Robert T Dorr

  • 9048 Citations
  • 49 h-Index
1976 …2021
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Research Output 1976 2016

  • 9048 Citations
  • 49 h-Index
  • 236 Article
  • 3 Chapter
Article
24 Citations (Scopus)

1,4-disubstituted anthracene antitumor agents

Iyengar, B. S., Dorr, R. T., Alberts, D. S., Sólyom, A. M., Krutzsch, M. & Remers, W. A., 1997, In : Journal of Medicinal Chemistry. 40, 23, p. 3734-3738 5 p.

Research output: Contribution to journalArticle

Hydrazones
Anthracenes
Antineoplastic Agents
Tumors
Cells
35 Citations (Scopus)
Quantitative Structure-Activity Relationship
Tumors
Cells
Leukemia L1210
Cytotoxicity
64 Citations (Scopus)

2-Substituted 1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones. A new class of antitumor agent

Sami, S. M., Dorr, R. T., Alberts, D. S. & Remers, W. A., 1993, In : Journal of Medicinal Chemistry. 36, 6, p. 765-770 6 p.

Research output: Contribution to journalArticle

amonafide
Antineoplastic Agents
Nitrogen
lissamine rhodamine B
Cells
29 Citations (Scopus)
Quantitative Structure-Activity Relationship
Cells
Tumors
Leukemia L1210
Mitoxantrone
6 Citations (Scopus)

Absorption enhancement of melanotan-l: Comparison of the caco-2 and rat in situ models

Surendran, N., Ugwu, S. O., Nguyen, L. D., Sterling, E. J., Dorr, R. T. & Blanchard, J., 1995, In : Drug Delivery. 2, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

Aprotinin
Cyclodextrins
Biological Availability
Sodium
Protease Inhibitors
7 Citations (Scopus)

A comparison of HPLC and bioassay methods for plasma melanotan-II (MT-II) determination: Application to a pharmacokinetic study in rats

Ugwu, S. O., Blanchard, J., Nguyen, L. D., Hadley, M. E. & Dorr, R. T., 1994, In : Biopharmaceutics and Drug Disposition. 15, 5, p. 383-390 8 p.

Research output: Contribution to journalArticle

Biological Assay
Pharmacokinetics
High Pressure Liquid Chromatography
Area Under Curve
Regression Analysis
10 Citations (Scopus)

Additional nucleotide derivatives of mitosenes. Synthesis and activity against parental and multidrug resistant L1210 leukemia

Iyengar, B. S., Dorr, R. T. & Dorr, R. T., 1991, In : Journal of Medicinal Chemistry. 34, 7, p. 1947-1951 5 p.

Research output: Contribution to journalArticle

Leukemia L1210
Mitomycin
Nucleotides
Derivatives
Ribonucleosides
5 Citations (Scopus)

Administration of melanotropic peptides during gestation in the rodent

Dawson, B. V., Ford, C. A., Holloway, H., Dorr, R. T. & Johnson, P., Jan 29 1993, In : Toxicology. 77, 1-2, p. 91-101 11 p.

Research output: Contribution to journalArticle

Melanocyte-Stimulating Hormones
Rodentia
Pregnancy
Peptides
Fetal Development
8 Citations (Scopus)

Adult rat myocardial slices: A tool for studies of comparative cardiotoxicity

Parrish, A. R., Dorr, R. T., Gandolfi, A. J. & Brendel, K., 1994, In : Toxicology in Vitro. 8, 6, p. 1233-1237 5 p.

Research output: Contribution to journalArticle

Allylamine
Doxorubicin
Rats
Lipid Peroxidation
Adenosine Triphosphate
24 Citations (Scopus)

Alkylation of DNA by C-10 of 2,7-diaminomitosene

Iyengar, B. S., Dorr, R. T., Dorr, R. T. & Remers, W. A., 1990, In : Journal of Medicinal Chemistry. 33, 1, p. 253-257 5 p.

Research output: Contribution to journalArticle

Alkylation
Dithionite
DNA
Mitomycin
Methyl Methanesulfonate
43 Citations (Scopus)

Allopurinol kinetics and bioavailability - Intravenous, oral and rectal administration

Appelbaum, S. J., Mayersohn, M., Dorr, R. T. & Perrier, D., 1982, In : Cancer Chemotherapy and Pharmacology. 8, 1, p. 93-98 6 p.

Research output: Contribution to journalArticle

Rectal Administration
Allopurinol
Intravenous Administration
Oxypurinol
Biological Availability
43 Citations (Scopus)

Alpha-globulins suppress human leukocyte tumor necrosis factor secretion

Scuderi, P., Dorr, R. T., Liddil, J. D., Finley, P. R., Meltzer, P., Raitano, A. B. & Rybski, J., 1989, In : European Journal of Immunology. 19, 5, p. 939-942 4 p.

Research output: Contribution to journalArticle

Alpha-Globulins
Leukocytes
Globulins
Tumor Necrosis Factor-alpha
Interferons
47 Citations (Scopus)
Quantitative Structure-Activity Relationship
amonafide
Tumors
Anthracenes
Leukemia P388
60 Citations (Scopus)

Analogues of amonafide and azonafide with novel ring systems

Sami, S. M., Dorr, R. T., Alberts, D. S., Solyom, A. M. & Remers, W. A., Aug 10 2000, In : Journal of Medicinal Chemistry. 43, 16, p. 3067-3073 7 p.

Research output: Contribution to journalArticle

amonafide
Tumors
Anthracenes
Cells
Chromophores
7 Citations (Scopus)

Analytical and biological inequivalence of two commercial formulations of the antitumor agent bleomycin

Dorr, R. T., Meyers, R., Snead, K. & Liddil, J. D., 1998, In : Cancer Chemotherapy and Pharmacology. 42, 2, p. 149-154 6 p.

Research output: Contribution to journalArticle

Bleomycin
Antineoplastic Agents
Tumors
Bearings (structural)
Leukemia L1210
278 Citations (Scopus)

Anticancer drug renal toxicity and elimination: dosing guidelines for altered renal function

Kintzel, P. E. & Dorr, R. T., 1995, In : Cancer Treatment Reviews. 21, 1, p. 33-64 32 p.

Research output: Contribution to journalArticle

Drug-Related Side Effects and Adverse Reactions
Guidelines
Kidney
Pharmaceutical Preparations
Renal Elimination
118 Citations (Scopus)

Antidotes to vesicant chemotherapy extravasations

Dorr, R. T., 1990, In : Blood Reviews. 4, 1, p. 41-60 20 p.

Research output: Contribution to journalArticle

Antidotes
Irritants
Mitomycin
Dimethyl Sulfoxide
Drug Therapy
13 Citations (Scopus)

Antidote studies of vinorelbine-induced skin ulceration in the mouse

Dorr, R. T. & Bool, K. L., Jul 1995, In : Cancer Chemotherapy and Pharmacology. 36, 4, p. 290-292 3 p.

Research output: Contribution to journalArticle

Antidotes
Skin
Hyaluronoglucosaminidase
hyaluronate lyase
Vinca Alkaloids
33 Citations (Scopus)

Antiproliferative and antitumor activity of the 2-cyanoaziridine compound imexon on tumor cell lines and fresh tumor cells in vitro

Hersh, E. M., Gschwind, C. R., Taylor, C. W., Dorr, R. T., Taetle, R. & Salmon, S. E., Aug 19 1992, In : Journal of the National Cancer Institute. 84, 16, p. 1238-1244 7 p.

Research output: Contribution to journalArticle

Tumor Cell Line
Tumors
Tumor
Cells
Line
7 Citations (Scopus)

Anti-tumor activity and mechanism of action for a cyanoaziridine- derivative, AMP423

Dorr, R. T., Wisner, L., Samulitis, B. K., Landowski, T. H. & Remers, W. A., Apr 2012, In : Cancer Chemotherapy and Pharmacology. 69, 4, p. 1039-1049 11 p.

Research output: Contribution to journalArticle

Tumors
Bearings (structural)
Derivatives
Cells
Neoplasms
80 Citations (Scopus)

Antitumor activity and murine pharmacokinetics of parenteral acronycine

Dorr, R. T., Liddil, J. D., Von Hoff, D. D., Soble, M. & Osborne, C. K., 1989, In : Cancer Research. 49, 2, p. 340-344 5 p.

Research output: Contribution to journalArticle

Acronine
Pharmacokinetics
Plasmacytoma
Etoposide
Neoplasms
59 Citations (Scopus)

Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor

Dorr, R. T., Dvorakova, K., Snead, K., Alberts, D. S., Salmon, S. E. & Pettit, G. R., 1996, In : Investigational New Drugs. 14, 2, p. 131-137 7 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Biological Products
Inhibitory Concentration 50
Melanoma
Neoplasms
16 Citations (Scopus)

A phase 1-2 study of imexon plus dacarbazine in patients with unresectable metastatic melanoma

Weber, J. S., Samlowski, W. E., Gonzalez, R., Ribas, A., Stephenson, J., O'Day, S., Sato, T., Dorr, R. T., Grenier, K. & Hersh, E. M., Aug 1 2010, In : Cancer. 116, 15, p. 3683-3691 9 p.

Research output: Contribution to journalArticle

Dacarbazine
Melanoma
Maximum Tolerated Dose
Pharmacokinetics
Survival
24 Citations (Scopus)

A phase I/II trial of paclitaxel for non-Hodgkin's lymphoma followed by paclitaxel plus quinine in drug-resistant disease

Miller, T. P., Chase, E. M., Dorr, R. T., Dalton, W. S., Lam, K. S. & Salmon, S. E., 1998, In : Anti-Cancer Drugs. 9, 2, p. 135-140 6 p.

Research output: Contribution to journalArticle

Quinine
Paclitaxel
Non-Hodgkin's Lymphoma
Pharmaceutical Preparations
Pharmacokinetics
37 Citations (Scopus)

A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated L-asparaginase in patients with advanced solid tumors

Taylor, C. W., Dorr, R. T., Fanta, P., Hersh, E. M. & Salmon, S. E., 2001, In : Cancer Chemotherapy and Pharmacology. 47, 1, p. 83-88 6 p.

Research output: Contribution to journalArticle

Pharmacodynamics
Asparaginase
Tumors
Asparagine
Neoplasms
18 Citations (Scopus)

A phase i study of imexon plus gemcitabine as first-line therapy for advanced pancreatic cancer

Cohen, S. J., Zalupski, M. M., Modiano, M. R., Conkling, P., Patt, Y. Z., Davis, P., Dorr, R. T., Boytim, M. L. & Hersh, E. M., Jul 2010, In : Cancer Chemotherapy and Pharmacology. 66, 2, p. 287-294 8 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Toxicity
Maximum Tolerated Dose
Abdominal Pain
Ifosfamide
Carboplatin
Granulocyte Colony-Stimulating Factor
Doxorubicin
Area Under Curve
20 Citations (Scopus)

A phase i trial of imexon, a pro-oxidant, in combination with docetaxel for the treatment of patients with advanced breast, non-small cell lung and prostate cancer

Moulder, S., Dhillon, N., Ng, C., Hong, D., Wheler, J., Naing, A., Tse, S., La Paglia, A., Dorr, R. T., Hersh, E. M., Boytim, M. & Kurzrock, R., Oct 2010, In : Investigational New Drugs. 28, 5, p. 634-640 7 p.

Research output: Contribution to journalArticle

docetaxel
Non-Small Cell Lung Carcinoma
Reactive Oxygen Species
Prostatic Neoplasms
Breast
63 Citations (Scopus)

A phase I trial of β-all-trans-retinoic acid delivered via a collagen sponge and a cervical cap for mild or moderate intraepithelial cervical neoplasia

Meyskens, F. L., Graham, V., Chvapil, M., Dorr, R. T., Alberts, D. S. & Surwit, E. A., 1983, In : Journal of the National Cancer Institute. 71, 5, p. 921-925 5 p.

Research output: Contribution to journalArticle

Female Contraceptive Devices
Cervical Intraepithelial Neoplasia
Porifera
Tretinoin
Collagen
28 Citations (Scopus)

Approaches to reducing toxicity of parenteral anticancer drug formulations using cyclodextrins

Bhardwaj, R., Dorr, R. T. & Blanchard, J., May 2000, In : PDA Journal of Pharmaceutical Science and Technology. 54, 3, p. 233-239 7 p.

Research output: Contribution to journalArticle

Drug Compounding
Cyclodextrins
Mitomycin
Mannitol
Skin
34 Citations (Scopus)

Association of lysosomal activity with sensitivity and resistance to tumor necrosis factor in murine L929 cells

Liddil, J. D., Dorr, R. T. & Scuderi, P., 1989, In : Cancer Research. 49, 10, p. 2722-2728 7 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor-alpha
Glutathione
Glucaric Acid
Adenosine Triphosphate
Serial Passage
83 Citations (Scopus)
NAD(P)H Dehydrogenase (Quinone)
Indoles
Structure-Activity Relationship
Cytotoxicity
Antineoplastic Agents
328 Citations (Scopus)

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: A Southwest Oncology Group study

List, A. F., Kopecky, K. J., Willman, C. L., Head, D. R., Persons, D. L., Slovak, M. L., Dorr, R. T., Karanes, C., Hynes, H. E., Doroshow, J. H., Shurafa, M. & Appelbaum, F. R., Dec 1 2001, In : Blood. 98, 12, p. 3212-3220 9 p.

Research output: Contribution to journalArticle

Oncology
Drug Resistance
Acute Myeloid Leukemia
Cyclosporine
Modulation
6 Citations (Scopus)

Biochemical effects and toxicity of mitoxantrone in cultured heart cells

Shipp, N. G. & Dorr, R. T., 1991, In : Advances in Experimental Medicine and Biology. 283, p. 821-825 5 p.

Research output: Contribution to journalArticle

Razoxane
Mitoxantrone
Malondialdehyde
Lipid Peroxidation
Toxicity
2 Citations (Scopus)

Biologic activity of a nucleotide conjugate between mitomycin C and cytarabine monophosphate

Dorr, R. T., Liddil, J. D., Iyengar, B. S., List, A. F. & Remers, W. A., 1994, In : Nucleosides and Nucleotides. 13, 8, p. 1655-1667 13 p.

Research output: Contribution to journalArticle

Cytarabine
Mitomycin
Bearings (structural)
Nucleotides
Antimetabolites
3 Citations (Scopus)
bisantrene
Antidotes
Sodium Bicarbonate
Solubility
Skin
1 Citation (Scopus)

Bleomycin compatibility with selected intravenous medications

Dorr, R. T., Peng, Y. M. & Alberts, D. S., 1982, In : Journal of Medicine. 13, 1-2, p. 121-130 10 p.

Research output: Contribution to journalArticle

Bleomycin
Antineoplastic Antimetabolites
Ascorbic Acid
Salts
Vinca Alkaloids
77 Citations (Scopus)

Bleomycin pharmacology: Mechanism of action and resistance, and clinical pharmacokinetics

Dorr, R. T., 1992, In : Seminars in Oncology. 19, 2 SUPPL. 5, p. 3-8 6 p.

Research output: Contribution to journalArticle

Bleomycin
Iron
Pharmacokinetics
Pharmacology
Free Radicals
39 Citations (Scopus)

Cardioprotection of rat heart myocytes with amifostine (Ethyol®) and its free thiol, WR-1065, in vitro

Dorr, R. T., Lagel, K. & McLean, S., 1996, In : European Journal of Cancer. 32, SUPPL. 4

Research output: Contribution to journalArticle

Amifostine
Sulfhydryl Compounds
Muscle Cells
Doxorubicin
In Vitro Techniques
4 Citations (Scopus)

Cardiotoxicity of mitomycin A, mitomycin C, and seven N7 analogs in vitro

Dorr, R. T., Shipp, N. G., Liddil, J. D., Iyengar, B. S., Kunz, K. R. & Remers, W. A., Jan 1992, In : Cancer Chemotherapy and Pharmacology. 31, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Mitomycin
Mitomycins
Doxorubicin
Tumors
Cardiotoxins
37 Citations (Scopus)

Case report: topical DMSO for mitomycin-C-induced skin ulceration.

Alberts, D. S. & Dorr, R. T., May 1991, In : Oncology Nursing Forum. 18, 4, p. 693-695 3 p.

Research output: Contribution to journalArticle

Mitomycin
Dimethyl Sulfoxide
Skin
Antidotes
Skin Transplantation
1 Citation (Scopus)

Characterization of a membrane-active anti-tumor agent, UA8967

Dorr, R. T., Samulitis, B. K., Wisner, L., Han, H., Zhao, Y., Beroza, P., Damodaran, K., Igarashi, S., Landowski, T. H. & Von Hoff, D. D., Jun 2013, In : Investigational New Drugs. 31, 3, p. 576-586 11 p.

Research output: Contribution to journalArticle

Membranes
Colonic Neoplasms
Neoplasms
Trypan Blue
Cell Membrane
31 Citations (Scopus)

Characterization of experimental mitoxantrone cardiotoxicity and its partial inhibition by ICRF-187 in cultured neonatal rat heart cells

Shipp, N. G., Dorr, R. T., Alberts, D. S., Dawson, B. V. & Hendrix, M., Feb 1 1993, In : Cancer Research. 53, 3, p. 550-556 7 p.

Research output: Contribution to journalArticle

Dexrazoxane
Mitoxantrone
Muscle Cells
Metals
Cardiotoxicity
23 Citations (Scopus)

Characterization of novel diaryl oxazole-based compounds as potential agents to treat pancreatic cancer

Shaw, A. Y., Henderson, M. C., Flynn, G., Samulitis, B., Han, H., Stratton, S. P., Chow, H-H., Hurley, L. & Dorr, R. T., Nov 2009, In : Journal of Pharmacology and Experimental Therapeutics. 331, 2, p. 636-647 12 p.

Research output: Contribution to journalArticle

Oxazoles
Pancreatic Neoplasms
Kinesin
Cell Line
Protein Kinases
47 Citations (Scopus)

Chemical Basis for the Biological Activity of Imexon and Related Cyanoaziridines

Iyengar, B. S., Dorr, R. T. & Remers, W. A., Jan 1 2004, In : Journal of Medicinal Chemistry. 47, 1, p. 218-223 6 p.

Research output: Contribution to journalArticle

Bioactivity
Sulfhydryl Compounds
Oxidative stress
Cytotoxicity
Lysine
4 Citations (Scopus)

Chemistry and pharmacology of imexon and related cyanoaziridines

Remers, W. A. & Dorr, R. T., 2012, In : Current Medicinal Chemistry. 19, 33, p. 5745-5753 9 p.

Research output: Contribution to journalArticle

gemcitabine
Pharmacology
Tumors
Cell culture
Sulfhydryl Compounds
78 Citations (Scopus)

Chemoprevention of human actinic keratoses by topical 2-(Difluoromethyl)-dl-ornithine

Alberts, D. S., Dorr, R. T., Einspahr, J. G., Aickin, M., Saboda, K., Xu, M. J., Peng, Y. M., Goldman, R., Foote, J. A., Warneke, J. A., Salasche, S., Roe, D. & Bowden, G. T., 2000, In : Cancer Epidemiology Biomarkers and Prevention. 9, 12, p. 1281-1286 6 p.

Research output: Contribution to journalArticle

Eflornithine
Actinic Keratosis
Ornithine
Chemoprevention
Forearm
54 Citations (Scopus)

Chemoprotectants for cancer chemotherapy

Dorr, R. T., 1991, In : Seminars in Oncology. 18, 1 SUPPL. 2, p. 48-58 11 p.

Research output: Contribution to journalArticle

Dexrazoxane
Mesna
Doxorubicin
Ifosfamide
Alkylating Agents

Choosing a sunscreen

Relling, M. V. & Dorr, R. T., 1983, In : Arizona Medicine. 40, 8, p. 550-554 5 p.

Research output: Contribution to journalArticle

Sunburn
4-Aminobenzoic Acid
Sunscreening Agents
Skin Neoplasms
31 Citations (Scopus)

Cimetidine enhancement of cyclophosphamide antitumour activity

Dorr, R. T. & Alberts, D. S., 1982, In : British Journal of Cancer. 45, 1, p. 35-43 9 p.

Research output: Contribution to journalArticle

Cimetidine
Cyclophosphamide
Survival
Pentobarbital
Phenobarbital