Robert T Dorr

  • 9069 Citations
  • 49 h-Index
1976 …2021
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Research Output 1976 2016

  • 9069 Citations
  • 49 h-Index
  • 236 Article
  • 3 Chapter
2001
38 Citations (Scopus)

A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated L-asparaginase in patients with advanced solid tumors

Taylor, C. W., Dorr, R. T., Fanta, P., Hersh, E. M. & Salmon, S. E., 2001, In : Cancer Chemotherapy and Pharmacology. 47, 1, p. 83-88 6 p.

Research output: Contribution to journalArticle

Pharmacodynamics
Asparaginase
Tumors
Asparagine
Neoplasms
83 Citations (Scopus)
NAD(P)H Dehydrogenase (Quinone)
Indoles
Structure-Activity Relationship
Cytotoxicity
Antineoplastic Agents
330 Citations (Scopus)

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: A Southwest Oncology Group study

List, A. F., Kopecky, K. J., Willman, C. L., Head, D. R., Persons, D. L., Slovak, M. L., Dorr, R. T., Karanes, C., Hynes, H. E., Doroshow, J. H., Shurafa, M. & Appelbaum, F. R., Dec 1 2001, In : Blood. 98, 12, p. 3212-3220 9 p.

Research output: Contribution to journalArticle

Oncology
Drug Resistance
Acute Myeloid Leukemia
Cyclosporine
Modulation
38 Citations (Scopus)

Design and synthesis of a novel DNA-DNA interstrand adenine-guanine cross-linking agent [1]

Zhou, Q., Duan, W., Simmons, D., Shayo, Y., Raymond, M. A., Dorr, R. T. & Hurley, L., 2001, In : Journal of the American Chemical Society. 123, 20, p. 4865-4866 2 p.

Research output: Contribution to journalArticle

Alkylating Antineoplastic Agents
Antitumor Drug Screening Assays
Cross-Linking Reagents
Cultured Tumor Cells
Indoles
47 Citations (Scopus)

Drug interactions with the taxanes: Clinical implications

Baker, A. F. & Dorr, R. T., 2001, In : Cancer Treatment Reviews. 27, 4, p. 221-233 13 p.

Research output: Contribution to journalArticle

Taxoids
Paclitaxel
Drug Interactions
docetaxel
Anticonvulsants
71 Citations (Scopus)

Induction of mitochondrial changes in myeloma cells by imexon

Dvorakova, K., Waltmire, C. N., Payne, C. M., Tome, M. E., Briehl, M. M. & Dorr, R. T., Jun 1 2001, In : Blood. 97, 11, p. 3544-3551 8 p.

Research output: Contribution to journalArticle

Cells
Cell Line
Acute Promyelocytic Leukemia
4-imino-1,3-diazabicyclo(3.1.0)hexan-2-one
Reactive Oxygen Species
16 Citations (Scopus)

Pharmacokinetic analysis by high-performance liquid chromatography of intravenous nordihydroguaiaretic acid in the mouse

Lambert, J. D., Meyers, R. O., Timmermann, B. N. & Dorr, R. T., Apr 15 2001, In : Journal of Chromatography B: Biomedical Sciences and Applications. 754, 1, p. 85-90 6 p.

Research output: Contribution to journalArticle

Masoprocol
Pharmacokinetics
High performance liquid chromatography
Plasmas
Arachidonate 5-Lipoxygenase
76 Citations (Scopus)

Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia

Dorr, R. T., Karanes, C., Perry, C. S., Grogan, T., Greer, J., Moore, J., Weinberger, B., Schiller, G., Pearce, T., Litchman, M., Dalton, W., Roe, D. & List, A. F., Mar 15 2001, In : Journal of Clinical Oncology. 19, 6, p. 1589-1599 11 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Daunorubicin
Acute Myeloid Leukemia
Maximum Tolerated Dose
Cytarabine
347 Citations (Scopus)

Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and Polyphenon E

Chow, H-H., Cai, Y., Alberts, D. S., Hakim, I. A., Dorr, R. T., Shahi, F., Crowell, J. A., Yang, C. S. & Hara, Y., 2001, In : Cancer Epidemiology Biomarkers and Prevention. 10, 1, p. 53-58 6 p.

Research output: Contribution to journalArticle

Polyphenols
Tea
Pharmacokinetics
Catechin
Area Under Curve
16 Citations (Scopus)

Preclinical antitumor activity of the azonafide series of anthracene-based DNA intercalators

Dorr, R. T., Liddil, J. D., Sami, S. M., Remers, W., Hersh, E. M. & Alberts, D. S., 2001, In : Anti-Cancer Drugs. 12, 3, p. 213-220 8 p.

Research output: Contribution to journalArticle

Intercalating Agents
Adenosine Monophosphate
DNA
Lung Neoplasms
Neoplasms
5 Citations (Scopus)
Carboplatin
Paclitaxel
Combination Drug Therapy
Ovarian Neoplasms
Lung Neoplasms
52 Citations (Scopus)

tetra-O-Methylnordihydroguaiaretic acid inhibits melanoma in vivo

Lambert, J. D., Meyers, R. O., Timmermann, B. N. & Dorr, R. T., Aug 28 2001, In : Cancer Letters. 171, 1, p. 47-56 10 p.

Research output: Contribution to journalArticle

Masoprocol
Melanoma
Lignans
G2 Phase
Growth
2000
60 Citations (Scopus)

Analogues of amonafide and azonafide with novel ring systems

Sami, S. M., Dorr, R. T., Alberts, D. S., Solyom, A. M. & Remers, W. A., Aug 10 2000, In : Journal of Medicinal Chemistry. 43, 16, p. 3067-3073 7 p.

Research output: Contribution to journalArticle

amonafide
Tumors
Anthracenes
Cells
Chromophores
Ifosfamide
Carboplatin
Granulocyte Colony-Stimulating Factor
Doxorubicin
Area Under Curve
28 Citations (Scopus)

Approaches to reducing toxicity of parenteral anticancer drug formulations using cyclodextrins

Bhardwaj, R., Dorr, R. T. & Blanchard, J., May 2000, In : PDA Journal of Pharmaceutical Science and Technology. 54, 3, p. 233-239 7 p.

Research output: Contribution to journalArticle

Drug Compounding
Cyclodextrins
Mitomycin
Mannitol
Skin
78 Citations (Scopus)

Chemoprevention of human actinic keratoses by topical 2-(Difluoromethyl)-dl-ornithine

Alberts, D. S., Dorr, R. T., Einspahr, J. G., Aickin, M., Saboda, K., Xu, M. J., Peng, Y. M., Goldman, R., Foote, J. A., Warneke, J. A., Salasche, S., Roe, D. & Bowden, G. T., 2000, In : Cancer Epidemiology Biomarkers and Prevention. 9, 12, p. 1281-1286 6 p.

Research output: Contribution to journalArticle

Eflornithine
Actinic Keratosis
Ornithine
Chemoprevention
Forearm
6 Citations (Scopus)
Research Personnel
Clinical Trials
Education
Lung
Skin
19 Citations (Scopus)

Dermal toxicity of topical (-)epigallocatechin-3-gallate in BALB/c and SKH1 mice

Stratton, S. P., Bangert, J. L., Alberts, D. S. & Dorr, R. T., Sep 29 2000, In : Cancer Letters. 158, 1, p. 47-52 6 p.

Research output: Contribution to journalArticle

Skin
Ointments
Hair Removal
Hairless Mouse
Tea
25 Citations (Scopus)

Design of cancer-specific antitumor agents based on aziridinylcyclopent[b]indoloquinones

Xing, C., Wu, P., Skibo, E. B. & Dorr, R. T., Feb 10 2000, In : Journal of Medicinal Chemistry. 43, 3, p. 457-466 10 p.

Research output: Contribution to journalArticle

Indolequinones
Antineoplastic Agents
NAD(P)H Dehydrogenase (Quinone)
Indoles
Alkylation
15 Citations (Scopus)

Development and testing of an improved parenteral formulation of phenytoin using 2-hydroxypropyl-β-cyclodextrin

Blanchard, J., Ugwu, S. O., Bhardwaj, R. & Dorr, R. T., 2000, In : Pharmaceutical Development and Technology. 5, 3, p. 333-338 6 p.

Research output: Contribution to journalArticle

Cyclodextrins
Phenytoin
Solubility
Injections
125 Citations (Scopus)

Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction

Wessells, H., Gralnek, D., Dorr, R. T., Hruby, V. J., Hadley, M. E. & Levine, N., Oct 2000, In : Urology. 56, 4, p. 641-646 6 p.

Research output: Contribution to journalArticle

Penile Erection
alpha-MSH
Erectile Dysfunction
Placebos
Nausea
48 Citations (Scopus)

Increased eumelanin expression and tanning is induced by a superpotent melanotropin [Nle4-D-Phe7]-α-MSH in humans

Dorr, R. T., Dvorakova, K., Brooks, C., Lines, R., Levine, N., Schram, K., Miketova, P., Hruby, V. J. & Alberts, D. S., Oct 1 2000, In : Photochemistry and Photobiology. 72, 4, p. 526-532 7 p.

Research output: Contribution to journalArticle

Tanning
forearm
Melanocyte-Stimulating Hormones
Skin
Forearm
72 Citations (Scopus)

Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon

Dvorakova, K., Payne, C. M., Tome, M. E., Briehl, M. M., McClure, T. & Dorr, R. T., Sep 15 2000, In : Biochemical Pharmacology. 60, 6, p. 749-758 10 p.

Research output: Contribution to journalArticle

Oxidative stress
Oxidative Stress
Apoptosis
Cytotoxicity
Sulfhydryl Compounds
84 Citations (Scopus)

Melanocortin receptor agonists, penile erection, and sexual motivation: Human studies Melanotan II

Wessells, H., Levine, N., Hadley, M. E., Dorr, R. T., Hruby, V. J., Broderick & Nehra, 2000, In : International Journal of Impotence Research. 12, SUPPL. 4

Research output: Contribution to journalArticle

Melanocortin Receptors
Penile Erection
Erectile Dysfunction
Nausea
Yawning
10 Citations (Scopus)

Pharmacologic response of a controlled-release PLGA formulation for the alpha-melanocyte stimulating hormone analog, Melanotan-I

Bhardwaj, R., Hadley, M. E., Dorr, R. T., Dvorakova, K., Brooks, C. & Blanchard, J., 2000, In : Pharmaceutical Research. 17, 5, p. 593-599 7 p.

Research output: Contribution to journalArticle

alpha-MSH
Skin
Pigmentation
Anura
Skin Pigmentation
84 Citations (Scopus)

The state-of-the-art in chemoprevention of skin cancer

Stratton, S. P., Dorr, R. T. & Alberts, D. S., Jun 2000, In : European Journal of Cancer. 36, 10, p. 1292-1297 6 p.

Research output: Contribution to journalArticle

Chemoprevention
Skin Neoplasms
Melanoma
perilla alcohol
Biomarkers
1999
29 Citations (Scopus)

Dosing considerations with amifostine: A review of the literature and clinical experience

Dorr, R. T. & Holmes, B. C., 1999, In : Seminars in Oncology. 26, 2 SUPPL. 7, p. 108-119 12 p.

Research output: Contribution to journalArticle

Amifostine
Cytoprotection
Hypocalcemia
Myelodysplastic Syndromes
Hematopoiesis
13 Citations (Scopus)

Effects of a potent synthetic melanotropin, Nle4-D-Phe7-α-MSH (Melanotan-I) on tanning: A dose-ranging study

Levine, N., Dorr, R. T., Ertl, G. A., Brooks, C. & Alberts, D. S., 1999, In : Journal of Dermatological Treatment. 10, 2, p. 127-132 6 p.

Research output: Contribution to journalArticle

Tanning
Melanocyte-Stimulating Hormones
Skin Pigmentation
Chin
Skin
3 Citations (Scopus)
Confocal Microscopy
Pharmaceutical Preparations
Cricetulus
azonafide
In Vitro Techniques
17 Citations (Scopus)

Novel antitumor 2-cyanoaziridine-1-carboxamides

Iyengar, B. S., Dorr, R. T., Alberts, D. S., Hersh, E. M., Salmon, S. E. & Remers, W. A., 1999, In : Journal of Medicinal Chemistry. 42, 3, p. 510-514 5 p.

Research output: Contribution to journalArticle

Tumors
Isocyanates
Mitoxantrone
Cell culture
Doxorubicin
80 Citations (Scopus)

Pharmacokinetics of the green tea derivative, EGCG, by the topical route of administration in mouse and human skin

Dvorakova, K., Dorr, R. T., Valcic, S., Timmermann, B. & Alberts, D. S., 1999, In : Cancer Chemotherapy and Pharmacology. 43, 4, p. 331-335 5 p.

Research output: Contribution to journalArticle

Topical Administration
Pharmacokinetics
Tea
Skin
Derivatives
96 Citations (Scopus)
Dimethyl Sulfoxide
Doxorubicin
Refractory materials
Chemotherapy
Cytarabine
1998
7 Citations (Scopus)

Analytical and biological inequivalence of two commercial formulations of the antitumor agent bleomycin

Dorr, R. T., Meyers, R., Snead, K. & Liddil, J. D., 1998, In : Cancer Chemotherapy and Pharmacology. 42, 2, p. 149-154 6 p.

Research output: Contribution to journalArticle

Bleomycin
Antineoplastic Agents
Tumors
Bearings (structural)
Leukemia L1210
25 Citations (Scopus)

A phase I/II trial of paclitaxel for non-Hodgkin's lymphoma followed by paclitaxel plus quinine in drug-resistant disease

Miller, T. P., Chase, E. M., Dorr, R. T., Dalton, W. S., Lam, K. S. & Salmon, S. E., 1998, In : Anti-Cancer Drugs. 9, 2, p. 135-140 6 p.

Research output: Contribution to journalArticle

Quinine
Paclitaxel
Non-Hodgkin's Lymphoma
Pharmaceutical Preparations
Pharmacokinetics
4 Citations (Scopus)

Correlation of cytotoxicity and protein-associated DNA strand breaks for 2-(arylmethylamino)-1,3-propanediols

Dorr, R. T., Bellamy, W., Liddil, J. D., Baker, A. F. & Bair, K. W., Oct 1998, In : Anti-Cancer Drug Design. 13, 7, p. 825-835 11 p.

Research output: Contribution to journalArticle

DNA Breaks
Cytotoxicity
DNA
Assays
Type II DNA Topoisomerase
27 Citations (Scopus)

Discovery and development of novel melanogenic drugs. Melanotan-I and -II.

Hadley, M. E., Hruby, V. J., Blanchard, J., Dorr, R. T., Levine, N., Dawson, B. V., al-Obeidi, F. & Sawyer, T. K., 1998, In : Pharmaceutical Biotechnology. 11, p. 575-595 21 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Anticarcinogenic Agents
alpha-MSH
Cyclic Peptides
Drug Design
8 Citations (Scopus)

Identification and characterization of in vitro metabolites of 2-[2'- (dimethylamino)ethyl]-1,2-dihydro-3h-dibenz[de,h]isoquinoline-1,3-dione (azonafide)

Mayr, C. A., Sami, S. M., Remers, W. A. & Dorr, R. T., Feb 1998, In : Drug Metabolism and Disposition. 26, 2, p. 105-109 5 p.

Research output: Contribution to journalArticle

Metabolites
Type II DNA Topoisomerase
Carboxylic Acids
Oxides
amonafide
54 Citations (Scopus)

New perspectives on an old friend: Optimizing carboplatin for the treatment of solid tumors

Alberts, D. S. & Dorr, R. T., 1998, In : Oncologist. 3, 1, p. 15-34 20 p.

Research output: Contribution to journalArticle

Carboplatin
Neoplasms
Body Surface Area
Therapeutics
Cisplatin
39 Citations (Scopus)

Radioprotectants: Pharmacology and clinical applications of amifostine

Dorr, R. T., 1998, In : Seminars in Radiation Oncology. 8, 4 SUPPL. 1, p. 10-13 4 p.

Research output: Contribution to journalArticle

pharmacology
Amifostine
Clinical Pharmacology
radiation
Radiation
160 Citations (Scopus)

Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: Double-blind, placebo controlled crossover study

Wessells, H., Fuciarelli, K., Hansen, J., Hadley, M. E., Hruby, V. J., Dorr, R. T. & Levine, N., Aug 1998, In : Journal of Urology. 160, 2, p. 389-393 5 p.

Research output: Contribution to journalArticle

Erectile Dysfunction
Cross-Over Studies
Placebos
Peptides
Yawning
1997
25 Citations (Scopus)

1,4-disubstituted anthracene antitumor agents

Iyengar, B. S., Dorr, R. T., Alberts, D. S., Sólyom, A. M., Krutzsch, M. & Remers, W. A., 1997, In : Journal of Medicinal Chemistry. 40, 23, p. 3734-3738 5 p.

Research output: Contribution to journalArticle

Hydrazones
Anthracenes
Antineoplastic Agents
Tumors
Cells
1 Citation (Scopus)

Clinical pharmacology of taxanes as radiosensitizers and the thiol- based radioprotectant amifostine

Dorr, R. T., 1997, In : Seminars in Radiation Oncology. 7, 3 SUPPL. 2, p. 66-76 11 p.

Research output: Contribution to journalArticle

pharmacology
Amifostine
Taxoids
Clinical Pharmacology
Paclitaxel
34 Citations (Scopus)
Quinine
Vincristine
Verapamil
Combination Drug Therapy
Doxorubicin
60 Citations (Scopus)

Human tumor models in the severe combined immune deficient (scid) mouse

Paine-Murrieta, G. D., Taylor, C. W., Curtis, R. A., Lopez, M. H. A., Dorr, R. T., Johnson, C. S., Funk, C. Y., Thompson, F. & Hersh, E. M., 1997, In : Cancer Chemotherapy and Pharmacology. 40, 3, p. 209-214 6 p.

Research output: Contribution to journalArticle

Tumors
Carmustine
Melanoma
Cyclophosphamide
Growth
8 Citations (Scopus)

Inhibition of intracellular Ca2+ signalling, cytotoxicity and antitumor activity of the herbicide oryzalin and its analogues

Powis, G., Gallegos, A., Abraham, R. T., Ashendel, C. L., Zalkow, L. H., Dorr, R. T., Dvorakova, K., Salmon, S., Harrison, S. & Worzalla, J., 1997, In : Cancer Chemotherapy and Pharmacology. 41, 1, p. 22-28 7 p.

Research output: Contribution to journalArticle

Herbicides
Cytotoxicity
Inhibitory Concentration 50
Tumors
Cells
13 Citations (Scopus)
Type II DNA Topoisomerase
Cricetulus
DNA Damage
Ovary
amonafide
8 Citations (Scopus)

Pharmacokinetic studies of the herbicide and antitumor compound oryzalin in mice

Dvorakova, K., Dorr, R. T., Gallegos, A., McClure, T. & Powis, G., Aug 29 1997, In : Journal of Chromatography B: Biomedical Applications. 696, 2, p. 275-281 7 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Herbicides
Metabolites
Plasmas
Animals
35 Citations (Scopus)

Pharmacology of the taxanes

Dorr, R. T., Sep 1997, In : Pharmacotherapy. 17, 5 II SUPPL.

Research output: Contribution to journalArticle

docetaxel
Taxoids
Paclitaxel
Pharmacology
Cytochrome P-450 Enzyme System
32 Citations (Scopus)

Skin pigmentation and pharmacokinetics of melanotan-I in humans

Ugwu, S. O., Blanchard, J., Dorr, R. T., Levine, N., Brooks, C., Hadley, M. E., Aickin, M. & Hruby, V. J., 1997, In : Biopharmaceutics and Drug Disposition. 18, 3, p. 259-269 11 p.

Research output: Contribution to journalArticle

Tanning
Skin Pigmentation
Pharmacokinetics
Forehead
Pharmaceutical Preparations