Raymond B Nagle

  • 11228 Citations
  • 57 h-Index
1968 …2021
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Research Output 1968 2019

  • 11228 Citations
  • 57 h-Index
  • 271 Article
  • 3 Chapter
  • 1 Conference contribution
  • 1 Review article
2007
50 Citations (Scopus)

A new rabbit monoclonal antibody (4B5) for the immunohistochemical (IHC) determination of the HER2 status in breast cancer: Comparison with CB11, fluorescence in situ hybridization (FISH), and interlaboratory reproducibility

Powell, W. C., Hicks, D. G., Prescott, N., Tarr, S. M., Laniauskas, S., Williams, T., Short, S., Pettay, J., Nagle, R. B., Dabbs, D. J., Scott, K. M., Brown, R. W., Grogan, T., Roche, P. C. & Tubbs, R. R., Mar 2007, In : Applied Immunohistochemistry and Molecular Morphology. 15, 1, p. 94-102 9 p.

Research output: Contribution to journalArticle

Fluorescence In Situ Hybridization
Monoclonal Antibodies
Staining and Labeling
Breast Neoplasms
Rabbits
189 Citations (Scopus)

A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors

Mahadevan, D., Cooke, L., Riley, C., Swart, R., Simons, B., Della Croce, K., Wisner, L., Iorio, M., Shakalya, K., Garewal, H., Nagle, R. B. & Bearss, D., Jun 7 2007, In : Oncogene. 26, 27, p. 3909-3919 11 p.

Research output: Contribution to journalArticle

Gastrointestinal Stromal Tumors
Protein-Tyrosine Kinases
docetaxel
Phosphotransferases
Stromal Cells
26 Citations (Scopus)

Breast cancer among hispanic and non-hispanic white women in Arizona

Martínez, M. E., Nielson, C. M., Nagle, R. B., Lopez, A. M., Kim, C. & Thompson, P., Nov 2007, In : Journal of Health Care for the Poor and Underserved. 18, 4 SUPPL., p. 130-145 16 p.

Research output: Contribution to journalArticle

Hispanic Americans
cancer
Breast Neoplasms
Neoplasms
underage
216 Citations (Scopus)

Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer

Gatenby, R. A., Smallbone, K., Maini, P. K., Rose, F., Averill, J., Nagle, R. B., Worrall, L. & Gillies, R. J., Aug 28 2007, In : British Journal of Cancer. 97, 5, p. 646-653 8 p.

Research output: Contribution to journalArticle

Clonal Evolution
Acidosis
Breast Neoplasms
Sodium-Hydrogen Antiporter
Carcinoma, Intraductal, Noninfiltrating
46 Citations (Scopus)

Integrin α6 cleavage: A novel modification to modulate cell migration

Pawar, S. C., Demetriou, M. C., Nagle, R. B., Bowden, G. T. & Cress, A. E., Apr 1 2007, In : Experimental Cell Research. 313, 6, p. 1080-1089 10 p.

Research output: Contribution to journalArticle

Integrins
Cell Movement
Laminin
Urokinase-Type Plasminogen Activator
Prostatic Neoplasms
50 Citations (Scopus)
Matrix Metalloproteinase 14
JNK Mitogen-Activated Protein Kinases
Prostate
Phosphotransferases
Neoplasms
71 Citations (Scopus)

Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer

King, T., Vardanyan, A., Majuta, L., Melemedjian, O., Nagle, R. B., Cress, A. E., Vanderah, T. W., Lai, J. & Porreca, F., Nov 2007, In : Pain. 132, 1-2, p. 154-168 15 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Spontaneous Fractures
Bone Fractures
Sarcoma
Morphine
166 Citations (Scopus)

Phase II study of erlotinib in patients with malignant pleural mesothelioma: A Southwest Oncology Group study

Garland, L. L., Rankin, C., Gandara, D. R., Rivkin, S. E., Scott, K. M., Nagle, R. B., Klein-Szanto, A. J. P., Testa, J. R., Altomare, D. A. & Borden, E. C., Jun 10 2007, In : Journal of Clinical Oncology. 25, 17, p. 2406-2413 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Phosphatidylinositol 3-Kinase
Extracellular Signal-Regulated MAP Kinases
Protein-Tyrosine Kinases
Phosphoric Monoester Hydrolases
2006
21 Citations (Scopus)

90K/Mac-2 binding protein is expressed in prostate cancer and induces promatrilysin expression

Bair, E. L., Nagle, R. B., Ulmer, T. A., Laferté, S. & Bowden, G. T., Feb 15 2006, In : Prostate. 66, 3, p. 283-293 11 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Carrier Proteins
Prostate
Cell Line
Neoplasms
133 Citations (Scopus)

Expression of mTOR signaling pathway markers in prostate cancer progression

Kremer, C. L., Klein, R. R., Mendelson, J., Browne, W., Samadzedeh, L. K., Vanpatten, K., Highstrom, L., Pestano, G. A. & Nagle, R. B., Aug 1 2006, In : Prostate. 66, 11, p. 1203-1212 10 p.

Research output: Contribution to journalArticle

Sirolimus
Prostatic Neoplasms
Prostate
Neoplasms
Phosphatidylinositol 3-Kinases
5 Citations (Scopus)

Human laminin-5 and laminin-10 mediated gene expression of prostate carcinoma cells

Calaluce, R., Beck, S. K., Bair, E. L., Pandey, R., Greer, K. A., Hoying, A. M., Hoying, J. B., Mount, D. W. & Nagle, R. B., Sep 13 2006, In : Prostate. 66, 13, p. 1381-1390 10 p.

Research output: Contribution to journalArticle

Prostate
Carcinoma
Gene Expression
Prostatic Neoplasms
Genes
37 Citations (Scopus)

Role of c-Myc in intestinal tumorigenesis of the ApcMin/+ mouse

Ignatenko, N., Holubec, H., Besselsen, D. G., Blohm-Mangone, K. A., Padilla-Torres, J. L., Nagle, R. B., De Alboránç, I. M., Guillen-R, J. M. & Gerner, E. W., Dec 2006, In : Cancer Biology and Therapy. 5, 12, p. 1658-1664 7 p.

Research output: Contribution to journalArticle

Adenomatous Polyposis Coli
Carcinogenesis
Colon
Transcriptional Regulatory Elements
Proto-Oncogene Proteins c-myc
2005
49 Citations (Scopus)

Aurora-A over-expression in high-grade PIN lesions and prostate cancer

Buschhorn, H. M., Klein, R. R., Chambers, S. M., Hardy, M. C., Green, S., Bearss, D. & Nagle, R. B., Sep 1 2005, In : Prostate. 64, 4, p. 341-346 6 p.

Research output: Contribution to journalArticle

Prostatic Intraepithelial Neoplasia
Prostatic Neoplasms
Prostate
Aurora Kinase A
Staining and Labeling
5 Citations (Scopus)
Transcriptional Silencer Elements
G-Quadruplexes
Mutation
Therapeutics
45 Citations (Scopus)

Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes cancer cell migration

Bair, E. L., Man, L. C., McDaniel, K., Sekiguchi, K., Cress, A. E., Nagle, R. B. & Bowden, G. T., Apr 2005, In : Neoplasia. 7, 4, p. 380-389 10 p.

Research output: Contribution to journalArticle

Metalloproteases
Cell Movement
Prostatic Neoplasms
Membranes
Neoplasms
24 Citations (Scopus)

Stimulated endothelial cell adhesion and angiogenesis with laminin-5 modification of expanded polytetrafluoroethylene

Kidd, K. R., Dal Ponte, D., Stone, A. L., Hoying, J. B., Nagle, R. B. & Williams, S. K., Sep 2005, In : Tissue Engineering. 11, 9-10, p. 1379-1391 13 p.

Research output: Contribution to journalArticle

Cell adhesion
Endothelial cells
Polytetrafluoroethylene
Polytetrafluoroethylenes
Cell Adhesion
2004

Erratum: PEAZ-1: A new human prostate neoplastic epithelial cell line (Prostate (2001) 48 (79-92))

Schmelz, M., Cress, A. E., Barrera, J., McDaniel, K. M., Davis, T. L., Fuchs, L., Dalkin, B. L. & Nagle, R. B., Dec 1 2004, In : Prostate. 61, 4, p. 375 1 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Extracellular alpha 6 integrin cleavage by urokinase-type plasminogen activator in human prostate cancer

Demetriou, M. C., Pennington, M. E., Nagle, R. B. & Cress, A. E., Apr 1 2004, In : Experimental Cell Research. 294, 2, p. 550-558 9 p.

Research output: Contribution to journalArticle

Integrin alpha6
Urokinase-Type Plasminogen Activator
Integrins
Prostatic Neoplasms
Antifibrinolytic Agents
31 Citations (Scopus)

Fibroblast Growth Factor-I Transcriptionally Induces Membrane Type-I Matrix Metalloproteinase Expression in Prostate Carcinoma Cell Line

Udayakumar, T. S., Nagle, R. B. & Bowden, G. T., Jan 1 2004, In : Prostate. 58, 1, p. 66-75 10 p.

Research output: Contribution to journalArticle

Membrane-Associated Matrix Metalloproteinases
Matrix Metalloproteinase 14
Fibroblast Growth Factor 1
Fibroblast Growth Factors
Prostate
84 Citations (Scopus)

Identification of human polo-like kinase 1 as a potential therapeutic target in pancreatic cancer

Gray, P. J., Bearss, D. J., Han, H., Nagle, R. B., Tsao, M. S., Dean, N. & Von Hoff, D. D., May 2004, In : Molecular Cancer Therapeutics. 3, 5, p. 641-646 6 p.

Research output: Contribution to journalArticle

Forensic Anthropology
Pancreatic Neoplasms
Therapeutics
G2 Phase Cell Cycle Checkpoints
Neoplasms
9 Citations (Scopus)

Immunohistochemical comparison of vascular and sinusoidal adherens junctions in cavernosal endothelium

Wessells, H., King, S. H., Schmelz, M., Nagle, R. B. & Heimark, R. L., Jan 2004, In : Urology. 63, 1, p. 201-206 6 p.

Research output: Contribution to journalArticle

Adherens Junctions
Vinculin
Endothelium
Blood Vessels
Arterioles
10 Citations (Scopus)

Kimura disease with advanced renal damage with anti-tubular basement membrane antibody

Dixit, M. P., Scott, K. M., Bracamonte, E., Dixit, N. M., Schumacher, M. J., Hutter, J. & Nagle, R. B., Dec 2004, In : Pediatric Nephrology. 19, 12, p. 1404-1407 4 p.

Research output: Contribution to journalArticle

Angiolymphoid Hyperplasia with Eosinophilia
Nephrotic Syndrome
Basement Membrane
African Americans
Platelet Count
25 Citations (Scopus)

Laminin-5 β3A expression in LNCaP human prostate carcinoma cells increases cell migration and tumorigenicity

Calaluce, R., Bearss, D. J., Barrera, J., Zhao, Y., Han, H., Beck, S. K., McDaniel, K. & Nagle, R. B., Sep 2004, In : Neoplasia. 6, 5, p. 468-479 12 p.

Research output: Contribution to journalArticle

Cell Movement
Prostate
Carcinoma
Protein Isoforms
Signal Transduction
1 Citation (Scopus)

Modern Data Security

Klein, R. R., Mount, D. W. & Nagle, R. B., Mar 2004, In : Archives of Pathology and Laboratory Medicine. 128, 3, p. 338-340 3 p.

Research output: Contribution to journalArticle

Computerized Medical Records Systems
Computer Security
Clinical Pathology
Confidentiality

Modern data security [2] (multiple letters)

Ulirsch, R. C., Klein, R. R., Mount, D. W. & Nagle, R. B., Oct 2004, In : Archives of Pathology and Laboratory Medicine. 128, 10, p. 1080 1 p.

Research output: Contribution to journalArticle

Security Measures
Computer Security
Information Systems
51 Citations (Scopus)

Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue

Grand, C. L., Powell, T. J., Nagle, R. B., Bearss, D. J., Tye, D., Gleason-Guzman, M. & Hurley, L., Apr 20 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 16, p. 6140-6145 6 p.

Research output: Contribution to journalArticle

Transcriptional Silencer Elements
G-Quadruplexes
Mutation
Therapeutics
Cell Line
29 Citations (Scopus)

Role of the extracellular matrix in prostate carcinogenesis

Nagle, R. B., Jan 2004, In : Journal of Cellular Biochemistry. 91, 1, p. 36-40 5 p.

Research output: Contribution to journalArticle

Lamins
Extracellular Matrix Proteins
Glycosaminoglycans
Extracellular Matrix
Prostate
45 Citations (Scopus)

Selenium and selenomethionine levels in prostate cancer patients

Nyman, D. W., Stratton, M. S., Kopplin, M. J., Dalkin, B. L., Nagle, R. B. & Gandolfi, A. J., 2004, In : Cancer Detection and Prevention. 28, 1, p. 8-16 9 p.

Research output: Contribution to journalArticle

Selenomethionine
Selenium
Prostatic Neoplasms
Prostate
Serum
77 Citations (Scopus)

The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer

Rojanala, S., Han, H., Muñoz, R. M., Browne, W., Nagle, R. B., Von Hoff, D. D. & Bearss, D. J., Apr 2004, In : Molecular Cancer Therapeutics. 3, 4, p. 451-457 7 p.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
Human Development
Pancreatic Neoplasms
Centrosome
Pharmaceutical Preparations
2003
24 Citations (Scopus)

Laminin Alpha-1, Alpha-3, and Alpha-5 chain expression in human prepubetal benign prostate glands and adult benign and malignant prostate glands

Brar, P. K., Dalkin, B. L., Weyer, C., Sallam, K., Virtanen, I. & Nagle, R. B., Apr 1 2003, In : Prostate. 55, 1, p. 65-70 6 p.

Research output: Contribution to journalArticle

Prostate
Laminin
Basement Membrane
Term Birth
Carcinoma
107 Citations (Scopus)

Membrane type-1-matrix metalloproteinase expressed by prostate carcinoma cells cleaves human laminin-5 β3 chain and induces cell migration

Udayakumar, T. S., Chen, M. L., Bair, E. L., Von Bredow, D. C., Cress, A. E., Nagle, R. B. & Bowden, G. T., May 1 2003, In : Cancer Research. 63, 9, p. 2292-2299 8 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 14
Cell Movement
Prostate
Carcinoma
Oligonucleotides
19 Citations (Scopus)

Pharmacological inhibition of FGF receptor signaling inhibits LNCaP prostate tumor growth, promatrilysin, and PSA expression

Udayakumar, T. S., Bair, E. L., Nagle, R. B. & Bowden, G. T., Oct 2003, In : Molecular Carcinogenesis. 38, 2, p. 70-77 8 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Prostate-Specific Antigen
Prostate
Fibroblasts
Pharmacology
27 Citations (Scopus)
Prostatectomy
Biopsy
Neoplasms
Margins of Excision
Outcome Assessment (Health Care)
2002
2 Citations (Scopus)

Androgens block interleukin-1β-induced promatrilysin expression in prostate carcinoma cells

Stratton, M. S., Greenstein, B., Udayakumar, T. S., Nagle, R. B. & Bowden, G. T., Sep 15 2002, In : Prostate. 53, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Interleukin-1
Androgens
Prostate
Interleukin-6
Testosterone
47 Citations (Scopus)

Angiogenesis and neovascularization associated with extracellular matrix-modified porous implants

Kidd, K. R., Nagle, R. B. & Williams, S. K., 2002, In : Journal of Biomedical Materials Research. 59, 2, p. 366-377 12 p.

Research output: Contribution to journalArticle

Polytetrafluoroethylene
Polytetrafluoroethylenes
Rats
Tissue
Blood vessels
8 Citations (Scopus)

Cell line-specific translation of two laminin 5 β3 chain isoforms

Hao, J., McDaniel, K., Weyer, C., Barrera, J. & Nagle, R. B., Jan 23 2002, In : Gene. 283, 1-2, p. 237-244 8 p.

Research output: Contribution to journalArticle

Protein Isoforms
Cell Line
Complementary DNA
Clone Cells
RNA Isoforms
89 Citations (Scopus)

Clinical laboratory assays for HER-2/neu amplification and overexpression: Quality assurance, standardization, and proficiency testing

Nagle, R. B., Tubbs, R. R., Roche, P. C., Hsi, E. D., Linden, M. D., Ormsby, A., Pettigrew, N. M., Rickert, R. R., Said, J. W., Bayer-Garner, I. B., Cooley, L. D., Brothman, A. R., Persons, D. L., Vance, G. H., Mascarello, J. T., Rao, K. W., Herrmann, M., Dewald, G. & Park, J. P., 2002, In : Archives of Pathology and Laboratory Medicine. 126, 7, p. 803-808 6 p.

Research output: Contribution to journalArticle

Fluorescence In Situ Hybridization
Immunohistochemistry
Cytogenetics
Interphase
Surveys and Questionnaires
4 Citations (Scopus)

Consensual interpretive guidelines for diagnostic immunohistochemistry [3] multiple letters

Nagle, R. B. & Fitzgibbons, P. L., 2002, In : American Journal of Surgical Pathology. 26, 6, p. 816-818 3 p.

Research output: Contribution to journalArticle

Surgical Pathology
Medical Societies
Practice Guidelines
Immunohistochemistry
Guidelines
26 Citations (Scopus)

Culturing precision-cut human prostate slices as an in vitro model of prostate pathobiology

Parrish, A. R., Sallam, K., Nyman, D. W., Orozco, J., Cress, A. E., Dalkin, B. L., Nagle, R. B. & Gandolfi, A. J., 2002, In : Cell Biology and Toxicology. 18, 3, p. 205-219 15 p.

Research output: Contribution to journalArticle

Dihydrotestosterone
Prostate-Specific Antigen
Prostate
Cells
Tissue
61 Citations (Scopus)

Different phenotypes in human prostate cancer: α6 or α3 integrin in cell-extracellular adhesion sites

Schmelz, M., Cress, A. E., Scott, K. M., Bürgery, F., Cui, H., Sallam, K., McDaniel, K. M., Dalkin, B. L. & Nagle, R. B., 2002, In : Neoplasia. 4, 3, p. 243-254 12 p.

Research output: Contribution to journalArticle

Cell Adhesion
Integrins
Prostatic Neoplasms
Phenotype
Neoplasm Grading

Erratum: Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray (Cancer Research (May 15, 2002) (2890-2896))

Han, H., Bearss, D. J., Browne, L. W., Calaluce, R., Nagle, R. B. & Von Hoff, D. D., Aug 1 2002, In : Cancer Research. 62, 15, p. 4532 1 p.

Research output: Contribution to journalArticle

Oligonucleotide Array Sequence Analysis
Pancreatic Neoplasms
Research
Genes
Neoplasms
39 Citations (Scopus)

Fibroblast growth factor-1 induced promatrilysin expression through the activation of extracellular-regulated kinases and STAT3

Udayakumar, T. S., Stratton, M. S., Nagle, R. B. & Bowden, G. T., 2002, In : Neoplasia. 4, 1, p. 60-67 8 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 1
STAT3 Transcription Factor
Phosphotransferases
Matrix Metalloproteinase 7
Phosphorylation
326 Citations (Scopus)

Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray

Han, H., Bearss, D. J., Browne, L. W., Calaluce, R., Nagle, R. B. & Von Hoff, D. D., May 15 2002, In : Cancer Research. 62, 10, p. 2890-2896 7 p.

Research output: Contribution to journalArticle

Oligonucleotide Array Sequence Analysis
Pancreatic Neoplasms
Messenger RNA
Pancreas
Genes
2001
21 Citations (Scopus)

Aberrant expression of fibroblast growth factor receptor-1 in prostate epithelial cells allows induction of promatrilysin expression by fibroblast growth factors

Udayakumar, T. S., Klein, R. D., Maliner, M. S., Nagle, R. B. & Bowden, G. T., Jan 15 2001, In : International Journal of Cancer. 91, 2, p. 187-192 6 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 1
Fibroblast Growth Factors
Fibroblast Growth Factor Receptors
Prostate
Epithelial Cells
11 Citations (Scopus)

Expression of the matrix metalloproteinase promatrilysin in coculture of prostate carcinoma cell lines

Stratton, M. S., Sirvent, H., Udayakumar, T. S., Nagle, R. B. & Bowden, G. T., 2001, In : Prostate. 48, 3, p. 206-209 4 p.

Research output: Contribution to journalArticle

Coculture Techniques
Matrix Metalloproteinases
Prostate
Carcinoma
Conditioned Culture Medium
21 Citations (Scopus)

Interleukin-1β-induced promatrilysin expression is mediated by NFκB-regulated synthesis of interleukin-6 in the prostate carcinoma cell line, LNCaP1

Maliner-Stratton, M. S., Klein, R. D., Udayakumar, T. S., Nagle, R. B. & Bowden, G. T., 2001, In : Neoplasia. 3, 6, p. 509-520 12 p.

Research output: Contribution to journalArticle

NF-kappa B
Interleukin-1
Prostate
Interleukin-6
Carcinoma
57 Citations (Scopus)

Investigation into the mechanism of the loss of laminin 5 (α3β3γ2) expression in prostate cancer

Hao, J., Jackson, L., Calaluce, R., McDaniel, K., Dalkin, B. L. & Nagle, R. B., 2001, In : American Journal of Pathology. 158, 3, p. 1129-1135 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Proteins
Messenger RNA
Cell Movement
In Situ Hybridization
11 Citations (Scopus)

New molecular approaches to tissue analysis

Nagle, R. B., 2001, In : Journal of Histochemistry and Cytochemistry. 49, 8, p. 1063-1064 2 p.

Research output: Contribution to journalArticle

Laser Capture Microdissection
Human Genome Project
Technology
Proteins
Gene Amplification
8 Citations (Scopus)

PEAZ-1: A new human prostate neoplastic epithelial cell line

Schmelz, M., Cress, A. E., Barrera, J., McDaniel, K. M., Davis, T. L., Fuchs, L., Dalkin, B. L. & Nagle, R. B., Jul 1 2001, In : Prostate. 48, 2, p. 79-92 14 p.

Research output: Contribution to journalArticle

Prostate
Epithelial Cells
Cell Line
Cadherins
gamma Catenin
91 Citations (Scopus)

Signal transduction through the Ras/Erk pathway is essential for the mycoestrogen Zearalenone-induced cell-cycle progression in MCF-7 cells

Calaluce, R., Kunkel, M. W., Watts, G. S., Schmelz, M., Hao, J., Barrera, J., Gleason-Guzman, M., Isett, R., Fitchmun, M., Tim Bowden, G., Cress, A. E., Futscher, B. W. & Nagle, R. B., 2001, In : Molecular Carcinogenesis. 30, 2, p. 88-98 11 p.

Research output: Contribution to journalArticle

Zearalenone
MCF-7 Cells
Signal Transduction
Cell Cycle
G2 Phase