• 1102 Citations
  • 19 h-Index
1987 …2018
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Research Output 1987 2018

  • 1102 Citations
  • 19 h-Index
  • 44 Article
2018

Modelling Cryptosporidium infection in human small intestinal and lung organoids

Heo, I., Dutta, D., Schaefer, D. A., Iakobachvili, N., Artegiani, B., Sachs, N., Boonekamp, K. E., Bowden, G., Hendrickx, A. P. A., Willems, R. J. L., Peters, P. J., Riggs, M. W., O'Connor, R. & Clevers, H., Jul 1 2018, In : Nature Microbiology. 3, 7, p. 814-823 10 p.

Research output: Contribution to journalArticle

Organoids
Cryptosporidium
Lung
Infection
Life Cycle Stages
2017
2 Citations

5-Aminopyrazole-4-carboxamide-based compounds prevent the growth of Cryptosporidium parvum

Huang, W., Choi, R., Hulverson, M. A., Zhang, Z., McCloskey, M. C., Schaefer, D. A., Whitman, G. R., Barrett, L. K., Vidadala, R. S. R., Riggs, M. W., Maly, D. J., Van Voorhis, W. C., Ojo, K. K. & Fan, E., Aug 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 8, e00020

Research output: Contribution to journalArticle

Cryptosporidium parvum
Cryptosporidiosis
Growth
Protein Kinase C
Parasites
4 Citations

Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis

Hulverson, M. A. , Choi, R. , Arnold, S. L. M. , Schaefer, D. A. , Hemphill, A. , McCloskey, M. C. , Betzer, D. P. , Müller, J. , Vidadala, R. S. R. , Whitman, G. R. , Rivas, K. L. , Barrett, L. K. , Hackman, R. C. , Love, M. S. , McNamara, C. W. , Shaughnessy, T. K. , Kondratiuk, A. , Kurnick, M. , Banfor, P. N. , Lynch, J. J. & 6 others Freiberg, G. M., Kempf, D. J., Maly, D. J., Riggs, M. W., Ojo, K. K. & Van Voorhis, W. C., 2017, (Accepted/In press) In : International Journal for Parasitology.

Research output: Contribution to journalArticle

Cryptosporidiosis
Phosphotransferases
Safety
Therapeutics
11 Citations

Bumped-kinase inhibitors for cryptosporidiosis therapy

Hulverson, M. A., Vinayak, S., Choi, R., Schaefer, D. A., Castellanos-Gonzalez, A., Vidadala, R. S. R., Brooks, C. F., Herbert, G. T., Betzer, D. P., Whitman, G. R., Sparks, H. N., Arnold, S. L. M., Rivas, K. L., Barrett, L. K., White, A. C., Maly, D. J., Riggs, M. W., Striepen, B., Van Voorhis, W. C. & Ojo, K. K., 2017, In : Journal of Infectious Diseases. 215, 8, p. 1275-1284 10 p.

Research output: Contribution to journalArticle

Cryptosporidiosis
Cryptosporidium parvum
Phosphotransferases
High-Throughput Screening Assays
Therapeutics
7 Citations

Extended-spectrum antiprotozoal bumped kinase inhibitors: A review

Van Voorhis, W. C., Doggett, J. S., Parsons, M., Hulverson, M. A., Choi, R., Arnold, S., Riggs, M. W., Hemphill, A., Howe, D. K., Mealey, R. H., Lau, A. O. T., Merritt, E. A., Maly, D. J., Fan, E. & Ojo, K. K., 2017, (Accepted/In press) In : Experimental Parasitology.

Research output: Contribution to journalArticle

Parasites
Phosphotransferases
Protein Kinases
Parasitic Diseases
Life Cycle Stages
4 Citations

Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection

Arnold, S. L. M., Choi, R., Hulverson, M. A., Schaefer, D. A., Vinayak, S., Vidadala, R. S. R., McCloskey, M. C., Whitman, G. R., Huang, W., Barrett, L. K., Ojo, K. K., Fan, E., Maly, D. J., Riggs, M. W., Striepen, B. & Van Voorhis, W. C., Jul 1 2017, In : Journal of Infectious Diseases. 216, 1, p. 55-63 9 p.

Research output: Contribution to journalArticle

Cryptosporidium
Phosphotransferases
Pharmacokinetics
Infection
Large Intestine
2016
14 Citations

Novel bumped kinase inhibitors are safe and effective therapeutics in the calf clinical model for cryptosporidiosis

Schaefer, D. A., Betzer, D. P., Smith, K. D., Millman, Z. G., Michalski, H. C., Menchaca, S. E., Zambriski, J. A., Ojo, K. K., Hulverson, M. A., Arnold, S. L. M., Rivas, K. L., Vidadala, R. S. R., Huang, W., Barrett, L. K., Maly, D. J., Fan, E., Van Voorhis, W. C. & Riggs, M. W., Dec 1 2016, In : Journal of Infectious Diseases. 214, 12, p. 1856-1864 9 p.

Research output: Contribution to journalArticle

Cryptosporidiosis
Cryptosporidium parvum
Phosphotransferases
Parasites
Therapeutics
2015
1 Citations

The secreted effector protein EspZ is essential for virulence of rabbit enteropathogenic Escherichia coli

Wilbur, J. S., Byrd, W., Ramamurthy, S., Ledvina, H. E., Khirfan, K., Riggs, M. W., Boedeker, E. C., Vedantam, G. & Viswanathan, V. K., 2015, In : Infection and Immunity. 83, 3, p. 1139-1149 11 p.

Research output: Contribution to journalArticle

Enteropathogenic Escherichia coli
Virulence
Rabbits
Infection
Enterocytes
2013
20 Citations

Cathelicidin-like Helminth Defence Molecules (HDMs): Absence of Cytotoxic, Anti-microbial and Anti-protozoan Activities Imply a Specific Adaptation to Immune Modulation

Thivierge, K., Cotton, S., Schaefer, D. A., Riggs, M. W., To, J., Lund, M. E., Robinson, M. W., Dalton, J. P. & Donnelly, S. M., Jul 2013, In : PLoS Neglected Tropical Diseases. 7, 7, e2307

Research output: Contribution to journalArticle

Helminths
Peptides
Fasciola hepatica
Macrophage Activation
Schistosoma mansoni
2012
8 Citations

Antibody fusions reduce onset of experimental Cryptosporidium parvum infection in calves

Imboden, M., Schaefer, D. A., Bremel, R. D., Homan, E. J. & Riggs, M. W., Aug 13 2012, In : Veterinary Parasitology. 188, 1-2, p. 41-47 7 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Oocysts
oocysts
calves
antibodies
15 Citations

Phospholipases and cationic peptides inhibit Cryptosporidium parvum sporozoite infectivity by parasiticidal and non-parasiticidal mechanisms

Carryn, S., Schaefer, D. A., Imboden, M., Homan, E. J., Bremel, R. D. & Riggs, M. W., Feb 2012, In : Journal of Parasitology. 98, 1, p. 199-204 6 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Sporozoites
Phospholipases
sporozoites
infectivity
2010
14 Citations

Antibodies fused to innate immune molecules reduce initiation of Cryptosporidium parvum infection in mice

Imboden, M., Riggs, M. W., Schaefer, D. A., Homan, E. J. & Bremel, R. D., Apr 2010, In : Antimicrobial Agents and Chemotherapy. 54, 4, p. 1385-1392 8 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Disinfectants
Antibodies
Infection
Proteins
19 Citations

Cryptosporidiosis in Neonatal Calves

Wyatt, C. R., Riggs, M. W. & Fayer, R., Mar 2010, In : Veterinary Clinics of North America - Food Animal Practice. 26, 1, p. 89-103 15 p.

Research output: Contribution to journalArticle

Cryptosporidiosis
cryptosporidiosis
calves
Infection
infection
2008
11 Citations
Cryptosporidium parvum
Cryptosporidium
Membrane Proteins
Monoclonal Antibodies
Epitopes
2003
17 Citations

Characterization of a Low Molecular Weight Glycolipid Antigen from Cryptosporidium parvum

Priest, J. W., Mehlert, A., Arrowood, M. J., Riggs, M. W. & Ferguson, M. A. J., Dec 26 2003, In : Journal of Biological Chemistry. 278, 52, p. 52212-52222 11 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Glycolipids
Phospholipids
Molecular Weight
Molecular weight
2002
10 Citations

Association of IL-10 expression by mucosal lymphocytes with increased expression of Cryptosporidium parvum epitopes in infected epithelium

Wyatt, C. R., Barrett, W. J., Brackett, E. J., Schaefer, D. A. & Riggs, M. W., 2002, In : Journal of Parasitology. 88, 2, p. 281-286 6 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
interleukin-10
Interleukin-10
epitopes
RNA
31 Citations

Efficacy of monoclonal antibodies against defined antigens for passive immunotherapy of chronic gastrointestinal cryptosporidiosis

Riggs, M. W., Schaefer, D. A., Kapil, S. J., Barley-Maloney, L. & Perryman, L. E., 2002, In : Antimicrobial Agents and Chemotherapy. 46, 2, p. 275-282 8 p.

Research output: Contribution to journalArticle

Cryptosporidiosis
Passive Immunization
Monoclonal Antibodies
Cryptosporidium parvum
Antigens
97 Citations

Recent advances in cryptosporidiosis: The immune response

Riggs, M. W., Aug 2002, In : Microbes and Infection. 4, 10, p. 1067-1080 14 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Cryptosporidiosis
Passive Immunization
Humoral Immunity
Cellular Immunity
2001
27 Citations

Characterization of an intestinal epithelial cell receptor recognized by the Cryptosporidium parvum sporozoite ligand CSL

Langer, R. C., Schaefer, D. A. & Riggs, M. W., 2001, In : Infection and Immunity. 69, 3, p. 1661-1670 10 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Sporozoites
Caco-2 Cells
Epithelial Cells
Ligands
1 Citations

Targeted disruption of CSL ligand - Host cell receptor interaction in treatment of Cryptosporidium parvum infection

Riggs, M. W., Schaefer, D. A., Kapil, S. J., Barley-Maloney, U., Ferryman, L. E. & McNeil, M. R., 2001, In : The Journal of eukaryotic microbiology. 48, SUPPL.

Research output: Contribution to journalArticle

Protozoan Antibodies
Cryptosporidium parvum
Cryptosporidiosis
Passive Immunization
Membrane Glycoproteins
2000
30 Citations

Characterization and formulation of multiple epitope-specific neutralizing monoclonal antibodies for passive immunization against cryptosporidiosis

Schaefer, D. A., Auerbach-Dixon, B. A. & Riggs, M. W., May 2000, In : Infection and Immunity. 68, 5, p. 2608-2616 9 p.

Research output: Contribution to journalArticle

Cryptosporidiosis
Passive Immunization
Neutralizing Antibodies
Epitopes
Monoclonal Antibodies
1999
40 Citations

Cryptosporidium parvum apical complex glycoprotein CSL contairσ a sporozoite ligand for intestinal epithelial cells

Langer, R. C. & Riggs, M. W., 1999, In : Infection and Immunity. 67, 10, p. 5282-5291 10 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Sporozoites
Glycoproteins
Epithelial Cells
Ligands
31 Citations

Cryptosporidium parvum sporozoite pellicle antigen recognized by a neutralizing monoclonal antibody is a β-mannosylated glycolipid

Riggs, M. W., McNeil, M. R., Perryman, L. E., Stone, A. L., Scherman, M. S. & O'Connor, R. M., 1999, In : Infection and Immunity. 67, 3, p. 1317-1322 6 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Sporozoites
Glycolipids
Neutralizing Antibodies
Monoclonal Antibodies
8 Citations

Evidence of thymus-independent local and systemic antibody responses to Cryptosporidium parvum infection in nude mice

Adjei, A. A., Jones, J. T., Riggs, M. W. & Enriquez, F. J., Aug 1999, In : Infection and Immunity. 67, 8, p. 3947-3951 5 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Nude Mice
Thymus Gland
Antibody Formation
Infection
1998
54 Citations

Role of immunoglobulin a monoclonal antibodies against P23 in controlling murine Cryptosporidium parvum infection

Javier Enriquez, F. & Riggs, M. W., 1998, In : Infection and Immunity. 66, 9, p. 4469-4473 5 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Immunoglobulins
Monoclonal Antibodies
Immunoglobulin A
Sporozoites
1997
58 Citations

Protective Monoclonal Antibody Defines a Circumsporozoite-Like Glycoprotein Exoantigen of Cryptosporidium parvum Sporozoites and Merozoites

Riggs, M. W., Stone, A. L., Yount, P. A., Langer, R. C., Arrowood, M. J. & Bentley, D. L., Feb 15 1997, In : Journal of Immunology. 158, 4, p. 1787-1795 9 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Merozoites
Sporozoites
Glycoproteins
Monoclonal Antibodies
1996
74 Citations

A cloned gene of Cryptosporidium parvum encodes neutralization-sensitive epitopes

Perryman, L. E., Jasmer, D. P., Riggs, M. W., Bohnet, S. G., McGuire, T. C. & Arrowood, M. J., Oct 1 1996, In : Molecular and Biochemical Parasitology. 80, 2, p. 137-147 11 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Epitopes
Sporozoites
Peptides
Open Reading Frames
11 Citations
Protozoan Antibodies
Cryptosporidium parvum
Sporozoites
Neutralization Tests
Caco-2 Cells
2 Citations
1995
23 Citations

Neuroaxonal degeneration in sheep grazing Sorghum pastures.

Bradley, G. A., Metcalf, H. C., Reggiardo, C., Noon, T. H., Bicknell, E. J., Lozano-Alarcon, F., Reed, R. E. & Riggs, M. W., Apr 1995, In : Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 7, 2, p. 229-236 8 p.

Research output: Contribution to journalArticle

Sorghum
Sorghum (Poaceae)
Sheep
lambs
pastures
1994
51 Citations
Cryptosporidium parvum
Cryptosporidiosis
Sporozoites
Antibodies
Oocysts
1992
11 Citations

Neutralization-sensitive epitopes are conserved among geographically diverse isolates of Cryptosporidium parvum

Uhl, E. W., O'Connor, R. M., Perryman, L. E. & Riggs, M. W., 1992, In : Infection and Immunity. 60, 4, p. 1703-1706 4 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Epitopes
Sporozoites
Mexico
Brazil
1991
14 Citations

Cranial teratomas in two domestic ducks (Anas platyrhynchos domesticus).

Homer, B. L. & Riggs, M. W. Oct 1991 In : Avian Diseases. 35, 4, p. 994-998 5 p.

Research output: Contribution to journalArticle

Ducks
Teratoma
Anas platyrhynchos
ducks
neoplasms
35 Citations

Monoclonal antibody immunotherapy in nude mice persistently infected with CRyptosporidium parvum

Bjorneby, J. M., Hunsaker, B. D., Riggs, M. W. & Perryman, L. E., 1991, In : Infection and Immunity. 59, 3, p. 1172-1176 5 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Nude Mice
Immunotherapy
Monoclonal Antibodies
Oocysts
1990
35 Citations

Cryptosporidium parvum merozoites share neutralization-sensitive epitopes with sporozoites

Bjorneby, J. M., Riggs, M. W. & Ferryman, L. E., Jul 1 1990, In : Journal of Immunology. 145, 1, p. 298-304 7 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Merozoites
Sporozoites
Epitopes
Indirect Fluorescent Antibody Technique
39 Citations

Detection of Cryptosporidium parvum oocysts in bovine feces by monoclonal antibody capture enzyme-linked immunosorbent assay

Anusz, K. Z., Mason, P. H., Riggs, M. W. & Perryman, L. E., 1990, In : Journal of Clinical Microbiology. 28, 12, p. 2770-2774 5 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Oocysts
Feces
Enzyme-Linked Immunosorbent Assay
Monoclonal Antibodies
54 Citations

Kinetics of Cryptosporidium parvum sporozoite neutralization by monoclonal antibodies, immune bovine serum, and immune bovine colostrum

Perryman, L. E., Riggs, M. W., Mason, P. H. & Fayer, R., 1990, In : Infection and Immunity. 58, 1, p. 257-259 3 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Sporozoites
Colostrum
Immune Sera
Monoclonal Antibodies
10 Citations

Mast cell tumors in three ferrets.

Stauber, E., Robinette, J., Basaraba, R., Riggs, M. & Bishop, C., Mar 1 1990, In : Journal of the American Veterinary Medical Association. 196, 5, p. 766-767 2 p.

Research output: Contribution to journalArticle

Ferrets
ferrets
mast cells
Mast Cells
neoplasms
8 Citations

Suspected ciliary dysfunction in Chinese Shar Pei pups with pneumonia.

Dhein, C. R., Prieur, D. J., Riggs, M. W., Potter, K. A. & Widders, P. R., Mar 1990, In : American Journal of Veterinary Research. 51, 3, p. 439-446 8 p.

Research output: Contribution to journalArticle

pups
pneumonia
Pneumonia
Dogs
dogs
1989
44 Citations

Hyperimmune bovine colostrum neutralizes Cryptosporidium sporozoites and protects mice against oocyst challenge

Fayer, R., Perryman, L. E. & Riggs, M. W., 1989, In : Journal of Parasitology. 75, 1, p. 151-153 3 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
cow colostrum
Sporozoites
Cryptosporidium
Colostrum
57 Citations

Neutralization-sensitive epitopes are exposed on the surface of infectious Cryptosporidium parvum sporozoites

Riggs, M. W., McGuire, T. C., Mason, P. H. & Perryman, L. E., 1989, In : Journal of Immunology. 143, 4, p. 1340-1345 6 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Sporozoites
Epitopes
Methionine
Immune Sera
1987
17 Citations

Detection by computed tomography of occult osteochondral defects in the fetlock of a horse.

Barbee, D. D., Allen, J. R., Grant, B. D., Riggs, M. W., Crawley, G. R. & Sande, R. D., Nov 1987, In : Equine Veterinary Journal. 19, 6, p. 556-558 3 p.

Research output: Contribution to journalArticle

11 Citations

Evaluation of foals for immune deficiency disorders.

Riggs, M. W. Dec 1987 In : The Veterinary clinics of North America. Equine practice. 3, 3, p. 515-528 14 p.

Research output: Contribution to journalArticle

deficiency diseases
immunosuppression
Immune System Diseases
foals
Horses
72 Citations

Infectivity and neutralization of Cryptosporidium parvum sporozoites

Riggs, M. W. & Perryman, L. E., 1987, In : Infection and Immunity. 55, 9, p. 2081-2087 7 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Sporozoites
Cryptosporidiosis
Oocysts
Hypochlorous Acid