Melissa Herbst-Kralovetz

  • 1272 Citations
  • 20 h-Index
20022019
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Research Output 2002 2019

  • 1272 Citations
  • 20 h-Index
  • 34 Article
  • 5 Review article
  • 1 Chapter
2019

Analysis of Host Responses to Neisseria gonorrhoeae Using a Human Three-Dimensional Endometrial Epithelial Cell Model

Łaniewski, P. & Herbst-Kralovetz, M. M., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 347-361 15 p. (Methods in Molecular Biology; vol. 1997).

Research output: Chapter in Book/Report/Conference proceedingChapter

Neisseria gonorrhoeae
Epithelial Cells
Technology
Endometritis
Pelvic Inflammatory Disease

Chronic immune barrier dysregulation among women with a history of violence victimization

Swaims-Kohlmeier, A., Haddad, L. B., Li, T. Z. R., Brookmeyer, K. A., Baker, J. M., Widom, C. S., Lamousin, J. C., Chi, K. H., Chen, C. Y., Kersh, E. N., Johnson, J. A., Herbst-Kralovetz, M., Hogben, M., Ofotokun, I. & Kohlmeier, J. E., Jan 1 2019, In : JCI Insight. 4, 10, e126097.

Research output: Contribution to journalArticle

Open Access
Crime Victims
Violence
Sexually Transmitted Diseases
Bacterial Vaginosis
Wounds and Injuries
5 Citations (Scopus)

Deciphering the complex interplay between microbiota, HPV, inflammation and cancer through cervicovaginal metabolic profiling

Ilhan, Z. E., Łaniewski, P., Thomas, N., Roe, D., Chase, D. M. & Herbst-Kralovetz, M., Jan 1 2019, In : EBioMedicine.

Research output: Contribution to journalArticle

Open Access
Microbiota
Metabolites
Metabolism
Glycochenodeoxycholic Acid
Gynecology
3 Citations (Scopus)

Features of the cervicovaginal microenvironment drive cancer biomarker signatures in patients across cervical carcinogenesis

Łaniewski, P., Cui, H., Roe, D., Barnes, D., Goulder, A., Monk, B. J., Greenspan, D. L., Chase, D. M. & Herbst-Kralovetz, M., Dec 1 2019, In : Scientific reports. 9, 1, 7333.

Research output: Contribution to journalArticle

Open Access
Tumor Biomarkers
Carcinogenesis
Microbiota
Carcinoma
Inflammation
1 Citation (Scopus)

IL-36γ is a key regulator of neutrophil infiltration in the vaginal microenvironment and limits neuroinvasion in genital HSV-2 infection

Gardner, J. K., Swaims-Kohlmeier, A. & Herbst-Kralovetz, M. M., Nov 15 2019, In : Journal of Immunology. 203, 10, p. 2655-2664 10 p.

Research output: Contribution to journalArticle

Human Herpesvirus 2
Neutrophil Infiltration
Infection
Viruses
Epithelium

Personal and Clinical Vaginal Lubricants: Impact on Local Vaginal Microenvironment and Implications for Epithelial Cell Host Response and Barrier Function

Wilkinson, E. M., Łaniewski, P., Herbst-Kralovetz, M. M. & Brotman, R. M., Nov 6 2019, In : The Journal of infectious diseases. 220, 12, p. 2009-2018 10 p.

Research output: Contribution to journalArticle

Lubricants
Epithelial Cells
Osmolar Concentration
Cell Survival
Nonoxynol
2018
6 Citations (Scopus)

IL-36γ induces a transient HSV-2 resistant environment that protects against genital disease and pathogenesis

Gardner, J. K. & Herbst-Kralovetz, M., Nov 1 2018, In : Cytokine. 111, p. 63-71 9 p.

Research output: Contribution to journalArticle

Human Herpesvirus 2
Viruses
Virus Diseases
Chemokine CCL20
Vaginal Douching
16 Citations (Scopus)
Microbiota
Hispanic Americans
Uterine Cervical Neoplasms
Carcinogenesis
Carcinoma
12 Citations (Scopus)

Microbiota–drug interactions: Impact on metabolism and efficacy of therapeutics

Wilkinson, E. M., Ilhan, Z. E. & Herbst-Kralovetz, M., Jun 1 2018, In : Maturitas. 112, p. 53-63 11 p.

Research output: Contribution to journalReview article

Microbiota
Metabolism
Pharmaceutical Preparations
Therapeutics
Biotransformation
28 Citations (Scopus)

Uterine microbiota: Residents, tourists, or invaders?

Baker, J. M., Chase, D. M. & Herbst-Kralovetz, M., Mar 2 2018, In : Frontiers in Immunology. 9, MAR, 208.

Research output: Contribution to journalReview article

Microbiota
Obstetrics
Uterus
Homeostasis
Bacteria
2017
54 Citations (Scopus)

Estrogen–gut microbiome axis: Physiological and clinical implications

Baker, J. M., Al-Nakkash, L. & Herbst-Kralovetz, M., Sep 1 2017, In : Maturitas. 103, p. 45-53 9 p.

Research output: Contribution to journalReview article

Microbiota
Estrogens
Metabolome
Cognition
Dysbiosis
16 Citations (Scopus)
Neisseria gonorrhoeae
Epithelial Cells
Bacteria
Toll-Like Receptors
Lipoproteins
2016
17 Citations (Scopus)

IL-36γ augments host defense and immune responses in human female reproductive tract epithelial cells

Winkle, S. M., Throop, A. L. & Herbst-Kralovetz, M., 2016, In : Frontiers in Microbiology. 7, JUN, 955.

Research output: Contribution to journalArticle

Epithelial Cells
Cytokines
Flagellin
Poly I-C
Interleukin-1
51 Citations (Scopus)

Menopause and the vaginal microbiome

Muhleisen, A. L. & Herbst-Kralovetz, M., Sep 1 2016, In : Maturitas. 91, p. 42-50 9 p.

Research output: Contribution to journalReview article

Microbiota
Menopause
Health
Hormones
Homeostasis
14 Citations (Scopus)

New Systems for Studying Intercellular Interactions in Bacterial Vaginosis

Herbst-Kralovetz, M., Pyles, R. B., Ratner, A. J., Sycuro, L. K. & Mitchell, C., Aug 15 2016, In : Journal of Infectious Diseases. 214, p. S6-S13

Research output: Contribution to journalArticle

Bacterial Vaginosis
Reproductive Health
Treatment Failure
Public Health
In Vitro Techniques
6 Citations (Scopus)

Three-dimensional rotating wall vessel-derived cell culture models for studying virus-host interactions

Gardner, J. K. & Herbst-Kralovetz, M., Nov 9 2016, In : Viruses. 8, 11, 304.

Research output: Contribution to journalReview article

Cell Culture Techniques
Viruses
Bioreactors
Virus Diseases
United States National Aeronautics and Space Administration
2015
56 Citations (Scopus)
Peptides
Microbiota
Pregnancy Complications
Pregnancy
Infection
34 Citations (Scopus)

The vaginal and gastrointestinal microbiomes in gynecologic cancers: A review of applications in etiology, symptoms and treatment

Chase, D., Goulder, A., Zenhausern, F., Monk, B. & Herbst-Kralovetz, M., Jul 1 2015, In : Gynecologic Oncology. 138, 1, p. 190-200 11 p.

Research output: Contribution to journalArticle

Microbiota
Neoplasms
Uterine Neoplasms
Second Primary Neoplasms
Probiotics
2014
92 Citations (Scopus)

Bacteria in the vaginal microbiome alter the innate immune response and barrier properties of the human vaginal epithelia in a species-specific manner

Doerflinger, S. Y., Throop, A. L. & Herbst-Kralovetz, M., Jun 15 2014, In : Journal of Infectious Diseases. 209, 12, p. 1989-1999 11 p.

Research output: Contribution to journalArticle

Microbiota
Bacterial Vaginosis
Innate Immunity
Epithelium
Epithelial Cells
10 Citations (Scopus)
Norovirus
Mucosal Immunity
Viruses
Virion
Capsid Proteins
1 Citation (Scopus)

Overcoming barriers in the mucosal delivery of virus-like particle-based vaccines

Herbst-Kralovetz, M., Jul 1 2014, In : Therapeutic Delivery. 5, 7, p. 741-744 4 p.

Research output: Contribution to journalArticle

Virus-Like Particle Vaccines
Mucosal Immunity
Nose
Virion
16 Citations (Scopus)

TLR7 and 9 agonists are highly effective mucosal adjuvants for norovirus virus-like particle vaccines

Hjelm, B. E., Kilbourne, J. & Herbst-Kralovetz, M., 2014, In : Human Vaccines and Immunotherapeutics. 10, 2, p. 410-416 7 p.

Research output: Contribution to journalArticle

Virus-Like Particle Vaccines
Norovirus
Virion
Norwalk virus
Technology Transfer
2013
53 Citations (Scopus)

Lack of norovirus replication and histo-blood group antigen expression in 3-dimensional intestinal epithelial cells

Herbst-Kralovetz, M., Radtke, A. L., Lay, M. K., Hjelm, B. E., Bolick, A. N., Sarker, S. S., Atmar, R. L., Kingsley, D. H., Arntzen, C. J., Estes, M. K. & Nickerson, C. A., Mar 2013, In : Emerging Infectious Diseases. 19, 3, p. 431-438 8 p.

Research output: Contribution to journalArticle

Norwalk virus
Norovirus
Blood Group Antigens
Epithelial Cells
Virus Replication
23 Citations (Scopus)

Mycoplasma genitalium infection activates cellular host defense and inflammation pathways in a 3-dimensional human endocervical epithelial cell model

McGowin, C. L., Radtke, A. L., Abraham, K., Martin, D. H. & Herbst-Kralovetz, M., Jun 15 2013, In : Journal of Infectious Diseases. 207, 12, p. 1857-1868 12 p.

Research output: Contribution to journalArticle

Mycoplasma genitalium
Mycoplasma Infections
Epithelial Cells
Inflammation
Infection
2012
26 Citations (Scopus)
Bioreactors
Epithelial Cells
Cell culture
Somatostatin-Secreting Cells
Tissue
Bioreactors
Epithelial Cells
Cell culture
Somatostatin-Secreting Cells
Tissue
28 Citations (Scopus)

Intranasal vaccination with murabutide enhances humoral and mucosal immune responses to a virus-like particle vaccine

Jackson, E. M. & Herbst-Kralovetz, M., Jul 25 2012, In : PLoS One. 7, 7, e41529.

Research output: Contribution to journalArticle

Virus-Like Particle Vaccines
virus-like particle vaccines
mucosal immunity
Mucosal Immunity
virus-like particles
27 Citations (Scopus)
Mucins
Mucus
Mycoplasma genitalium
Epithelial Cells
Peptides
16 Citations (Scopus)

Plant-derived antigens as mucosal vaccines

Mason, H. S. & Herbst-Kralovetz, M., 2012, In : Current Topics in Microbiology and Immunology. 354, 1, p. 101-120 20 p.

Research output: Contribution to journalArticle

Plant Antigens
Vaccines
Antibody Formation
Pattern Recognition Receptors
Antigens
2011
52 Citations (Scopus)

A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge

Phoolcharoen, W., Dye, J. M., Kilbourne, J., Piensook, K., Pratt, W. D., Arntzen, C. J., Chen, Q., Mason, H. S. & Herbst-Kralovetz, M., Dec 20 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20695-20700 6 p.

Research output: Contribution to journalArticle

Ebolavirus
Subunit Vaccines
Antigen-Antibody Complex
Ebola Hemorrhagic Fever
Ebola Vaccines
60 Citations (Scopus)

Intranasal delivery of Norwalk virus-like particles formulated in an in situ gelling, dry powder vaccine

Velasquez, L. S., Shira, S., Berta, A. N., Kilbourne, J., Medi, B. M., Tizard, I., Ni, Y., Arntzen, C. J. & Herbst-Kralovetz, M., Jul 18 2011, In : Vaccine. 29, 32, p. 5221-5231 11 p.

Research output: Contribution to journalArticle

Norwalk virus
virus-like particles
gelation
Virion
Powders
2010
33 Citations (Scopus)

An intranasally delivered toll-like receptor 7 agonist elicits robust systemic and mucosal responses to Norwalk virus-like particles

Velasquez, L. S., Hjelm, B. E., Arntzen, C. J. & Herbst-Kralovetz, M., Dec 2010, In : Clinical and Vaccine Immunology. 17, 12, p. 1850-1858 9 p.

Research output: Contribution to journalArticle

Norwalk virus
Toll-Like Receptor 7
Viruses
Virion
resiquimod
56 Citations (Scopus)

Development and characterization of a three-dimensional organotypic human vaginal epithelial cell model

Hjelm, B. E., Berta, A. N., Nickerson, C. A., Arntzen, C. J. & Herbst-Kralovetz, M., Mar 2010, In : Biology of Reproduction. 82, 3, p. 617-627 11 p.

Research output: Contribution to journalArticle

Anti-Infective Agents
Epithelial Cells
Bioreactors
Nonoxynol
Technology
87 Citations (Scopus)

Norwalk virus-like particles as vaccines

Herbst-Kralovetz, M., Mason, H. S. & Chen, Q., 2010, In : Expert Review of Vaccines. 9, 3, p. 299-307 9 p.

Research output: Contribution to journalArticle

Virus-Like Particle Vaccines
Norwalk virus
Virion
Norovirus
Plant Cells
152 Citations (Scopus)

Organotypic 3D cell culture models: Using the rotating wall vessel to study hostĝ€"pathogen interactions

Barrila, J., Radtke, A. L., Crabbé, A., Sarker, S. F., Herbst-Kralovetz, M., Ott, C. M. & Nickerson, C. A., Nov 2010, In : Nature Reviews Microbiology. 8, 11, p. 791-801 11 p.

Research output: Contribution to journalArticle

Host-Pathogen Interactions
Cell Culture Techniques
Bioreactors
Coculture Techniques
Communicable Diseases
2008
82 Citations (Scopus)

Quantification and comparison of toll-like receptor expression and responsiveness in primary and immortalized human female lower genital tract epithelia

Herbst-Kralovetz, M., Quayle, A. J., Ficarra, M., Greene, S., Rose, W. A., Chesson, R., Spagnuolo, R. A. & Pyles, R. B., Mar 2008, In : American Journal of Reproductive Immunology. 59, 3, p. 212-224 13 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Epithelium
Epithelial Cells
Cytokines
Sexually Transmitted Diseases
2006
56 Citations (Scopus)

Quantification of poly(I: C)-mediated protection against genital herpes simplex virus type 2 infection

Herbst-Kralovetz, M. & Pyles, R. B., Oct 2006, In : Journal of Virology. 80, 20, p. 9988-9997 10 p.

Research output: Contribution to journalArticle

Human herpesvirus 2
Herpes Genitalis
polyinosinic-polycytidylic acid
Human Herpesvirus 2
Virus Diseases
47 Citations (Scopus)

Toll-like receptors, innate immunity and HSV pathogenesis

Herbst-Kralovetz, M. & Pyles, R. B., Aug 2006, In : Herpes. 13, 2, p. 37-41 5 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Simplexvirus
Innate Immunity
Virus Diseases
Equipment and Supplies
2003
18 Citations (Scopus)

Immunostimulatory CpG treatment for genital HSV-2 infections

Herbst-Kralovetz, M. & Pyles, R. B., Dec 2003, In : Journal of Antimicrobial Chemotherapy. 52, 6, p. 887-889 3 p.

Research output: Contribution to journalArticle

Herpesvirus Vaccines
Viral Drug Resistance
Herpes Genitalis
Immunologic Adjuvants
CpG Islands
2002
18 Citations (Scopus)

Sequence and expression analysis of deer mouse interferon-γ, interleukin-10, tumor necrosis factor, and lymphotoxin-α

Herbst-Kralovetz, M., Prescott, J., Palmer, A. D. N. & Schountz, T., 2002, In : Cytokine. 17, 4, p. 203-213 11 p.

Research output: Contribution to journalArticle

Peromyscus
Lymphotoxin-alpha
Sin Nombre virus
Viruses
Interleukin-10