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1988 …2019
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Research Output 1988 2019

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Article
2019
1 Citation (Scopus)

Ropivacaine inhibits pressure-induced lung endothelial hyperpermeability in models of acute hypertension

Patel, M., Chignalia, A. Z., Isbatan, A., Bommakanti, N. & Dull, R. O., Apr 1 2019, In : Life Sciences. 222, p. 22-28 7 p.

Research output: Contribution to journalArticle

Hypertension
Pressure
Lung
Pulmonary Edema
Capillarity

Sevoflurane Promotes Bactericidal Properties of Macrophages through Enhanced Inducible Nitric Oxide Synthase Expression in Male Mice

Gerber, T. J., Fehr, V. C. O., Oliveira, S. D. S., Hu, G., Dull, R., Bonini, M. G., Beck-Schimmer, B. & Minshall, R. D., Dec 1 2019, In : Anesthesiology. 131, 6, p. 1301-1315 15 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type II
Nitric Oxide Synthase
Macrophages
Lipopolysaccharides
Escherichia coli
2 Citations (Scopus)

The GTPase Rab1 is required for NLRP3 inflammasome activation and inflammatory lung injury

Zhang, Y., Wang, L., Lv, Y., Jiang, C., Wu, G., Dull, R. O., Minshall, R. D., Malik, A. B. & Hu, G., Jan 1 2019, In : Journal of Immunology. 202, 1, p. 194-206 13 p.

Research output: Contribution to journalArticle

Inflammasomes
Interleukin-18
GTP Phosphohydrolases
Lung Injury
Interleukin-1
2018
6 Citations (Scopus)

Glycocalyx biomarker syndecan-1 is a stronger predictor of respiratory failure in patients with sepsis due to pneumonia, compared to endocan

Smart, L., Bosio, E., Macdonald, S. P. J., Dull, R., Fatovich, D. M., Neil, C. & Arendts, G., Oct 2018, In : Journal of Critical Care. 47, p. 93-98 6 p.

Research output: Contribution to journalArticle

Syndecan-1
Glycocalyx
Respiratory Insufficiency
Sepsis
Pneumonia
1 Citation (Scopus)

Pressure-dependent NOS activation contributes to endothelial hyperpermeability in a model of acute heart failure

Chignalia, A. Z., Isbatan, A., Patel, M., Ripper, R., Sharlin, J., Shosfy, J., Borlaug, B. A. & Dull, R. O., Nov 23 2018, In : Bioscience reports. 38, 6, BSR20181239.

Research output: Contribution to journalArticle

Open Access
Nitric Oxide Synthase
Pulmonary Edema
Heart Failure
Chemical activation
Pressure
10 Citations (Scopus)

Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study

Wagener, B. M., Hu, P. J., Oh, J. Y., Evans, C. A., Richter, J. R., Honavar, J., Brandon, A. P., Creighton, J., Stephens, S. W., Morgan, C., Dull, R. O., Marques, M. B., Kerby, J. D., Pittet, J. F. & Patel, R. P., Mar 2018, In : PLoS Medicine. 15, 3, e1002522.

Research output: Contribution to journalArticle

Open Access
Erythrocyte Transfusion
Heme
Bacterial Infections
Erythrocytes
Hemorrhage
2017
8 Citations (Scopus)

ACE Phenotyping as a Guide Toward Personalized Therapy with ACE Inhibitors

Danilov, S. M., Tovsky, S. I., Schwartz, D. E. & Dull, R. O., Jul 1 2017, In : Journal of Cardiovascular Pharmacology and Therapeutics. 22, 4, p. 374-386 13 p.

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Angiotensin-Converting Enzyme Inhibitors
Therapeutics
Blood Pressure
Enalapril
4 Citations (Scopus)

Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats

Changyaleket, B., Chong, Z. Z., Dull, R. O., Nanegrungsunk, D. & Xu, H., Jul 18 2017, In : Journal of Neuroinflammation. 14, 1, 137.

Research output: Contribution to journalArticle

Open Access
Subarachnoid Hemorrhage
Leukocytes
Venules
heparanase
Heparitin Sulfate
2 Citations (Scopus)

Hypercapnic acidosis attenuates pressure-dependent increase in whole-lung filtration coefficient (Kf)

Bommakanti, N., Isbatan, A., Bavishi, A., Dharmavaram, G., Chignalia, A. Z. & Dull, R. O., Jan 1 2017, In : Pulmonary Circulation. 7, 3, p. 719-726 8 p.

Research output: Contribution to journalArticle

Open Access
Acidosis
Pressure
Lung
Tidal Volume
Blood Vessels
7 Citations (Scopus)

Isoflurane promotes phagocytosis of apoptotic neutrophils through AMPK-mediated ADAM17/Mer signaling

Du, X., Jiang, C., Lv, Y., Dull, R. O., Zhao, Y. Y., Schwartz, D. E. & Hu, G., Jul 2017, In : PloS one. 12, 7, e0180213.

Research output: Contribution to journalArticle

Open Access
Disintegrins
AMP-activated protein kinase
AMP-Activated Protein Kinases
Isoflurane
isoflurane

The Role of HMGB1 in Pial Arteriole Dilating Reactivity following Subarachnoid Hemorrhage in Rats

Xu, H., Changyaleket, B., Valyi-Nagy, T., Dull, R. O., Pelligrino, D. A., Schwartz, D. E. & Chong, Z. Z., Jan 1 2017, In : Journal of Vascular Research. 53, 5-6, p. 349-357 9 p.

Research output: Contribution to journalArticle

HMGB1 Protein
Arterioles
Subarachnoid Hemorrhage
Intracranial Vasospasm
Sciatic Nerve
2016
11 Citations (Scopus)

Identifying S100B as a Biomarker and a Therapeutic Target For Brain Injury and Multiple Diseases

Chong, Z. Z., Changyaleket, B., Xu, H., Dull, R. O. & Schwartz, D. E., May 1 2016, In : Current medicinal chemistry. 23, 15, p. 1571-1596 26 p.

Research output: Contribution to journalArticle

Biomarkers
Brain Injuries
Brain
Therapeutics
Cerebrovascular Disorders
9 Citations (Scopus)

Lysozyme and bilirubin bind to ACE and regulate its conformation and shedding

Danilov, S. M., Lünsdorf, H., Akinbi, H. T., Nesterovitch, A. B., Epshtein, Y., Letsiou, E., Kryukova, O. V., Piegeler, T., Golukhova, E. Z., Schwartz, D. E., Dull, R. O., Minshall, R. D., Kost, O. A. & Garcia, J. G. N., Oct 13 2016, In : Scientific Reports. 6, 34913.

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Muramidase
Bilirubin
Mutation
Enzyme Therapy
23 Citations (Scopus)

Rab11a Mediates Vascular Endothelial-Cadherin Recycling and Controls Endothelial Barrier Function

Yan, Z., Wang, Z. G., Segev, N., Hu, S., Minshall, R. D., Dull, R. O., Zhang, M., Malik, A. B. & Hu, G., Feb 1 2016, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 2, p. 339-349 11 p.

Research output: Contribution to journalArticle

Open Access
Recycling
Blood Vessels
Adherens Junctions
Membrane Proteins
Proteins
7 Citations (Scopus)

The Biomechanical Effects of Resuscitation Colloids on the Compromised Lung Endothelial Glycocalyx

Job, K. M., O'Callaghan, R., Hlady, V., Barabanova, A. & Dull, R. O., Aug 1 2016, In : Anesthesia and analgesia. 123, 2, p. 382-393 12 p.

Research output: Contribution to journalArticle

Glycocalyx
Colloids
Resuscitation
Lung
Starch
2015
29 Citations (Scopus)

Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFα-induced invasion of lung adenocarcinoma cells in vitro by blocking the activation of Akt and focal adhesion kinase

Piegeler, T., Schläpfer, M., Dull, R. O., Schwartz, D. E., Borgeat, A., Minshall, R. D. & Beck-Schimmer, B., Nov 2015, In : British Journal of Anaesthesia. 115, 5, p. 784-791 8 p.

Research output: Contribution to journalArticle

Open Access
Focal Adhesion Protein-Tyrosine Kinases
Lidocaine
Focal Adhesion Kinase 1
Caveolin 1
Tumor Necrosis Factor-alpha
9 Citations (Scopus)

p120-catenin expressed in alveolar type II cells is essential for the regulation of lung innate immune response

Chignalia, A. Z., Vogel, S. M., Reynolds, A. B., Mehta, D., Dull, R. O., Minshall, R. D., Malik, A. B. & Liu, Y., May 1 2015, In : American Journal of Pathology. 185, 5, p. 1251-1263 13 p., 1988.

Research output: Contribution to journalArticle

Open Access
Alveolar Epithelial Cells
Innate Immunity
Lung
Adherens Junctions
Surface-Active Agents
21 Citations (Scopus)

Propofol increases morbidity and mortality in a rat model of sepsis

Schläpfer, M., Piegeler, T., Dull, R. O., Schwartz, D. E., Mao, M., Bonini, M. G., Z'Graggen, B. R., Beck-Schimmer, B. & Minshall, R. D., Feb 19 2015, In : Critical Care. 19, 1, 45.

Research output: Contribution to journalArticle

Open Access
Propofol
Punctures
Ligation
Sepsis
Morbidity
12 Citations (Scopus)

Role of Integrin β4 in Lung Endothelial Cell Inflammatory Responses to Mechanical Stress

Chen, W., Epshtein, Y., Ni, X., Dull, R. O., Cress, A. E., Garcia, J. G. N. & Jacobson, J. R., Nov 17 2015, In : Scientific Reports. 5, 16529.

Research output: Contribution to journalArticle

Mechanical Stress
Integrins
Ventilator-Induced Lung Injury
Endothelial Cells
Lung
17 Citations (Scopus)

Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms

Chignalia, A. Z., Oliveira, M. A., Debbas, V., Dull, R. O., Laurindo, F. R. M., Touyz, R. M., Carvalho, M. H. C., Fortes, Z. B. & Tostes, R. C., Jan 1 2015, In : Clinical Science. 129, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Testosterone
Reactive Oxygen Species
Leukocytes
Flutamide
10 Citations (Scopus)

Tissue specificity of human angiotensin I-converting enzyme

Kryukova, O. V., Tikhomirova, V. E., Golukhova, E. Z., Evdokimov, V. V., Kalantarov, G. F., Trakht, I. N., Schwartz, D. E., Dull, R. O., Gusakov, A. V., Uporov, I. V., Kost, O. A. & Danilov, S. M., Nov 1 2015, In : PloS one. 10, 11, e0143455.

Research output: Contribution to journalArticle

Open Access
Organ Specificity
peptidyl-dipeptidase A
Peptidyl-Dipeptidase A
Tissue
monoclonal antibodies
2014
39 Citations (Scopus)
Inflammasomes
Autophagy
Alveolar Macrophages
Lung Injury
Artificial Respiration
25 Citations (Scopus)

Ropivacaine attenuates endotoxin plus hyperinflation-mediated acute lung injury via inhibition of early-onset Src-dependent signaling

Piegeler, T., Dull, R. O., Hu, G., Castellon, M., Chignalia, A. Z., Koshy, R. G., Votta-Velis, E. G., Borgeat, A., Schwartz, D. E., Beck-Schimmer, B. & Minshall, R. D., Jul 19 2014, In : BMC Anesthesiology. 14, 57.

Research output: Contribution to journalArticle

Open Access
Acute Lung Injury
Endotoxins
Intercellular Adhesion Molecule-1
Caveolin 1
Lung
2013
38 Citations (Scopus)

The endothelial glycocalyx: Emerging concepts in pulmonary edema and acute lung injury

Collins, S. R., Blank, R. S., Deatherage, L. S. & Dull, R. O., Sep 1 2013, In : Anesthesia and analgesia. 117, 3, p. 664-674 11 p.

Research output: Contribution to journalArticle

Glycocalyx
Acute Lung Injury
Pulmonary Edema
Lung Injury
Vascular Endothelium
2012
27 Citations (Scopus)

Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury

Thomas, K. C., Roberts, J. K., Deering-Rice, C. E., Romero, E. G., Dull, R. O., Lee, J., Yost, G. S. & Reilly, C. A., Jan 1 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 302, 1, p. L111-L119

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Lung Injury
Cell Death
Lung
Lipopolysaccharides
31 Citations (Scopus)

Lung heparan sulfates modulate K fc during increased vascular pressure: Evidence for glycocalyx-mediated mechanotransduction

Dull, R. O., Cluff, M., Kingston, J., Hill, D., Chen, H., Hoehne, S., Malleske, D. T. & Kaur, R., May 1 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 302, 9, p. L816-L828

Research output: Contribution to journalArticle

Glycocalyx
Heparitin Sulfate
Blood Vessels
Pressure
Lung
10 Citations (Scopus)

Sevoflurane reduces clinical disease in a mouse model of multiple sclerosis

Polak, P. E., Dull, R. O., Kalinin, S., Sharp, A. J., Ripper, R., Weinberg, G., Schwartz, D. E., Rubinstein, I. & Feinstein, D. L., Dec 19 2012, In : Journal of Neuroinflammation. 9, 272.

Research output: Contribution to journalArticle

Open Access
Multiple Sclerosis
T-Lymphocytes
Myelin-Oligodendrocyte Glycoprotein
Anesthetics
Autoimmune Diseases
13 Citations (Scopus)
Interference Microscopy
Glycocalyx
heparitinsulfate lyase
Hyaluronic Acid
Compliance
2011
20 Citations (Scopus)

A murine model of inflammatory bladder disease: Cathelicidin peptide induced bladder inflammation and treatment with sulfated polysaccharides

Oottamasathien, S., Jia, W., McCoard, L., Slack, S., Zhang, J., Skardal, A., Job, K., Kennedy, T. P., Dull, R. O. & Prestwich, G. D., Oct 1 2011, In : Journal of Urology. 186, 4 SUPPL., p. 1684-1692 9 p.

Research output: Contribution to journalArticle

Urinary Bladder Diseases
Polysaccharides
Urinary Bladder
Inflammation
Glycosaminoglycans
28 Citations (Scopus)

IUGR decreases elastin MRNA expression in the developing rat lung and alters elastin content and lung compliance in the mature rat lung

Joss-Moore, L. A., Wang, Y., Yu, X., Campbell, M. S., Callaway, C. W., McKnight, R. A., Wint, A., Dahl, M. J., Dull, R. O., Albertine, K. H. & Lane, R. H., May 1 2011, In : Physiological Genomics. 43, 9, p. 499-505 7 p.

Research output: Contribution to journalArticle

Lung Compliance
Elastic Tissue
Elastin
Lung
Growth
38 Citations (Scopus)

Stiffness and heterogeneity of the pulmonary endothelial glycocalyx measured by atomic force microscopy

O'Callaghan, R., Job, K. M., Dull, R. O. & Hlady, V., Sep 1 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 3, p. L353-L360

Research output: Contribution to journalArticle

Glycocalyx
Atomic Force Microscopy
Lung
Hyaluronoglucosaminidase
Intercellular Junctions
11 Citations (Scopus)

Study of the therapeutic benefit of cationic copolymer administration to vascular endothelium under mechanical stress

Giantsos-Adams, K., Lopez-Quintero, V., Kopeckova, P., Kopecek, J., Tarbell, J. M. & Dull, R., Jan 1 2011, In : Biomaterials. 32, 1, p. 288-294 7 p.

Research output: Contribution to journalArticle

Mechanical Stress
Vascular Endothelium
hydroxypropyl methacrylate
Copolymers
Capillary Permeability
2009
11 Citations (Scopus)

The use of an endothelium-targeted cationic copolymer to enhance the barrier function of lung capillary endothelial monolayers

Giantsos, K. M., Kopeckova, P. & Dull, R. O., Oct 1 2009, In : Biomaterials. 30, 29, p. 5885-5891 7 p.

Research output: Contribution to journalArticle

Personal digital assistants
Biomimetics
Endothelium
Monolayers
Polymers
2007
49 Citations (Scopus)
Glycocalyx
Fluorescence Spectrometry
Albumins
Lung
Digestion
38 Citations (Scopus)
Heparitin Sulfate
Reactive Oxygen Species
Nitric Oxide
Pressure
Lung
216 Citations (Scopus)

The role of endothelial glycocalyx components in mechanotransduction of fluid shear stress

Pahakis, M. Y., Kosky, J. R., Dull, R. O. & Tarbell, J. M., Mar 30 2007, In : Biochemical and Biophysical Research Communications. 355, 1, p. 228-233 6 p.

Research output: Contribution to journalArticle

Glycocalyx
Epoprostenol
Shear stress
Nitric Oxide
Sialic Acids
2006
14 Citations (Scopus)

Digital imaging system and virtual instrument platform for measuring hydraulic conductivity of vascular endothelial monolayers

Hubert, C. G., McJames, S. W., Mecham, I. & Dull, R. O., Mar 1 2006, In : Microvascular Research. 71, 2, p. 135-140 6 p.

Research output: Contribution to journalArticle

Hydraulic conductivity
Imaging systems
Blood Vessels
Monolayers
Permeability
2005
43 Citations (Scopus)

Vascular smooth muscle cell glycocalyx influences shear stress-mediated contractile response

Ainslie, K. M., Garanich, J. S., Dull, R. O. & Tarbell, J. M., Jan 1 2005, In : Journal of Applied Physiology. 98, 1, p. 242-249 8 p.

Research output: Contribution to journalArticle

Glycocalyx
Vascular Smooth Muscle
Smooth Muscle Myocytes
Architectural Accessibility
heparitinsulfate lyase
2004
27 Citations (Scopus)

Quantitative assessment of hemoglobin-induced endothelial barrier dysfunction

Dull, R. O., DeWitt, B. J., Dinavahi, R., Schwartz, L., Hubert, C., Pace, N. & Fronticelli, C., Nov 1 2004, In : Journal of Applied Physiology. 97, 5, p. 1930-1937 8 p.

Research output: Contribution to journalArticle

Hemoglobins
Permeability
Electric Impedance
Vascular Resistance
Albumins
2003
358 Citations (Scopus)

Heparan sulfate proteoglycan is a mechanosensor on endothelial cells.

Florian, J. A., Kosky, J. R., Ainslie, K., Pang, Z., Dull, R. O. & Tarbell, J. M., Nov 14 2003, In : Circulation research. 93, 10, p. e136-142

Research output: Contribution to journalArticle

Heparan Sulfate Proteoglycans
heparitinsulfate lyase
Heparitin Sulfate
Endothelial Cells
Glycocalyx
53 Citations (Scopus)

Lung endothelial heparan sulfates mediate cationic peptide-induced barrier dysfunction: A new role for the glycocalyx

Dull, R. O., Dinavahi, R., Schwartz, L., Humphries, D. E., Berry, D., Sasisekharan, R. & Garcia, J. G. N., Nov 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 5 29-5

Research output: Contribution to journalArticle

Glycocalyx
Heparitin Sulfate
heparitinsulfate lyase
Lung
Peptides
2002
18 Citations (Scopus)

Leukocyte-induced microvascular permeability: How contractile tweaks lead to leaks

Dull, R. O. & Garcia, J. G. N., Jun 14 2002, In : Circulation Research. 90, 11, p. 1143-1144 2 p.

Research output: Contribution to journalArticle

Myosin-Light-Chain Kinase
Myosin Light Chains
Vascular Endothelium
Capillary Permeability
Endothelium
2001
24 Citations (Scopus)

Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation

Dull, R. O., Yuan, J., Chang, Y. S., Tarbell, J., Jain, R. K. & Munn, L. L., Jan 1 2001, In : Microvascular Research. 61, 2, p. 203-210 8 p.

Research output: Contribution to journalArticle

Endothelial cells
Hydraulic conductivity
Vascular Endothelial Growth Factor A
Endothelial Cells
Intercellular Signaling Peptides and Proteins
2000
105 Citations (Scopus)

Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties

Chang, Y. S., Munn, L. L., Hillsley, M. V., Dull, R. O., Yuan, J., Lakshminarayanan, S., Gardner, T. W., Jain, R. K. & Tarbell, J. M., Mar 2000, In : Microvascular Research. 59, 2, p. 265-277 13 p.

Research output: Contribution to journalArticle

Endothelial cells
Transport properties
Vascular Endothelial Growth Factor A
Cultured Cells
Monolayers
1998
10 Citations (Scopus)

Variations in the composition of spinal anesthetic solutions: The effects of drug addition order and preparation methods

Dull, R. O. & Peterfreund, R. A., Dec 1998, In : Anesthesia and analgesia. 87, 6, p. 1326-1330 5 p.

Research output: Contribution to journalArticle

Anesthetics
Methylene Blue
Syringes
Pharmaceutical Preparations
Needles
1995
74 Citations (Scopus)

Effects of wall shear stress and fluid recirculation on the localization of circulating monocytes in a three-dimensional flow model

Pritchard, W. F., Davies, P. F., Derafshi, Z., Polacek, D. C., Tsao, R., Dull, R. O., Jones, S. A. & Giddens, D. P., Dec 1995, In : Journal of Biomechanics. 28, 12, p. 1459-1469 11 p.

Research output: Contribution to journalArticle

Shear stress
Monocytes
Adhesion
U937 Cells
Fluids
1992
40 Citations (Scopus)

Hemodynamic forces and vascular cell communication in arteries

Davies, P. F., Robotewskyj, A., Griem, M. L., Dull, R. O. & Polacek, D. C., Dec 18 1992, In : Archives of Pathology and Laboratory Medicine. 116, 12, p. 1301-1306 6 p.

Research output: Contribution to journalArticle

Cell Communication
Endothelium
Blood Vessels
Arteries
Hemodynamics
41 Citations (Scopus)

Mechanisms of flow-mediated signal transduction in endothelial cells: Kinetics of ATP surface concentrations

Dull, R. O., Tarbell, J. M. & Davies, P. F., Jan 1 1992, In : Journal of Vascular Research. 29, 6, p. 405-419 15 p.

Research output: Contribution to journalArticle

Signal Transduction
Endothelial Cells
Adenosine Triphosphate
Purinergic Receptors
Endothelium
1991
162 Citations (Scopus)

Endothelial albumin permeability is shear dependent, time dependent, and reversible

Jo, H., Dull, R. O., Hollis, T. M. & Tarbell, J. M., Jan 1 1991, In : American Journal of Physiology - Heart and Circulatory Physiology. 260, 6 29-6, p. H1992-H1996

Research output: Contribution to journalArticle

Albumins
Permeability
polycarbonate
Endothelial Cells
Blood Vessels
173 Citations (Scopus)

Flow modulation of agonist (ATP)-response (Ca2+) coupling in vascular endothelial cells

Dull, R. O. & Davies, P. F., Jan 1 1991, In : American Journal of Physiology - Heart and Circulatory Physiology. 261, 1 30-1, p. H149-H154

Research output: Contribution to journalArticle

Endothelial Cells
Adenosine Triphosphate
Hemodynamics
Calcium
Enzymes