• 21324 Citations
  • 75 h-Index
1969 …2021
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Research Output 1969 2019

  • 21324 Citations
  • 75 h-Index
  • 272 Article
  • 3 Chapter
  • 1 Comment/debate
  • 1 Letter
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Article
2019
1 Citation (Scopus)

Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death

Song, J. H., Kang, H. J., Luevano, L. A., Gokhale, V., Wu, K., Pandey, R., Chow, H-H., Hurley, L. & Kraft, A., Aug 15 2019, In : Cell Chemical Biology. 26, 8, p. 1110-1121.e4

Research output: Contribution to journalArticle

G-Quadruplexes
Telomerase
Cell growth
Cell death
Prostatic Neoplasms
2018
3 Citations (Scopus)

HMGB1 binds to the KRAS promoter G-quadruplex: A new player in oncogene transcriptional regulation?

Amato, J., Madanayake, T. W., Iaccarino, N., Novellino, E., Randazzo, A., Hurley, L. & Pagano, B., Jan 1 2018, In : Chemical Communications. 54, 68, p. 9442-9445 4 p.

Research output: Contribution to journalArticle

HMGB1 Protein
Gene expression
Proteins
Communication
11 Citations (Scopus)

Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X

Weldon, C., Dacanay, J. G., Gokhale, V., Boddupally, P. V. L., Behm-Ansmant, I., Burley, G. A., Branlant, C., Hurley, L., Dominguez, C. & Eperon, I. C., Jan 25 2018, In : Nucleic Acids Research. 46, 2, p. 886-896 11 p.

Research output: Contribution to journalArticle

G-Quadruplexes
RNA Splice Sites
Alternative Splicing
Ligands
RNA Precursors
2 Citations (Scopus)
G-Quadruplexes
Guanine
Circular dichroism spectroscopy
Molecular recognition
Electrophoretic mobility
2017
23 Citations (Scopus)

Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA

Weldon, C., Behm-Ansmant, I., Hurley, L., Burley, G. A., Branlant, C., Eperon, I. C. & Dominguez, C., Jan 1 2017, In : Nature Chemical Biology. 13, 1, p. 18-20 3 p.

Research output: Contribution to journalArticle

G-Quadruplexes
RNA
Biological Phenomena
RNA Precursors
7-deazaguanine
33 Citations (Scopus)

Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression

Kaiser, C. E., Van Ert, N. A., Agrawal, P., Chawla, R., Yang, D. & Hurley, L., Jun 28 2017, In : Journal of the American Chemical Society. 139, 25, p. 8522-8536 15 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein K
G-Quadruplexes
Transcription
Gene expression
Benzophenanthridines
14 Citations (Scopus)

Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma

Liang, W. S., Hendricks, W., Kiefer, J., Schmidt, J., Sekar, S., Carpten, J., Craig, D. W., Adkins, J., Cuyugan, L., Manojlovic, Z., Halperin, R. F., Helland, A., Nasser, S., Legendre, C., Hurley, L., Sivaprakasam, K., Johnson, D. B., Crandall, H., Busam, K. J., Zismann, V. & 6 others, Deluca, V., Lee, J., Sekulic, A., Ariyan, C. E., Sosman, J. & Trent, J., Apr 1 2017, In : Genome Research. 27, 4, p. 524-532 9 p.

Research output: Contribution to journalArticle

Melanoma
Extremities
Skin
Mutation
Solar System
16 Citations (Scopus)

Simultaneous Drug Targeting of the Promoter MYC G-Quadruplex and BCL2 i-Motif in Diffuse Large B-Cell Lymphoma Delays Tumor Growth

Kendrick, S., Muranyi, A., Gokhale, V., Hurley, L. & Rimsza, L. M., Aug 10 2017, In : Journal of Medicinal Chemistry. 60, 15, p. 6587-6597 11 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
Drug Delivery Systems
ellipticine
27 Citations (Scopus)
G-Quadruplexes
Platelet-Derived Growth Factor Receptors
Cytosine
Platelets
Gene expression
2016
35 Citations (Scopus)

A Mechanosensor Mechanism Controls the G-Quadruplex/i-Motif Molecular Switch in the MYC Promoter NHE III1

Sutherland, C., Cui, Y., Mao, H. & Hurley, L., Oct 26 2016, In : Journal of the American Chemical Society. 138, 42, p. 14138-14151 14 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein K
G-Quadruplexes
Transcription
Chemical activation
Switches
29 Citations (Scopus)

A Pharmacological Chaperone Molecule Induces Cancer Cell Death by Restoring Tertiary DNA Structures in Mutant hTERT Promoters

Kang, H. J., Cui, Y., Yin, H., Scheid, A., Hendricks, W. P. D., Schmidt, J., Sekulic, A., Kong, D., Trent, J. M., Gokhale, V., Mao, H. & Hurley, L., Oct 19 2016, In : Journal of the American Chemical Society. 138, 41, p. 13673-13692 20 p.

Research output: Contribution to journalArticle

Cell death
Transcription
DNA
Cell Death
Pharmacology
22 Citations (Scopus)

Interaction of Individual Structural Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA

Roy, B., Talukder, P., Kang, H. J., Tsuen, S. S., Alam, M. P., Hurley, L. & Hecht, S. M., Aug 31 2016, In : Journal of the American Chemical Society. 138, 34, p. 10950-10962 13 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein L
Nucleotide Motifs
B-Cell Lymphoma
DNA
Genes
2014
23 Citations (Scopus)

Molecular population dynamics of DNA structures in a bcl-2 promoter sequence is regulated by small molecules and the transcription factor hnRNP LL

Cui, Y., Koirala, D., Kang, H., Dhakal, S., Yangyuoru, P., Hurley, L. & Mao, H., 2014, In : Nucleic Acids Research. 42, 9, p. 5755-5764 10 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoproteins
Population Dynamics
Molecular Dynamics Simulation
Transcription Factors
DNA
114 Citations (Scopus)

The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure

Kendrick, S., Kang, H. J., Alam, M. P., Madathil, M. M., Agrawal, P., Gokhale, V., Yang, D., Hecht, S. M. & Hurley, L., Mar 19 2014, In : Journal of the American Chemical Society. 136, 11, p. 4161-4171 11 p.

Research output: Contribution to journalArticle

Gene expression
DNA
Modulation
Gene Expression
Stabilization
101 Citations (Scopus)

The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules

Kang, H. J., Kendrick, S., Hecht, S. M. & Hurley, L., Mar 19 2014, In : Journal of the American Chemical Society. 136, 11, p. 4172-4185 14 p.

Research output: Contribution to journalArticle

Switch Genes
Heterogeneous-Nuclear Ribonucleoproteins
Gene expression
Switches
Gene Expression
2013
18 Citations (Scopus)

DNA structure: Visualizing the quadruplex

Siddiqui-Jain, A. & Hurley, L., Mar 2013, In : Nature Chemistry. 5, 3, p. 153-155 3 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Animals
DNA
2012
61 Citations (Scopus)

Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter

Boddupally, P. V. L., Hahn, S., Beman, C., De, B., Brooks, T. A., Gokhale, V. & Hurley, L., Jul 12 2012, In : Journal of Medicinal Chemistry. 55, 13, p. 6076-6086 11 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Transcriptional Silencer Elements
Burkitt Lymphoma
Gene Expression
Cell Line
50 Citations (Scopus)

Tertiary DNA structure in the single-stranded hTERT promoter fragment unfolds and refolds by parallel pathways via cooperative or sequential events

Yu, Z., Gaerig, V., Cui, Y., Kang, H., Gokhale, V., Zhao, Y., Hurley, L. & Mao, H., Mar 21 2012, In : Journal of the American Chemical Society. 134, 11, p. 5157-5164 8 p.

Research output: Contribution to journalArticle

G-Quadruplexes
DNA
Single-Stranded DNA
Optical Tweezers
Telomerase
32 Citations (Scopus)

The major G-quadruplex formed in the human platelet-derived growth factor receptor β promoter adopts a novel broken-strand structure in K+ solution

Chen, Y., Agrawal, P., Brown, R. V., Hatzakis, E., Hurley, L. & Yang, D., Aug 15 2012, In : Journal of the American Chemical Society. 134, 32, p. 13220-13223 4 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Platelet-Derived Growth Factor Receptors
Nucleotides
Platelets
Genes
2011

3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol

Nichol, G. S., Boddupally, P. V. L., De, B. & Hurley, L., Dec 2011, In : Acta Crystallographica Section E: Structure Reports Online. 67, 12

Research output: Contribution to journalArticle

quinoline
Propanol
Conformations
Hydrogen bonds
1-Propanol
84 Citations (Scopus)

Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex

Brown, R. V., Danford, F. L., Gokhale, V., Hurley, L. & Brooks, T. A., Nov 25 2011, In : Journal of Biological Chemistry. 286, 47, p. 41018-41027 10 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Non-Hodgkin's Lymphoma
Demonstrations
Down-Regulation
NSC 338258
9 Citations (Scopus)

DNA acting like RNA

Brown, R. V. & Hurley, L., Apr 2011, In : Biochemical Society Transactions. 39, 2, p. 635-640 6 p.

Research output: Contribution to journalArticle

RNA
G-Quadruplexes
DNA
Gene expression
Ions
169 Citations (Scopus)

Solution structure of a 2: 1 quindoline-c-MYC G-quadruplex: Insights into G-quadruplex-interactive small molecule drug design

Dai, J., Carver, M., Hurley, L. & Yang, D., Nov 9 2011, In : Journal of the American Chemical Society. 133, 44, p. 17673-17680 8 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Drug Design
DNA
Genes
Ligands
886 Citations (Scopus)

Targeting G-quadruplexes in gene promoters: A novel anticancer strategy?

Balasubramanian, S., Hurley, L. & Neidle, S., Apr 2011, In : Nature Reviews Drug Discovery. 10, 4, p. 261-275 15 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Genes
Oncogenes
Genetic Promoter Regions
Ligands
16 Citations (Scopus)

The vitamin E analog, alpha-tocopheryloxyacetic acid enhances the anti-tumor activity of trastuzumab against HER2/neu-expressing breast cancer

Hahn, T., Bradley-Dunlop, D. J., Hurley, L., Von-Hoff, D., Gately, S., Mary, D. L., Lu, H., Penichet, M. L., Besselsen, D. G., Cole, B. B., Meeuwsen, T., Walker, E. & Akporiaye, E. T., Nov 2 2011, In : BMC Cancer. 11, 471.

Research output: Contribution to journalArticle

Vitamin E
Breast Neoplasms
Neoplasms
Poisons
Heterografts
2010
34 Citations (Scopus)
Imidazoles
Cycloaddition
Cycloaddition Reaction
Proto-Oncogene Proteins B-raf
Phosphotransferases
72 Citations (Scopus)
G-Quadruplexes
Electrophoretic Mobility Shift Assay
DNA-Directed DNA Polymerase
Guanine
Genetic Promoter Regions
35 Citations (Scopus)

I-motif structures formed in the human c-MYC promoter are highly dynamic-insights into sequence redundancy and I-motif stability

Dai, J., Hatzakis, E., Hurley, L. & Yang, D., Jul 19 2010, In : PLoS One. 5, 7, e11647.

Research output: Contribution to journalArticle

nucleases
cytosine
Cytosine
hypersensitivity
Redundancy
261 Citations (Scopus)

Making sense of G-quadruplex and i-motif functions in oncogene promoters

Brooks, T. A., Kendrick, S. & Hurley, L., 2010, In : FEBS Journal. 277, 17, p. 3459-3469 11 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Bioinformatics
Oncogenes
DNA
Computational Biology
50 Citations (Scopus)

Molecular cloning of the human platelet-derived growth factor receptor β (PDGFR-β) promoter and drug targeting of the g-quadruplex-forming region to repress PDGFR-β expression

Qin, Y., Fortin, J. S., Tye, D., Gleason-Guzman, M., Brooks, T. A. & Hurley, L., May 18 2010, In : Biochemistry. 49, 19, p. 4208-4219 12 p.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor Receptors
Cloning
G-Quadruplexes
Molecular Cloning
Drug Delivery Systems
100 Citations (Scopus)

The c-MYC NHE III1: Function and regulation

Gonzalez, V. & Hurley, L., Feb 10 2010, In : Annual Review of Pharmacology and Toxicology. 50, p. 111-129 19 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Cell growth
Transcription
Antineoplastic Agents
Chemical activation
60 Citations (Scopus)

The C-terminus of nucleolin promotes the formation of the c-MYC G-quadruplex and inhibits c-MYC promoter activity

González, V. & Hurley, L., Nov 16 2010, In : Biochemistry. 49, 45, p. 9706-9714 9 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Transcription
Cell proliferation
Glycine
Cell Proliferation
74 Citations (Scopus)
Structural analysis
Phosphotransferases
Binding Sites
Adenosine Triphosphate
Allosteric Site
47 Citations (Scopus)

The role of G-quadruplex/i-motif secondary structures as cis-acting regulatory elements

Kendrick, S. & Hurley, L., 2010, In : Pure and Applied Chemistry. 82, 8, p. 1609-1621 13 p.

Research output: Contribution to journalArticle

DNA
Transcription
Conformations
Demonstrations
Genes
2009
32 Citations (Scopus)

A direct and nondestructive approach to determine the folding structure of the I-motif DNA secondary structure by NMR

Dai, J., Ambrus, A., Hurley, L. & Yang, D., May 6 2009, In : Journal of the American Chemical Society. 131, 17, p. 6102-6104 3 p.

Research output: Contribution to journalArticle

Nucleotide Motifs
DNA sequences
DNA
Cytosine
Nuclear magnetic resonance
23 Citations (Scopus)

Characterization of novel diaryl oxazole-based compounds as potential agents to treat pancreatic cancer

Shaw, A. Y., Henderson, M. C., Flynn, G., Samulitis, B., Han, H., Stratton, S. P., Chow, H-H., Hurley, L. & Dorr, R. T., Nov 2009, In : Journal of Pharmacology and Experimental Therapeutics. 331, 2, p. 636-647 12 p.

Research output: Contribution to journalArticle

Oxazoles
Pancreatic Neoplasms
Kinesin
Cell Line
Protein Kinases
139 Citations (Scopus)
G-Quadruplexes
Telomerase
Assays
Ligands
Taq Polymerase
150 Citations (Scopus)

Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein

González, V., Guo, K., Hurley, L. & Sun, D., Aug 28 2009, In : Journal of Biological Chemistry. 284, 35, p. 23622-23635 14 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Carrier Proteins
Proto-Oncogenes
Phosphoproteins
Guanine
16 Citations (Scopus)

Modulating the functional contributions of c-Myc to the human endothelial cell cyclic strain response

Hurley, N. E., Schildmeyer, L. A., Bosworth, K. A., Sakurai, Y., Eskin, S. G., Hurley, L. & McIntire, L. V., Jan 2009, In : Journal of Vascular Research. 47, 1, p. 80-90 11 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-myc
Human Umbilical Vein Endothelial Cells
Endothelial Cells
Vascular Diseases
Messenger RNA
65 Citations (Scopus)

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III 1

Dexheimer, T. S., Carey, S. S., Zuohe, S., Gokhale, V., Hu, X., Murata, L. B., Maes, E. M., Weichsel, A., Sun, D., Meuillet, E., Montfort, W. B. & Hurley, L., May 1 2009, In : Molecular Cancer Therapeutics. 8, 5, p. 1363-1377 15 p.

Research output: Contribution to journalArticle

myc Genes
G-Quadruplexes
Transcriptional Activation
NM23 Nucleoside Diphosphate Kinases
Gene Expression
21 Citations (Scopus)

Orally active α-tocopheryloxyacetic acid suppresses tumor growth and multiplicity of spontaneous murine breast cancer

Hahn, T., Fried, K., Hurley, L. & Akporiaye, E. T., Jun 2009, In : Molecular Cancer Therapeutics. 8, 6, p. 1570-1578 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Acids
Growth
Neoplasms
Drug-Related Side Effects and Adverse Reactions
86 Citations (Scopus)

The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8: 5:7 loop folding pattern

Kendrick, S., Akiyama, Y., Hecht, S. M. & Hurley, L., Dec 9 2009, In : Journal of the American Chemical Society. 131, 48, p. 17667-17676 10 p.

Research output: Contribution to journalArticle

Cytosine
Guanine
DNA
G-Quadruplexes
Thymine
216 Citations (Scopus)
G-Quadruplexes
Drug and Narcotic Control
Drug Delivery Systems
Gene Expression
Single-Stranded DNA
189 Citations (Scopus)

The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics

Brooks, T. A. & Hurley, L., Dec 2009, In : Nature Reviews Cancer. 9, 12, p. 849-861 13 p.

Research output: Contribution to journalArticle

DNA
Therapeutics
Oncogenes
Neoplasms
30 Citations (Scopus)

UA62784, a novel inhibitor of centromere protein E kinesin-like protein

Henderson, M. C., Shaw, Y. J. Y., Wang, H., Han, H., Hurley, L., Flynn, G., Dorr, R. T. & Von Hoff, D. D., Jan 1 2009, In : Molecular Cancer Therapeutics. 8, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

Kinesin
Proteins
Antimitotic Agents
Kinetochores
Gene Deletion
2008
122 Citations (Scopus)

A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity

Palumbo, S. L., Memmott, R. M., Uribe, D. J., Krotova-Khan, Y., Hurley, L. & Ebbinghaus, S. W., Apr 2008, In : Nucleic Acids Research. 36, 6, p. 1755-1769 15 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Circular DNA
Transcription Initiation Site
Zinc Fingers
DNA-Directed DNA Polymerase
105 Citations (Scopus)
G-Quadruplexes
Vascular Endothelial Growth Factor A
Cytosine
Guanine
Circular Dichroism
23 Citations (Scopus)

Molecular modeling and biophysical analysis of the c-MYC NHE-III1 silencer element

Cashman, D. J., Buscaglia, R., Freyer, M. W., Dettler, J., Hurley, L. & Lewis, E. A., Feb 2008, In : Journal of Molecular Modeling. 14, 2, p. 93-101 9 p.

Research output: Contribution to journalArticle

Transcriptional Silencer Elements
silencers
nuclease
G-Quadruplexes
Molecular modeling
3 Citations (Scopus)

Psorospermin structural requirements for P-glycoprotein resistance reversal

Carey, S. S., Gleason-Guzman, M., Gokhale, V. & Hurley, L., Nov 1 2008, In : Molecular Cancer Therapeutics. 7, 11, p. 3617-3623 7 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Multiple Myeloma
Doxorubicin
psorospermin
Drug Therapy
317 Citations (Scopus)

Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions

Qin, Y. & Hurley, L., Aug 2008, In : Biochimie. 90, 8, p. 1149-1171 23 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Genetic Promoter Regions
Genes
DNA
Cells