Michael S Kuhns

  • 2417 Citations
  • 16 h-Index
19992018
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Fingerprint Dive into the research topics where Michael S Kuhns is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 7 Similar Profiles
T-Cell Antigen Receptor Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
CD3 Antigens Medicine & Life Sciences
CTLA-4 Antigen Medicine & Life Sciences
T-cells Chemical Compounds
Peptides Medicine & Life Sciences
T-Cell Antigen Receptor-CD3 Complex Medicine & Life Sciences
Immunotherapy Medicine & Life Sciences

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Projects 2012 2016

T-Lymphocytes
T-Cell Antigen Receptor-CD3 Complex
Antigens
Antigen-Presenting Cells
Fluorescence Resonance Energy Transfer

Research Output 1999 2018

  • 2417 Citations
  • 16 h-Index
  • 25 Article

A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice

Deshpande, N. R., Uhrlaub, J. L., Way, S. S., Nikolich-Zugich, J. & Kuhns, M. S., Jun 1 2018, In : PLoS One. 13, 6, e0198354.

Research output: Contribution to journalArticle

T-cells
T-lymphocytes
T-Lymphocytes
mice
Immunization

Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed

Lichauco, K., Lee, M. S. & Kuhns, M. S., Jan 1 2018, (Accepted/In press) In : Immunity.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
CD3 Antigens
Immunity
T-Lymphocytes
3 Citations (Scopus)

Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex

Glassman, C. R., Parrish, H. L., Lee, M. S. & Kuhns, M. S., Jan 30 2018, In : Cell Reports. 22, 5, p. 1263-1275 13 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
CD3 Antigens
Membranes
Docks
17 Citations (Scopus)

Domain-swapped t cell receptors improve the safety of TCR gene therapy

Bethune, M. T., Gee, M. H., Bunse, M., Lee, M. S., Gschweng, E. H., Pagadala, M. S., Zhou, J., Cheng, D., Heath, J. R., Kohn, D. B., Kuhns, M. S., Uckert, W. & Baltimore, D., Nov 8 2016, In : eLife. 5, NOVEMBER2016, e19095.

Research output: Contribution to journalArticle

T-Cell Receptor Genes
Gene therapy
T-Cell Antigen Receptor
Genetic Therapy
Safety
1 Citation (Scopus)

Erratum: A transmembrane domain GGxxG motif in CD4 contributes to its lck-independent function but does not mediate CD4 Lmerization (PLoS ONE (2015) 10:7 (e0132333) DOI: 10.1371/journal.pone.0132333)

Parrish, H. L., Glassman, C. R., Keenen, M. M., Deshpande, N. R., Bronnimann, M. P. & Kuhns, M. S., Mar 1 2016, In : PLoS One. 11, 3, e0150876.

Research output: Contribution to journalArticle