Lee D Cranmer

  • 3947 Citations
  • 28 h-Index
1991 …2019

Research output per year

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Research Output

  • 3947 Citations
  • 28 h-Index
  • 52 Article
  • 10 Review article
  • 1 Letter
  • 1 Short survey
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Article
2019

Economic Evaluation of Talimogene Laherparepvec Plus Ipilimumab Combination Therapy vs Ipilimumab Monotherapy in Patients with Advanced Unresectable Melanoma

Almutairi, A. R., Alkhatib, N. S., Oh, M., Curiel-Lewandrowski, C., Babiker, H. M., Cranmer, L. D., McBride, A. & Abraham, I., Jan 2019, In : JAMA Dermatology. 155, 1, p. 22-28 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Systemic Interferon-g Increases MHC Class I Expression and T-cell Infiltration in Cold Tumors: Results of a phase 0 clinical trial

Zhang, S., Kohli, K., Graeme Black, R., Yao, L., Spadinger, S. M., He, Q., Pillarisetty, V. G., Cranmer, L. D., Van Tine, B. A., Yee, C., Pierce, R. H., Riddell, S. R., Jones, R. L. & Pollack, S. M., Jan 1 2019, In : Cancer Immunology Research. 7, 8, p. 1237-1243 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

A multi-center phase II study of high dose interleukin-2 sequenced with vemurafenib in patients with BRAF-V600 mutation positive metastatic melanoma

Clark, J. I., Singh, J., Ernstoff, M. S., Lao, C. D., Flaherty, L. E., Logan, T. F., Curti, B., Agarwala, S. S., Taback, B., Cranmer, L. D., Lutzky, J., Luna, T. L., Aung, S. & Lawson, D. H., Jul 27 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 76.

Research output: Contribution to journalArticle

6 Scopus citations

Performance of a prognostic 31-gene expression profile in an independent cohort of 523 cutaneous melanoma patients

Zager, J. S., Gastman, B. R., Leachman, S., Gonzalez, R. C., Fleming, M. D., Ferris, L. K., Ho, J., Miller, A. R., Cook, R. W., Covington, K. R., Meldi-Plasseraud, K., Middlebrook, B., Kaminester, L. H., Greisinger, A., Estrada, S. I., Pariser, D. M., Cranmer, L. D., Messina, J. L., Vetto, J. T., Wayne, J. D. & 3 others, Delman, K. A., Lawson, D. H. & Gerami, P., Feb 5 2018, In : BMC Cancer. 18, 1, 130.

Research output: Contribution to journalArticle

25 Scopus citations

Response to PD1 inhibition in conventional chondrosarcoma 11 Medical and Health Sciences 1103 Clinical Sciences 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis

Wagner, M. J., Ricciotti, R. W., Mantilla, J., Loggers, E. T., Pollack, S. M. & Cranmer, L. D., Sep 25 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 94.

Research output: Contribution to journalArticle

3 Scopus citations
2017

16S rRNA gene sequencing on a benchtop sequencer: accuracy for identification of clinically important bacteria

Watts, G. S., Youens-Clark, K., Slepian, M. J., Wolk, D., Oshiro, M. M., Metzger, G. S., Dhingra, D., Cranmer, L. D. & Hurwitz, B. L., Dec 1 2017, In : Journal of Applied Microbiology. 123, 6, p. 1584-1596 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Angiosarcoma treated successfully with anti-PD-1 therapy - a case report

Sindhu, S., Gimber, L. H., Cranmer, L., McBride, A. & Kraft, A. S., Jul 18 2017, In : Journal for ImmunoTherapy of Cancer. 5, 1, 58.

Research output: Contribution to journalArticle

28 Scopus citations

Doxorubicin plus evofosfamide versus doxorubicin alone in locally advanced, unresectable or metastatic soft-tissue sarcoma (TH CR-406/SARC021): an international, multicentre, open-label, randomised phase 3 trial

Tap, W. D., Papai, Z., Van Tine, B. A., Attia, S., Ganjoo, K. N., Jones, R. L., Schuetze, S., Reed, D., Chawla, S. P., Riedel, R. F., Krarup-Hansen, A., Toulmonde, M., Ray-Coquard, I., Hohenberger, P., Grignani, G., Cranmer, L. D., Okuno, S., Agulnik, M., Read, W., Ryan, C. W. & 8 others, Alcindor, T., del Muro, X. F. G., Budd, G. T., Tawbi, H., Pearce, T., Kroll, S., Reinke, D. K. & Schöffski, P., Aug 2017, In : The Lancet Oncology. 18, 8, p. 1089-1103 15 p.

Research output: Contribution to journalArticle

59 Scopus citations

Final analysis of a randomised trial comparing pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory advanced melanoma

Hamid, O., Puzanov, I., Dummer, R., Schachter, J., Daud, A., Schadendorf, D., Blank, C., Cranmer, L. D., Robert, C., Pavlick, A. C., Gonzalez, R., Hodi, F. S., Ascierto, P. A., Salama, A. K. S., Margolin, K. A., Gangadhar, T. C., Wei, Z., Ebbinghaus, S., Ibrahim, N. & Ribas, A., Nov 1 2017, In : European Journal of Cancer. 86, p. 37-45 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Impact of Sequencing Targeted Therapies With High-dose Interleukin-2 Immunotherapy: An Analysis of Outcome and Survival of Patients With Metastatic Renal Cell Carcinoma From an On-going Observational IL-2 Clinical Trial: PROCLAIMSM

Clark, J. I., Wong, M. K. K., Kaufman, H. L., Daniels, G. A., Morse, M. A., McDermott, D. F., Agarwala, S. S., Lewis, L. D., Stewart, J. H., Vaishampayan, U., Curti, B., Gonzalez, R., Lutzky, J., Rudraptna, V., Cranmer, L. D., Jeter, J. M., Hauke, R. J., Miletello, G., Milhem, M. M., Amin, A. & 14 others, Richart, J. M., Fishman, M., Hallmeyer, S., Patel, S. P., Van Veldhuizen, P., Agarwal, N., Taback, B., Treisman, J. S., Ernstoff, M. S., Perritt, J. C., Hua, H., Rao, T. B., Dutcher, J. P. & Aung, S., Feb 1 2017, In : Clinical Genitourinary Cancer. 15, 1, p. 31-41.e4

Research output: Contribution to journalArticle

16 Scopus citations

Recurrent Osteosarcoma Presenting as an Isolated Bone Marrow Relapse

Liu, J., Cranmer, L. D., Larsen, B. T., Kuo, P. H. & Kopp, L. M., 2017, In : Journal of Pediatric Hematology/Oncology. 39, 4, p. 302-305 4 p.

Research output: Contribution to journalArticle

T-cell infiltration and clonality correlate with programmed cell death protein 1 and programmed death-ligand 1 expression in patients with soft tissue sarcomas

Pollack, S. M., He, Q., Yearley, J. H., Emerson, R., Vignali, M., Zhang, Y., Redman, M. W., Baker, K. K., Cooper, S., Donahue, B., Loggers, E. T., Cranmer, L. D., Spraker, M. B., Seo, Y. D., Pillarisetty, V. G., Ricciotti, R. W., Hoch, B. L., Mcclanahan, T. K., Murphy, E., Blumenschein, W. M. & 4 others, Townson, S. M., Benzeno, S., Riddell, S. R. & Jones, R. L., 2017, (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

60 Scopus citations

Vemurafenib treatment for patients with locally advanced, unresectable stage IIIC or metastatic melanoma and activating exon 15 BRAF mutations other than V600E

Hallmeyer, S., Gonzalez, R., Lawson, D. H., Cranmer, L. D., Linette, G. P., Puzanov, I., Taback, B., Cowey, C. L., Ribas, A., Daniels, G. A., Moore, T., Gibney, G. T., Tawbi, H., Whitman, E., Lee, G., Mun, Y., Liu, S. & Hamid, O., 2017, In : Melanoma Research. 27, 6, p. 585-590 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016
3 Scopus citations

Health-related quality of life in the randomised KEYNOTE-002 study of pembrolizumab versus chemotherapy in patients with ipilimumab-refractory melanoma

Schadendorf, D., Dummer, R., Hauschild, A., Robert, C., Hamid, O., Daud, A., van den Eertwegh, A., Cranmer, L., O'Day, S., Puzanov, I., Schachter, J., Blank, C., Salama, A., Loquai, C., Mehnert, J. M., Hille, D., Ebbinghaus, S., Kang, S. P., Zhou, W. & Ribas, A., Nov 1 2016, In : European Journal of Cancer. 67, p. 46-54 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Patterns of Clinical Response with Talimogene Laherparepvec (T-VEC) in Patients with Melanoma Treated in the OPTiM Phase III Clinical Trial

Andtbacka, R. H. I., Ross, M., Puzanov, I., Milhem, M., Collichio, F., Delman, K. A., Amatruda, T., Zager, J. S., Cranmer, L. D., Hsueh, E., Chen, L., Shilkrut, M. & Kaufman, H. L., Dec 1 2016, In : Annals of Surgical Oncology. 23, 13, p. 4169-4177 9 p.

Research output: Contribution to journalArticle

95 Scopus citations

Quantitative histopathology identifies patients with thin melanomas who are at risk for metastases

Glazer, E. S., Bartels, P. H., Lian, F., Kha, S. T., Morgan, S. S., Da Silva, V. D., Yozwiak, M. L., Bartels, H. G., Cranmer, L. D., De Oliveira, J. K., Alberts, D. S., Warneke, J. A. & Krouse, R. S., Jan 1 2016, In : Melanoma Research. 26, 3, p. 261-266 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Characterization of a novel radiation-induced sarcoma cell line

Lang, J., Zhu, W., Nokes, B., Sheth, G., Novak, P., Fuchs, L., Watts, G., Futscher, B., Mineyev, N., Ring, A., Lebeau, L., Nagle, R. & Cranmer, L., May 1 2015, In : Journal of Surgical Oncology. 111, 6, p. 669-682 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Ipilimumab granulomatous interstitial nephritis

Thajudeen, B., Madhrira, M., Bracamonte, E. & Cranmer, L. D., May 16 2015, In : American journal of therapeutics. 22, 3, p. e84-e87

Research output: Contribution to journalArticle

40 Scopus citations

Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): A randomised, controlled, phase 2 trial

Ribas, A., Puzanov, I., Dummer, R., Schadendorf, D., Hamid, O., Robert, C., Hodi, F. S., Schachter, J., Pavlick, A. C., Lewis, K. D., Cranmer, L. D., Blank, C. U., O'Day, S. J., Ascierto, P. A., Salama, A. K. S., Margolin, K. A., Loquai, C., Eigentler, T. K., Gangadhar, T. C., Carlino, M. S. & 16 others, Agarwala, S. S., Moschos, S. J., Sosman, J. A., Goldinger, S. M., Shapira-Frommer, R., Gonzalez, R., Kirkwood, J. M., Wolchok, J. D., Eggermont, A., Li, X. N., Zhou, W., Zernhelt, A. M., Lis, J., Ebbinghaus, S., Kang, S. P. & Daud, A., Aug 1 2015, In : The Lancet Oncology. 16, 8, p. 908-918 11 p.

Research output: Contribution to journalArticle

840 Scopus citations

Phase 1 Study of Monotherapy with KHK2866, an Anti-Heparin-Binding Epidermal Growth Factor-Like Growth Factor Monoclonal Antibody, in Patients with Advanced Cancer

Sarantopoulos, J., Mita, M. M., Birrer, M. J., Cranmer, L. D., Campos, L. T., Zhang, X., Bristow, P., Kaito, H., Strout, V. & Camacho, L. H., Oct 27 2015, (Accepted/In press) In : Targeted Oncology.

Research output: Contribution to journalArticle

7 Scopus citations

Talimogene laherparepvec improves durable response rate in patients with advanced melanoma

Andtbacka, R. H. I., Kaufman, H. L., Collichio, F., Amatruda, T., Senzer, N., Chesney, J., Delman, K. A., Spitler, L. E., Puzanov, I., Agarwala, S. S., Milhem, M., Cranmer, L., Curti, B., Lewis, K., Ross, M., Guthrie, T., Linette, G. P., Daniels, G. A., Harrington, K., Middleton, M. R. & 9 others, Miller, W. H., Zager, J. S., Ye, Y., Yao, B., Li, A., Doleman, S., Van Der Walde, A., Gansert, J. & Coffin, R. S., Sep 1 2015, In : Journal of Clinical Oncology. 33, 25, p. 2780-2788 9 p.

Research output: Contribution to journalArticle

925 Scopus citations
2014

A single-arm, open-label, expanded access study of vemurafenib in patients with metastatic melanoma in the United States

Flaherty, L., Hamid, O., Linette, G., Schuchter, L., Hallmeyer, S., Gonzalez, R., Cowey, C. L., Pavlick, A., Kudrik, F., Curti, B., Lawson, D., Chapman, P. B., Margolin, K., Ribas, A., McDermott, D., Flaherty, K., Cranmer, L., Hodi, F. S., Day, B. M., Linke, R. & 1 others, Hainsworth, J., Jan 1 2014, In : Cancer Journal (United States). 20, 1, p. 18-24 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Phase II study of the safety and antitumor activity of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma

Chawla, S. P., Cranmer, L. D., Van Tine, B. A., Reed, D. R., Okuno, S. H., Butrynski, J. E., Adkins, D. R., Hendifar, A. E., Kroll, S. & Ganjoo, K. N., Oct 10 2014, In : Journal of Clinical Oncology. 32, 29, p. 3299-3306 8 p.

Research output: Contribution to journalArticle

82 Scopus citations
6 Scopus citations
2013

A novel therapeutic combination approach for treating multiple vemurafenib-induced keratoacanthomas: Systemic acitretin and intralesional fluorouracil

LaPresto, L., Cranmer, L., Morrison, L., Erickson, C. P. & Curiel-Lewandrowski, C., Mar 1 2013, In : JAMA Dermatology. 149, 3, p. 279-281 3 p.

Research output: Contribution to journalArticle

10 Scopus citations

Pleomorphic rhabdomyosarcoma in a patient with hereditary nonpolyposis colorectal cancer

Cranmer, L. D., Chen, C. C., Morgan, S., Martino, G. & Ray, J., Mar 1 2013, In : Journal of Clinical Oncology. 31, 7, p. e108-e110

Research output: Contribution to journalArticle

3 Scopus citations

Results of an International Randomized Phase III Trial of the Mammalian Target of Rapamycin Inhibitor Ridaforolimus Versus Placebo to Control Metastatic Sarcomas in Patients after Benefit from Prior Chemotherapy

Demetri, G. D., Chawla, S. P., Ray-Coquard, I., Le Cesne, A., Staddon, A. P., Milhem, M. M., Penel, N., Riedel, R. F., Bui-Nguyen, B., Cranmer, L. D., Reichardt, P., Bompas, E., Alcindor, T., Rushing, D., Song, Y., Lee, R. M., Ebbinghaus, S., Eid, J. E., Loewy, J. W., Haluska, F. G. & 2 others, Dodion, P. F. & Blay, J. Y., Jul 1 2013, In : Journal of Clinical Oncology. 31, 19, p. 2485-2492 8 p.

Research output: Contribution to journalArticle

141 Scopus citations
2012

Erythematous annular plaques on the trunk

LaPresto, L., Cranmer, L., Erickson, C. P., Morrison, L., Curiel-Lewandrowski, C. & Cohen, J. A., Apr 1 2012, In : Archives of Dermatology. 148, 4, p. 531+536

Research output: Contribution to journalArticle

1 Scopus citations

Roles for endothelin receptor B and BCL2A1 in spontaneous CNS metastasis of melanoma

Cruz-Muñoz, W., Jaramillo, M. L., Man, S., Xu, P., Banville, M., Collins, C., Nantel, A., Francia, G., Morgan, S. S., Cranmer, L. D., O'Connor-McCourt, M. D. & Kerbel, R. S., Oct 1 2012, In : Cancer Research. 72, 19, p. 4909-4919 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: Optimization of dosing regimens and schedules

Liu, Q., Sun, J. D., Wang, J., Ahluwalia, D., Baker, A. F., Cranmer, L. D., Ferraro, D., Wang, Y., Duan, J. X., Ammons, W. S., Curd, J. G., Matteucci, M. D. & Hart, C. P., Jun 1 2012, In : Cancer Chemotherapy And Pharmacology. 69, 6, p. 1487-1498 12 p.

Research output: Contribution to journalArticle

65 Scopus citations
2011

A multi-center phase II evaluation of the small molecule survivin suppressor YM155 in patients with unresectable stage III or IV melanoma

Lewis, K. D., Samlowski, W., Ward, J., Catlett, J., Cranmer, L., Kirkwood, J., Lawson, D., Whitman, E. & Gonzalez, R., Feb 1 2011, In : Investigational New Drugs. 29, 1, p. 161-166 6 p.

Research output: Contribution to journalArticle

101 Scopus citations

A phase 1 study of a vaccine targeting preferentially expressed antigen in melanoma and prostate-specific membrane antigen in patients with advanced solid tumors

Weber, J. S., Vogelzang, N. J., Ernstoff, M. S., Goodman, O. B., Cranmer, L. D., Marshall, J. L., Miles, S., Rosario, D., Diamond, D. C., Qiu, Z., Obrocea, M. & Bot, A., Sep 1 2011, In : Journal of Immunotherapy. 34, 7, p. 556-567 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-naïve patients with advanced melanoma

Hersh, E. M., O'Day, S. J., Powderly, J., Khan, K. D., Pavlick, A. C., Cranmer, L. D., Samlowski, W. E., Nichol, G. M., Yellin, M. J. & Weber, J. S., Jun 1 2011, In : Investigational New Drugs. 29, 3, p. 489-498 10 p.

Research output: Contribution to journalArticle

215 Scopus citations

A phase i study of the safety and pharmacokinetics of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma

Ganjoo, K. N., Cranmer, L. D., Butrynski, J. E., Rushing, D., Adkins, D., Okuno, S. H., Lorente, G., Kroll, S., Langmuir, V. K. & Chawla, S. P., Jun 1 2011, In : Oncology. 80, 1-2, p. 50-56 7 p.

Research output: Contribution to journalArticle

52 Scopus citations

Metastatic cutaneous squamous cell carcinoma responding to erlotinib therapy

Engelhardt, C., Curiel-Lewandrowski, C., Warneke, J. & Cranmer, L., Jul 2011, In : Journal of the American Academy of Dermatology. 65, 1, p. 237-238 2 p.

Research output: Contribution to journalArticle

17 Scopus citations
2010

The Role of Anti-Tumor Necrosis Factor Receptor Agents in Cancer Survivors: Does the Risk Justify the Benefit?

Chapman, P., Cranmer, L., Dixon, W. G., Hyrich, K. L., Patterson, J. R., Symmons, D. P. M., Toporcer, M. & Mastrangelo, M. J., Feb 1 2010, In : Seminars in Oncology. 37, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Treatment of unresectable and metastatic cutaneous squamous cell carcinoma

Cranmer, L. D., Engelhardt, C. & Morgan, S. S., Dec 1 2010, In : Oncologist. 15, 12, p. 1320-1328 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

Whole-brain radiation therapy in melanoma: an open question

Cranmer, L. D., Jeter, J. M., Morgan, S. S., Hersh, E. M. & Stea, B., Jan 2010, In : The Lancet Oncology. 11, 1, p. 13 1 p.

Research output: Contribution to journalArticle

4 Scopus citations
2009
5 Scopus citations

In-transit metastasis from melanoma presenting as lymphangiectasis: A case report

Shekhel, T., Glick, R. M. & Cranmer, L. D., Sep 1 2009, In : Cutis. 84, 3, p. 151-158 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
4 Scopus citations
2008

Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: A report from the 11715 study group

McDermott, D. F., Sosman, J. A., Gonzalez, R., Hodi, F. S., Linette, G. P., Richards, J., Jakub, J. W., Beeram, M., Tarantolo, S., Agarwala, S., Frenette, G., Puzanov, I., Cranmer, L., Lewis, K., Kirkwood, J., White, J. M., Xia, C., Patel, K. & Hersh, E., Sep 22 2008, In : Journal of Clinical Oncology. 26, 13, p. 2178-2185 8 p.

Research output: Contribution to journalArticle

216 Scopus citations
2005

A phase I study of the dolastatin-15 analogue tasidotin (ILX651) administered intravenously daily for 5 consecutive days every 3 weeks in patients with advanced solid tumors

Ebbinghaus, S., Rubin, E., Hersh, E., Cranmer, L. D., Bonate, P. L., Fram, R. J., Jekunen, A., Weitman, S. & Hammond, L. A., Nov 1 2005, In : Clinical Cancer Research. 11, 21, p. 7807-7816 10 p.

Research output: Contribution to journalArticle

38 Scopus citations
2002

61-year-old man with dyspnea and bilateral foot drop

Cranmer, L. D., Warrington, K. J. & Ytterberg, S. R., Jan 1 2002, In : Mayo Clinic Proceedings. 77, 4, p. 363-366 4 p., 61791.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2000

Suppression of murine cytomegalovirus (MCMV) replication with a DNA vaccine encoding MCMV M84 (a homolog of human cytomegalovirus pp65)

Morello, C. S., Cranmer, L. D. & Spector, D. H., Apr 12 2000, In : Journal of virology. 74, 8, p. 3696-3708 13 p.

Research output: Contribution to journalArticle

62 Scopus citations
1999
42 Scopus citations
1996

DNA immunization confers protection against murine cytomegalovirus infection

González Armas, J. C., Morello, C. S., Cranmer, L. D. & Spector, D. H., Nov 1 1996, In : Journal of virology. 70, 11, p. 7921-7928 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

Identification, analysis, and evolutionary relationships of the putative murine cytomegalovirus homologs of the human cytomegalovirus UL82 (pp71) and UL83 (pp65) matrix phosphoproteins

Cranmer, L. D., Clark, C. L., Morello, C. S., Farrell, H. E., Rawlinson, W. D. & Spector, D. H., Nov 1 1996, In : Journal of virology. 70, 11, p. 7929-7939 11 p.

Research output: Contribution to journalArticle

37 Scopus citations