A., Norret, M., Toshniwal, P., Veder, J. P., Jiang, H., Guagliardo, P., Munshi, A. M., Chawla, R., Evans, C. W., Clemons, T. D., Nguyen, M., Kretzmann, A. L., Blythe, A. J., Saunders, M., Archer, M., Fitzgerald, M., Keelan, J. A., Bond, C. S., Kilburn, M. R. & 3 others, Hurley, L., Smith, N. M. & Iyer, K. S., Dec 1 2018, In : Nature Nanotechnology. 13, 12, p. 1148-1153 6 p.

Research output: Contribution to journalLetter

6 Scopus citations

Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X

Weldon, C., Dacanay, J. G., Gokhale, V., Boddupally, P. V. L., Behm-Ansmant, I., Burley, G. A., Branlant, C., Hurley, L. H., Dominguez, C. & Eperon, I. C., Jan 25 2018, In : Nucleic acids research. 46, 2, p. 886-896 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
5 Scopus citations
2017

Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA

Weldon, C., Behm-Ansmant, I., Hurley, L. H., Burley, G. A., Branlant, C., Eperon, I. C. & Dominguez, C., Jan 1 2017, In : Nature chemical biology. 13, 1, p. 18-20 3 p.

Research output: Contribution to journalArticle

27 Scopus citations

Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression

Kaiser, C. E., Van Ert, N. A., Agrawal, P., Chawla, R., Yang, D. & Hurley, L., Jun 28 2017, In : Journal of the American Chemical Society. 139, 25, p. 8522-8536 15 p.

Research output: Contribution to journalArticle

44 Scopus citations

Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma

Liang, W. S., Hendricks, W., Kiefer, J., Schmidt, J., Sekar, S., Carpten, J., Craig, D. W., Adkins, J., Cuyugan, L., Manojlovic, Z., Halperin, R. F., Helland, A., Nasser, S., Legendre, C., Hurley, L., Sivaprakasam, K., Johnson, D. B., Crandall, H., Busam, K. J., Zismann, V. & 6 others, Deluca, V., Lee, J., Sekulic, A., Ariyan, C. E., Sosman, J. & Trent, J., Apr 1 2017, In : Genome Research. 27, 4, p. 524-532 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Simultaneous Drug Targeting of the Promoter MYC G-Quadruplex and BCL2 i-Motif in Diffuse Large B-Cell Lymphoma Delays Tumor Growth

Kendrick, S., Muranyi, A., Gokhale, V., Hurley, L. & Rimsza, L. M., Aug 10 2017, In : Journal of Medicinal Chemistry. 60, 15, p. 6587-6597 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
32 Scopus citations
2016

A Mechanosensor Mechanism Controls the G-Quadruplex/i-Motif Molecular Switch in the MYC Promoter NHE III1

Sutherland, C., Cui, Y., Mao, H. & Hurley, L. H., Oct 26 2016, In : Journal of the American Chemical Society. 138, 42, p. 14138-14151 14 p.

Research output: Contribution to journalArticle

46 Scopus citations

A Pharmacological Chaperone Molecule Induces Cancer Cell Death by Restoring Tertiary DNA Structures in Mutant hTERT Promoters

Kang, H. J., Cui, Y., Yin, H., Scheid, A., Hendricks, W. P. D., Schmidt, J., Sekulic, A., Kong, D., Trent, J. M., Gokhale, V., Mao, H. & Hurley, L. H., Oct 19 2016, In : Journal of the American Chemical Society. 138, 41, p. 13673-13692 20 p.

Research output: Contribution to journalArticle

35 Scopus citations

Interaction of Individual Structural Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA

Roy, B., Talukder, P., Kang, H. J., Tsuen, S. S., Alam, M. P., Hurley, L. & Hecht, S. M., Aug 31 2016, In : Journal of the American Chemical Society. 138, 34, p. 10950-10962 13 p.

Research output: Contribution to journalArticle

25 Scopus citations
2014

Molecular population dynamics of DNA structures in a bcl-2 promoter sequence is regulated by small molecules and the transcription factor hnRNP LL

Cui, Y., Koirala, D., Kang, H. J., Dhakal, S., Yangyuoru, P., Hurley, L. H. & Mao, H., May 2014, In : Nucleic acids research. 42, 9, p. 5755-5764 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure

Kendrick, S., Kang, H. J., Alam, M. P., Madathil, M. M., Agrawal, P., Gokhale, V., Yang, D., Hecht, S. M. & Hurley, L. H., Mar 19 2014, In : Journal of the American Chemical Society. 136, 11, p. 4161-4171 11 p.

Research output: Contribution to journalArticle

126 Scopus citations

The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules

Kang, H. J., Kendrick, S., Hecht, S. M. & Hurley, L. H., Mar 19 2014, In : Journal of the American Chemical Society. 136, 11, p. 4172-4185 14 p.

Research output: Contribution to journalArticle

110 Scopus citations
2013

DNA structure: Visualizing the quadruplex

Siddiqui-Jain, A. & Hurley, L. H., Mar 1 2013, In : Nature Chemistry. 5, 3, p. 153-155 3 p.

Research output: Contribution to journalArticle

19 Scopus citations

Gaining insights into the small molecule targeting of the G-QUADRUPLEX in the c-MYC promoter using NMR and an allele-specific transcriptional assay

Kaiser, C. E., Gokhale, V., Yang, D. & Hurley, L. H., Apr 11 2013, Quadruplex Nucleic Acids. Chaires, J. B. & Graves, D. (eds.). p. 1-22 22 p. (Topics in Current Chemistry; vol. 330).

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations
2012

Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter

Boddupally, P. V. L., Hahn, S., Beman, C., De, B., Brooks, T. A., Gokhale, V. & Hurley, L. H., Jul 12 2012, In : Journal of Medicinal Chemistry. 55, 13, p. 6076-6086 11 p.

Research output: Contribution to journalArticle

64 Scopus citations

Tertiary DNA structure in the single-stranded hTERT promoter fragment unfolds and refolds by parallel pathways via cooperative or sequential events

Yu, Z., Gaerig, V., Cui, Y., Kang, H., Gokhale, V., Zhao, Y., Hurley, L. H. & Mao, H., Mar 21 2012, In : Journal of the American Chemical Society. 134, 11, p. 5157-5164 8 p.

Research output: Contribution to journalArticle

52 Scopus citations

The major G-quadruplex formed in the human platelet-derived growth factor receptor β promoter adopts a novel broken-strand structure in K+ solution

Chen, Y., Agrawal, P., Brown, R. V., Hatzakis, E., Hurley, L. & Yang, D., Aug 15 2012, In : Journal of the American Chemical Society. 134, 32, p. 13220-13223 4 p.

Research output: Contribution to journalArticle

34 Scopus citations
2011

3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol

Nichol, G. S., Boddupally, P. V. L., De, B. & Hurley, L. H., Dec 1 2011, In : Acta Crystallographica Section E: Structure Reports Online. 67, 12, p. o3465-o3466

Research output: Contribution to journalArticle

Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex

Brown, R. V., Danford, F. L., Gokhale, V., Hurley, L. H. & Brooks, T. A., Nov 25 2011, In : Journal of Biological Chemistry. 286, 47, p. 41018-41027 10 p.

Research output: Contribution to journalArticle

92 Scopus citations

DNA acting like RNA

Brown, R. V. & Hurley, L. H., Apr 1 2011, In : Biochemical Society transactions. 39, 2, p. 635-640 6 p.

Research output: Contribution to journalReview article

9 Scopus citations

Solution structure of a 2:1 quindoline-c-MYC G-quadruplex: Insights into G-quadruplex-interactive small molecule drug design

Dai, J., Carver, M., Hurley, L. H. & Yang, D., Nov 9 2011, In : Journal of the American Chemical Society. 133, 44, p. 17673-17680 8 p.

Research output: Contribution to journalArticle

188 Scopus citations

Targeting G-quadruplexes in gene promoters: A novel anticancer strategy?

Balasubramanian, S., Hurley, L. H. & Neidle, S., Apr 1 2011, In : Nature Reviews Drug Discovery. 10, 4, p. 261-275 15 p.

Research output: Contribution to journalArticle

963 Scopus citations

The vitamin E analog, alpha-tocopheryloxyacetic acid enhances the anti-tumor activity of trastuzumab against HER2/neu-expressing breast cancer

Hahn, T., Bradley-Dunlop, D. J., Hurley, L. H., Von-Hoff, D., Gately, S., Mary, D. L., Lu, H., Penichet, M. L., Besselsen, D. G., Cole, B. B., Meeuwsen, T., Walker, E. & Akporiaye, E. T., Nov 2 2011, In : BMC Cancer. 11, 471.

Research output: Contribution to journalArticle

16 Scopus citations
2010
37 Scopus citations
79 Scopus citations

I-motif structures formed in the human c-MYC promoter are highly dynamic-insights into sequence redundancy and I-motif stability

Dai, J., Hatzakis, E., Hurley, L. H. & Yang, D., Jul 19 2010, In : PloS one. 5, 7, e11647.

Research output: Contribution to journalArticle

38 Scopus citations

Making sense of G-quadruplex and i-motif functions in oncogene promoters

Brooks, T. A., Kendrick, S. & Hurley, L., Sep 2010, In : FEBS Journal. 277, 17, p. 3459-3469 11 p.

Research output: Contribution to journalShort survey

279 Scopus citations

Molecular cloning of the human platelet-derived growth factor receptor β (PDGFR-β) promoter and drug targeting of the g-quadruplex-forming region to repress PDGFR-β expression

Qin, Y., Fortin, J. S., Tye, D., Gleason-Guzman, M., Brooks, T. A. & Hurley, L. H., May 18 2010, In : Biochemistry. 49, 19, p. 4208-4219 12 p.

Research output: Contribution to journalArticle

52 Scopus citations

The c-MYC NHE III1: Function and regulation

Gonzalez, V. & Hurley, L. H., Feb 10 2010, In : Annual Review of Pharmacology and Toxicology. 50, p. 111-129 19 p.

Research output: Contribution to journalReview article

105 Scopus citations

The C-terminus of nucleolin promotes the formation of the c-MYC G-quadruplex and inhibits c-MYC promoter activity

González, V. & Hurley, L. H., Nov 16 2010, In : Biochemistry. 49, 45, p. 9706-9714 9 p.

Research output: Contribution to journalArticle

67 Scopus citations
79 Scopus citations

The role of G-quadruplex/i-motif secondary structures as cis-acting regulatory elements

Kendrick, S. & Hurley, L. H., Sep 6 2010, In : Pure and Applied Chemistry. 82, 8, p. 1609-1621 13 p.

Research output: Contribution to journalArticle

49 Scopus citations
2009

A direct and nondestructive approach to determine the folding structure of the I-motif DNA secondary structure by NMR

Dai, J., Ambrus, A., Hurley, L. H. & Yang, D., May 6 2009, In : Journal of the American Chemical Society. 131, 17, p. 6102-6104 3 p.

Research output: Contribution to journalArticle

32 Scopus citations

Characterization of novel diaryl oxazole-based compounds as potential agents to treat pancreatic cancer

Shaw, A. Y., Henderson, M. C., Flynn, G., Samulitis, B., Han, H., Stratton, S. P., Chow, H. H. S., Hurley, L. H. & Dorr, R. T., Nov 1 2009, In : Journal of Pharmacology and Experimental Therapeutics. 331, 2, p. 636-647 12 p.

Research output: Contribution to journalArticle

27 Scopus citations
146 Scopus citations

Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein

González, V., Guo, K., Hurley, L. & Sun, D., Aug 28 2009, In : Journal of Biological Chemistry. 284, 35, p. 23622-23635 14 p.

Research output: Contribution to journalArticle

168 Scopus citations

Modulating the functional contributions of c-Myc to the human endothelial cell cyclic strain response

Hurley, N. E., Schildmeyer, L. A., Bosworth, K. A., Sakurai, Y., Eskin, S. G., Hurley, L. H. & McIntire, L. V., Jan 1 2009, In : Journal of Vascular Research. 47, 1, p. 80-90 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III 1

Dexheimer, T. S., Carey, S. S., Zuohe, S., Gokhale, V. M., Hu, X., Murata, L. B., Maes, E. M., Weichsel, A., Sun, D., Meuillet, E. J., Montfort, W. R. & Hurley, L. H., May 1 2009, In : Molecular Cancer Therapeutics. 8, 5, p. 1363-1377 15 p.

Research output: Contribution to journalArticle

71 Scopus citations

Orally active α-tocopheryloxyacetic acid suppresses tumor growth and multiplicity of spontaneous murine breast cancer

Hahn, T., Fried, K., Hurley, L. H. & Akporiaye, E. T., Jun 2009, In : Molecular Cancer Therapeutics. 8, 6, p. 1570-1578 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern

Kendrick, S., Akiyama, Y., Hecht, S. M. & Hurley, L. H., Dec 9 2009, In : Journal of the American Chemical Society. 131, 48, p. 17667-17676 10 p.

Research output: Contribution to journalArticle

92 Scopus citations
228 Scopus citations

The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics

Brooks, T. A. & Hurley, L. H., Dec 1 2009, In : Nature Reviews Cancer. 9, 12, p. 849-861 13 p.

Research output: Contribution to journalReview article

198 Scopus citations

UA62784, a novel inhibitor of centromere protein E kinesin-like protein

Henderson, M. C., Shaw, Y. J. Y., Wang, H., Han, H., Hurley, L. H., Flynn, G., Dorr, R. T. & Von Hoff, D. D., Jan 1 2009, In : Molecular Cancer Therapeutics. 8, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

30 Scopus citations