• 1083 Citations
  • 22 h-Index
1978 …2020

Research output per year

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Research Output

  • 1083 Citations
  • 22 h-Index
  • 43 Article
  • 3 Review article
  • 2 Conference contribution
  • 1 Comment/debate
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Article
2020

Synthesis and Structure-Activity Relationships of N-(4-Benzamidino)-Oxazolidinones: Potent and Selective Inhibitors of Kallikrein-Related Peptidase 6

De Vita, E., Smits, N., van den Hurk, H., Beck, E. M., Hewitt, J., Baillie, G., Russell, E., Pannifer, A., Hamon, V., Morrison, A., McElroy, S. P., Jones, P., Ignatenko, N. A., Gunkel, N. & Miller, A. K., Jan 7 2020, In : ChemMedChem. 15, 1, p. 79-95 17 p.

Research output: Contribution to journalArticle

Open Access
2019

Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein

Chen, H., Sells, E., Pandey, R., Abril, E. R., Hsu, C. H., Krouse, R. S., Nagle, R. B., Pampalakis, G., Sotiropoulou, G. & Ignatenko, N. A., Jan 1 2019, In : Oncotarget. 10, 58, p. 6062-6078 17 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Somatic evolution and global expansion of an ancient transmissible cancer lineage

Baez-Ortega, A., Gori, K., Strakova, A., Allen, J. L., Allum, K. M., Bansse-Issa, L., Bhutia, T. N., Bisson, J. L., Briceño, C., Domracheva, A. C., Corrigan, A. M., Cran, H. R., Crawford, J. T., Davis, E., De Castro, K. F., De Nardi, A. B., De Vos, A. P., Keenan, L. D., Donelan, E. M., Espinoza Huerta, A. R. & 60 others, Faramade, I. A., Fazil, M., Fotopoulou, E., Fruean, S. N., Gallardo-Arrieta, F., Glebova, O., Gouletsou, P. G., Häfelin Manrique, R. F., Henriques, J. J. G. P., Horta, R. S., Ignatenko, N., Kane, Y., King, C., Koenig, D., Krupa, A., Kruzeniski, S. J., Kwon, Y. M., Lanza-Perea, M., Lazyan, M., Lopez Quintana, A. M., Losfelt, T., Marino, G., Castañeda, S. M., Martínez-López, M. F., Meyer, M., Migneco, E. J., Nakanwagi, B., Neal, K. B., Neunzig, W., Leathlobhair, M. N., Nixon, S. J., Ortega-Pacheco, A., Pedraza-Ordoñez, F., Peleteiro, M. C., Polak, K., Pye, R. J., Reece, J. F., Gutierrez, J. R., Sadia, H., Schmeling, S. K., Shamanova, O., Sherlock, A. G., Stammnitz, M., Steenland-Smit, A. E., Svitich, A., Tapia Martínez, L. J., Ngoka, I. T., Torres, C. G., Tudor, E. M., Van Der Wel, M. G., Viţălaru, B. A., Vural, S. A., Walkinton, O., Wang, J., Wehrle-Martinez, A. S., Widdowson, S. A. E., Stratton, M. R., Alexandrov, L. B., Martincorena, I. & Murchison, E. P., Aug 2 2019, In : Science. 365, 6452, 464.

Research output: Contribution to journalArticle

9 Scopus citations
2018

Detection of Enzyme Activity and Inhibition during Studies in Solution, In Vitro and In Vivo with CatalyCEST MRI

Sinharay, S., Randtke, E. A., Howison, C. M., Ignatenko, N. A. & Pagel, M. D., Apr 1 2018, In : Molecular Imaging and Biology. 20, 2, p. 240-248 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Does mutated K-RAS oncogene attenuate the effect of sulindac in colon cancer chemoprevention?

Rice, P. F. S., Ehrichs, K. G., Jones, M. S., Chen, H. D. R., Hsu, C-H., Abril, E. R., Nagle, R. B., Besselsen, D. G., Barton, J. K. & Ignatenko, N., Jan 1 2018, In : Cancer Prevention Research. 11, 1, p. 16-26 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Specific microRNA–mRNA Regulatory Network of Colon Cancer Invasion Mediated by Tissue Kallikrein–Related Peptidase 6

Sells, E., Pandey, R., Chen, H. D. R., Skovan, B. A., Cui, H. & Ignatenko, N., May 1 2017, In : Neoplasia (United States). 19, 5, p. 396-411 16 p.

Research output: Contribution to journalArticle

15 Scopus citations
2016

Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

Strakova, A., Leathlobhair, M. N., Wang, G. D., Yin, T. T., Airikkala-Otter, I., Allen, J. L., Allum, K. M., Bansse-Issa, L., Bisson, J. L., Domracheva, A. C., De Castro, K. F., Corrigan, A. M., Cran, H. R., Crawford, J. T., Cutter, S. M., Keenan, L. D., Donelan, E. M., Faramade, I. A., Reynoso, E. F., Fotopoulou, E. & 41 others, Fruean, S. N., Gallardo-Arrieta, F., Glebova, O., Häfelin Manrique, R. F., Henriques, J. J. G. P., Ignatenko, N., Koenig, D., Lanza-Perea, M., Lobetti, R., Lopezquintana, A. M., Losfelt, T., Marino, G., Martincorena, I., Castañeda, S. M., Martínez-López, M. F., Meyer, M., Nakanwagi, B., De Nardi, A. B., Neunzig, W., Nixon, S. J., Onsare, M. M., Ortega-Pacheco, A., Peleteiro, M. C., Pye, R. J., Reece, J. F., Gutierrez, J. R., Sadia, H., Schmeling, S. K., Shamanova, O., Ssuna, R. K., Steenland-Smitsvitich, A. E. A., Ngoka, I. T., Vitǎlaru, B. A., De Vos, A. P., De Vos, J. P., Walkinton, O., Wedge, D. C., Wehrle-Martinez, A. S., Van Der Wel, M. G., Widdowson, S. A. & Murchison, E. P., May 17 2016, In : eLife. 5, MAY2016, e14552.

Research output: Contribution to journalArticle

29 Scopus citations
2015

Erratum: Caveolin-1 is a novel regulator of K-RASdependent migration in colon carcinogenesis (International Journal of Cancer (2013) 133: 1 (43-57) DOI: 10.1002/ijc.28001)

Roy, U. K. B., Henkhaus, R. S., Loupakis, F., Cremolini, C., Gerner, E. W. & Ignatenko, N., Oct 15 2015, In : International Journal of Cancer. 137, 8, p. E18

Research output: Contribution to journalArticle

2013

Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis

Basu Roy, U. K., Henkhaus, R. S., Loupakis, F., Cremolini, C., Gerner, E. W. & Ignatenko, N. A., Jul 2013, In : International Journal of Cancer. 133, 1, p. 43-57 15 p.

Research output: Contribution to journalArticle

40 Scopus citations
2011

Polyamines in cancer

Paz, E. A., Garcia-Huidobro, J. & Ignatenko, N. A., Apr 18 2011, In : Advances in Clinical Chemistry. 54, p. 45-70 26 p.

Research output: Contribution to journalArticle

25 Scopus citations
2009

Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival

Zell, J. A., Ziogas, A., Ignatenko, N., Honda, J., Qu, N., Bobbs, A. S., Neuhausen, S. L., Gerner, E. W. & Anton-Culver, H., Oct 1 2009, In : Clinical Cancer Research. 15, 19, p. 6208-6216 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Gene expression analysis of HCT116 colon tumor-derived cells treated with the polyamine analog PG-11047

Ignatenko, N. A., Yerushalmi, H. F., Pandey, R., Kachel, K. L., Stringer, D. E., Marton, L. J. & Gerner, E. W., Jan 1 2009, In : Cancer Genomics and Proteomics. 6, 3, p. 161-176 16 p.

Research output: Contribution to journalArticle

11 Scopus citations
2008

Caveolin-1 mediated expression and secretion of Kallikrein 6 in colon cancer cells

Henkhaus, R. S., Roy, U. K. B., Cavallo-Medved, D., Sloane, B. F., Gerner, E. W. & Ignatenko, N. A., Feb 2008, In : Neoplasia. 10, 2, p. 140-148 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Combination chemoprevention of intestinal carcinogenesis in a murine model of familial adenomatous polyposis

Ignatenko, N. A., Besselsen, D. G., Stringer, D. E., Blohm-Mangone, K. A., Cui, H. & Gerner, E. W., Nov 18 2008, In : Nutrition and cancer. 60, SUPPL. 1, p. 30-35 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells

Henkhaus, R. S., Gerner, E. W. & Ignatenko, N. A., Jun 1 2008, In : Biological Chemistry. 389, 6, p. 757-764 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc

Roy, U. K. B., Henkhaus, R. S., Ignatenko, N. A., Mora, J., Fultz, K. E. & Gerner, E. W., Dec 1 2008, In : Molecular Carcinogenesis. 47, 12, p. 947-955 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
2007

Deoxycholate-induced colitis is markedly attenuated in Nos2 knockout mice in association with modulation of gene expression profiles

Bernstein, H., Holubec, H., Bernstein, C., Ignatenko, N. A., Gerner, E., Dvorak, K., Besselsen, D., Blohm-Mangone, K. A., Padilla-Torres, J., Dvorakova, B., Garewal, H. & Payne, C. M., Mar 1 2007, In : Digestive Diseases and Sciences. 52, 3, p. 628-642 15 p.

Research output: Contribution to journalArticle

18 Scopus citations

Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival

Zell, J. A., Ignatenko, N. A., Yerushalmi, H. F., Ziogas, A., Besselsen, D. G., Gerner, E. W. & Anton-Culver, H., Feb 1 2007, In : International Journal of Cancer. 120, 3, p. 459-468 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography

Hariri, L. P., Qiu, Z., Tumlinson, A. R., Besselsen, D. G., Gerner, E. W., Ignatenko, N. A., Považay, B., Hermann, B., Sattmann, H., McNally, J., Unterhuber, A., Drexler, W. & Barton, J. K., Nov 2007, In : Cancer Biology and Therapy. 6, 11, p. 1753-1762 10 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations
2006

Dietary putrescine reduces the intestinal anticarcinogenic activity of sulindac in a murine model of familial adenomatous polyposis

Ignatenko, N. A., Besselsen, D. G., Basu Roy, U. K., Stringer, D. E., Blohm-Mangone, K. A., Padilla-Torres, J. L., Guillen-R, J. M. & Gerner, E. W., Dec 1 2006, In : Nutrition and cancer. 56, 2, p. 172-181 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
Open Access
4 Scopus citations

Role of c-Myc in intestinal tumorigenesis of the ApcMin/+ mouse

Ignatenko, N. A., Holubec, H., Besselsen, D. G., Blohm-Mangone, K. A., Padilla-Torres, J. L., Nagle, R. B., De Alboránç, I. M., Guillen-R, J. M. & Gerner, E. W., Dec 2006, In : Cancer Biology and Therapy. 5, 12, p. 1658-1664 7 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations

Role of polyamines in arginine-dependent colon carcinogenesis in Apc Min/+ mice

Yerushalmi, H. F., Besselsen, D. G., Ignatenko, N. A., Blohm-Mangone, K. A., Padilla-Torres, J. L., Stringer, D. E., Guillen, J. M., Holubec, H., Payne, C. M. & Gerner, E. W., Oct 1 2006, In : Molecular Carcinogenesis. 45, 10, p. 764-773 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

The role of NO synthases in arginine-dependent small intestinal and colonic carcinogenesis

Yerushalmi, H. F., Besselsen, D. G., Ignatenko, N. A., Blohm-Mangone, K. A., Padilla-Torres, J. L., Stringer, D. E., Cui, H., Holubec, H., Payne, C. M. & Gerner, E. W., Feb 1 2006, In : Molecular Carcinogenesis. 45, 2, p. 93-105 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Unique dietary-related mouse model of colitis

Bernstein, H., Holubec, H., Bernstein, C., Ignatenko, N., Gerner, E., Dvorak, K., Besselsen, D., Ramsey, L., Dall'Agnol, M., Blohm-Mangone, K. A., Padilla-Torres, J., Cui, H., Garewal, H. & Payne, C. M., Apr 1 2006, In : Inflammatory bowel diseases. 12, 4, p. 278-293 16 p.

Research output: Contribution to journalArticle

32 Scopus citations
2005
14 Scopus citations
2004

Role of polyamines in the function of nuclear transcription factor NF-κB in breast cancer cells

Zaletok, S., Alexandrova, N., Berdynskykh, N., Ignatenko, N., Gogol, S., Orlovsky, O., Tregubova, N., Gerner, E. & Chekhun, V., Sep 1 2004, In : Experimental Oncology. 26, 3, p. 221-225 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Suppression of Polyamine Catabolism by Activated Ki-ras in Human Colon Cancer Cells

Ignatenko, N. A., Babbar, N., Mehta, D., Casero, R. A. & Gerner, E. W., Feb 1 2004, In : Molecular Carcinogenesis. 39, 2, p. 91-102 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

The Chemopreventive Agent α-Difluoromethylornithine Blocks Ki-ras-Dependent Tumor Formation and Specific Gene Expression in Caco-2 Cells

Ignatenko, N. A., Zhang, H., Watts, G. S., Skovan, B. A., Stringer, D. E. & Gerner, E. W., Apr 1 2004, In : Molecular Carcinogenesis. 39, 4, p. 221-233 13 p.

Research output: Contribution to journalArticle

39 Scopus citations
2003

Cyclooxygenase-independent Induction of Apoptosis by Sulindac Sulfone Is Mediated by Polyamines in Colon Cancer

Babbar, N., Ignatenko, N. A., Casero, R. A. & Gerner, E. W., Nov 28 2003, In : Journal of Biological Chemistry. 278, 48, p. 47762-47775 14 p.

Research output: Contribution to journalArticle

113 Scopus citations

Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine

Ning, Q. U., Ignatenko, N. A., Yamauchi, P., Stringer, D. E., Levenson, C., Shannon, P., Perrin, S. & Gerner, E. W., Oct 15 2003, In : Biochemical Journal. 375, 2, p. 465-470 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Regulation of the HIV1 long terminal repeat by mutant heat shock factor

Ignatenko, N. A. & Gerner, E. W., Aug 1 2003, In : Experimental Cell Research. 288, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2000

Influence of K-ras activation on the survival responses of Caco-2 cells to the chemopreventive agents sulindac and difluoromethylornithine

Lawson, K. R., Ignatenko, N. A., Piazza, G. A., Cui, H. & Gerner, E. W., Jan 1 2000, In : Cancer Epidemiology Biomarkers and Prevention. 9, 11, p. 1155-1162 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells

Taylor, M. T., Lawson, K. R., Ignatenko, N. A., Marek, S. E., Stringer, D. E., Skovan, B. A. & Gerner, E. W., Dec 1 2000, In : Cancer Research. 60, 23, p. 6607-6610 4 p.

Research output: Contribution to journalArticle

42 Scopus citations
1999

APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse

Erdman, S. H., Ignatenko, N. A., Powell, M. B., Blohm-Mangone, K. A., Holubec, H., Guillén-Rodriguez, J. M. & Gerner, E. W., Sep 8 1999, In : Carcinogenesis. 20, 9, p. 1709-1713 5 p.

Research output: Contribution to journalArticle

73 Scopus citations
1996

Expression of the human spermidine/spermine N1-acetyltransferase in spermidine acetylation-deficient Escherichia coli

Ignatenko, N. A., Fish, J. L., Shassetz, L. R., Woolridge, D. P. & Gerner, E. W., Oct 15 1996, In : Biochemical Journal. 319, 2, p. 435-440 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Growth arrest- and polyamine-dependent expression of spermidine/spermine N1-acetyltransferase in human tumor cells

Ignatenko, N. A. & Gerner, E. W., Apr 1 1996, In : Cell Growth and Differentiation. 7, 4, p. 481-486 6 p.

Research output: Contribution to journalArticle

14 Scopus citations
1994

The effect of polyhexamethyleneguanidine on some indices of polyamine metabolism in rats with transplantable hepatoma H-27

Zaletok, S. P., Berdinskikh, N. K., Ignatenko, N. A., Baumanis, E. A., Lidak Yu., M. & Lyalyushko, N. M., Jan 1 1994, In : Eksperimentalnaya Onkologiya. 16, 2-3, p. 136-139 4 p.

Research output: Contribution to journalArticle

1993

The influence of polyhexamethyleneguanidine on polyamine metabolism in mongrel rats and on the growth and metastatic spreading of transplantable Lewis lung carcinoma in C57Bl mice

Zaletok, S. P., Lyalyushko, N. M., Berdinskikh, N. K., Ignatenko, N. A., Lidak Yu., M., Baumanis, E. A. & Birska, I. A., Dec 1 1993, In : Eksperimentalnaya Onkologiya. 15, 6, p. 36-40 5 p.

Research output: Contribution to journalArticle

1991

Ornithine decarboxylase activity and polyamine content in adenocarcinomas of human stomach and large intestine

Berdinskikh, N. K., Ignatenko, N. A., Zaletok, S. P., Ganina, K. P. & Chorniy, V. A., Feb 20 1991, In : International Journal of Cancer. 47, 4, p. 496-498 3 p.

Research output: Contribution to journalArticle

42 Scopus citations
1990

Aktivnost' ornitindekarboksilazy i soderzhanie poliaminov pri indutsirovannom 1,2-dimetilgidrazinom kantserogeneze kishechnika u krys.

Translated title of the contribution: Ornithine decarboxylase activity and polyamine contents in 1,2-dimethylhydrazine-induced carcinogenesis of the intestines in ratsBerdinskikh, N. K., Ignatenko, N. A. & Zaletok, S. P., Dec 1 1990, In : Eksperimentalnaa onkologia. 12, 6, p. 34-36 3 p.

Research output: Contribution to journalArticle

1988

Aktivnost' ornitindekarboksilazy i soderzhanie poliaminov v adenokartsinomakh zheludka i tolstogo kishechnika cheloveka.

Translated title of the contribution: Ornithine decarboxylase activity and polyamine content in human adenocarcinomas of the stomach and large intestineBerdinskikh, N. K., Zaletok, S. P., Bobro, L. I. & Ignatenko, N. A., Dec 1 1988, In : Eksperimental"naia onkologiia. 10, 6, p. 39-41 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Uvelichenie aktivnosti ornitindekarboksilazy i soderzhaniia poliaminov v pecheni krys v ranniǐ period gepatokantserogeneza.

Translated title of the contribution: Increase in ornithine decarboxylase activity and polyamine levels of the rat liver during an early period of hepatocarcinogenesisBerdinskikh, N. K., Zaletok, S. P., Ignatenko, N. A. & Draga, N. V., Jan 1 1988, In : Ukrainskii biokhimicheskii zhurnal. 60, 1, p. 94-97 4 p.

Research output: Contribution to journalArticle

1 Scopus citations