• 1888 Citations
  • 19 h-Index
1980 …2019

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Article
2019

Endonuclease activity inhibition of the NS1 protein of parvovirus B19 as a novel target for antiviral drug development

Xu, P., Ganaie, S. S., Wang, X., Wang, Z., Kleiboeker, S., Horton, N. C., Heier, R. F., Meyers, M. J., Tavis, J. E. & Qiu, J., Mar 1 2019, In : Antimicrobial Agents and Chemotherapy. e01879-18.

Research output: Contribution to journalArticle

4 Scopus citations

Mechanism of Filamentation-Induced Allosteric Activation of the SgrAI Endonuclease

Polley, S., Lyumkis, D. & Horton, N. C., Oct 1 2019, In : Structure. 27, 10, p. 1497-1507.e3

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

The Need for Speed: Run-On Oligomer Filament Formation Provides Maximum Speed with Maximum Sequestration of Activity

Barahona, C. J., Basantes, L. E., Tompkins, K. J., Heitman, D. M., Chukwu, B. I., Sanchez, J., Sanchez, J. L., Ghadirian, N., Park, C. K. & Horton, N. C., Mar 1 2019, In : Journal of virology. 93, 5

Research output: Contribution to journalArticle

3 Scopus citations
2018

The run-on oligomer filament enzyme mechanism of SgrAI: Part 1. Assembly kinetics of the run-on oligomer filament

Park, C. K., Sanchez, J. L., Barahona, C., Basantes, L. E., Sanchez, J., Hernandez, C. & Horton, N. C., Jan 1 2018, In : Journal of Biological Chemistry. 293, 38, p. 14585-14598 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

The run-on oligomer filament enzyme mechanism of SgrAI: Part 2. Kinetic modeling of the full DNA cleavage pathway

Park, C. K., Sanchez, J. L., Barahona, C., Basantes, L. E., Sanchez, J., Hernandez, C. & Horton, N. C., Jan 1 2018, In : Journal of Biological Chemistry. 293, 38, p. 14599-14615 17 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

DNA Binding and Cleavage by the Human Parvovirus B19 NS1 Nuclease Domain

Sanchez, J. L., Romero, Z., Quinones, A., Torgeson, K. R. & Horton, N. C., Nov 29 2016, In : Biochemistry. 55, 47, p. 6577-6593 17 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Probing the run-on oligomer of activated SgrAI bound to DNA

Shah, S., Sanchez, J., Stewart, A., Piperakis, M. M., Cosstick, R., Nichols, C., Park, C. K., Ma, X., Wysocki, V., Bitinaite, J. & Horton, N. C., Apr 16 2015, In : PloS one. 10, 4, e0124783.

Research output: Contribution to journalArticle

7 Scopus citations

Structure and specificity of FEN-1 from Methanopyrus kandleri

Shah, S., Dunten, P., Stiteler, A., Park, C. K. & Horton, N. C., 2015, In : Proteins: Structure, Function and Genetics. 83, 1, p. 188-194 7 p.

Research output: Contribution to journalArticle

2013

Allosteric regulation of DNA cleavage and sequence-specificity through run-on oligomerization

Lyumkis, D., Talley, H., Stewart, A., Shah, S., Park, C. K., Tama, F., Potter, C. S., Carragher, B. & Horton, N. C., Oct 8 2013, In : Structure. 21, 10, p. 1848-1858 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Structural analysis of activated SgrAI-DNA oligomers using ion mobility mass spectrometry

Ma, X., Shah, S., Zhou, M., Park, C. K., Wysocki, V. H. & Horton, N. C., Jun 25 2013, In : Biochemistry. 52, 25, p. 4373-4381 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
2011
8 Scopus citations
2010

Activation of DNA cleavage by oligomerization of DNA-bound SgrAI

Park, C. K., Stiteler, A. P., Shah, S., Ghare, M. I., Bitinaite, J. & Horton, N. C., Oct 19 2010, In : Biochemistry. 49, 41, p. 8818-8830 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Domain swapping in allosteric modulation of DNA specificity

Park, C. K., Joshi, H. K., Agrawal, A., Ghare, M. I., Little, E. J., Dunten, P. W., Bitinaite, J. & Horton, N. C., Dec 1 2010, In : PLoS biology. 8, 12, e1000554.

Research output: Contribution to journalArticle

13 Scopus citations
2009

The restriction enzyme SgrAI: Structure solution via combination of poor MIRAS and MR phases

Dunten, P. W., Little, E. J. & Horton, N. C., Mar 19 2009, In : Acta Crystallographica Section D: Biological Crystallography. 65, 4, p. 393-398 6 p.

Research output: Contribution to journalArticle

2008

DNA Distortion and Specificity in a Sequence-Specific Endonuclease

Babic, A. C., Little, E. J., Manohar, V. M., Bitinaite, J. & Horton, N. C., Oct 31 2008, In : Journal of Molecular Biology. 383, 1, p. 186-204 19 p.

Research output: Contribution to journalArticle

7 Scopus citations

Early Interrogation and Recognition of DNA Sequence by Indirect Readout

Little, E. J., Babic, A. C. & Horton, N. C., Dec 12 2008, In : Structure. 16, 12, p. 1828-1837 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

The structure of SgrAI bound to DNA; recognition of an 8 base pair target

Dunten, P. W., Little, E. J., Gregory, M. T., Manohar, V. M., Dalton, M., Hough, D., Bitinaite, J. & Horton, N. C., Oct 1 2008, In : Nucleic acids research. 36, 16, p. 5405-5416 12 p.

Research output: Contribution to journalArticle

24 Scopus citations
2006

Alteration of sequence specificity of the type II restriction endonuclease HincII through an indirect readout mechanism

Joshi, H. K., Etzkorn, C., Chatwell, L., Bitinaite, J. & Horton, N. C., Aug 18 2006, In : Journal of Biological Chemistry. 281, 33, p. 23852-23869 18 p.

Research output: Contribution to journalArticle

21 Scopus citations

Structure of Aart, a Designed Six-finger Zinc Finger Peptide, Bound to DNA

Segal, D. J., Crotty, J. W., Bhakta, M. S., Barbas, C. F. & Horton, N. C., Oct 20 2006, In : Journal of Molecular Biology. 363, 2, p. 405-421 17 p.

Research output: Contribution to journalArticle

74 Scopus citations
2005
5 Scopus citations

DNA-induced conformational changes in type II restriction endonucleases: The structure of unliganded HincII

Little, E. J. & Horton, N. C., Aug 5 2005, In : Journal of Molecular Biology. 351, 1, p. 76-88 13 p.

Research output: Contribution to journalArticle

3 Scopus citations
2004

Ca2+ binding in the active site of HincII: Implications for the catalytic mechanism

Etzkorn, C. & Horton, N. C., Oct 26 2004, In : Biochemistry. 43, 42, p. 13256-13270 15 p.

Research output: Contribution to journalArticle

24 Scopus citations

DNA cleavage by EcoRV endonuclease: Two metal ions in three metal ion binding sites

Horton, N. C. & Perona, J. J., Jun 8 2004, In : Biochemistry. 43, 22, p. 6841-6857 17 p.

Research output: Contribution to journalArticle

76 Scopus citations

Mechanistic insights from the structures of HincII bound to cognate DNA cleaved from addition of Mg2+ and Mn2+

Etzkorn, C. & Horton, N. C., Oct 29 2004, In : Journal of Molecular Biology. 343, 4, p. 833-849 17 p.

Research output: Contribution to journalArticle

16 Scopus citations
2002

Electrostatic contributions to site specific DNA cleavage by EcoRV endonuclease

Horton, N. C., Otey, C., Lusetti, S., Sam, M. D., Kohn, J., Martin, A. M., Ananthnarayan, V. & Perona, J. J., Sep 3 2002, In : Biochemistry. 41, 35, p. 10754-10763 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Sequence selectivity and degeneracy of a restriction endonuclease mediated by dna intercalation

Horton, N. C., Dorner, L. F. & Perona, J. J., Jan 1 2002, In : Nature Structural Biology. 9, 1, p. 42-47 6 p.

Research output: Contribution to journalArticle

48 Scopus citations
2001

Catalytic efficiency and sequence selectivity of a restriction endonuclease modulated by a distal manganese ion binding site

Sam, M. D., Horton, N. C., Nissan, T. A. & Perona, J. J., Mar 2 2001, In : Journal of Molecular Biology. 306, 4, p. 851-861 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2000

Crystallographic snapshots along a protein-induced DNA-bending pathway

Horton, N. C. & Perona, J. J., May 23 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 11, p. 5729-5734 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Inhibition of EcoRV endonuclease by deoxyribo-3'-S-phosphorothiolates: A high-resolution X-ray crystallographic study

Horton, N. C., Connolly, B. A. & Perona, J. J., Apr 12 2000, In : Journal of the American Chemical Society. 122, 14, p. 3314-3324 11 p.

Research output: Contribution to journalArticle

33 Scopus citations
1999

Crystallization and preliminary diffraction analysis of the HincII restriction endonuclease-DNA complex

Horton, N. C., Dorner, L. F., Schildkraut, I. & Perona, J. J., Nov 1 1999, In : Acta Crystallographica Section D: Biological Crystallography. 55, 11, p. 1943-1945 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

Divalent metal dependence of site-specific DNA binding by EcoRV endonuclease

Martin, A. M., Horton, N. C., Lusetti, S., Reich, N. O. & Perona, J. J., Jun 29 1999, In : Biochemistry. 38, 26, p. 8430-8439 10 p.

Research output: Contribution to journalArticle

61 Scopus citations
1998

Cation binding to the integrin CD11b I domain and activation model assessment

Baldwin, E. T., Sarver, R. W., Bryant, G. L., Curry, K. A., Fairbanks, M. B., Finzel, B. C., Garlick, R. L., Heinrikson, R. L., Horton, N. C., Kelley, L. L. C., Mildner, A. M., Moon, J. B., Mott, J. E., Mutchler, V. T., Tomich, C. S. C., Watenpaugh, K. D. & Wiley, V. H., Jul 15 1998, In : Structure. 6, 7, p. 923-935 13 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations

Metal ion-mediated substrate-assisted catalysis in type II restriction endonucleases

Horton, N. C., Newberry, K. J. & Perona, J. J., Nov 10 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 23, p. 13489-13494 6 p.

Research output: Contribution to journalArticle

100 Scopus citations

Recognition of flanking DNA sequences by EcoRV endonuclease involves alternative patterns of water-mediated contacts

Horton, N. C. & Perona, J. J., Aug 21 1998, In : Journal of Biological Chemistry. 273, 34, p. 21721-21729 9 p.

Research output: Contribution to journalArticle

32 Scopus citations
37 Scopus citations
1996

Crystal structure of the lactose operon represser and its complexes with DNA and inducer

Lewis, M., Chang, G., Horton, N. C., Kercher, M. A., Pace, H. C., Schumacher, M. A., Brennan, R. G. & Lu, P., Mar 1 1996, In : Science. 271, 5253, p. 1247-1254 8 p.

Research output: Contribution to journalArticle

616 Scopus citations

Structure and genetics of the lactose operon repressor

Kercher, M. A., Chang, G., Horton, N. C., Lu, P., Miller, J. H., Pace, H. C. & Lewis, M., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1136

Research output: Contribution to journalArticle

The structure of an RNA/DNA hybrid: A substrate of the ribonuclease activity of HIV-1 reverse transcriptase

Horton, N. C. & Finzel, B. C., Dec 6 1996, In : Journal of Molecular Biology. 264, 3, p. 521-533 13 p.

Research output: Contribution to journalArticle

77 Scopus citations
1992

Calculation of the free energy of association for protein complexes

Horton, N. & Lewis, M., Jan 1992, In : Protein Science. 1, 1, p. 169-181 13 p.

Research output: Contribution to journalArticle

312 Scopus citations