Research Output 1987 2017

  • 1035 Citations
  • 18 h-Index
  • 43 Article
2017

5-Aminopyrazole-4-carboxamide-based compounds prevent the growth of Cryptosporidium parvum

Huang, W., Choi, R., Hulverson, M. A., Zhang, Z., McCloskey, M. C., Schaefer, D. A., Whitman, G. R., Barrett, L. K., Vidadala, R. S. R., Riggs, M. W., Maly, D. J., Van Voorhis, W. C., Ojo, K. K. & Fan, E. Aug 1 2017 In : Antimicrobial Agents and Chemotherapy. 61, 8, e00020

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Growth
5-aminopyrazole
calcium-dependent protein kinase
Cryptosporidiosis
1 Citations

Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis

Hulverson, M. A. , Choi, R. , Arnold, S. L. M. , Schaefer, D. A. , Hemphill, A. , McCloskey, M. C. , Betzer, D. P. , Müller, J. , Vidadala, R. S. R. , Whitman, G. R. , Rivas, K. L. , Barrett, L. K. , Hackman, R. C. , Love, M. S. , McNamara, C. W. , Shaughnessy, T. K. , Kondratiuk, A. , Kurnick, M. , Banfor, P. N. , Lynch, J. J. & 6 others Freiberg, G. M., Kempf, D. J., Maly, D. J., Riggs, M. W., Ojo, K. K. & Van Voorhis, W. C. 2017 (Accepted/In press) In : International Journal for Parasitology.

Research output: Research - peer-reviewArticle

Cryptosporidiosis
Phosphotransferases
Therapeutics
Safety
Lead
6 Citations

Bumped-kinase inhibitors for cryptosporidiosis therapy

Hulverson, M. A., Vinayak, S., Choi, R., Schaefer, D. A., Castellanos-Gonzalez, A., Vidadala, R. S. R., Brooks, C. F., Herbert, G. T., Betzer, D. P., Whitman, G. R., Sparks, H. N., Arnold, S. L. M., Rivas, K. L., Barrett, L. K., White, A. C., Maly, D. J., Riggs, M. W., Striepen, B., Van Voorhis, W. C. & Ojo, K. K. 2017 In : Journal of Infectious Diseases. 215, 8, p. 1275-1284 10 p.

Research output: Research - peer-reviewArticle

Cryptosporidiosis
Phosphotransferases
Therapeutics
Cryptosporidium parvum
In Vitro Techniques
2 Citations

Extended-spectrum antiprotozoal bumped kinase inhibitors: A review

Van Voorhis, W. C., Doggett, J. S., Parsons, M., Hulverson, M. A., Choi, R., Arnold, S., Riggs, M. W., Hemphill, A., Howe, D. K., Mealey, R. H., Lau, A. O. T., Merritt, E. A., Maly, D. J., Fan, E. & Ojo, K. K. 2017 (Accepted/In press) In : Experimental Parasitology.

Research output: Research - peer-reviewArticle

Parasites
Phosphotransferases
Protein Kinases
Parasitic Diseases
Life Cycle Stages
2 Citations

Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection

Arnold, S. L. M., Choi, R., Hulverson, M. A., Schaefer, D. A., Vinayak, S., Vidadala, R. S. R., McCloskey, M. C., Whitman, G. R., Huang, W., Barrett, L. K., Ojo, K. K., Fan, E., Maly, D. J., Riggs, M. W., Striepen, B. & Van Voorhis, W. C. Jul 1 2017 In : Journal of Infectious Diseases. 216, 1, p. 55-63 9 p.

Research output: Research - peer-reviewArticle

Cryptosporidium
Phosphotransferases
Pharmacokinetics
Infection
Pharmaceutical Preparations
2016
7 Citations

Novel bumped kinase inhibitors are safe and effective therapeutics in the calf clinical model for cryptosporidiosis

Schaefer, D. A., Betzer, D. P., Smith, K. D., Millman, Z. G., Michalski, H. C., Menchaca, S. E., Zambriski, J. A., Ojo, K. K., Hulverson, M. A., Arnold, S. L. M., Rivas, K. L., Vidadala, R. S. R., Huang, W., Barrett, L. K., Maly, D. J., Fan, E., Van Voorhis, W. C. & Riggs, M. W. Dec 1 2016 In : Journal of Infectious Diseases. 214, 12, p. 1856-1864 9 p.

Research output: Research - peer-reviewArticle

Cryptosporidiosis
Phosphotransferases
Therapeutics
Parasites
Cryptosporidium parvum
2015
1 Citations

The secreted effector protein EspZ is essential for virulence of rabbit enteropathogenic Escherichia coli

Wilbur, J. S., Byrd, W., Ramamurthy, S., Ledvina, H. E., Khirfan, K., Riggs, M. W., Boedeker, E. C., Vedantam, G. & Viswanathan, V. K. 2015 In : Infection and Immunity. 83, 3, p. 1139-1149 11 p.

Research output: Research - peer-reviewArticle

Enteropathogenic Escherichia coli
Virulence
Rabbits
Infection
Proteins
2013
18 Citations

Cathelicidin-like Helminth Defence Molecules (HDMs): Absence of Cytotoxic, Anti-microbial and Anti-protozoan Activities Imply a Specific Adaptation to Immune Modulation

Thivierge, K., Cotton, S., Schaefer, D. A., Riggs, M. W., To, J., Lund, M. E., Robinson, M. W., Dalton, J. P. & Donnelly, S. M. Jul 2013 In : PLoS Neglected Tropical Diseases. 7, 7, e2307

Research output: Research - peer-reviewArticle

Helminths
CAP18 lipopolysaccharide-binding protein
Peptides
Fasciola hepatica
Macrophage Activation
2012
5 Citations

Antibody fusions reduce onset of experimental Cryptosporidium parvum infection in calves

Imboden, M., Schaefer, D. A., Bremel, R. D., Homan, E. J. & Riggs, M. W. Aug 13 2012 In : Veterinary Parasitology. 188, 1-2, p. 41-47 7 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
calves
antibodies
infection
animals
13 Citations

Phospholipases and cationic peptides inhibit Cryptosporidium parvum sporozoite infectivity by parasiticidal and non-parasiticidal mechanisms

Carryn, S., Schaefer, D. A., Imboden, M., Homan, E. J., Bremel, R. D. & Riggs, M. W. Feb 2012 In : Journal of Parasitology. 98, 1, p. 199-204 6 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
sporozoites
pathogenicity
peptides
phospholipases
2010
12 Citations

Antibodies fused to innate immune molecules reduce initiation of Cryptosporidium parvum infection in mice

Imboden, M., Riggs, M. W., Schaefer, D. A., Homan, E. J. & Bremel, R. D. Apr 2010 In : Antimicrobial Agents and Chemotherapy. 54, 4, p. 1385-1392 8 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Antibodies
Infection
Disinfectants
Proteins
16 Citations

Cryptosporidiosis in Neonatal Calves

Wyatt, C. R., Riggs, M. W. & Fayer, R. Mar 2010 In : Veterinary Clinics of North America - Food Animal Practice. 26, 1, p. 89-103 15 p.

Research output: Research - peer-reviewArticle

cryptosporidiosis
calves
infection
Cryptosporidiosis
Infection
2008
11 Citations
Cryptosporidium parvum
Cryptosporidium
Membrane Proteins
Monoclonal Antibodies
protein p23
2003
17 Citations

Characterization of a Low Molecular Weight Glycolipid Antigen from Cryptosporidium parvum

Priest, J. W., Mehlert, A., Arrowood, M. J., Riggs, M. W. & Ferguson, M. A. J. Dec 26 2003 In : Journal of Biological Chemistry. 278, 52, p. 52212-52222 11 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Glycolipids
Phospholipids
Molecular Weight
Antigens
2002
7 Citations

Association of IL-10 expression by mucosal lymphocytes with increased expression of Cryptosporidium parvum epitopes in infected epithelium

Wyatt, C. R., Barrett, W. J., Brackett, E. J., Schaefer, D. A. & Riggs, M. W. 2002 In : Journal of Parasitology. 88, 2, p. 281-286 6 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Interleukin-10
Epitopes
Epithelium
Lymphocytes
28 Citations

Efficacy of monoclonal antibodies against defined antigens for passive immunotherapy of chronic gastrointestinal cryptosporidiosis

Riggs, M. W., Schaefer, D. A., Kapil, S. J., Barley-Maloney, L. & Perryman, L. E. 2002 In : Antimicrobial Agents and Chemotherapy. 46, 2, p. 275-282 8 p.

Research output: Research - peer-reviewArticle

Cryptosporidiosis
Passive Immunization
Monoclonal Antibodies
Antigens
Infection
93 Citations

Recent advances in cryptosporidiosis: The immune response

Riggs, M. W. Aug 2002 In : Microbes and Infection. 4, 10, p. 1067-1080 14 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Cryptosporidiosis
Passive Immunization
Humoral Immunity
Cellular Immunity
2001
27 Citations

Characterization of an intestinal epithelial cell receptor recognized by the Cryptosporidium parvum sporozoite ligand CSL

Langer, R. C., Schaefer, D. A. & Riggs, M. W. 2001 In : Infection and Immunity. 69, 3, p. 1661-1670 10 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Sporozoites
Caco-2 Cells
Epithelial Cells
Ligands
1 Citations

Targeted disruption of CSL ligand - Host cell receptor interaction in treatment of Cryptosporidium parvum infection

Riggs, M. W., Schaefer, D. A., Kapil, S. J., Barley-Maloney, U., Ferryman, L. E. & McNeil, M. R. 2001 In : The Journal of eukaryotic microbiology. 48, SUPPL.

Research output: Research - peer-reviewArticle

2000
30 Citations

Characterization and formulation of multiple epitope-specific neutralizing monoclonal antibodies for passive immunization against cryptosporidiosis

Schaefer, D. A., Auerbach-Dixon, B. A. & Riggs, M. W. May 2000 In : Infection and Immunity. 68, 5, p. 2608-2616 9 p.

Research output: Research - peer-reviewArticle

Cryptosporidiosis
Passive Immunization
Neutralizing Antibodies
Epitopes
Monoclonal Antibodies
1999
38 Citations

Cryptosporidium parvum apical complex glycoprotein CSL contairσ a sporozoite ligand for intestinal epithelial cells

Langer, R. C. & Riggs, M. W. 1999 In : Infection and Immunity. 67, 10, p. 5282-5291 10 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Sporozoites
Glycoproteins
Epithelial Cells
Ligands
31 Citations

Cryptosporidium parvum sporozoite pellicle antigen recognized by a neutralizing monoclonal antibody is a β-mannosylated glycolipid

Riggs, M. W., McNeil, M. R., Perryman, L. E., Stone, A. L., Scherman, M. S. & O'Connor, R. M. 1999 In : Infection and Immunity. 67, 3, p. 1317-1322 6 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Sporozoites
Glycolipids
Neutralizing Antibodies
Monoclonal Antibodies
7 Citations

Evidence of thymus-independent local and systemic antibody responses to Cryptosporidium parvum infection in nude mice

Adjei, A. A., Jones, J. T., Riggs, M. W. & Enriquez, F. J. Aug 1999 In : Infection and Immunity. 67, 8, p. 3947-3951 5 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Nude Mice
Thymus Gland
Antibody Formation
Infection
1998
52 Citations

Role of immunoglobulin a monoclonal antibodies against P23 in controlling murine Cryptosporidium parvum infection

Javier Enriquez, F. & Riggs, M. W. 1998 In : Infection and Immunity. 66, 9, p. 4469-4473 5 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Immunoglobulins
Monoclonal Antibodies
Infection
Immunoglobulin A
1997
55 Citations

Protective Monoclonal Antibody Defines a Circumsporozoite-Like Glycoprotein Exoantigen of Cryptosporidium parvum Sporozoites and Merozoites

Riggs, M. W., Stone, A. L., Yount, P. A., Langer, R. C., Arrowood, M. J. & Bentley, D. L. Feb 15 1997 In : Journal of Immunology. 158, 4, p. 1787-1795 9 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Merozoites
Sporozoites
Glycoproteins
Monoclonal Antibodies
1996
73 Citations

A cloned gene of Cryptosporidium parvum encodes neutralization-sensitive epitopes

Perryman, L. E., Jasmer, D. P., Riggs, M. W., Bohnet, S. G., McGuire, T. C. & Arrowood, M. J. Oct 1 1996 In : Molecular and Biochemical Parasitology. 80, 2, p. 137-147 11 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Epitopes
Peptides
Genes
Sporozoites
11 Citations
2 Citations
1995
21 Citations

Neuroaxonal degeneration in sheep grazing Sorghum pastures.

Bradley, G. A., Metcalf, H. C., Reggiardo, C., Noon, T. H., Bicknell, E. J., Lozano-Alarcon, F., Reed, R. E. & Riggs, M. W. Apr 1995 In : Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 7, 2, p. 229-236 8 p.

Research output: Research - peer-reviewArticle

Sorghum
Sheep
Sorghum (Poaceae)
lambs
pastures
1994
50 Citations
Cryptosporidium parvum
Cryptosporidiosis
Antibodies
Sporozoites
Oocysts
1992
10 Citations

Neutralization-sensitive epitopes are conserved among geographically diverse isolates of Cryptosporidium parvum

Uhl, E. W., O'Connor, R. M., Perryman, L. E. & Riggs, M. W. 1992 In : Infection and Immunity. 60, 4, p. 1703-1706 4 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Epitopes
Sporozoites
Mexico
Brazil
1991
14 Citations

Cranial teratomas in two domestic ducks (Anas platyrhynchos domesticus).

Homer, B. L. & Riggs, M. W. Oct 1991 In : Avian Diseases. 35, 4, p. 994-998 5 p.

Research output: Research - peer-reviewArticle

Ducks
Teratoma
Neoplasms
Anas platyrhynchos
ducks
34 Citations

Monoclonal antibody immunotherapy in nude mice persistently infected with CRyptosporidium parvum

Bjorneby, J. M., Hunsaker, B. D., Riggs, M. W. & Perryman, L. E. 1991 In : Infection and Immunity. 59, 3, p. 1172-1176 5 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Nude Mice
Immunotherapy
Monoclonal Antibodies
Infection
1990
34 Citations

Cryptosporidium parvum merozoites share neutralization-sensitive epitopes with sporozoites

Bjorneby, J. M., Riggs, M. W. & Ferryman, L. E. Jul 1 1990 In : Journal of Immunology. 145, 1, p. 298-304 7 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Merozoites
Sporozoites
Epitopes
Infection
39 Citations

Detection of Cryptosporidium parvum oocysts in bovine feces by monoclonal antibody capture enzyme-linked immunosorbent assay

Anusz, K. Z., Mason, P. H., Riggs, M. W. & Perryman, L. E. 1990 In : Journal of Clinical Microbiology. 28, 12, p. 2770-2774 5 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Oocysts
Feces
Enzyme-Linked Immunosorbent Assay
Monoclonal Antibodies
53 Citations

Kinetics of Cryptosporidium parvum sporozoite neutralization by monoclonal antibodies, immune bovine serum, and immune bovine colostrum

Perryman, L. E., Riggs, M. W., Mason, P. H. & Fayer, R. 1990 In : Infection and Immunity. 58, 1, p. 257-259 3 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Sporozoites
Colostrum
Immune Sera
Monoclonal Antibodies
9 Citations

Mast cell tumors in three ferrets.

Stauber, E., Robinette, J., Basaraba, R., Riggs, M. & Bishop, C. Mar 1 1990 In : Journal of the American Veterinary Medical Association. 196, 5, p. 766-767 2 p.

Research output: Research - peer-reviewArticle

Ferrets
Mast Cells
Neoplasms
ferrets
mast cells
8 Citations

Suspected ciliary dysfunction in Chinese Shar Pei pups with pneumonia.

Dhein, C. R., Prieur, D. J., Riggs, M. W., Potter, K. A. & Widders, P. R. Mar 1990 In : American Journal of Veterinary Research. 51, 3, p. 439-446 8 p.

Research output: Research - peer-reviewArticle

pups
pneumonia
dogs
Pneumonia
Dogs
1989
44 Citations

Hyperimmune bovine colostrum neutralizes Cryptosporidium sporozoites and protects mice against oocyst challenge

Fayer, R., Perryman, L. E. & Riggs, M. W. 1989 In : Journal of Parasitology. 75, 1, p. 151-153 3 p.

Research output: Research - peer-reviewArticle

cow colostrum
Cryptosporidium parvum
sporozoites
Cryptosporidium
oocysts
55 Citations

Neutralization-sensitive epitopes are exposed on the surface of infectious Cryptosporidium parvum sporozoites

Riggs, M. W., McGuire, T. C., Mason, P. H. & Perryman, L. E. 1989 In : Journal of Immunology. 143, 4, p. 1340-1345 6 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Sporozoites
Epitopes
Methionine
Immune Sera
1987
17 Citations

Detection by computed tomography of occult osteochondral defects in the fetlock of a horse.

Barbee, D. D., Allen, J. R., Grant, B. D., Riggs, M. W., Crawley, G. R. & Sande, R. D. Nov 1987 In : Equine Veterinary Journal. 19, 6, p. 556-558 3 p.

Research output: Research - peer-reviewArticle

11 Citations

Evaluation of foals for immune deficiency disorders.

Riggs, M. W. Dec 1987 In : The Veterinary clinics of North America. Equine practice. 3, 3, p. 515-528 14 p.

Research output: Research - peer-reviewArticle

deficiency diseases
immunosuppression
foals
Immune System Diseases
Horses
70 Citations

Infectivity and neutralization of Cryptosporidium parvum sporozoites

Riggs, M. W. & Perryman, L. E. 1987 In : Infection and Immunity. 55, 9, p. 2081-2087 7 p.

Research output: Research - peer-reviewArticle

Cryptosporidium parvum
Sporozoites
Cryptosporidiosis
Oocysts
Hypochlorous Acid