• 6536 Citations
  • 43 h-Index
1973 …2019
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Fingerprint Dive into the research topics where Leslie Gunatilaka is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Celastraceae Medicine & Life Sciences
Fungi Chemical Compounds
Alkaloids Chemical Compounds
Nuclear magnetic resonance Chemical Compounds
Biological Products Medicine & Life Sciences
Cells Chemical Compounds
Endophytes Medicine & Life Sciences
Metabolites Chemical Compounds

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Research Output 1973 2019

  • 6536 Citations
  • 43 h-Index
  • 220 Article
  • 2 Chapter
  • 1 Comment/debate
  • 1 Review article
1 Citation (Scopus)

(-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels

Cai, S., Bellampalli, S. S., Yu, J., Li, W., Ji, Y., Wijeratne, E. M. K., Dorame, A., Luo, S., Shan, Z., Khanna, M., Moutal, A., Streicher, J. M., Gunatilaka, L. & Khanna, R., Mar 20 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1716-1728 13 p.

Research output: Contribution to journalArticle

Sodium Channels
Tetrodotoxin
Calcium Channels
Chronic Pain
Voltage-Gated Sodium Channels
1 Citation (Scopus)

An Isoform-Selective PTP1B Inhibitor Derived from Nitrogen-Atom Augmentation of Radicicol

Shi, T., Kithsiri Wijeratne, E. M., Solano, C., Ambrose, A. J., Ross, A. B., Norwood, C., Orido, C. K., Grigoryan, T., Tillotson, J., Kang, M., Luo, G., Keegan, B. M., Hu, W., Blagg, B. S. J., Zhang, D., Gunatilaka, L. & Chapman, E., Jul 30 2019, In : Biochemistry. 58, 30, p. 3225-3231 7 p.

Research output: Contribution to journalArticle

hydrazine
Protein Isoforms
Nitrogen
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Derivatives
5 Citations (Scopus)

Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels

Bellampalli, S. S., Ji, Y., Moutal, A., Cai, S., Wijeratne, E. M. K., Gandini, M. A., Yu, J., Chefdeville, A., Dorame, A., Chew, L. A., Madura, C. L., Luo, S., Molnar, G., Khanna, M., Streicher, J. M., Zamponi, G. W., Gunatilaka, L. & Khanna, R., Jan 1 2019, In : Pain. 160, 1, p. 117-135 19 p.

Research output: Contribution to journalArticle

Hyptis
T-Type Calcium Channels
N-Type Calcium Channels
Lavandula
Peripheral Nervous System Diseases

Non-covalent NRF2 Activation Confers Greater Cellular Protection than Covalent Activation

Liu, P., Tian, W., Tao, S., Tillotson, J., Wijeratne, E. M. K., Gunatilaka, A. A. L., Zhang, D. D. & Chapman, E., Oct 17 2019, In : Cell Chemical Biology. 26, 10, p. 1427-1435.e5

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Kaurane Diterpenes
Chemical activation
Degradation
Diterpenes
1 Citation (Scopus)

Rational Reprogramming of O-Methylation Regioselectivity for Combinatorial Biosynthetic Tailoring of Benzenediol Lactone Scaffolds

Wang, X., Wang, C., Duan, L., Zhang, L., Liu, H., Xu, Y. M., Liu, Q., Mao, T., Zhang, W., Chen, M., Lin, M., Gunatilaka, L., Xu, Y. & Molnar, I., Mar 13 2019, In : Journal of the American Chemical Society. 141, 10, p. 4355-4364 10 p.

Research output: Contribution to journalArticle

Open Access
Regioselectivity
Methylation
Lactones
Drug Discovery
Scaffolds