• 2329 Citations
  • 26 h-Index
19952018
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Research Output 1995 2018

  • 2329 Citations
  • 26 h-Index
  • 42 Article
2018

The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner

Bhagwandin, C., Ashbeck, E. L., Whalen, M., Bandola-Simon, J., Roche, P. A., Szajman, A., Truong, S. M., Wertheim, B. C., Klimentidis, Y. C., Ishido, S., Renquist, B. J. & Lybarger, L., Oct 1 2018, In : PLoS One. 13, 10, e0204898.

Research output: Contribution to journalArticle

ubiquitin-protein ligase
Ubiquitin-Protein Ligases
glucose tolerance
Membranes
Lipids
2013
15 Citations (Scopus)

Low GILT expression is associated with poor patient survival in diffuse large B-cell lymphoma

Phipps-Yonas, H., Cui, H., Sebastiao, N., Brunhoeber, P. S., Haddock, E., Deymier, M. J., Klapper, W., Lybarger, L., Roe, D. & Hastings, K. T., 2013, In : Frontiers in Immunology. 4, DEC, Article 425.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Sulfhydryl Compounds
Interferon-gamma
Oxidoreductases
Major Histocompatibility Complex
2011
11 Citations (Scopus)

Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules

Rizvi, S. M., Del Cid, N., Lybarger, L. & Raghavan, M., Feb 15 2011, In : Journal of Immunology. 186, 4, p. 2309-2320 12 p.

Research output: Contribution to journalArticle

Polysaccharides
Calreticulin
Peptides
Binding Sites
tapasin
35 Citations (Scopus)

Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1)

Corcoran, K., Jabbour, M., Bhagwandin, C., Deymier, M. J., Theisen, D. L. & Lybarger, L., Oct 28 2011, In : Journal of Biological Chemistry. 286, 43, p. 37168-37180 13 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Ligases
Ubiquitin
Membranes
Ubiquitination
2010
4 Citations (Scopus)
Cytotoxic T-Lymphocytes
Vaccines
Antigens
Peptides
Melanoma-Specific Antigens
2009
4 Citations (Scopus)

Adapter-mediated substrate selection for endoplasmic reticulum-associated degradation

Corcoran, K., Wang, X. & Lybarger, L., Jun 26 2009, In : Journal of Biological Chemistry. 284, 26, p. 17475-17487 13 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum-Associated Degradation
Ubiquitin-Protein Ligases
Endoplasmic Reticulum
Degradation
Substrates
29 Citations (Scopus)

A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire

Wang, B., Primeau, T. M., Myers, N., Rohrs, H. W., Gross, M. L., Lybarger, L., Hansen, T. H. & Connolly, J. M., Nov 6 2009, In : Science. 326, 5954, p. 871-874 4 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
T-Lymphocytes
Peptides
T-Cell Antigen Receptor Specificity
Thymus Gland
34 Citations (Scopus)

Discrete domains of MARCH1 mediate its localization, functional interactions, and posttranscriptional control of expression

Jabbour, M., Campbell, E. M., Fares, H. F. & Lybarger, L., Nov 15 2009, In : Journal of Immunology. 183, 10, p. 6500-6512 13 p.

Research output: Contribution to journalArticle

Dendritic Cells
Half-Life
Cysteine Proteinase Inhibitors
Messenger RNA
Ubiquitin-Protein Ligases
Hepatitis B Surface Antigens
Green Fluorescent Proteins
Adenoviridae
Epitopes
Genes
2008
14 Citations (Scopus)

Human Major Histocompatibility Complex (MHC) class I molecules with disulfide traps secure disease-related antigenic peptides and exclude competitor peptides

Truscott, S. M., Wang, X., Lybarger, L., Biddison, W. E., McBerry, C., Martinko, J. M., Connolly, J. M., Linette, G. P., Fremont, D. H., Hansen, T. H. & Carreno, B. M., Mar 21 2008, In : Journal of Biological Chemistry. 283, 12, p. 7480-7490 11 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Disulfides
Peptides
Molecules
T-cells
2007
30 Citations (Scopus)

Disulfide bond engineering to trap peptides in the MHC class I binding groove

Truscott, S. M., Lybarger, L., Martinko, J. M., Mitaksov, V. E., Kranz, D. M., Connolly, J. M., Fremont, D. H. & Hansen, T. H., May 15 2007, In : Journal of Immunology. 178, 10, p. 6280-6289 10 p.

Research output: Contribution to journalArticle

Disulfides
Peptides
T-Lymphocytes
Endoplasmic Reticulum
Vaccination
31 Citations (Scopus)

Structural Engineering of pMHC Reagents for T Cell Vaccines and Diagnostics

Mitaksov, V., Truscott, S. M., Lybarger, L., Connolly, J. M., Hansen, T. H. & Fremont, DH., Aug 24 2007, In : Chemistry and Biology. 14, 8, p. 909-922 14 p.

Research output: Contribution to journalArticle

T-cells
Structural design
Disulfides
Vaccines
T-Lymphocytes
2 Citations (Scopus)

TCRβ enhancer activation in early and late lymphoid progenitors

Norris, H. H., Martin, A. J., Lybarger, L., Andersen, H., Chervenak, D. C. & Chervenak, R., Jun 2007, In : Cellular Immunology. 247, 2, p. 59-71 13 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Green Fluorescent Proteins
Population
Lymphoid Progenitor Cells
Lymphocytes
185 Citations (Scopus)

Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3

Wang, X., Herr, R. A., Chua, W. J., Lybarger, L., Wiertz, E. J. H. J. & Hansen, T. H., May 21 2007, In : Journal of Cell Biology. 177, 4, p. 613-624 12 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Ubiquitination
Threonine
Serine
Lysine
2006
7 Citations (Scopus)

Exciting applications of single chain trimers of MHC-I molecules.

Hansen, T. H. & Lybarger, L., Feb 2006, In : Cancer Immunology, Immunotherapy. 55, 2, p. 235-236 2 p.

Research output: Contribution to journalArticle

HLA-A2 Antigen
Histocompatibility Antigens Class I
Peptide Fragments
Cytotoxic T-Lymphocytes
2005
18 Citations (Scopus)

Applications of major histocompatibility complex class I molecules expressed as single chains

Primeau, T., Myers, N. B., Yu, Y. Y. L., Lybarger, L., Wang, X., Truscott, S. M., Hansen, T. H. & Connolly, J. M., 2005, In : Immunologic Research. 32, 1-3, p. 109-121 13 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Immune Evasion
Peptides
T-Lymphocytes
Vesicular Stomatitis
95 Citations (Scopus)

Evidence for MR1 antigen presentation to mucosal-associated invariant T cells

Huang, S., Gilfillan, S., Cella, M., Miley, M. J., Lantz, O., Lybarger, L., Fremont, D. H. & Hansen, T. H., Jun 3 2005, In : Journal of Biological Chemistry. 280, 22, p. 21183-21193 11 p.

Research output: Contribution to journalArticle

T-cells
Antigen Presentation
T-Cell Antigen Receptor
Antigens
Molecules
854 Citations (Scopus)

Licensing of natural killer cells by host major histocompatibility complex class I molecules

Kim, S., Poursine-Laurent, J., Truscott, S. M., Lybarger, L., Song, Y. J., Yang, L., French, A. R., Sunwoo, J. B., Lemieux, S., Hansen, T. H. & Yokoyama, W. M., Aug 4 2005, In : Nature. 436, 7051, p. 709-713 5 p.

Research output: Contribution to journalArticle

Licensure
Major Histocompatibility Complex
Natural Killer Cells
Self Tolerance
Vertebrates
29 Citations (Scopus)

Recognition of open conformers of classical MHC by chaperones and monoclonal antibodies

Hansen, T. H., Lybarger, L., Yu, L., Mitaksov, V. & Fremont, D. H., Oct 2005, In : Immunological Reviews. 207, p. 100-111 12 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Monoclonal Antibodies
Peptides
Molecular Chaperones
Ligation
28 Citations (Scopus)

Requirements for the selective degradation of endoplasmic reticulum-resident major histocompatibility complex class I proteins by the viral immune evasion molecule mK3

Wang, X., Connors, R., Harris, M. R., Hansen, T. H. & Lybarger, L., Apr 2005, In : Journal of Virology. 79, 7, p. 4099-4108 10 p.

Research output: Contribution to journalArticle

immune evasion
Immune Evasion
major histocompatibility complex
Viral Proteins
Major Histocompatibility Complex
37 Citations (Scopus)

Viral immune evasion molecules attack the ER peptide-loading complex and exploit ER-associated degradation pathways

Lybarger, L., Wang, X., Harris, M. & Hansen, T. H., Feb 2005, In : Current Opinion in Immunology. 17, 1, p. 71-78 8 p.

Research output: Contribution to journalArticle

Immune Evasion
Viruses
Peptides
Endoplasmic Reticulum-Associated Degradation
Endoplasmic Reticulum
2004
45 Citations (Scopus)

Model for the interaction of gammaherpesvirus 68 RING-CH finger protein mK3 with major histocompatibility complex class I and the peptide-loading complex

Wang, X., Lybarger, L., Connors, R., Harris, M. R. & Hansen, T. H., Aug 2004, In : Journal of Virology. 78, 16, p. 8673-8686 14 p.

Research output: Contribution to journalArticle

major histocompatibility complex
substrate specificity
Major Histocompatibility Complex
Fingers
Human herpesvirus 8
46 Citations (Scopus)

Recognition of HLA-A2-restricted mammaglobin-A-derived epitopes by CD8+ cytotoxic T lymphocytes from breast cancer patients

Jaramillo, A., Narayanan, K., Campbell, L. G., Benshoff, N. D., Lybarger, L., Hansen, T. H., Fleming, T. P., Dietz, J. R. & Mohanakumar, T., Nov 2004, In : Breast Cancer Research and Treatment. 88, 1, p. 29-41 13 p.

Research output: Contribution to journalArticle

Mammaglobin A
HLA-A2 Antigen
Cytotoxic T-Lymphocytes
Epitopes
Breast Neoplasms
2003
67 Citations (Scopus)

Biochemical features of the MHC-related protein 1 consistent with an immunological function

Miley, M. J., Truscott, S. M., Yu, Y. Y. L., Gilfillan, S., Fremont, D. H., Hansen, T. H. & Lybarger, L., Jun 15 2003, In : Journal of Immunology. 170, 12, p. 6090-6098 9 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 1
Insects
Mammals
Proteins
Ligands
41 Citations (Scopus)

Enhanced immune presentation of a single-chain major histocompatibility complex class I molecule engineered to optimize linkage of a C-terminally extended peptide

Lybarger, L., Lawrence Yu, Y. Y., Miley, M. J., Fremont, D. H., Myers, N., Primeau, T., Truscott, S. M., Connolly, J. M. & Hansen, T. H., Jul 18 2003, In : Journal of Biological Chemistry. 278, 29, p. 27105-27111 7 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Peptides
Molecules
Natural Killer T-Cells
T-cells
1 Citation (Scopus)

TCRβ enhancer activation occurs in some but not all cells with T cell lineage developmental potential

Norris, H. H., Lybarger, L., Martin, A. J., Andersen, H., Chervenak, D. C. & Chervenak, R., Apr 2003, In : Cellular Immunology. 222, 2, p. 164-174 11 p.

Research output: Contribution to journalArticle

Cell Lineage
T-Lymphocytes
Population
Bone Marrow Examination
T-Cell Receptor Genes
105 Citations (Scopus)

Virus subversion of the MHC class I peptide-loading complex

Lybarger, L., Wang, X., Harris, M. R., Virgin IV, H. W. & Hansen, T. H., Jan 1 2003, In : Immunity. 18, 1, p. 121-130 10 p.

Research output: Contribution to journalArticle

Viruses
Peptides
Herpesviridae
Ubiquitination
Viral Proteins
2002
78 Citations (Scopus)

Cutting edge: Single-chain trimers of MHC class I molecules form stable structures that potently stimulate antigen-specific T cells and B cells

Yu, Y. Y. L., Netuschil, N., Lybarger, L., Connolly, J. M. & Hansen, T. H., Apr 1 2002, In : Journal of Immunology. 168, 7, p. 3145-3149 5 p.

Research output: Contribution to journalArticle

B-Lymphocytes
T-Lymphocytes
Antigens
Peptides
Tumor Virus Infections
39 Citations (Scopus)

Physical association of the K3 protein of gamma-2 herpesvirus 68 with major histocompatibility complex class I molecules with impaired peptide and β2-microglobulin assembly

Yu, L. Y. L., Harris, M. R., Lybarger, L., Kimpler, L. A., Myers, N. B., Virgin IV, H. W. & Hansen, T. H., 2002, In : Journal of Virology. 76, 6, p. 2796-2803 8 p.

Research output: Contribution to journalArticle

Herpesviridae
major histocompatibility complex
Major Histocompatibility Complex
peptides
calreticulin
2001
46 Citations (Scopus)

Association of ERp57 with mouse MHC class I molecules is tapasin dependent and mimics that of calreticulin and not calnexin

Harris, M. R., Lybarger, L., Yu, Y. Y. L., Myers, N. B. & Hansen, T. H., May 1 2001, In : Journal of Immunology. 166, 11, p. 6686-6692 7 p.

Research output: Contribution to journalArticle

Calnexin
Calreticulin
Peptides
Sulfhydryl Compounds
Endoplasmic Reticulum
31 Citations (Scopus)

Functional roles of TAP and tapasin in the assembly of M3-N-formylated peptide complexes

Chun, T., Grandea, A. G., Lybarger, L., Forman, J., Van Kaer, L. & Wang, C. R., Aug 1 2001, In : Journal of Immunology. 167, 3, p. 1507-1514 8 p.

Research output: Contribution to journalArticle

N-Formylmethionine Leucyl-Phenylalanine
Endoplasmic Reticulum
Molecular Chaperones
tapasin
Peptides
47 Citations (Scopus)

Interactions of HLA-B27 with the peptide loading complex as revealed by heavy chain mutations

Harris, M. R., Lybarger, L., Myers, N. B., Hilbert, C., Solheim, J. C., Hansen, T. H. & Yu, Y. Y. L., 2001, In : International Immunology. 13, 10, p. 1275-1282 8 p.

Research output: Contribution to journalArticle

HLA-B27 Antigen
Calreticulin
Peptides
Mutation
Endoplasmic Reticulum
36 Citations (Scopus)

Tapasin enhances peptide-induced expression of H2-M3 molecules, but is not required for the retention of open conformers

Lybarger, L., Yu, Y. Y. L., Chun, T., Wang, C. R., Grandea, A. G., Van Kaer, L. & Hansen, T. H., Aug 15 2001, In : Journal of Immunology. 167, 4, p. 2097-2105 9 p.

Research output: Contribution to journalArticle

Peptides
Endoplasmic Reticulum
Ligands
Cell Line
tapasin
2000
56 Citations (Scopus)

Kb, K(d), and L(d) molecules share common tapasin dependencies as determined using a novel epitope tag

Myers, N. B., Harris, M. R., Connolly, J. M., Lybarger, L., Yu, Y. Y. L. & Hansen, T. H., Nov 15 2000, In : Journal of Immunology. 165, 10, p. 5656-5663 8 p.

Research output: Contribution to journalArticle

Epitopes
Peptides
Endoplasmic Reticulum
Alleles
tapasin
1999
3 Citations (Scopus)

Flow cytometric analysis of transcription: Use of green fluorescent protein variants to control transfection efficiency

Lybarger, L. & Chervenak, R., 1999, In : Methods in Enzymology. 302, p. 199-206 8 p.

Research output: Contribution to journalArticle

Luminescent Proteins
Genetic Transcription
Antigen Receptors, T-Cell, alpha-beta
Green Fluorescent Proteins
Transfection
4 Citations (Scopus)

Fluorescent proteins in single- and multicolor flow cytometry

Lybarger, L. & Chervenak, R., 1999, In : Methods in Enzymology. 302, p. 189-199 11 p.

Research output: Contribution to journalArticle

Luminescent Proteins
Recombinant Fusion Proteins
Bacterial Proteins
Flow cytometry
Fluorescence microscopy
1998
34 Citations (Scopus)

Dual-color flow cytometric detection of fluorescent proteins using single-laser (488-nm) excitation

Lybarger, L., Dempsey, D., Patterson, G. H., Piston, D. W., Kain, S. R. & Chervenak, R., Mar 1 1998, In : Cytometry. 31, 3, p. 147-152 6 p.

Research output: Contribution to journalArticle

Lasers
Color
Reporter Genes
Flow Cytometry
Proteins
116 Citations (Scopus)

Improved fluorescence and dual color detection with enhanced blue and green variants of the green fluorescent protein

Yang, T. T., Sinai, P., Green, G., Kitts, P. A., Chen, Y. T., Lybarger, L., Chervenak, R., Patterson, G. H., Piston, D. W. & Kain, S. R., Apr 3 1998, In : Journal of Biological Chemistry. 273, 14, p. 8212-8216 5 p.

Research output: Contribution to journalArticle

Green Fluorescent Proteins
Color
Fluorescence
Proteins
Point Mutation
1996
8 Citations (Scopus)

Pre-thymic transcription of TCR genes by adult murine bone marrow cells

Wang, T. G., Lybarger, L., Soloff, R., Dempsey, D. & Chervenak, R., Aug 1996, In : Molecular Immunology. 33, 11-12, p. 957-964 8 p.

Research output: Contribution to journalArticle

Bone Marrow Cells
T-Lymphocytes
Recombinases
Bone Marrow
Genes
42 Citations (Scopus)

Rapid generation and flow cytometric analysis of stable GFP-expressing cells

Lybarger, L., Dempsey, D., Franek, K. J. & Chervenak, R., Nov 1 1996, In : Cytometry. 25, 3, p. 211-220 10 p.

Research output: Contribution to journalArticle

Green Fluorescent Proteins
Fluorescence
NIH 3T3 Cells
hygromycin-B kinase
Phycoerythrin
1995
17 Citations (Scopus)

Transcription of the TCR-β locus initiates in adult murine bone marrow

Soloff, R. S., Wang, T. G., Lybarger, L., Dempsey, D. & Chervenak, R., 1995, In : Journal of Immunology. 154, 8, p. 3888-3901 14 p.

Research output: Contribution to journalArticle

Bone Marrow
Genes
Bone Marrow Cells
Population
RNA
5 Citations (Scopus)

Transcription of the TCR-β locus initiates in adult murine bone marrow

Soloff, R. S., Wang, T. G., Lybarger, L., Dempsey, D. & Chervenak, R., 1995, In : Journal of Immunology. 154, 8, p. 3902-3911 10 p.

Research output: Contribution to journalArticle

Bone Marrow
Genes
Bone Marrow Cells
Population
RNA