Margaret E Tome

  • 1452 Citations
  • 23 h-Index
1985 …2019

Research output per year

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Research Output

  • 1452 Citations
  • 23 h-Index
  • 49 Article
  • 2 Chapter
  • 2 Review article
  • 1 Comment/debate
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Article
2019

Thiol regulation by Mn porphyrins, commonly known as SOD mimics

Batinic-Haberle, I. & Tome, M. E., Jul 2019, In : Redox Biology. 25, 101139.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2018

Acute pain alters P-glycoprotein-containing protein complexes in rat cerebral microvessels: Implications for P-glycoprotein trafficking

Tome, M. E., Jarvis, C. K., Schaefer, C. P., Jacobs, L. M., Herndon, J. M., Hunn, K. C., Arkwright, N. B., Kellohen, K. L., Mierau, P. C. & Davis, T. P., Dec 1 2018, In : Journal of Cerebral Blood Flow and Metabolism. 38, 12, p. 2209-2222 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Chronic morphine exposure potentiates p-glycoprotein trafficking from nuclear reservoirs in cortical rat brain microvessels

Schaefer, C. P., Arkwright, N. B., Jacobs, L. M., Jarvis, C. K., Hunn, K. C., Largent-Milnes, T. M., Tome, M. E. & Davis, T. P., Feb 2018, In : PloS one. 13, 2, e0192340.

Research output: Contribution to journalArticle

6 Scopus citations

Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery

Cottier, K. E., Galloway, E. A., Calabrese, E. C., Tome, M. E., Liktor-Busa, E., Kim, J., Davis, T. P., Vanderah, T. W. & Largent-Milnes, T. M., Jul 1 2018, In : eNeuro. 5, 4

Research output: Contribution to journalArticle

6 Scopus citations

Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate

Tovmasyan, A., Bueno-Janice, J. C., Jaramillo, M. C., Sampaio, R. S., Reboucas, J. S., Kyui, N., Benov, L., Deng, B., Huang, T. T., Tome, M. E., Spasojevic, I. & Batinic-Haberle, I., Nov 1 2018, In : Antioxidants and Redox Signaling. 29, 13, p. 1196-1214 19 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain

Tome, M. E., Herndon, J. M., Schaefer, C. P., Jacobs, L. M., Zhang, Y., Jarvis, C. K. & Davis, T. P., Nov 1 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 11, p. 1913-1928 16 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Identification of P-glycoprotein co-fractionating proteins and specific binding partners in rat brain microvessels

Tome, M. E., Schaefer, C. P., Jacobs, L. M., Zhang, Y., Herndon, J. M., Matty, F. O. & Davis, T. P., Jul 1 2015, In : Journal of Neurochemistry. 134, 2, p. 200-210 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
25 Scopus citations
2014

Mitochondria and redox homoeostasis as chemotherapeutic targets

Briehl, M. M., Tome, M. E., Wilkinson, S. T., Jaramillo, M. C. & Lee, K., Aug 2014, In : Biochemical Society transactions. 42, 4, p. 939-944 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

The copper chelator ATN-224 induces caspase-independent cell death in diffuse large B cell lymphoma

Lee, K., Hart, M. R., Briehl, M. M., Mazar, A. P. & Tome, M. E., Jul 2014, In : International journal of oncology. 45, 1, p. 439-447 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2013

The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies

Lee, K., Briehl, M. M., Mazar, A. P., Batinic-Haberle, I., Reboucas, J. S., Glinsmann-Gibson, B., Rimsza, L. M. & Tome, M. E., Jul 1 2013, In : Free Radical Biology and Medicine. 60, p. 157-167 11 p.

Research output: Contribution to journalArticle

22 Scopus citations
2012

Factors determining sensitivity and resistance of tumor cells to arsenic trioxide

Sertel, S., Tome, M., Briehl, M. M., Bauer, J., Hock, K., Plinkert, P. K. & Efferth, T., May 10 2012, In : PloS one. 7, 5, e35584.

Research output: Contribution to journalArticle

17 Scopus citations

Lymphoma cells with increased anti-oxidant defenses acquire chemoresistance

Tome, M. E., Frye, J. B., Coyle, D. L., Jacobson, E. L., Samulitis, B. K., Dvorak, K., Dorr, R. T. & Briehl, M. M., May 2012, In : Experimental and Therapeutic Medicine. 3, 5, p. 845-852 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Manganese porphyrin, MnTE-2-PyP 5+, acts as a pro-oxidant to potentiate glucocorticoid-induced apoptosis in lymphoma cells

Jaramillo, M. C., Briehl, M. M., Crapo, J. D., Batinic-Haberle, I. & Tome, M. E., Apr 15 2012, In : Free Radical Biology and Medicine. 52, 8, p. 1272-1284 13 p.

Research output: Contribution to journalArticle

49 Scopus citations

Mitochondria are the primary source of the H 2O 2 signal for glucocorticoid-induced apoptosis of lymphoma cells

Tome, M. E., Lee, K., Jaramillo, M. C. & Briehl, M. M., Aug 2012, In : Experimental and Therapeutic Medicine. 4, 2, p. 237-242 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mitochondrial adaptations to oxidative stress confer resistance to apoptosis in lymphoma cells

Wilkinson, S. T., Tome, M. E. & Briehl, M. M., Aug 2012, In : International journal of molecular sciences. 13, 8, p. 10212-10228 17 p.

Research output: Contribution to journalArticle

6 Scopus citations
2011

A strategy for full interrogation of prognostic gene expression patterns: Exploring the biology of diffuse large B cell lymphoma

Rimsza, L. M., Unger, J. M., Tome, M. E. & LeBlanc, M. L., 2011, In : PloS one. 6, 8, e22267.

Research output: Contribution to journalArticle

6 Scopus citations

Characterization of squamous esophageal cells resistant to bile acids at acidic pH: Implication for Barrett's esophagus pathogenesis

Goldman, A., Chen, H. D. R., Roesly, H. B., Hill, K. A., Tome, M. E., Dvorak, B., Bernstein, H. & Dvorak, K., Feb 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 2, p. G292-G302

Research output: Contribution to journalArticle

31 Scopus citations

Hydrogen peroxide signaling is required for glucocorticoid-induced apoptosis in lymphoma cells

Tome, M. E., Jaramillo, M. C. & Briehl, M. M., Dec 1 2011, In : Free Radical Biology and Medicine. 51, 11, p. 2048-2059 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2010

Increased cytochrome c correlates with poor survival in aggressive lymphoma

Wilkinson, S., Johnson, D. B. F., Tardif, H. L., Tome, M. E. & Briehl, M. M., Mar 1 2010, In : Oncology Letters. 1, 2, p. 227-230 4 p.

Research output: Contribution to journalArticle

7 Scopus citations
2009

Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells

Jaramillo, M. C., Frye, J. B., Crapo, J. D., Briehl, M. M. & Tome, M. E., Jul 1 2009, In : Cancer Research. 69, 13, p. 5450-5457 8 p.

Research output: Contribution to journalArticle

49 Scopus citations
2007

Modulation of human glutathione S-transferases by polyphenon E intervention

Chow, H. H. S., Hakim, I. A., Vining, D. R., Crowell, J. A., Tome, M. E., Ranger-Moore, J., Cordova, C. A., Mikhael, D. M., Briehl, M. M. & Alberts, D. S., Aug 1 2007, In : Cancer Epidemiology Biomarkers and Prevention. 16, 8, p. 1662-1666 5 p.

Research output: Contribution to journalArticle

66 Scopus citations
2006

Catalase reverses tumorigenicity in a malignant cell line by an epidermal growth factor receptor pathway

Finch, J. S., Tome, M. E., Kwei, K. A. & Bowden, G. T., Mar 1 2006, In : Free Radical Biology and Medicine. 40, 5, p. 863-875 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Glucose 6-phosphate dehydrogenase overexpression models glucose deprivation and sensitizes lymphoma cells to apoptosis

Tome, M. E., Johnson, D. B. F., Samulitis, B. K., Dorr, R. T. & Briehl, M. M., Jul 1 2006, In : Antioxidants and Redox Signaling. 8, 7-8, p. 1315-1327 13 p.

Research output: Contribution to journalArticle

19 Scopus citations
2005

A redox signature score identifies diffuse large B-cell lymphoma patients with a poor prognosis

Tome, M. E., Johnson, D. B. F., Rimsza, L. M., Roberts, R. A., Grogan, T. M., Miller, T. P., Oberley, L. W. & Briehl, M. M., Nov 15 2005, In : Blood. 106, 10, p. 3594-3601 8 p.

Research output: Contribution to journalArticle

73 Scopus citations
5 Scopus citations

Molecular modes of action of cantharidin in tumor cells

Efferth, T., Rauh, R., Kahl, S., Tomicic, M., Böchzelt, H., Tome, M. E., Briehl, M. M., Bauer, R. & Kaina, B., Mar 1 2005, In : Biochemical Pharmacology. 69, 5, p. 811-818 8 p.

Research output: Contribution to journalArticle

86 Scopus citations
2004
27 Scopus citations
2003

Early changes in glucose and phospholipid metabolism following apoptosis induction by IFN-γ/TNF-α in HT-29 cells

Lutz, N. W., Tome, M. E. & Cozzone, P. J., Jun 5 2003, In : FEBS Letters. 544, 1-3, p. 123-128 6 p.

Research output: Contribution to journalArticle

26 Scopus citations
24 Scopus citations

Role of antioxidant genes for the activity of artesunate against tumor cells.

Efferth, T., Briehl, M. M. & Tome, M. E., Oct 2003, In : International journal of oncology. 23, 4, p. 1231-1235 5 p.

Research output: Contribution to journalArticle

71 Scopus citations
2002
14 Scopus citations

Imexon activates an intrinsic apoptosis pathway in RPMI8226 myeloma cells

Dvorakova, K., Payne, C. M., Landowski, T. H., Tome, M. E., Halperin, D. S. & Dorr, R. T., Nov 1 2002, In : Anti-cancer drugs. 13, 10, p. 1031-1042 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Molecular and cellular characterization of imexon-resistant RPMI8226/I myeloma cells

Dvorakova, K., Payne, C. M., Tome, M. E., Briehl, M. M., Vasquez, M. A., Waltmire, C. N., Coon, A. & Dorr, R. T., Jan 1 2002, In : Molecular Cancer Therapeutics. 1, 3, p. 185-195 11 p.

Research output: Contribution to journalArticle

32 Scopus citations
2001

Catalase-overexpressing thymocytes are resistant to glucocorticoid-induced apoptosis and exhibit increased net tumor growth

Tome, M. E., Baker, A. F., Powis, G., Payne, C. M. & Briehl, M. M., Mar 15 2001, In : Cancer Research. 61, 6, p. 2766-2773 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

Induction of mitochondrial changes in myeloma cells by imexon

Dvorakova, K., Waltmire, C. N., Payne, C. M., Tome, M. E., Briehl, M. M. & Dorr, R. T., Jun 1 2001, In : Blood. 97, 11, p. 3544-3551 8 p.

Research output: Contribution to journalArticle

72 Scopus citations
34 Scopus citations
2000

Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon

Dvorakova, K., Payne, C. M., Tome, M. E., Briehl, M. M., McClure, T. & Dorr, R. T., Sep 15 2000, In : Biochemical Pharmacology. 60, 6, p. 749-758 10 p.

Research output: Contribution to journalArticle

75 Scopus citations
1997

Cellular eukaryotic initiation factor 5A content as a mediator of polyamine effects on growth and apoptosis

Tome, M. E. & Gerner, E. W., Jan 1 1997, In : NeuroSignals. 6, 3, p. 150-156 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis

Tome, M. E., Fiser, S. M., Payne, C. M. & Gerner, E. W., Dec 15 1997, In : Biochemical Journal. 328, 3, p. 847-854 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

Loss of intracellular putrescine pool-size regulation induces apoptosis

Xie, X., Tome, M. E. & Gerner, E. W., Feb 1 1997, In : Experimental Cell Research. 230, 2, p. 386-392 7 p.

Research output: Contribution to journalArticle

46 Scopus citations
1996
8 Scopus citations
1994

Consequences of aberrant ornithine decarboxylase regulation in rat hepatoma cells

Tome, M. E., Fiser, S. M. & Gerner, E. W., Feb 1994, In : Journal of Cellular Physiology. 158, 2, p. 237-244 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
1991

Mechanisms of accelerated proteolysis in rat soleus muscle atrophy induced by unweighting or denervation.

Tischler, M. E., Kirby, C., Rosenberg, S., Tome, M. & Chase, P., Feb 1991, In : The Physiologist. 34, 1 Suppl, p. S177-178

Research output: Contribution to journalArticle

3 Scopus citations

Polyamine catabolism in rodent and human cells in culture

Carper, S. W., Tome, M. E., Fuller, D. J. M., Chen, J. R., Harari, P. M. & Gerner, E. W., Jan 1 1991, In : Biochemical Journal. 280, 2, p. 289-294 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
1990

Different mechanisms of increased proteolysis in atrophy induced by denervation or unweighting of rat soleus muscle

Tischler, M. E., Rosenberg, S., Satarug, S., Henriksen, E. J., Kirby, C. R., Tome, M. & Chase, P., Jul 1990, In : Metabolism. 39, 7, p. 756-763 8 p.

Research output: Contribution to journalArticle

74 Scopus citations
1989

Effects of diethyldithiocarbamate and endogenous polyamine content on cellular responses to hydrogen peroxide cytotoxicity

Harari, P. M., Tome, M. E., Fuller, D. J. M., Carper, S. W. & Gerner, E. W., Jan 1 1989, In : Biochemical Journal. 260, 2, p. 487-490 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
1988

Inhibition of Ionizing Radiation Recovery Processes in Polyamine-depleted Chinese Hamster Cells

Gerner, E. W., Tome, M. E., Fry, S. E. & Bowden, G. T., Sep 1 1988, In : Cancer Research. 48, 17, p. 4881-4885 5 p.

Research output: Contribution to journalArticle

20 Scopus citations
1985

Adrenal responses to chronic and acute water stress in japanese quail Coturnix japonica

Tome, M. E., McNabb, F. M. A. & Gwazdauskas, F. C., 1985, In : Comparative Biochemistry and Physiology -- Part A: Physiology. 81, 1, p. 171-179 9 p.

Research output: Contribution to journalArticle

3 Scopus citations