Margaret E Tome

  • 1387 Citations
  • 22 h-Index
1985 …2019
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Research Output 1985 2019

  • 1387 Citations
  • 22 h-Index
  • 52 Article
  • 1 Chapter
  • 1 Review article
2019
2 Citations (Scopus)

Thiol regulation by Mn porphyrins, commonly known as SOD mimics

Batinic-Haberle, I. & Tome, M. E., Jan 1 2019, In : Redox Biology. 101139.

Research output: Contribution to journalArticle

Open Access
Porphyrins
Sulfhydryl Compounds
Oxidation-Reduction
Oncology
Protein S
2018
2 Citations (Scopus)

Acute pain alters P-glycoprotein-containing protein complexes in rat cerebral microvessels: Implications for P-glycoprotein trafficking

Tome, M. E., Jarvis, C. K., Schaefer, C. P., Jacobs, L. M., Herndon, J. M., Hunn, K. C., Arkwright, N. B., Kellohen, K. L., Mierau, P. C. & Davis, T. P., Dec 1 2018, In : Journal of Cerebral Blood Flow and Metabolism. 38, 12, p. 2209-2222 14 p.

Research output: Contribution to journalArticle

Acute Pain
P-Glycoprotein
Microvessels
Proteins
Pain
4 Citations (Scopus)

Chronic morphine exposure potentiates p-glycoprotein trafficking from nuclear reservoirs in cortical rat brain microvessels

Schaefer, C. P., Arkwright, N. B., Jacobs, L. M., Jarvis, C. K., Hunn, K. C., Largent-Milnes, T. M., Tome, M. E. & Davis, T. P., Feb 1 2018, In : PLoS One. 13, 2, e0192340.

Research output: Contribution to journalArticle

morphine
Microvessels
Morphine
Rats
glycoproteins
3 Citations (Scopus)

Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery

Cottier, K. E., Galloway, E. A., Calabrese, E. C., Tome, M. E., Liktor-Busa, E., Kim, J., Davis, T. P., Vanderah, T. W. & Largent-Milnes, T. M., Jul 1 2018, In : eNeuro. 5, 4

Research output: Contribution to journalArticle

Cortical Spreading Depression
Blood-Brain Barrier
Headache
Sumatriptan
Permeability
6 Citations (Scopus)

Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate

Tovmasyan, A., Bueno-Janice, J. C., Jaramillo, M. C., Sampaio, R. S., Reboucas, J. S., Kyui, N., Benov, L., Deng, B., Huang, T. T., Tome, M. E., Spasojevic, I. & Batinic-Haberle, I., Nov 1 2018, In : Antioxidants and Redox Signaling. 29, 13, p. 1196-1214 19 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Tumors
Glutathione Disulfide
Radiation
Cells
2017
2 Citations (Scopus)

Development and Maintenance of the Blood-Brain Barrier

Herndon, J. M., Tome, M. E. & Davis, T. P., Mar 7 2017, Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc., p. 51-56 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Blood-Brain Barrier
Maintenance
Pericytes
Microglia
Astrocytes
7 Citations (Scopus)

The opioid epidemic: A central role for the blood brain barrier in opioid analgesia and abuse

Schaefer, C. P., Tome, M. E. & Davis, T. P., Nov 29 2017, In : Fluids and Barriers of the CNS. 14, 1, 32.

Research output: Contribution to journalReview article

Blood-Brain Barrier
Analgesia
Opioid Analgesics
Acute Pain
Chronic Pain
2016
9 Citations (Scopus)

P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain

Tome, M. E., Herndon, J. M., Schaefer, C. P., Jacobs, L. M., Zhang, Y., Jarvis, C. K. & Davis, T. P., Nov 1 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 11, p. 1913-1928 16 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Endothelium
Cell Membrane
Pain
Central Nervous System Agents
2015
12 Citations (Scopus)

Identification of P-glycoprotein co-fractionating proteins and specific binding partners in rat brain microvessels

Tome, M. E., Schaefer, C. P., Jacobs, L. M., Zhang, Y., Herndon, J. M., Matty, F. O. & Davis, T. P., Jul 1 2015, In : Journal of Neurochemistry. 134, 2, p. 200-210 11 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Microvessels
Protein Binding
Rats
Brain
24 Citations (Scopus)
Chemotherapy
Electron Transport
Energy Metabolism
Reactive Oxygen Species
Lymphoma
2014
8 Citations (Scopus)

Mitochondria and redox homoeostasis as chemotherapeutic targets

Briehl, M. M., Tome, M. E., Wilkinson, S. T., Jaramillo, M. C. & Lee, K., 2014, In : Biochemical Society Transactions. 42, 4, p. 939-944 6 p.

Research output: Contribution to journalArticle

Mitochondria
Oxidation-Reduction
Lymphoma
Homeostasis
Apoptosis
20 Citations (Scopus)

P-glycoprotein trafficking as a therapeutic target to optimize CNS drug delivery

Davis, T. P., Sanchez-Covarubias, L. & Tome, M. E., 2014, In : Advances in Pharmacology. 71, p. 25-44 20 p.

Research output: Contribution to journalArticle

Central Nervous System Agents
P-Glycoprotein
Protein Transport
Blood-Brain Barrier
Caveolin 1
7 Citations (Scopus)

The copper chelator ATN-224 induces caspase-independent cell death in diffuse large B cell lymphoma

Lee, K., Hart, M. R., Briehl, M. M., Mazar, A. P. & Tome, M. E., 2014, In : International Journal of Oncology. 45, 1, p. 439-447 9 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Chelating Agents
Caspases
Copper
Cell Death
2013
21 Citations (Scopus)

The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies

Lee, K., Briehl, M. M., Mazar, A. P., Batinic-Haberle, I., Reboucas, J. S., Glinsmann-Gibson, B., Rimsza, L. M. & Tome, M. E., Jul 2013, In : Free Radical Biology and Medicine. 60, p. 157-167 11 p.

Research output: Contribution to journalArticle

Peroxynitrous Acid
Cell death
Hematologic Neoplasms
Chelating Agents
Copper
2012
17 Citations (Scopus)

Factors determining sensitivity and resistance of tumor cells to arsenic trioxide

Sertel, S., Tome, M. E., Briehl, M. M., Bauer, J., Hock, K., Plinkert, P. K. & Efferth, T., May 10 2012, In : PLoS One. 7, 5, e35584.

Research output: Contribution to journalArticle

arsenic
Tumors
Cells
Neoplasms
Genes
18 Citations (Scopus)

Lymphoma cells with increased anti-oxidant defenses acquire chemoresistance

Tome, M. E., Frye, J. B., Coyle, D. L., Jacobson, E. L., Samulitis, B. K., Dvorak, K., Dorr, R. T. & Briehl, M. M., May 2012, In : Experimental and Therapeutic Medicine. 3, 5, p. 845-852 8 p.

Research output: Contribution to journalArticle

Oxidants
Lymphoma
Oxidation-Reduction
Reactive Oxygen Species
Enzymes
46 Citations (Scopus)

Manganese porphyrin, MnTE-2-PyP 5+, acts as a pro-oxidant to potentiate glucocorticoid-induced apoptosis in lymphoma cells

Jaramillo, M. C., Briehl, M. M., Crapo, J. D., Batinic-Haberle, I. & Tome, M. E., Apr 15 2012, In : Free Radical Biology and Medicine. 52, 8, p. 1272-1284 13 p.

Research output: Contribution to journalArticle

Porphyrins
Manganese
Glucocorticoids
Reactive Oxygen Species
Lymphoma
14 Citations (Scopus)

Mitochondria are the primary source of the H 2O 2 signal for glucocorticoid-induced apoptosis of lymphoma cells

Tome, M. E., Lee, K., Jaramillo, M. C. & Briehl, M. M., Aug 2012, In : Experimental and Therapeutic Medicine. 4, 2, p. 237-242 6 p.

Research output: Contribution to journalArticle

Glucocorticoids
Lymphoma
Mitochondria
Apoptosis
Hydrogen Peroxide
5 Citations (Scopus)

Mitochondrial adaptations to oxidative stress confer resistance to apoptosis in lymphoma cells

Wilkinson, S. T., Tome, M. E. & Briehl, M. M., Aug 2012, In : International Journal of Molecular Sciences. 13, 8, p. 10212-10228 17 p.

Research output: Contribution to journalArticle

Oxidative stress
apoptosis
Cell death
Lymphoma
Oxidative Stress
2011
5 Citations (Scopus)

A strategy for full interrogation of prognostic gene expression patterns: Exploring the biology of diffuse large B cell lymphoma

Rimsza, L. M., Unger, J. M., Tome, M. E. & LeBlanc, M. L., 2011, In : PLoS One. 6, 8, e22267.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
lymphoma
Gene expression
B-lymphocytes
Genes
30 Citations (Scopus)

Characterization of squamous esophageal cells resistant to bile acids at acidic pH: Implication for Barrett's esophagus pathogenesis

Goldman, A., Chen, H. D. R., Roesly, H. B., Hill, K. A., Tome, M. E., Dvorak, B., Bernstein, H. & Dvorak, K., Feb 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 2

Research output: Contribution to journalArticle

Barrett Esophagus
Bile Acids and Salts
Epithelial Cells
Adenocarcinoma
Keratin-8
17 Citations (Scopus)

Hydrogen peroxide signaling is required for glucocorticoid-induced apoptosis in lymphoma cells

Tome, M. E., Jaramillo, M. C. & Briehl, M. M., Dec 1 2011, In : Free Radical Biology and Medicine. 51, 11, p. 2048-2059 12 p.

Research output: Contribution to journalArticle

Hydrogen Peroxide
Glucocorticoids
Lymphoma
Apoptosis
Mitogen-Activated Protein Kinase Kinases
2010
7 Citations (Scopus)

Increased cytochrome c correlates with poor survival in aggressive lymphoma

Wilkinson, S., Johnson, D. B. F., Tardif, H. L., Tome, M. E. & Briehl, M. M., Mar 2010, In : Oncology Letters. 1, 2, p. 227-230 4 p.

Research output: Contribution to journalArticle

Cytochromes c
Drug Resistance
Lymphoma
Mitochondria
Mantle-Cell Lymphoma
2009
48 Citations (Scopus)

Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells

Jaramillo, M. C., Frye, J. B., Crapo, J. D., Briehl, M. M. & Tome, M. E., Jul 1 2009, In : Cancer Research. 69, 13, p. 5450-5457 8 p.

Research output: Contribution to journalArticle

Porphyrins
Manganese
Dexamethasone
Superoxide Dismutase
Lymphoma
2007
65 Citations (Scopus)

Modulation of human glutathione S-transferases by polyphenon E intervention

Chow, H-H., Hakim, I. A., Vining, D. R., Crowell, J. A., Tome, M. E., Ranger-Moore, J., Cordova, C. A., Mikhael, D. M., Briehl, M. M. & Alberts, D. S., Aug 1 2007, In : Cancer Epidemiology Biomarkers and Prevention. 16, 8, p. 1662-1666 5 p.

Research output: Contribution to journalArticle

Glutathione Transferase
Tea
Polyphenols
Lymphocytes
polyphenon E
2006
25 Citations (Scopus)

Catalase reverses tumorigenicity in a malignant cell line by an epidermal growth factor receptor pathway

Finch, J. S., Tome, M. E., Kwei, K. A. & Bowden, G. T., Mar 1 2006, In : Free Radical Biology and Medicine. 40, 5, p. 863-875 13 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Catalase
Cells
Cell Line
Hydrogen Peroxide
18 Citations (Scopus)

Glucose 6-phosphate dehydrogenase overexpression models glucose deprivation and sensitizes lymphoma cells to apoptosis

Tome, M. E., Johnson, D. B. F., Samulitis, B. K., Dorr, R. T. & Briehl, M. M., Jul 2006, In : Antioxidants and Redox Signaling. 8, 7-8, p. 1315-1327 13 p.

Research output: Contribution to journalArticle

Glucosephosphate Dehydrogenase
Lymphoma
Apoptosis
Glucocorticoids
Glucose
2005
70 Citations (Scopus)

A redox signature score identifies diffuse large B-cell lymphoma patients with a poor prognosis

Tome, M. E., Johnson, D. B. F., Rimsza, L. M., Roberts, R. A., Grogan, T. M., Miller, T. P., Oberley, L. W. & Briehl, M. M., Nov 15 2005, In : Blood. 106, 10, p. 3594-3601 8 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Oxidation-Reduction
Thioredoxins
Chemotherapy
Antioxidants
5 Citations (Scopus)
Metabolome
Antioxidants
Inflammation
Neoplasms
Thioredoxins
86 Citations (Scopus)

Molecular modes of action of cantharidin in tumor cells

Efferth, T., Rauh, R., Kahl, S., Tomicic, M., Böchzelt, H., Tome, M. E., Briehl, M. M., Bauer, R. & Kaina, B., Mar 1 2005, In : Biochemical Pharmacology. 69, 5, p. 811-818 8 p.

Research output: Contribution to journalArticle

Cantharidin
Tumors
Cells
Neoplasms
Oxidative stress
2004
25 Citations (Scopus)

Overexpression of catalase or Bcl-2 alters glucose and energy metabolism concomitant with dexamethasone resistance

Tome, M. E., Lutz, N. W. & Briehl, M. M., Jul 23 2004, In : BBA - Molecular Cell Research. 1693, 1, p. 57-72 16 p.

Research output: Contribution to journalArticle

Catalase
Energy Metabolism
Dexamethasone
Apoptosis
Glucose
2003
26 Citations (Scopus)

Early changes in glucose and phospholipid metabolism following apoptosis induction by IFN-γ/TNF-α in HT-29 cells

Lutz, N. W., Tome, M. E. & Cozzone, P. J., Jun 5 2003, In : FEBS Letters. 544, 1-3, p. 123-128 6 p.

Research output: Contribution to journalArticle

HT29 Cells
Metabolism
Interferons
Phospholipids
Tumor Necrosis Factor-alpha

Erratum: Early changes in glucose and phospholipid metabolism following apoptosis induction by IFN-γ/TNF-α in HT-29 cells (FEBS Letters (2003) 544 (123-128))

Lutz, N. W., Tome, M. E. & Cozzone, P. J., Sep 25 2003, In : FEBS Letters. 552, 2-3, p. 264 1 p.

Research output: Contribution to journalArticle

HT29 Cells
Phospholipids
Tumor Necrosis Factor-alpha
Apoptosis
Glucose
24 Citations (Scopus)
Catalase
Glucocorticoids
Phospholipids
Apoptosis
Dexamethasone
71 Citations (Scopus)

Role of antioxidant genes for the activity of artesunate against tumor cells.

Efferth, T., Briehl, M. M. & Tome, M. E., Oct 2003, In : International Journal of Oncology. 23, 4, p. 1231-1235 5 p.

Research output: Contribution to journalArticle

Antioxidants
Genes
Neoplasms
Tumor Cell Line
Inhibitory Concentration 50
2002
13 Citations (Scopus)
Thymoma
Metabolism
Dexamethasone
Antioxidants
Steroids
19 Citations (Scopus)

Imexon activates an intrinsic apoptosis pathway in RPMI8226 myeloma cells

Dvorakova, K., Payne, C. M., Landowski, T. H., Tome, M. E., Halperin, D. S. & Dorr, R. T., Nov 2002, In : Anti-Cancer Drugs. 13, 10, p. 1031-1042 12 p.

Research output: Contribution to journalArticle

Apoptosis
Caspase 9
Caspase 3
Caspase 8
4-imino-1,3-diazabicyclo(3.1.0)hexan-2-one
31 Citations (Scopus)

Molecular and cellular characterization of imexon-resistant RPMI8226/I myeloma cells

Dvorakova, K., Payne, C. M., Tome, M. E., Briehl, M. M., Vasquez, M. A., Waltmire, C. N., Coon, A. & Dorr, R. T., Jan 2002, In : Molecular Cancer Therapeutics. 1, 3, p. 185-195 11 p.

Research output: Contribution to journalArticle

irinotecan
Glutathione
Mitochondria
Oxidative Stress
4-imino-1,3-diazabicyclo(3.1.0)hexan-2-one
2001
84 Citations (Scopus)

Catalase-overexpressing thymocytes are resistant to glucocorticoid-induced apoptosis and exhibit increased net tumor growth

Tome, M. E., Baker, A. F., Powis, G., Payne, C. M. & Briehl, M. M., Mar 15 2001, In : Cancer Research. 61, 6, p. 2766-2773 8 p.

Research output: Contribution to journalArticle

Thymocytes
Catalase
Glucocorticoids
Apoptosis
Growth
71 Citations (Scopus)

Induction of mitochondrial changes in myeloma cells by imexon

Dvorakova, K., Waltmire, C. N., Payne, C. M., Tome, M. E., Briehl, M. M. & Dorr, R. T., Jun 1 2001, In : Blood. 97, 11, p. 3544-3551 8 p.

Research output: Contribution to journalArticle

Cells
Cell Line
Acute Promyelocytic Leukemia
4-imino-1,3-diazabicyclo(3.1.0)hexan-2-one
Reactive Oxygen Species
34 Citations (Scopus)
Thymocytes
Hydrogen Peroxide
Dexamethasone
Antioxidants
Apoptosis
2000
71 Citations (Scopus)

Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon

Dvorakova, K., Payne, C. M., Tome, M. E., Briehl, M. M., McClure, T. & Dorr, R. T., Sep 15 2000, In : Biochemical Pharmacology. 60, 6, p. 749-758 10 p.

Research output: Contribution to journalArticle

Oxidative stress
Oxidative Stress
Apoptosis
Cytotoxicity
Sulfhydryl Compounds
1997
32 Citations (Scopus)

Cellular eukaryotic initiation factor 5A content as a mediator of polyamine effects on growth and apoptosis

Tome, M. E. & Gerner, E. W., 1997, In : Biological Signals. 6, 3, p. 150-156 7 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factors
Polyamines
Apoptosis
Growth
Putrescine
83 Citations (Scopus)

Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis

Tome, M. E., Fiser, S. M., Payne, C. M. & Gerner, E. W., Dec 15 1997, In : Biochemical Journal. 328, 3, p. 847-854 8 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factors
Putrescine
Eflornithine
Ornithine Decarboxylase
Apoptosis
46 Citations (Scopus)

Loss of intracellular putrescine pool-size regulation induces apoptosis

Xie, X., Tome, M. E. & Gerner, E. W., Feb 1 1997, In : Experimental Cell Research. 230, 2, p. 386-392 7 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Putrescine
Apoptosis
Polyamines
Cell Line
1996
8 Citations (Scopus)
Eukaryotic Initiation Factors
Ornithine Decarboxylase
Rodentia
Spermidine
Growth
1994
26 Citations (Scopus)

Consequences of aberrant ornithine decarboxylase regulation in rat hepatoma cells

Tome, M. E., Fiser, S. M. & Gerner, E. W., Feb 1994, In : Journal of Cellular Physiology. 158, 2, p. 237-244 8 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Putrescine
Polyamines
Eflornithine
Rats
1991
3 Citations (Scopus)

Mechanisms of accelerated proteolysis in rat soleus muscle atrophy induced by unweighting or denervation.

Tischler, M. E., Kirby, C., Rosenberg, S., Tome, M. E. & Chase, P., Feb 1991, In : The Physiologist. 34, 1 Suppl

Research output: Contribution to journalArticle

Proteolysis
Weightlessness
Muscular Atrophy
Denervation
Lysosomes
12 Citations (Scopus)

Polyamine catabolism in rodent and human cells in culture

Carper, S. W., Tome, M. E., Fuller, D. J. M., Chen, J. R., Harari, P. M. & Gerner, E. W., 1991, In : Biochemical Journal. 280, 2, p. 289-294 6 p.

Research output: Contribution to journalArticle

Polyamines
Cell culture
Rodentia
Putrescine
Cell Culture Techniques
1990
73 Citations (Scopus)

Different mechanisms of increased proteolysis in atrophy induced by denervation or unweighting of rat soleus muscle

Tischler, M. E., Rosenberg, S., Satarug, S., Henriksen, E. J., Kirby, C. R., Tome, M. E. & Chase, P., 1990, In : Metabolism: Clinical and Experimental. 39, 7, p. 756-763 8 p.

Research output: Contribution to journalArticle

Denervation
Proteolysis
Atrophy
Skeletal Muscle
Muscles