• 1856 Citations
  • 19 h-Index
1980 …2019
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Fingerprint Dive into the research topics where Nancy C Horton is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
DNA Medicine & Life Sciences
DNA Cleavage Medicine & Life Sciences
Type II Site Specific Deoxyribonucleases Medicine & Life Sciences
Ions Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Metals Medicine & Life Sciences
Base Pairing Medicine & Life Sciences
Lac Repressors Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1980 2015

DNA
Enzymes
Type II Site Specific Deoxyribonucleases
Crystallography
DNA sequences

SYNCHROTRON RADIATION BIOTECHNOLOGY

Horton, N. C., Phizackerley, P., Boxer, S., Suresh, S., Bernstein, B., Scavetta, R., Borhani, D., Kuhn, P., Alechine, A., Pohl, E., Pelletier, H., Laporte, S., Irving, T., Deisenhofer, J., Delarue, M., Holbrook, S., Chen, Y., Fletterick, R., Rosenzweig, A., Goodwill, K. E. N., Sage, C., Kim, K., Sundaramoorthy, M., Bergmann, U. W. E., Narayana, N., Enemark, J., Hart, P., Tiede, D., Olah, G., Unknown, [. V., Neidigh, K., Ying, S., Hwang, P., Gardea-Torresdey, J., Kiefhaber, T., Bjorkman, P., [No Value], K. R., Kirk, M., Keenan, R., Mondrag, A., Chiu, W. A. H., Chen, P., Rupp, B., Greenwald, J., Louie, G., Brinen, L., Ranganathan, R., Whitlow, M. D., Hung, L., Schuller, D., Joseph, J., Butte, M., Brudler, R., Beernink, P., Bargar, J., Raman, C., Rabedeau, T., George, M., Terry, N., Rosenfeld, R., Borgstahl, G., Bellamy, H., Iacovoni, J., Salerno, C., Plaxco, K. W., Bhaskar, B., Feher, G., Phizackerley, R. P., Ellis, P., Nautiyal, S., Rehr, J., Silberg, J., Morel, F., Knapp, M., Bott, R., Zhang, Z., Haas, E., Reiling, K., Borngraber, S., Firestone, M., Poulos, T. L., Geistlinger, T., Wilson, C., Zubieta, C., Jurnak, F., Frydman, J., Blanchard, H., Kamata, K., Williams, P., Stroud, R., Martin, J., Mazlo, J., Sevrioukova, I., Huff, C., Bingdong, S., Xuong, N., Gray, H., Robinson, R., Barondeau, D., Baldwin, E., Seungil, H., Orville, A., Funke, P., [No Value], Q., Verdecia, M., Plecs, J., Yu, E., Nguyen, J., Perona, J. J., Miller, M., Cupp-Vickery, J., Yanshun, L., Hosfield, D., Cheng, X., Sussman, D., Lacy, B., Antonysamy, S., MacHius, M., Bergmann, E., Pickering, J., Daniels, D., Everse, S., Holton, J., Harris, S., Peters, J., Cecchini, G., Usher, K., Akamine, P., Su, L. I., Bringer, A., Hausrath, A., Wilcox, S., Sagermann, M., Kresge, N., van Roey, P., Zhang, H., Stroupe, M. B., Steussy, N. I. C., Hirsch, J., Aevarsson, A., Baker, D., Hosfield, C., Rose, R., Strynadka, N., Wang, Z., Zhang, M. A. N., Leighton, T., McWhirter, S., Martinez, S., Prasad, S., Brennan, R. G., Finer-Moore, J. S., Ybe, J., Kim, K., McPhillips, T., Fisher, A., Shaw, A., Prosise, G., Sindelar, C., Parikh, S., Kovall, R., Cramer, S. P., Stevens, R., Parge, H., Mol, C., Wilson, I., Penner-Hahn, J. E., Foster, P., Borhani, D., Redinbo, M., Putnam, C., Lay, P., Kuhn, P., Wagner, R., Pohl, E., Irving, T., Deisenhofer, J., Choe, S., Merritt, E., Delarue, M., Chen, J., Lippard, S., Rudenko, G., Jardetzky, T., Fink, A., Blackburn, N., Genick, U., Skidmore, M., Safinya, C., Rosenzweig, A., Rayment, I., Shiau, A., Sauter, N., Stenkamp, R., Dewitt, J., Luecke, H., Crane, B., Doolittle, R., Arvai, A., Sundaramoorthy, M., Huang, L. A. N., Anderson, A. C., Huiying, L., Horjales, E., Focia, P., Stezowski, J., Bergmann, U. W. E., Endrizzi, J., Burgess, B., Narayana, N., Enemark, J., Prince, R., Tiede, D., Olah, G., Hedman, B., Vickery, L., Waksman, G., Rees, D., Scott, R., Kiefhaber, T., Bjorkman, P., [No Value], K. R., Salt, D., George, G., Wiener, M. C., Marks, C., David, P., Kirk, M., Keenan, R., Tsuruta, H., McKay, D., De Vos, A., Chiu, W. A. H., Hill, C. P., Chen, P., Rupp, B., Mendelson, R., Lo, T., Trewhella, J., Yeh, J., Soltis, S., Solomon, E., Ming, L., Starks, C., Thayer, M., Guan, Y. U. E., Stout, C., Rutenber, E., Klein, M., Varughese, K., Baker, E., Crowder, S., Warburton, W., Greenwald, J., Yonath, A., Berry, E., Johnson, J., Templeton, D., Curmi, P., Riggs-Gelasco, P., Weis, W., Doniach, S., Bruns, C., Brinen, L., Whitlow, M. D., Freymann, D., Einspahr, H., Bilwes, A., Schuller, D., Suresh, S., Gillmor, S., Bernstein, B., Han, G., Bourne, Y., Scavetta, R., Amzel, L., Harrison, S., Terwilliger, T. C., Redford, S., Alechine, A., Buchbinder, J., Pelletier, H., Laporte, S., Schafmeister, C., Gatewood, J. M., Jennings, P., Sablin, E., McTigue, M., Holbrook, S., Chen, Y., Frederick, C., Lattman, E., Raghunathan, S., Vivien, Y., Somoza, J., Fletterick, R., Korolev, S., Fields, B., Stowell, M., Hendle, J., Sage, C., Kim, K., Hellinga, H. W., Edwards, A., Hidong, K., Hales, B., Yu, C., Hart, P., Forest, K., Freeman, H., Rader, S., Almo, S. C., Sawaya, M., Eisenberg, D., Friedman, R. M., Neidigh, K., Ying, S., Hwang, P., Gardea-Torresdey, J., Adams, M. W., Lee, J., Ralston, C., Smith, T., Edwards, S., Lawrence, M., Kim, S., Rich, A., Mondragsn, A., Nelson, H., Kull, F., Lin, K. A. I., Canady, M., Louie, G., Grush, M., Whitby, F., Hogle, J., Fu, J., Ranganathan, R., Izard, T., Hackert, M., Hung, L., Aoyagi, M., Sonnenburg, E. D., McRee, D. E., Terry, N., Craig, L., Bhaskar, B., Garcin, E., Wallace, E., Ellis, P., Guss, M., Robert, B., Licata, V., Detitta, G., Balendiran, G., McPhillips, T. M., Latimer, M., Pickering, I. J., Borglin, S., Chan, D., Sevrioukova, I. F., Julie, H., Focia, P., Tubbs, J., Didonato, M., Larsen, E., Verdecia, M., Juers, D. H., Yang, X., Austin, M., Kornfield, J., Drennan, C., Salt, D., Daniels, D., Egea, P. F., Chiu, W. A. H., Schumacher, M., Stroupe, M. B., Carmel, A., Russo, D., Freymann, D. M., Randal, M., Swairjo, M., Strynadka, N., Riggs-Gelasco, P., Doniach, S., Vrielink, A., Goodin, D. B., Whitlow, M. D., Roosild, T., Shiou-Chuan, T., Wood, T., Smolsky, I. L., Hirsch, G., Kazuki, I., Cohen, A., Garcia, K. C., Wilson, M., Maher, M., Fink, A., Sundaresan, V., Herschlag, D., Montfort, W. R., Lanyi, J., Feher, G., Ross, J., Bjorkman, P., Baker, E., Brennan, R. G., Redinbo, M., Richard, S., Rosenzweig, A., Zhang, K., Nichol, H., Chan, M., Peters-Libeu, C., Rehr, J., Baldwin, E., Perona, J. J., Liddington, R., Scott, W., Varughese, K., Stevens, R., Eigenbrot, C., Schimmel, P., Wilson, I., Penner-Hahn, J. E., Raman, C., Rabedeau, T., George, M., Kantrowitz, E., Snell, E., Wilson, D., Lippard, S., Blackburn, N., Safinya, C., Yachandra, V. K., Getzoff, E., Stout, T., Stenkamp, R., De Beer George, S., Barondeau, D., Huiying, L., Gonzalez, A., Bussiere, D., Khosla, C., Hedman, B., Mooers, B., Bushnell, D., Fee, J., Rees, D. C., Scott, R., Stemmler, T. L., George, G., Tsuruta, H., McKay, D., Peters, J., Deacon, A. M., Soltis, S., Lawrence, Q., Ming, L., Stout, C., Brunger, A. T., Johnson, J., Weis, W., Murphy, M., Chang, G., Fisher, A., Kornberg, R., Mathews, I., Jude, K., Miller, G. A., He, M., Harrington, D., Schulze-Gahmen, U., Ailong, K., Benfatto, M., [No Value], W. G. J., Shafer, R., Luening, K., Krishnamoorthy, T., Stroud, R., Harbury, P., Villasenor, A., Shen, W., Yamagata, A., Cingolani, G., Bracey, M., Rosengarth, A., Genick, U., Vickery, J., Ghosh, P., Jordan, S., Cate, J., MacKinnon, R., Berry, E., Andrews, J., Choe, S., Kang, C., Gardea-Torresdey, J., Snell, G., Tsai, S., Ping, L., Brejc, K., Jalilehvand, F., Smith, C., Kennepohl, P., Brzustowicz, M., Noller, H., Lawrence, C. M., Green, M. T., Brinen, L., George, S., Aoyagi, M., Joost, P. H., Wimberly, B., Craig, L., Coleman, R., Kieft, J., Doolittle, R., Sevrioukova, I. F., Schulman, H., Julie, H., Focia, P., Hocking, R., Tubbs, J., Didonato, M., Verdecia, M., Juers, D. H., Morse, D., Egea, P. F., Jianghai, Z., Moriyama, H., Trewhella, J., Harris, H., Hjelm, R., Pingitore, N., Kenneth, N., Walter, M., Goodin, D. B., Lewis, H. A. L., Lay, P., Terry, N., Kihara, H., Baker, K., Remington, S. J., Somoza, J., Poulos, T. L., Kreusch, A., Hitomi, K., Noel, J., Matsuda, S., Weiss, A., Bullitt, E., Guss, J. M., Hur, S. U. N., Wakatsuki, S., Schreiter, E., Austin, M., Ralston, C., Salt, D., Kirk, M., Kim, S., Huang, Z., Foster, A., Bubacco, L., Russo, D., Freymann, D. M., Knighton, D., Curmi, P., Doniach, S., Mondragon, A., Tierney, D., Kuriyan, J., Salom Arbona, D., Chih-Chia, S., Warner, J., Neese, F., Luhmann, N., Stewart, L., Stec, B., Sundaramoorthy, M., Mattison, K., Zhang, Q., Bergmann, E., Parsons, J., Allen, J. P., Niebuhr, M., Noveron, J., Ikonen, T., Pojer, F., Strynadka, N., Arai, Y., Whitlow, M. D., Matthews, B., Prosise, G., Licata, V., Detitta, G., Doonan, C., [No Value], K. R., Nilsson, A., Schumacher, M., Agard, D., Goldenberg, D. N., Wakabayashi, K., Vrielink, A., Romanowski, M., McRee, D. E., Knobler, C., Bott, R., Newcomer, M. E., Pathuri, P., Balendiran, G., Carr, P., Carroll, K., Lee, S., Frydman, J., Tang, K., Auldridge, M., Kang, S. W. A., Jessica, V., Szilagyi, R. K., Kuhn, P., Wong, G., Quake, S., Latimer, M., Pickering, I. J., Maroney, M., Iverson, T., Stagno, J., Zamble, D., Pozharskiy, E., Bergmann, U. W. E., Malkowski, M., Turley, S., Yang, X., Hurley, J. B., Hill, C. P., Saphire, E. O., Solomon, E., Tang, Y. I., Swairjo, M., Riggs-Gelasco, P., Okamura, M., Groppe, J. C., Barry, C., van Petegem, F., Matsudaira, P. T., Mang, Y., Allen, K. N., O'Connor, D., Takagi, Y., Perez-Mendez, L., Murr, M., Daniel, L., Prach, L., Nimigean, C. M., Wenqing, X., Lemieux, J., Gouaux, J. E., Berger, J., Keatinge-Clay, A., Lee, T., Chen, X., Flynn, E., Streli, C., Chen, Y. U., Lamers, M., Lombana, T. N., Maris, A. N. N., Cunningham, E., Fraser, J., Ho Leung, N., Jacobs, M., Mieczkowski, C., Lacy, D. B., Gay, L., Kanai, S., Vigers, A., Zhou, Y., Baer, C., Alber, T., Gee, C., Spraggon, G., Anderson, M., Grundner, C., Scott, P., Fenton, A., Rosen, B. P., Jedrzejas, M., Roberts, S., Maduke, M., Frei, H., Nowakowski, J., Merritt, E., Weiss, T., Wedekind, J., Hidong, K., Nettles, K., Stubbs, G., Sutton, R., Garcia, K. C., McFarlane, K., Kohzuma, T., Brayer, G., Kelly, M., Roosild, T., Singh, S., Hall, S., Cohen, A., Hung, L., Clemons, W. M., Jensen, G., Junjun, G., Coleman, R., Blanchard, H., Stephenson, S., Pianetta, P., Lee, J., Froester, F., Carter, A. J., Lam, P., Abendroth, J. A. N., Tari, L., Lindhout, D., Wilce, M., Lingel, A., Kuglstatter, A., MacHeboeuf, P., Hansel, C., Kinney, J. H., Roca, A., Craig, L., Rosenfeld, R., Metcalf, P., Habel, L., Gupta, K., Choe, J., Doukov, T., Marcu, O., Eun-Young, K., Kantardjieff, K., Jardetzky, T., Reichow, S. L., Wasinger, E., Bateman, K., Boulanger, M., Goulding, C., Zajonc, D., Sevrioukova, I., Qing, H., Tezcan, F. A., Lograsso, P., Ozorowski, G., Tang, L., Blumenthal, D., Peisley, A., McNulty, R., Sproules, S., Sagermann, M., Holyoak, T., Pazicni, S., Kuske, C., Goodin, D. B., Brandt, G., Gouaux, J., Jungwook, K., Prach, L. M., Kerkow, D., Abbate, E., Palmer, A., Earnest, T., Card, G., Jayaraman, S., van Den Akker, F., Lay, P., Garcin, E., Changgong, L., van Petegem, F., Aniruddha, D., Viadiu, H., Kwiatkowski, W., Tung-Chung, M., Lee, K., He, M., Rubin, S. M., Lancaster, K., Wilbanks, S., Jing, H. U. A., Soutter, H., Stasser, J., Rexach, M., Webb, S., Nicholas Graham, F., Chaudhuri, B., Waters, D., Goldman, P., Louie, M., Bertin, A., Scott, E., Harris, H., Brock, J. S., Curmi, P., Kenneth, N., Patty, C. A., Sarangi, S., Tsai, C., Walter, M., Izard, T., Lieh Yoon, L., Zhang, Y. A. N., Yang, K., Huajun, F., Fortoul, T., Bingdong, S., Sousa, M. C., Zongchao, J., Schaible, E., Fenn, R. S., Liu, X. I. N., Pushie, M. J., Lyubimov, A., Xuan-Zheng, S., Chuenchor, W., Mangani, S., Kielkopf, C., Punshon, T., Clemons, W. M., Johnson, S., Betts, L., Oganesyan, V., dervan, P., MacRae, I. J., Vakulenko, S., Ficko-Blean, E., Hamaoka, B. Y., Martel, A., Subramaniapillai, K., Mayo, S., Cherezov, V. G., Changping, Z., Chan, D., Fu, L. I., Joubert, L., Tian, S., Della Longa, S., Gray, H., Bosch, J. P., Stoltz, B., Hjelm, R. P., Zheng, J. C., Tang, P. E. I., Pushkar, K., Wilmot, C. M., Arnold, F., Holman, K. M., Tong, L., Bercaw, J., Schultz, W., Palmer, J. H., Guan, L. A. N., Fuller, G., Bjorkman, P., Herschlag, D., Porta, J., Grossman, J. G., Sazinsky, M., Barton, J., Voegtli, W., Harris, S., Xu, H. E., Wang, D., Sali, A., Zhang, C., Meyer-Klaucke, W., Dong, B., Mijovilovich, A. N. A., Gulick, A., Doniach, S., Menichelli, E. R. A., Williams, J. C., Higgins, K. A., Grubbs, R. H., Gerratana, B., Carter, L., Stevens, J., Zhu, J. I., Wang, X., Jennings, P., Cody, V., Lemieux, M. J., Pruneda, J., Lilyestrom, W. G., Matsui, T., Meng-Chiao, H., Ho, S., Zuber, H., Black, F., White, M. A., Wolfe-Simon, F., Weng, T., Tang, M., Reese, M. L., Rajagopal, P., Nichol, H., Rongsheng, J., Wang, Y., Angel, L., Saltzberg, D., McCormick, M., Guo, M. I. N., Seelig, B., Luger, K., Yongqun, H., Nicholas, H., Stahanam, N., Schick, B., Cherbavaz, D., Irving, C., Hadman, B., Perry, K., Powers, L., Nanni, R., Mande, S., Brunger, A., Elder, R., Anthony, C., Ramalingam, V., Mylvaganam, S., Gillmor, S., Cramer, S. P., Stevens, R., Parge, H., Mol, C., Wilson, I., Han, G., Bourne, Y., Penner-Hahn, J. E., Amzel, L., Foster, P., Harrison, S., Redinbo, M., George, M., Putnam, C., Lay, P., Terwilliger, T. C., Bellamy, H., Redford, S., Wagner, R., Buchbinder, J., Phizackerley, R. P., Schafmeister, C., Gatewood, J. M., Jennings, P., Rehr, J., Sablin, E., Choe, S., Merritt, E., Chen, J., McTigue, M., Lippard, S., Rudenko, G., Jardetzky, T., Frederick, C., Fink, A., Blackburn, N., Lattman, E., Raghunathan, S., Vivien, Y., Pickering, I. J., Genick, U., Somoza, J., Korolev, S., Skidmore, M., Safinya, C., Rayment, I., Shiau, A., Fields, B., Sauter, N., Stenkamp, R., Stowell, M., Hendle, J., Dewitt, J., Luecke, H., Crane, B., Doolittle, R., Arvai, A., Hellinga, H. W., Huang, L. A. N., Anderson, A. C., Huiying, L., Horjales, E., Focia, P., Edwards, A., Stezowski, J., Hidong, K., Endrizzi, J., Burgess, B., Hales, B., Yu, C., Prince, R., Forest, K., Freeman, H., Rader, S., Almo, S. C., Sawaya, M., Hedman, B., Vickery, L., Waksman, G., Eisenberg, D., Friedman, R. M., Rees, D., Scott, R., Adams, M. W., Lee, J., Ralston, C., Salt, D., Smith, T., George, G., Edwards, S., Wiener, M. C., Marks, C., David, P., Lawrence, M., Tsuruta, H., McKay, D., Kim, S., De Vos, A., Hill, C. P., Mendelson, R., Rich, A., Lo, T., Trewhella, J., Yeh, J., Soltis, S., Solomon, E., Ming, L., Starks, C., Thayer, M., Nelson, H., Kull, F., Lin, K. A. I., Guan, Y. U. E., Stout, C., Canady, M., Rutenber, E., Klein, M., Varughese, K., Baker, E., Crowder, S., Warburton, W., Yonath, A., Berry, E., Johnson, J., Templeton, D., Curmi, P., Riggs-Gelasco, P., Weis, W., Doniach, S., Grush, M., Bruns, C., Whitby, F., Hogle, J., Fu, J., Izard, T., Freymann, D., Einspahr, H., Bilwes, A., Hackert, M., McRee, D. E., Skinner, M., Mondragon, A., Goodwill, K. & Hodgson, K.

National Institutes of Health

3/1/802/28/15

Project: Research project

synchrotron radiation
deoxyribonucleic acid
oxygen metabolism
nitrogenation
leadership

Research Output 1992 2019

  • 1856 Citations
  • 19 h-Index
  • 41 Article
  • 1 Chapter
  • 1 Comment/debate
2 Citations (Scopus)

Endonuclease activity inhibition of the NS1 protein of parvovirus B19 as a novel target for antiviral drug development

Xu, P., Ganaie, S. S., Wang, X., Wang, Z., Kleiboeker, S., Horton, N. C., Heier, R. F., Meyers, M. J., Tavis, J. E. & Qiu, J., Mar 1 2019, In : Antimicrobial Agents and Chemotherapy. e01879-18.

Research output: Contribution to journalArticle

Endonucleases
Antiviral Agents
DNA Replication
Replication Origin
Terminal Repeat Sequences
1 Citation (Scopus)

Mechanism of Filamentation-Induced Allosteric Activation of the SgrAI Endonuclease

Polley, S., Lyumkis, D. & Horton, N. C., Oct 1 2019, In : Structure. 27, 10, p. 1497-1507.e3

Research output: Contribution to journalArticle

Open Access
Type II Site Specific Deoxyribonucleases
DNA Cleavage
DNA
Enzymes
endodeoxyribonuclease SgrAI

Novel insights into filament-forming enzymes

Park, C. K. & Horton, N. C., Jan 1 2019, (Accepted/In press) In : Nature Reviews Molecular Cell Biology.

Research output: Contribution to journalComment/debate

Enzymes
2 Citations (Scopus)

The Need for Speed: Run-On Oligomer Filament Formation Provides Maximum Speed with Maximum Sequestration of Activity

Barahona, C. J., Basantes, L. E., Tompkins, K. J., Heitman, D. M., Chukwu, B. I., Sanchez, J., Sanchez, J. L., Ghadirian, N., Park, C. K. & Horton, N. C., Mar 1 2019, In : Journal of virology. 93, 5

Research output: Contribution to journalArticle

DNA Cleavage
Enzymes
enzymes
DNA
Virus Diseases
3 Citations (Scopus)

The run-on oligomer filament enzyme mechanism of SgrAI: Part 2. Kinetic modeling of the full DNA cleavage pathway

Park, C. K., Sanchez, J. L., Barahona, C., Basantes, L. E., Sanchez, J., Hernandez, C. & Horton, N. C., Jan 1 2018, In : Journal of Biological Chemistry. 293, 38, p. 14599-14615 17 p.

Research output: Contribution to journalArticle

DNA Cleavage
Oligomers
Kinetics
DNA
Type II Site Specific Deoxyribonucleases