Research Output 1982 2017

  • 19444 Citations
  • 77 h-Index
  • 226 Article
  • 12 Chapter
  • 1 Conference contribution
  • 1 Review article
2017
4 Citations

AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions

Paice, J. A., Mulvey, M., Bennett, M., Dougherty, P. M., Farrar, J. T., Mantyh, P. W., Miaskowski, C., Schmidt, B. & Smith, T. J. Mar 1 2017 In : Journal of Pain. 18, 3, p. 233-246 14 p.

Research output: Research - peer-reviewReview article

Chronic Pain
aminoalcoholphosphotransferase
Cancer Pain
Pain
Clinical Trials

Anti-nerve growth factor therapy increases spontaneous day/night activity in mice with orthopedic surgery-induced pain

Majuta, L. A., Guedon, J. M. G., Mitchell, S. A. T., Ossipov, M. H. & Mantyh, P. W. Apr 1 2017 In : Pain. 158, 4, p. 605-617 13 p.

Research output: Research - peer-reviewArticle

Nerve Growth Factor
Orthopedics
Pain
Therapeutics
Knee Replacement Arthroplasties
2016
5 Citations

Dissociation between the relief of skeletal pain behaviors and skin hypersensitivity in a model of bone cancer pain

Guedon, J. M. G., Longo, G., Majuta, L. A., Thomspon, M. L., Fealk, M. N. & Mantyh, P. W. Jun 1 2016 In : Pain. 157, 6, p. 1239-1247 9 p.

Research output: Research - peer-reviewArticle

Bone Neoplasms
Hypersensitivity
Pain
Skin
Cancer Pain

Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent

Hanlon, K. E., Lozano-Ondoua, A. N., Umaretiya, P. J., Symons-Liguori, A. M., Chandramouli, A., Moy, J. K., Kwass, W. K., Mantyh, P. W., Nelson, M. A. & Vanderah, T. W. Apr 15 2016 In : Breast Cancer: Targets and Therapy. 8, p. 59-71 13 p.

Research output: Research - peer-reviewArticle

Cannabinoid Receptor Agonists
Cell Survival
Breast Neoplasms
Calcium
JHW 015
2 Citations
Periosteum
Bone Fractures
Geriatrics
Femur
Cell Proliferation
3 Citations

Sclerostin Immunoreactivity Increases in Cortical Bone Osteocytes and Decreases in Articular Cartilage Chondrocytes in Aging Mice

Thompson, M. L., Jimenez-Andrade, J. M. & Mantyh, P. W. Mar 1 2016 In : Journal of Histochemistry and Cytochemistry. 64, 3, p. 179-189 11 p.

Research output: Research - peer-reviewArticle

Osteocytes
Articular Cartilage
Chondrocytes
Femur
Cortical Bone
3 Citations

The cystine/glutamate antiporter system xc - drives breast tumor cell glutamate release and cancer-induced bone pain

Slosky, L. M., BassiriRad, N. M., Symons, A. M., Thompson, M., Doyle, T., Forte, B. L., Staatz, W. D., Bui, L., Neumann, W. L., Mantyh, P. W., Salvemini, D., Largent-Milnes, T. M. & Vanderah, T. W. Aug 19 2016 In : Pain. 157, 11, p. 2605-2616 12 p.

Research output: Research - peer-reviewArticle

Antiporters
Bone Neoplasms
Cystine
Glutamic Acid
Breast Neoplasms
2015

Bone cancer pain: Translation of preclinical studies to human clinical trials

Jimenez-Andrade, J. M. & Mantyh, P. W. Jun 1 2015 Pain Models: Translational Relevance and Applications. Wolters Kluwer Health

Research output: ResearchChapter

Bone-related nociception

Mantyh, P. W. Jun 1 2015 Musculoskeletal Pain: Basic Mechanisms and Implications. Wolters Kluwer Health Adis (ESP)

Research output: ResearchChapter

Mechanisms of malignant bone pain

Mantyh, P. Jun 1 2015 Cancer Pain: From Molecules to Suffering. Wolters Kluwer Health Adis (ESP)

Research output: ResearchChapter

10 Citations

Orthopedic surgery and bone fracture pain are both significantly attenuated by sustained blockade of nerve growth factor

Majuta, L. A., Longo, G., Fealk, M. N., McCaffrey, G. & Mantyh, P. W. Jan 1 2015 In : Pain. 156, 1, p. 157-165 9 p.

Research output: Research - peer-reviewArticle

Bone Fractures
Nerve Growth Factor
Orthopedics
Pain
Therapeutics
9 Citations

Spinal dopaminergic projections control the transition to pathological pain plasticity via a D<inf>1</inf>/D<inf>5</inf>-mediated mechanism

Kim, J. Y. V., Tillu, D. V., Quinn, T. L., Mejia, G. L., Shy, A., Asiedu, M. N. K., Murad, E., Schumann, A. P., Totsch, S. K., Sorge, R. E., Mantyh, P. W., Dussor, G. & Price, T. J. Apr 22 2015 In : Journal of Neuroscience. 35, 16, p. 6307-6317 11 p.

Research output: Research - peer-reviewArticle

Hypersensitivity
Pain
Chronic Pain
Carrageenan
Prostaglandins E
4 Citations

Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer

Thompson, M. L., Jimenez-Andrade, J. M., Chartier, S., Tsai, J., Burton, E. A., Habets, G., Lin, P. S., West, B. L. & Mantyh, P. W. Sep 1 2015 In : Pain. 156, 9, p. 1692-1702 11 p.

Research output: Research - peer-reviewArticle

Bone Neoplasms
Cell Lineage
Disease Progression
Prostate
Pain
2014

Bone cancer: Current opinion in palliative care

Mantyh, P. W., Thompson, M. L., Chartier, S. & Fealk, M. Aug 27 2014 Bone Cancer: Primary Bone Cancers and Bone Metastases: Second Edition. Elsevier Inc., p. 579-589 11 p.

Research output: ResearchChapter

Bone Neoplasms
Palliative Care
Bone and Bones
Neoplasms
Nerve Fibers
32 Citations

Bone cancer pain: From mechanism to therapy

Mantyh, P. W. 2014 In : Current Opinion in Supportive and Palliative Care. 8, 2, p. 83-90 8 p.

Research output: Research - peer-reviewArticle

Bone Neoplasms
Therapeutics
Cancer Pain
Neoplasms
Nerve Fibers
8 Citations

Exuberant sprouting of sensory and sympathetic nerve fibers in nonhealed bone fractures and the generation and maintenance of chronic skeletal pain

Chartier, S. R., Thompson, M. L., Longo, G., Fealk, M. N., Majuta, L. A. & Mantyh, P. W. 2014 In : Pain. 155, 11, p. 2323-2336 14 p.

Research output: Research - peer-reviewArticle

Adrenergic Fibers
Bone Fractures
Nerve Fibers
Chronic Pain
Maintenance
14 Citations

NGF blockade at early times during bone cancer development attenuates bone destruction and increases limb use

McCaffrey, G., Thompson, M. L., Majuta, L., Fealk, M. N., Chartier, S., Longo, G. & Mantyh, P. W. Dec 1 2014 In : Cancer Research. 74, 23, p. 7014-7023 10 p.

Research output: Research - peer-reviewArticle

Bone Neoplasms
Bone Development
Nerve Growth Factor
Extremities
Bone and Bones
36 Citations

The ACTTION-American Pain Society Pain Taxonomy (AAPT): An evidence-based and multidimensional approach to classifying chronic pain conditions

Fillingim, R. B. , Bruehl, S. , Dworkin, R. H. , Dworkin, S. F. , Loeser, J. D. , Turk, D. C. , Widerstrom-Noga, E. , Arnold, L. , Bennett, R. , Edwards, R. R. , Freeman, R. , Gewandter, J. , Hertz, S. , Hochberg, M. , Krane, E. , Mantyh, P. W. , Markman, J. , Neogi, T. , Ohrbach, R. , Paice, J. A. & 8 others Porreca, F., Rappaport, B. A., Smith, S. M., Smith, T. J., Sullivan, M. D., Verne, G. N., Wasan, A. D. & Wesselmann, U. Mar 2014 In : Journal of Pain. 15, 3, p. 241-249 9 p.

Research output: Research - peer-reviewArticle

Chronic Pain
Clinical Trials
Pain
Comorbidity
Protective Factors
22 Citations

The neurobiology of skeletal pain

Mantyh, P. W. Feb 2014 In : European Journal of Neuroscience. 39, 3, p. 508-519 12 p.

Research output: Research - peer-reviewArticle

Neurobiology
Chronic Pain
Pain
Skeleton
Therapeutics
2013
68 Citations

Bone cancer pain: Causes, consequences, and therapeutic opportunities

Mantyh, P. Dec 2013 In : Pain. 154, SUPPL. 1

Research output: Research - peer-reviewArticle

Bone Neoplasms
Bone and Bones
Neoplasms
Therapeutics
Cancer Pain
21 Citations

Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists

Lozano-Ondoua, A. N., Hanlon, K. E., Symons-Liguori, A. M., Largent-Milnes, T. M., Havelin, J. J., Ferland, H. L., Chandramouli, A., Owusu-Ankomah, M., Nikolich-Zugich, T., Bloom, A. P., Jimenez-Andrade, J. M., King, T., Porreca, F., Nelson, M. A., Mantyh, P. W. & Vanderah, T. W. Jan 2013 In : Journal of Bone and Mineral Research. 28, 1, p. 92-107 16 p.

Research output: Research - peer-reviewArticle

Cannabinoid Receptor Agonists
Bone Neoplasms
Bone Remodeling
Breast Neoplasms
Pain
2012
47 Citations

Neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic joint

Ghilardi, J. R., Freeman, K. T., Jimenez-Andrade, J. M., Coughlin, K. A., Kaczmarska, M. J., Castaneda-Corral, G., Bloom, A. P., Kuskowski, M. A. & Mantyh, P. W. Jul 2012 In : Arthritis and Rheumatism. 64, 7, p. 2223-2232 10 p.

Research output: Research - peer-reviewArticle

Adrenergic Fibers
Neuronal Plasticity
Nerve Fibers
Arthritis
Joints
32 Citations

Pathophysiology and medical treatment of pain in fibrous dysplasia of bone

Chapurlat, R. D., Gensburger, D., Jimenez-Andrade, J. M., Ghilardi, J. R., Kelly, M. & Mantyh, P. 2012 In : Orphanet Journal of Rare Diseases. 7, SUPPL. 1, S3

Research output: Research - peer-reviewArticle

Fibrous Dysplasia of Bone
Pain
Therapeutics
Bone and Bones
Adrenergic Fibers
44 Citations

Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature

Reilly, R. M. , McDonald, H. A. , Puttfarcken, P. S. , Joshi, S. K. , Lewis, L. , Pai, M. , Franklin, P. H. , Segreti, J. A. , Neelands, T. R. , Han, P. , Chen, J. , Mantyh, P. W. , Ghilardi, J. R. , Turner, T. M. , Voight, E. A. , Daanen, J. F. , Schmidt, R. G. , Gomtsyan, A. , Kort, M. E. , Faltynek, C. R. & 1 others Kym, P. R. Aug 2012 In : Journal of Pharmacology and Experimental Therapeutics. 342, 2, p. 416-428 13 p.

Research output: Research - peer-reviewArticle

Body Temperature
Pharmacology
vanilloid receptor subtype 1
Acids
Capsaicin

Reply

Mantyh, P. W. Nov 2012 In : Arthritis and Rheumatism. 64, 11, p. 3825-3826 2 p.

Research output: Research - peer-reviewArticle

30 Citations
Adrenergic Fibers
Neuroma
Nerve Fibers
Geriatrics
Arthritis
16 Citations

The effect of aging on the density of the sensory nerve fiber innervation of bone and acute skeletal pain

Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Freeman, K. T., Ghilardi, J. R., Kuskowski, M. A. & Mantyh, P. W. May 2012 In : Neurobiology of Aging. 33, 5, p. 921-932 12 p.

Research output: Research - peer-reviewArticle

Acute Pain
Nerve Fibers
Bone and Bones
Musculoskeletal Pain
Calcitonin Gene-Related Peptide
2011
103 Citations

Antagonism of nerve growth factor-TrkA signaling and the relief of pain

Mantyh, P. W., Koltzenburg, M., Mendell, L. M., Tive, L. & Shelton, D. L. Jul 2011 In : Anesthesiology. 115, 1, p. 189-204 16 p.

Research output: Research - peer-reviewArticle

Nerve Growth Factor
Pain
Nociceptors
tropomyosin kinase
Nerve Growth Factors
62 Citations

Breast cancer-induced bone remodeling, skeletal pain, and sprouting of sensory nerve fibers

Bloom, A. P., Jimenez-Andrade, J. M., Taylor, R. N., Castañeda-Corral, G., Kaczmarska, M. J., Freeman, K. T., Coughlin, K. A., Ghilardi, J. R., Kuskowski, M. A. & Mantyh, P. W. Jun 2011 In : Journal of Pain. 12, 6, p. 698-711 14 p.

Research output: Research - peer-reviewArticle

Bone Neoplasms
Bone Remodeling
Nerve Fibers
Breast Neoplasms
Pain
71 Citations

Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain

Jimenez-Andrade, J. M., Ghilardi, J. R., Castañeda-Corral, G., Kuskowski, M. A. & Mantyh, P. W. Nov 2011 In : Pain. 152, 11, p. 2564-2574 11 p.

Research output: Research - peer-reviewArticle

Neuroma
Nerve Growth Factor
Neoplasms
Therapeutics
Cancer Pain
34 Citations

Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers

Ghilardi, J. R., Freeman, K. T., Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Bouhana, K. S., Trollinger, D., Winkler, J., Lee, P., Andrews, S. W., Kuskowski, M. A. & Mantyh, P. W. Feb 1 2011 In : Bone. 48, 2, p. 389-398 10 p.

Research output: Research - peer-reviewArticle

Nerve Growth Factor Receptors
Adrenergic Fibers
Nerve Fibers
Phosphotransferases
Maintenance
52 Citations

The majority of myelinated and unmyelinated sensory nerve fibers that innervate bone express the tropomyosin receptor kinase A

Castañeda-Corral, G., Jimenez-Andrade, J. M., Bloom, A. P., Taylor, R. N., Mantyh, W. G., Kaczmarska, M. J., Ghilardi, J. R. & Mantyh, P. W. Mar 31 2011 In : Neuroscience. 178, p. 196-207 12 p.

Research output: Research - peer-reviewArticle

Unmyelinated Nerve Fibers
Bone and Bones
tropomyosin kinase
Pain
Nerve Growth Factor Receptor
2010
46 Citations

A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss

Lozano-Ondoua, A. N., Wright, C., Vardanyan, A., King, T., Largent-Milnes, T. M., Nelson, M., Jimenez-Andrade, J. M., Mantyh, P. W. & Vanderah, T. W. Apr 2010 In : Life Sciences. 86, 17-18, p. 646-653 8 p.

Research output: Research - peer-reviewArticle

Cannabinoid Receptor Agonists
Bone Neoplasms
Cancer Pain
Cannabinoids
Bone
40 Citations

Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain

Ghilardi, J. R., Freeman, K. T., Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Kuskowski, M. A. & Mantyh, P. W. Dec 7 2010 In : Molecular Pain. 6, 87

Research output: Research - peer-reviewArticle

Neuroma
Bone Neoplasms
Sarcoma
Neoplasms
tropomyosin kinase

An integrative approach to the control of cancer pain

Mantyh, P. W. & Yaksh, T. L. Jan 1 2010 The Neurobiology of Pain: (Molecular and Cellular Neurobiology). Oxford University Press

Research output: ResearchChapter

Neoplasms
Cancer Pain
Sense Organs
Central Nervous System Sensitization
Afferent Neurons
68 Citations

A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: Therapeutic opportunity for treating skeletal pain

Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Xu, H., Ferng, A. S., Dussor, G., Vanderah, T. W. & Mantyh, P. W. Feb 2010 In : Bone. 46, 2, p. 306-313 8 p.

Research output: Research - peer-reviewArticle

Nerve Fibers
Bone and Bones
Pain
Skin
Therapeutics
78 Citations

Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain

Mantyh, W. G., Jimenez-Andrade, J. M., Stake, J. I., Bloom, A. P., Kaczmarska, M. J., Taylor, R. N., Freeman, K. T., Ghilardi, J. R., Kuskowski, M. A. & Mantyh, P. W. Dec 1 2010 In : Neuroscience. 171, 2, p. 588-598 11 p.

Research output: Research - peer-reviewArticle

Neuroma
Nerve Block
Cancer Pain
Neoplasms
Adrenergic Fibers
118 Citations

Bone cancer pain

Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Ferng, A. S., Geffre, C. P. & Mantyh, P. W. Jun 2010 Annals of the New York Academy of Sciences. Vol. 1198, p. 173-181 9 p. (Annals of the New York Academy of Sciences; vol. 1198)

Research output: ResearchConference contribution

Bone Neoplasms
Cancer Pain
Bone
Neoplasms
Therapeutics

Erratum to A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: Therapeutic opportunity for treating skeletal pain [Bone, 46, (2010), 306-313]

Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Xu, H., Ferng, A. S., Dussor, G., Vanderah, T. W. & Mantyh, P. W. Jun 2010 In : Bone. 46, 6, p. 1670-1671 2 p.

Research output: Research - peer-reviewArticle

Malignant skeletal pain: Mechanisms and potential therapeutic opportunities

Herrera, M., Jimenez-Andrade, J. M., Vardanyan, M. & Mantyh, P. W. 2010 Bone Cancer. Elsevier Inc., p. 321-332 12 p.

Research output: ResearchChapter

Bone Neoplasms
Pain
Neoplasms
Therapeutics
Cancer Pain

Neuropeptides Internalization

Jimenez-Andrade, J. M. & Mantyh, P. W. 2010 Encyclopedia of Neuroscience. Elsevier Ltd, p. 867-871 5 p.

Research output: ResearchChapter

Neuropeptide Receptors
Neurokinin-1 Receptors
Substance P
Neuropeptides
Cell Membrane
81 Citations

Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain

Jimenez-Andrade, J. M., Bloom, A. P., Stake, J. I., Mantyh, W. G., Taylor, R. N., Freeman, K. T., Ghilardi, J. R., Kuskowski, M. A. & Mantyh, P. W. Nov 3 2010 In : Journal of Neuroscience. 30, 44, p. 14649-14656 8 p.

Research output: Research - peer-reviewArticle

Bone Neoplasms
Nociceptors
Nerve Fibers
Prostatic Neoplasms
Pain

Spinal delivery of drugs in pain control

Yaksh, T. L. & Mantyh, P. W. Jan 1 2010 The Neurobiology of Pain: (Molecular and Cellular Neurobiology). Oxford University Press

Research output: ResearchChapter

Pain
Pharmaceutical Preparations
Pharmacology
Aptitude
Touch
2 Citations

TRPV1 and Bone Cancer Pain

Jimenez-Andrade, J. M. & Mantyh, P. Feb 22 2010 Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders. John Wiley and Sons, p. 191-205 15 p.

Research output: ResearchChapter

2009
28 Citations

Capsaicin-sensitive sensory nerve fibers contribute to the generation and maintenance of skeletal fracture pain

Jimenez-Andrade, J. M., Bloom, A. P., Mantyh, W. G., Koewler, N. J., Freeman, K. T., Delong, D., Ghilardi, J. R., Kuskowski, M. A. & Mantyh, P. W. Sep 15 2009 In : Neuroscience. 162, 4, p. 1244-1254 11 p.

Research output: Research - peer-reviewArticle

Capsaicin
Nerve Fibers
Maintenance
Pain
Periosteum
41 Citations

New advances in musculoskeletal pain

Bove, S. E., Flatters, S. J. L., Inglis, J. J. & Mantyh, P. W. Apr 2009 In : Brain Research Reviews. 60, 1, p. 187-201 15 p.

Research output: Research - peer-reviewArticle

Musculoskeletal Pain
Pain
Therapeutics
Bone Fractures
Osteoarthritis

Pathophysiology of malignant bone pain

Jimenez-Andrade, J. M., Herrera, M. & Mantyh, P. Jan 1 2009 Cancer Pain: Assessment and Management, Second Edition. Cambridge University Press, p. 23-34 12 p.

Research output: ResearchChapter

Bone and Bones
Pain
Neoplasms
Cancer Pain
Bone Neoplasms
99 Citations

Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

Honore, P. , Chandran, P. , Hernandez, G. , Gauvin, D. M. , Mikusa, J. P. , Zhong, C. , Joshi, S. K. , Ghilardi, J. R. , Sevcik, M. A. , Fryer, R. M. , Segreti, J. A. , Banfor, P. N. , Marsh, K. , Neelands, T. , Bayburt, E. , Daanen, J. F. , Gomtsyan, A. , Lee, C. H. , Kort, M. E. , Reilly, R. M. & 6 others Surowy, C. S., Kym, P. R., Mantyh, P. W., Sullivan, J. P., Jarvis, M. F. & Faltynek, C. R. Mar 2009 In : Pain. 142, 1-2, p. 27-35 9 p.

Research output: Research - peer-reviewArticle

Induced Hyperthermia
Analgesics
Rodentia
vanilloid receptor subtype 1
ABT 102
2008
25 Citations

A fracture pain model in the rat: Adaptation of a closed femur fracture model to study skeletal pain

Freeman, K. T., Koewler, N. J., Jimenez-Andrade, J. M., Buus, R. J., Herrera, M. B., Martin, C. D., Ghilardi, J. R., Kuskowski, M. A. & Mantyh, P. W. Mar 2008 In : Anesthesiology. 108, 3, p. 473-483 11 p.

Research output: Research - peer-reviewArticle

Closed Fractures
Femur
Pain
Diaphyses
Stainless Steel
9 Citations

Intravenous Ibandronate Rapidly Reduces Pain, Neurochemical Indices of Central Sensitization, Tumor Burden, and Skeletal Destruction in a Mouse Model of Bone Cancer

Halvorson, K. G., Sevcik, M. A., Ghilardi, J. R., Sullivan, L. J., Koewler, N. J., Bauss, F. & Mantyh, P. W. Sep 2008 In : Journal of Pain and Symptom Management. 36, 3, p. 289-303 15 p.

Research output: Research - peer-reviewArticle

Central Nervous System Sensitization
Bone Neoplasms
Tumor Burden
Bone and Bones
Pain