• 7055 Citations
  • 45 h-Index
1975 …2019

Research output per year

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Research Output

  • 7055 Citations
  • 45 h-Index
  • 145 Article
  • 6 Chapter
  • 4 Review article
  • 1 Conference contribution
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Article
2019

Cholesterol Effects on the Physical Properties of Lipid Membranes Viewed by Solid-state NMR Spectroscopy

Molugu, T. R. & Brown, M. F., Jan 1 2019, In : Advances in Experimental Medicine and Biology. 1115, p. 99-133 35 p.

Research output: Contribution to journalArticle

2 Scopus citations

Flexible lipid nanomaterials studied by NMR spectroscopy

Mallikarjunaiah, K. J., Kinnun, J. J., Petrache, H. I. & Brown, M. F., Jan 1 2019, In : Physical Chemistry Chemical Physics. 21, 34, p. 18422-18457 36 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Small-Angle Neutron Scattering Reveals Energy Landscape for Rhodopsin Photoactivation

Perera, S. M. D. C., Chawla, U., Shrestha, U. R., Bhowmik, D., Struts, A. V., Qian, S., Chu, X. Q. & Brown, M. F., Dec 20 2018, In : Journal of Physical Chemistry Letters. 9, 24, p. 7064-7071 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Synthesis of 9-CD3-9-cis-retinal cofactor of isorhodopsin

Navidi, M., Yadav, S., Struts, A. V., Brown, M. F. & Nesnas, N., Dec 19 2018, In : Tetrahedron Letters. 59, 51, p. 4521-4524 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

A Usual G-Protein-Coupled Receptor in Unusual Membranes

Chawla, U., Jiang, Y., Zheng, W., Kuang, L., Perera, S. M. D. C., Pitman, M. C., Brown, M. F. & Liang, H., Jan 11 2016, In : Angewandte Chemie - International Edition. 55, 2, p. 588-592 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cholesterol-induced suppression of membrane elastic fluctuations at the atomistic level

Molugu, T. R. & Brown, M. F., Sep 1 2016, In : Chemistry and Physics of Lipids. 199, p. 39-51 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Powdered G-Protein-Coupled Receptors

Perera, S. M. D. C., Chawla, U. & Brown, M. F., Oct 20 2016, In : Journal of Physical Chemistry Letters. 7, 20, p. 4230-4235 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Quasi-elastic Neutron Scattering Reveals Ligand-Induced Protein Dynamics of a G-Protein-Coupled Receptor

Shrestha, U. R., Perera, S. M. D. C., Bhowmik, D., Chawla, U., Mamontov, E., Brown, M. F. & Chu, X. Q., Oct 20 2016, In : Journal of Physical Chemistry Letters. 7, 20, p. 4130-4136 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Spectral methods for study of the G-protein-coupled receptor rhodopsin. II. Magnetic resonance methods

Struts, A. V., Barmasov, A. V. & Brown, M. F., Feb 1 2016, In : Optics and Spectroscopy (English translation of Optika i Spektroskopiya). 120, 2, p. 286-293 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Investigation of rhodopsin dynamics in its signaling state by solid-state deuterium nmr spectroscopy

Struts, A. V., Chawla, U., Perera, S. M. D. C. & Brown, M. F., 2015, In : Methods in molecular biology (Clifton, N.J.). 1271, p. 133-158 26 p.

Research output: Contribution to journalArticle

Investigation of rhodopsin dynamics in its signaling state by solid-state deuterium NMR spectroscopy

Struts, A. V., Chawla, U., Perera, S. M. D. C. & Brown, M. F., 2015, In : Methods in molecular biology (Clifton, N.J.). 1271, p. 133-158 26 p.

Research output: Contribution to journalArticle

2 Scopus citations

Retinal Flip in Rhodopsin Activation?

Feng, J., Brown, M. F. & Mertz, B., Jun 18 2015, In : Biophysical Journal. 108, 12, p. 2767-2770 4 p.

Research output: Contribution to journalArticle

5 Scopus citations
6 Scopus citations
2014

Area per lipid and cholesterol interactions in membranes from separated local-field 13C NMR spectroscopy

Leftin, A., Molugu, T. R., Job, C., Beyer, K. & Brown, M. F., Nov 18 2014, In : Biophysical Journal. 107, 10, p. 2274-2286 13 p.

Research output: Contribution to journalArticle

35 Scopus citations

Generalized model-free analysis of nuclear spin relaxation experiments

Xu, X., Struts, A. V. & Brown, M. F., 2014, In : eMagRes. 3, 3, p. 275-286 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Phospholipid bilayer membranes: Deuterium and carbon-13 NMR spectroscopy

Leftin, A., Xu, X. & Brown, M. F., 2014, In : eMagRes. 3, 3, p. 199-214 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Retinal ligand mobility explains internal hydration and reconciles active rhodopsin structures

Leioatts, N., Mertz, B., Martínez-Mayorga, K., Romo, T. D., Pitman, M. C., Feller, S. E., Grossfield, A. & Brown, M. F., Jan 21 2014, In : Biochemistry. 53, 2, p. 376-385 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
2013

High-resolution NMR reveals secondary structure and folding of amino acid transporter from outer chloroplast membrane.

Zook, J. D., Molugu, T. R., Jacobsen, N. E., Lin, G., Soll, J., Cherry, B. R., Brown, M. F. & Fromme, P., 2013, In : PLoS One. 8, 10, e78116.

Research output: Contribution to journalArticle

Retinal conformation governs pKa of protonated schiff base in rhodopsin activation

Zhu, S., Brown, M. F. & Feller, S. E., Jun 26 2013, In : Journal of the American Chemical Society. 135, 25, p. 9391-9398 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Solid-State 13C NMR reveals annealing of raft-like membranes containing cholesterol by the intrinsically disordered protein α-synuclein

Leftin, A., Job, C., Beyer, K. & Brown, M. F., Aug 23 2013, In : Journal of Molecular Biology. 425, 16, p. 2973-2987 15 p.

Research output: Contribution to journalArticle

43 Scopus citations

Solid-state NMR spectroscopy for the physical chemistry laboratory

Kinnun, J. J., Leftin, A. & Brown, M. F., Jan 8 2013, In : Journal of Chemical Education. 90, 1, p. 123-128 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
2012

Curvature forces in membrane lipid-protein interactions

Brown, M. F., Dec 11 2012, In : Biochemistry. 51, 49, p. 9782-9795 14 p.

Research output: Contribution to journalArticle

76 Scopus citations

Molecular dynamics simulations reveal specific interactions of post-translational palmitoyl modifications with rhodopsin in membranes

Olausson, B. E. S., Grossfield, A., Pitman, M. C., Brown, M. F., Feller, S. E. & Vogel, A., Mar 7 2012, In : Journal of the American Chemical Society. 134, 9, p. 4324-4331 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Molecular simulations and solid-state NMR investigate dynamical structure in rhodopsin activation

Mertz, B., Struts, A. V., Feller, S. E. & Brown, M. F., Feb 2012, In : BBA - Biomembranes. 1818, 2, p. 241-251 11 p.

Research output: Contribution to journalArticle

26 Scopus citations
2011

An NMR database for simulations of membrane dynamics

Leftin, A. & Brown, M. F., Mar 2011, In : BBA - Biomembranes. 1808, 3, p. 818-839 22 p.

Research output: Contribution to journalArticle

65 Scopus citations

Retinal dynamics underlie its switch from inverse agonist to agonist during rhodopsin activation

Struts, A. V., Salgado, G. F. J., Martínez-Mayorga, K. & Brown, M. F., Mar 2011, In : Nature Structural and Molecular Biology. 18, 3, p. 392-394 3 p.

Research output: Contribution to journalArticle

55 Scopus citations
37 Scopus citations

Solid-state 2H NMR shows equivalence of dehydration and osmotic pressures in lipid membrane deformation

Mallikarjunaiah, K. J., Leftin, A., Kinnun, J. J., Justice, M. J., Rogozea, A. L., Petrache, H. I. & Brown, M. F., Jan 5 2011, In : Biophysical Journal. 100, 1, p. 98-107 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Steric and electronic influences on the torsional energy landscape of retinal

Mertz, B., Lu, M., Brown, M. F. & Feller, S. E., Aug 3 2011, In : Biophysical Journal. 101, 3

Research output: Contribution to journalArticle

13 Scopus citations
2010

Retinal dynamics during light activation of rhodopsin revealed by solid-state NMR spectroscopy

Brown, M. F., Salgado, G. F. J. & Struts, A. V., Feb 2010, In : BBA - Biomembranes. 1798, 2, p. 177-193 17 p.

Research output: Contribution to journalArticle

29 Scopus citations

Sequential rearrangement of interhelical networks upon rhodopsin activation in membranes: The meta IIa conformational substate

Zaitseva, E., Brown, M. F. & Vogel, R., Apr 7 2010, In : Journal of the American Chemical Society. 132, 13, p. 4815-4821 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding

Bartels, T., Ahlstrom, L. S., Leftin, A., Kamp, F., Haass, C., Brown, M. F. & Beyer, K., Oct 6 2010, In : Biophysical Journal. 99, 7, p. 2116-2124 9 p.

Research output: Contribution to journalArticle

134 Scopus citations
2009

Phase separation in binary mixtures of bipolar and monopolar lipid dispersions revealed by 2H NMR spectroscopy, small angle x-ray scattering, and molecular theory

Brownholland, D. P., Longo, G. S., Struts, A. V., Justice, M. J., Szleifer, I., Petrache, H. I., Brown, M. F. & Thompson, D. H., Nov 15 2009, In : Biophysical Journal. 97, 10, p. 2700-2709 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Retinal conformation and dynamics in activation of rhodopsin illuminated by solid-state 2H NMR spectroscopy

Brown, M. F., Martínez-Mayorga, K., Nakanishi, K., Salgado, G. F. J. & Struts, A. V., Mar 2009, In : Photochemistry and Photobiology. 85, 2, p. 442-453 12 p.

Research output: Contribution to journalArticle

17 Scopus citations
2008

Bolalipid membrane structure revealed by solid-state 2H NMR spectroscopy

Holland, D. P., Struts, A. V., Brown, M. F. & Thompson, D. H., Apr 9 2008, In : Journal of the American Chemical Society. 130, 14, p. 4584-4585 2 p.

Research output: Contribution to journalArticle

19 Scopus citations

Fluid mechanical matching of H +-ATP synthase subunit c-ring with lipid membranes revealed by 2H solid-state NMR

Kobayashi, M., Struts, A. V., Fujiwara, T., Brown, M. F. & Akutsu, H., Jun 1 2008, In : Biophysical Journal. 94, 11, p. 4339-4347 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Raftlike mixtures of sphingomyelin and cholesterol investigated by solid-state 2H NMR spectroscopy

Bartels, T., Lankalapalli, R. S., Bittman, R., Beyer, K. & Brown, M. F., Nov 5 2008, In : Journal of the American Chemical Society. 130, 44, p. 14521-14532 12 p.

Research output: Contribution to journalArticle

80 Scopus citations

Reconstitution of rhodopsin into polymerizable planar supported lipid bilayers: Influence of dienoyl monomer structure on photoactivation

Subramaniam, V., D'Ambruoso, G. D., Hall, H. K., Wysocki, R. J., Brown, M. F. & Saavedra, S. S., Oct 7 2008, In : Langmuir. 24, 19, p. 11067-11075 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Two protonation switches control rhodopsin activation in membranes

Mahalingam, M., Martínez-Mayorga, K., Brown, M. F. & Vogel, R., Nov 18 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 46, p. 17795-17800 6 p.

Research output: Contribution to journalArticle

118 Scopus citations

Ultra-high vacuum surface analysis study of rhodopsin incorporation into supported lipid bilayers

Michel, R., Subramaniam, V., McArthur, S. L., Bondurant, B., D'Ambruoso, G. D., Hall, H. K., Brown, M. F., Ross, E. E., Saavedra, S. S. & Castner, D. G., May 6 2008, In : Langmuir. 24, 9, p. 4901-4906 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
2007

Dynamic Structure of Retinylidene Ligand of Rhodopsin Probed by Molecular Simulations

Lau, P. W., Grossfield, A., Feller, S. E., Pitman, M. C. & Brown, M. F., Sep 28 2007, In : Journal of Molecular Biology. 372, 4, p. 906-917 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Flexibility of ras lipid modifications studied by 2H solid-state NMR and molecular dynamics simulations

Vogel, A., Tan, K. T., Waldmann, H., Feller, S. E., Brown, M. F. & Huster, D., Oct 2007, In : Biophysical Journal. 93, 8, p. 2697-2712 16 p.

Research output: Contribution to journalArticle

49 Scopus citations

Solid-State 2H NMR spectroscopy of retinal proteins in aligned membranes

Brown, M. F., Heyn, M. P., Job, C., Kim, S., Moltke, S., Nakanishi, K., Nevzorov, A. A., Struts, A. V., Salgado, G. F. J. & Wallat, I., Dec 2007, In : BBA - Biomembranes. 1768, 12, p. 2979-3000 22 p.

Research output: Contribution to journalArticle

34 Scopus citations

Structural Analysis and Dynamics of Retinal Chromophore in Dark and Meta I States of Rhodopsin from 2H NMR of Aligned Membranes

Struts, A. V., Salgado, G. F. J., Tanaka, K., Krane, S., Nakanishi, K. & Brown, M. F., Sep 7 2007, In : Journal of Molecular Biology. 372, 1, p. 50-66 17 p.

Research output: Contribution to journalArticle

45 Scopus citations

Synthesis of CD3-labeled 11-cis-retinals and application to solid-state deuterium NMR spectroscopy of rhodopsin

Tanaka, K., Struts, A. V., Krane, S., Fujioka, N., Salgado, G. F. J., Martínez-Mayorga, K., Brown, M. F. & Nakanishi, K., 2007, In : Bulletin of the Chemical Society of Japan. 80, 11, p. 2177-2184 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
2006

Curvature and Hydrophobic forces drive oligomerization and modulate activity of rhodopsin in membranes

Botelho, A. V., Huber, T., Sakmar, T. P. & Brown, M. F., Dec 2006, In : Biophysical Journal. 91, 12, p. 4464-4477 14 p.

Research output: Contribution to journalArticle

196 Scopus citations

Retinal counterion switch mechanism in vision evaluated by molecular simulations

Martínez-Mayorga, K., Pitman, M. C., Grossfield, A., Feller, S. E. & Brown, M. F., Dec 27 2006, In : Journal of the American Chemical Society. 128, 51, p. 16502-16503 2 p.

Research output: Contribution to journalArticle

64 Scopus citations

Solid-state 2H NMR structure of retinal in metarhodopsin I

Salgado, G. F. J., Struts, A. V., Tanaka, K., Krane, S., Nakanishi, K. & Brown, M. F., Aug 30 2006, In : Journal of the American Chemical Society. 128, 34, p. 11067-11071 5 p.

Research output: Contribution to journalArticle

37 Scopus citations