Research Output 1982 2018

  • 19929 Citations
  • 78 h-Index
  • 228 Article
  • 12 Chapter
  • 1 Conference contribution
  • 1 Review article
2018

The Changing Sensory and Sympathetic Innervation of the Young, Adult and Aging Mouse Femur

Chartier, S. R., Mitchell, S. A. T., Majuta, L. A. & Mantyh, P. W. Jan 1 2018 (Accepted/In press) In : Neuroscience.

Research output: Contribution to journalArticle

Adrenergic Fibers
Nerve Fibers
Femur
Young Adult
Periosteum
2017
5 Citations

AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions

Paice, J. A., Mulvey, M., Bennett, M., Dougherty, P. M., Farrar, J. T., Mantyh, P. W., Miaskowski, C., Schmidt, B. & Smith, T. J. Mar 1 2017 In : Journal of Pain. 18, 3, p. 233-246 14 p.

Research output: Contribution to journalReview article

Chronic Pain
Pain
Clinical Trials
Bone Neoplasms
Peripheral Nervous System Diseases
1 Citations

Anti-nerve growth factor therapy increases spontaneous day/night activity in mice with orthopedic surgery-induced pain

Majuta, L. A., Guedon, J. M. G., Mitchell, S. A. T., Ossipov, M. H. & Mantyh, P. W. Apr 1 2017 In : Pain. 158, 4, p. 605-617 13 p.

Research output: Contribution to journalArticle

Nerve Growth Factor
Orthopedics
Pain
Knee Replacement Arthroplasties
Opiate Alkaloids

Immunohistochemical localization of nerve growth factor, tropomyosin receptor kinase A, and p75 in the bone and articular cartilage of the mouse femur

Chartier, S. R., Mitchell, S. A. T., Majuta, L. A. & Mantyh, P. W. Dec 1 2017 In : Molecular Pain. 13

Research output: Contribution to journalArticle

Nerve Growth Factor Receptor
Articular Cartilage
Femur
Nerve Growth Factor
Bone and Bones
2016
6 Citations

Dissociation between the relief of skeletal pain behaviors and skin hypersensitivity in a model of bone cancer pain

Guedon, J. M. G., Longo, G., Majuta, L. A., Thomspon, M. L., Fealk, M. N. & Mantyh, P. W. Jun 1 2016 In : Pain. 157, 6, p. 1239-1247 9 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Hypersensitivity
Pain
Skin
Purinergic P2X3 Receptors
1 Citations

Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent

Hanlon, K. E., Lozano-Ondoua, A. N., Umaretiya, P. J., Symons-Liguori, A. M., Chandramouli, A., Moy, J. K., Kwass, W. K., Mantyh, P. W., Nelson, M. A. & Vanderah, T. W. Apr 15 2016 In : Breast Cancer: Targets and Therapy. 8, p. 59-71 13 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor Agonists
Cell Survival
Breast Neoplasms
Calcium
Cannabinoid Receptors
3 Citations
Periosteum
Bone Fractures
Geriatrics
Femur
Cell Proliferation
5 Citations

Sclerostin Immunoreactivity Increases in Cortical Bone Osteocytes and Decreases in Articular Cartilage Chondrocytes in Aging Mice

Thompson, M. L., Jimenez-Andrade, J. M. & Mantyh, P. W. Mar 1 2016 In : Journal of Histochemistry and Cytochemistry. 64, 3, p. 179-189 11 p.

Research output: Contribution to journalArticle

Osteocytes
Articular Cartilage
Chondrocytes
Femur
Skeleton
6 Citations

The cystine/glutamate antiporter system xc - drives breast tumor cell glutamate release and cancer-induced bone pain

Slosky, L. M., BassiriRad, N. M., Symons, A. M., Thompson, M., Doyle, T., Forte, B. L., Staatz, W. D., Bui, L., Neumann, W. L., Mantyh, P. W., Salvemini, D., Largent-Milnes, T. M. & Vanderah, T. W. Aug 19 2016 In : Pain. 157, 11, p. 2605-2616 12 p.

Research output: Contribution to journalArticle

Antiporters
Bone Neoplasms
Cystine
Glutamic Acid
Breast Neoplasms
2015

Bone cancer pain: Translation of preclinical studies to human clinical trials

Jimenez-Andrade, J. M. & Mantyh, P. W. Jun 1 2015 Pain Models: Translational Relevance and Applications. Wolters Kluwer Health

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone Neoplasms
Clinical Trials
Cancer Pain

Bone-related nociception

Mantyh, P. W. Jun 1 2015 Musculoskeletal Pain: Basic Mechanisms and Implications. Wolters Kluwer Health Adis (ESP)

Research output: Chapter in Book/Report/Conference proceedingChapter

Nociception
Bone and Bones

Mechanisms of malignant bone pain

Mantyh, P. Jun 1 2015 Cancer Pain: From Molecules to Suffering. Wolters Kluwer Health Adis (ESP)

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone and Bones
Pain
11 Citations

Orthopedic surgery and bone fracture pain are both significantly attenuated by sustained blockade of nerve growth factor

Majuta, L. A., Longo, G., Fealk, M. N., McCaffrey, G. & Mantyh, P. W. Jan 1 2015 In : Pain. 156, 1, p. 157-165 9 p.

Research output: Contribution to journalArticle

Bone Fractures
Nerve Growth Factor
Orthopedics
Pain
Opiate Alkaloids
11 Citations

Spinal dopaminergic projections control the transition to pathological pain plasticity via a D<inf>1</inf>/D<inf>5</inf>-mediated mechanism

Kim, J. Y. V., Tillu, D. V., Quinn, T. L., Mejia, G. L., Shy, A., Asiedu, M. N. K., Murad, E., Schumann, A. P., Totsch, S. K., Sorge, R. E., Mantyh, P. W., Dussor, G. & Price, T. J. Apr 22 2015 In : Journal of Neuroscience. 35, 16, p. 6307-6317 11 p.

Research output: Contribution to journalArticle

Hypersensitivity
Chronic Pain
Carrageenan
Pain
Prostaglandins E
4 Citations

Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer

Thompson, M. L., Jimenez-Andrade, J. M., Chartier, S., Tsai, J., Burton, E. A., Habets, G., Lin, P. S., West, B. L. & Mantyh, P. W. Sep 1 2015 In : Pain. 156, 9, p. 1692-1702 11 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Cell Lineage
Disease Progression
Prostate
Pain
2014

Bone cancer: Current opinion in palliative care

Mantyh, P. W., Thompson, M. L., Chartier, S. & Fealk, M. Aug 27 2014 Bone Cancer: Primary Bone Cancers and Bone Metastases: Second Edition. Elsevier Inc., p. 579-589 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone Neoplasms
Palliative Care
Nerve Fibers
Bone and Bones
Adrenergic Fibers
37 Citations

Bone cancer pain: From mechanism to therapy

Mantyh, P. W. 2014 In : Current Opinion in Supportive and Palliative Care. 8, 2, p. 83-90 8 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Nerve Fibers
Bone and Bones
Neoplasms
Therapeutics
10 Citations

Exuberant sprouting of sensory and sympathetic nerve fibers in nonhealed bone fractures and the generation and maintenance of chronic skeletal pain

Chartier, S. R., Thompson, M. L., Longo, G., Fealk, M. N., Majuta, L. A. & Mantyh, P. W. 2014 In : Pain. 155, 11, p. 2323-2336 14 p.

Research output: Contribution to journalArticle

Adrenergic Fibers
Bone Fractures
Nerve Fibers
Chronic Pain
Maintenance
15 Citations

NGF blockade at early times during bone cancer development attenuates bone destruction and increases limb use

McCaffrey, G., Thompson, M. L., Majuta, L., Fealk, M. N., Chartier, S., Longo, G. & Mantyh, P. W. Dec 1 2014 In : Cancer Research. 74, 23, p. 7014-7023 10 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Bone Development
Nerve Growth Factor
Extremities
Bone and Bones
50 Citations

The ACTTION-American Pain Society Pain Taxonomy (AAPT): An evidence-based and multidimensional approach to classifying chronic pain conditions

Fillingim, R. B. , Bruehl, S. , Dworkin, R. H. , Dworkin, S. F. , Loeser, J. D. , Turk, D. C. , Widerstrom-Noga, E. , Arnold, L. , Bennett, R. , Edwards, R. R. , Freeman, R. , Gewandter, J. , Hertz, S. , Hochberg, M. , Krane, E. , Mantyh, P. W. , Markman, J. , Neogi, T. , Ohrbach, R. , Paice, J. A. & 8 others Porreca, F., Rappaport, B. A., Smith, S. M., Smith, T. J., Sullivan, M. D., Verne, G. N., Wasan, A. D. & Wesselmann, U. Mar 2014 In : Journal of Pain. 15, 3, p. 241-249 9 p.

Research output: Contribution to journalArticle

Chronic Pain
Clinical Trials
Pain
Comorbidity
Public-Private Sector Partnerships
29 Citations

The neurobiology of skeletal pain

Mantyh, P. W. Feb 2014 In : European Journal of Neuroscience. 39, 3, p. 508-519 12 p.

Research output: Contribution to journalArticle

Neurobiology
Chronic Pain
Skeleton
Pain
Nerve Fibers
2013
79 Citations

Bone cancer pain: Causes, consequences, and therapeutic opportunities

Mantyh, P. Dec 2013 In : Pain. 154, SUPPL. 1

Research output: Contribution to journalArticle

Bone Neoplasms
Nerve Fibers
Bone and Bones
Adrenergic Fibers
Neoplasms
21 Citations

Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists

Lozano-Ondoua, A. N., Hanlon, K. E., Symons-Liguori, A. M., Largent-Milnes, T. M., Havelin, J. J., Ferland, H. L., Chandramouli, A., Owusu-Ankomah, M., Nikolich-Zugich, T., Bloom, A. P., Jimenez-Andrade, J. M., King, T., Porreca, F., Nelson, M. A., Mantyh, P. W. & Vanderah, T. W. Jan 2013 In : Journal of Bone and Mineral Research. 28, 1, p. 92-107 16 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor Agonists
Bone Neoplasms
Bone Remodeling
Breast Neoplasms
Pain
2012
51 Citations

Neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic joint

Ghilardi, J. R., Freeman, K. T., Jimenez-Andrade, J. M., Coughlin, K. A., Kaczmarska, M. J., Castaneda-Corral, G., Bloom, A. P., Kuskowski, M. A. & Mantyh, P. W. Jul 2012 In : Arthritis and Rheumatism. 64, 7, p. 2223-2232 10 p.

Research output: Contribution to journalArticle

Adrenergic Fibers
Neuronal Plasticity
Nerve Fibers
Arthritis
Joints
37 Citations

Pathophysiology and medical treatment of pain in fibrous dysplasia of bone

Chapurlat, R. D., Gensburger, D., Jimenez-Andrade, J. M., Ghilardi, J. R., Kelly, M. & Mantyh, P. 2012 In : Orphanet Journal of Rare Diseases. 7, SUPPL. 1, S3

Research output: Contribution to journalArticle

Fibrous Dysplasia of Bone
Pain
Bone and Bones
Therapeutics
Adrenergic Fibers
47 Citations

Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature

Reilly, R. M. , McDonald, H. A. , Puttfarcken, P. S. , Joshi, S. K. , Lewis, L. , Pai, M. , Franklin, P. H. , Segreti, J. A. , Neelands, T. R. , Han, P. , Chen, J. , Mantyh, P. W. , Ghilardi, J. R. , Turner, T. M. , Voight, E. A. , Daanen, J. F. , Schmidt, R. G. , Gomtsyan, A. , Kort, M. E. , Faltynek, C. R. & 1 others Kym, P. R. Aug 2012 In : Journal of Pharmacology and Experimental Therapeutics. 342, 2, p. 416-428 13 p.

Research output: Contribution to journalArticle

Body Temperature
Pharmacology
Capsaicin
Acids
Dopamine

Reply

Mantyh, P. W. Nov 2012 In : Arthritis and Rheumatism. 64, 11, p. 3825-3826 2 p.

Research output: Contribution to journalArticle

34 Citations
Adrenergic Fibers
Neuroma
Nerve Fibers
Geriatrics
Arthritis
16 Citations

The effect of aging on the density of the sensory nerve fiber innervation of bone and acute skeletal pain

Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Freeman, K. T., Ghilardi, J. R., Kuskowski, M. A. & Mantyh, P. W. May 2012 In : Neurobiology of Aging. 33, 5, p. 921-932 12 p.

Research output: Contribution to journalArticle

Acute Pain
Nerve Fibers
Bone and Bones
Musculoskeletal Pain
Calcitonin Gene-Related Peptide
2011
115 Citations

Antagonism of nerve growth factor-TrkA signaling and the relief of pain

Mantyh, P. W., Koltzenburg, M., Mendell, L. M., Tive, L. & Shelton, D. L. Jul 2011 In : Anesthesiology. 115, 1, p. 189-204 16 p.

Research output: Contribution to journalArticle

Nerve Growth Factor
Pain
Nociceptors
Nerve Growth Factors
Acute Pain
67 Citations

Breast cancer-induced bone remodeling, skeletal pain, and sprouting of sensory nerve fibers

Bloom, A. P., Jimenez-Andrade, J. M., Taylor, R. N., Castañeda-Corral, G., Kaczmarska, M. J., Freeman, K. T., Coughlin, K. A., Ghilardi, J. R., Kuskowski, M. A. & Mantyh, P. W. Jun 2011 In : Journal of Pain. 12, 6, p. 698-711 14 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Bone Remodeling
Nerve Fibers
Breast Neoplasms
Pain
74 Citations

Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain

Jimenez-Andrade, J. M., Ghilardi, J. R., Castañeda-Corral, G., Kuskowski, M. A. & Mantyh, P. W. Nov 2011 In : Pain. 152, 11, p. 2564-2574 11 p.

Research output: Contribution to journalArticle

Neuroma
Nerve Growth Factor
Neoplasms
Nerve Growth Factor Receptor
Bone Neoplasms
36 Citations

Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers

Ghilardi, J. R., Freeman, K. T., Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Bouhana, K. S., Trollinger, D., Winkler, J., Lee, P., Andrews, S. W., Kuskowski, M. A. & Mantyh, P. W. Feb 1 2011 In : Bone. 48, 2, p. 389-398 10 p.

Research output: Contribution to journalArticle

Nerve Growth Factor Receptors
Adrenergic Fibers
Nerve Fibers
Phosphotransferases
Maintenance
55 Citations

The majority of myelinated and unmyelinated sensory nerve fibers that innervate bone express the tropomyosin receptor kinase A

Castañeda-Corral, G., Jimenez-Andrade, J. M., Bloom, A. P., Taylor, R. N., Mantyh, W. G., Kaczmarska, M. J., Ghilardi, J. R. & Mantyh, P. W. Mar 31 2011 In : Neuroscience. 178, p. 196-207 12 p.

Research output: Contribution to journalArticle

Unmyelinated Nerve Fibers
Bone and Bones
Nerve Growth Factor Receptor
Periosteum
Nerve Fibers
2010
46 Citations

A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss

Lozano-Ondoua, A. N., Wright, C., Vardanyan, A., King, T., Largent-Milnes, T. M., Nelson, M., Jimenez-Andrade, J. M., Mantyh, P. W. & Vanderah, T. W. Apr 2010 In : Life Sciences. 86, 17-18, p. 646-653 8 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor Agonists
Bone Neoplasms
Cannabinoids
Bone
Opiate Alkaloids
43 Citations

Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain

Ghilardi, J. R., Freeman, K. T., Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Kuskowski, M. A. & Mantyh, P. W. Dec 7 2010 In : Molecular Pain. 6, 87

Research output: Contribution to journalArticle

Neuroma
Bone Neoplasms
Sarcoma
Neoplasms
Nerve Fibers

An integrative approach to the control of cancer pain

Mantyh, P. W. & Yaksh, T. L. Jan 1 2010 The Neurobiology of Pain: (Molecular and Cellular Neurobiology). Oxford University Press

Research output: Chapter in Book/Report/Conference proceedingChapter

Sense Organs
Central Nervous System Sensitization
Afferent Neurons
Neoplasms
Nociceptors
71 Citations

A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: Therapeutic opportunity for treating skeletal pain

Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Xu, H., Ferng, A. S., Dussor, G., Vanderah, T. W. & Mantyh, P. W. Feb 2010 In : Bone. 46, 2, p. 306-313 8 p.

Research output: Contribution to journalArticle

Nerve Fibers
Bone and Bones
Pain
Skin
Peptides
80 Citations

Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain

Mantyh, W. G., Jimenez-Andrade, J. M., Stake, J. I., Bloom, A. P., Kaczmarska, M. J., Taylor, R. N., Freeman, K. T., Ghilardi, J. R., Kuskowski, M. A. & Mantyh, P. W. Dec 1 2010 In : Neuroscience. 171, 2, p. 588-598 11 p.

Research output: Contribution to journalArticle

Neuroma
Nerve Block
Adrenergic Fibers
Nerve Growth Factor
Nerve Fibers
125 Citations

Bone cancer pain

Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Ferng, A. S., Geffre, C. P. & Mantyh, P. W. Jun 2010 Annals of the New York Academy of Sciences. Vol. 1198, p. 173-181 9 p. (Annals of the New York Academy of Sciences; vol. 1198)

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bone Neoplasms
Bone
Tumors
Neoplasms
Bone and Bones

Erratum to A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: Therapeutic opportunity for treating skeletal pain [Bone, 46, (2010), 306-313]

Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Xu, H., Ferng, A. S., Dussor, G., Vanderah, T. W. & Mantyh, P. W. Jun 2010 In : Bone. 46, 6, p. 1670-1671 2 p.

Research output: Contribution to journalArticle

Nerve Fibers
Bone and Bones
Pain
Skin
Therapeutics

Malignant skeletal pain: Mechanisms and potential therapeutic opportunities

Herrera, M., Jimenez-Andrade, J. M., Vardanyan, M. & Mantyh, P. W. 2010 Bone Cancer. Elsevier Inc., p. 321-332 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone Neoplasms
Pain
Disease Progression
Osteoprotegerin
Bone and Bones

Neuropeptides Internalization

Jimenez-Andrade, J. M. & Mantyh, P. W. 2010 Encyclopedia of Neuroscience. Elsevier Ltd, p. 867-871 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neuropeptide Receptors
Neurokinin-1 Receptors
Substance P
Neuropeptides
Cell Membrane
87 Citations

Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain

Jimenez-Andrade, J. M., Bloom, A. P., Stake, J. I., Mantyh, W. G., Taylor, R. N., Freeman, K. T., Ghilardi, J. R., Kuskowski, M. A. & Mantyh, P. W. Nov 3 2010 In : Journal of Neuroscience. 30, 44, p. 14649-14656 8 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Nociceptors
Nerve Fibers
Prostatic Neoplasms
Pain

Spinal delivery of drugs in pain control

Yaksh, T. L. & Mantyh, P. W. Jan 1 2010 The Neurobiology of Pain: (Molecular and Cellular Neurobiology). Oxford University Press

Research output: Chapter in Book/Report/Conference proceedingChapter

Pain
Pharmaceutical Preparations
Pharmacology
Aptitude
Touch
2 Citations

TRPV1 and Bone Cancer Pain

Jimenez-Andrade, J. M. & Mantyh, P. Feb 22 2010 Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders. John Wiley and Sons, p. 191-205 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone Neoplasms
Cancer Pain
2009
28 Citations

Capsaicin-sensitive sensory nerve fibers contribute to the generation and maintenance of skeletal fracture pain

Jimenez-Andrade, J. M., Bloom, A. P., Mantyh, W. G., Koewler, N. J., Freeman, K. T., Delong, D., Ghilardi, J. R., Kuskowski, M. A. & Mantyh, P. W. Sep 15 2009 In : Neuroscience. 162, 4, p. 1244-1254 11 p.

Research output: Contribution to journalArticle

Capsaicin
Nerve Fibers
Maintenance
Pain
Periosteum
42 Citations

New advances in musculoskeletal pain

Bove, S. E., Flatters, S. J. L., Inglis, J. J. & Mantyh, P. W. Apr 2009 In : Brain Research Reviews. 60, 1, p. 187-201 15 p.

Research output: Contribution to journalArticle

Musculoskeletal Pain
Pain
Bone Fractures
Osteoarthritis
Therapeutics

Pathophysiology of malignant bone pain

Jimenez-Andrade, J. M., Herrera, M. & Mantyh, P. Jan 1 2009 Cancer Pain: Assessment and Management, Second Edition. Cambridge University Press, p. 23-34 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone Neoplasms
Bone and Bones
Pain
Neoplasms
Bone Diseases
103 Citations

Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

Honore, P. , Chandran, P. , Hernandez, G. , Gauvin, D. M. , Mikusa, J. P. , Zhong, C. , Joshi, S. K. , Ghilardi, J. R. , Sevcik, M. A. , Fryer, R. M. , Segreti, J. A. , Banfor, P. N. , Marsh, K. , Neelands, T. , Bayburt, E. , Daanen, J. F. , Gomtsyan, A. , Lee, C. H. , Kort, M. E. , Reilly, R. M. & 6 others Surowy, C. S., Kym, P. R., Mantyh, P. W., Sullivan, J. P., Jarvis, M. F. & Faltynek, C. R. Mar 2009 In : Pain. 142, 1-2, p. 27-35 9 p.

Research output: Contribution to journalArticle

Induced Hyperthermia
Analgesics
Rodentia
Bone Neoplasms
Pain