Robert T Dorr

  • 9226 Citations
  • 49 h-Index
1976 …2016

Research output per year

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Research Output

  • 9226 Citations
  • 49 h-Index
  • 220 Article
  • 7 Letter
  • 7 Review article
  • 5 Comment/debate
2001

A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated L-asparaginase in patients with advanced solid tumors

Taylor, C. W., Dorr, R. T., Fanta, P., Hersh, E. M. & Salmon, S. E., Jul 31 2001, In : Cancer Chemotherapy And Pharmacology. 47, 1, p. 83-88 6 p.

Research output: Contribution to journalArticle

39 Scopus citations
84 Scopus citations

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: A Southwest Oncology Group study

List, A. F., Kopecky, K. J., Willman, C. L., Head, D. R., Persons, D. L., Slovak, M. L., Dorr, R., Karanes, C., Hynes, H. E., Doroshow, J. H., Shurafa, M. & Appelbaum, F. R., Dec 1 2001, In : Blood. 98, 12, p. 3212-3220 9 p.

Research output: Contribution to journalArticle

334 Scopus citations

Design and synthesis of a novel DNA-DNA interstrand adenine-guanine cross-linking agent [1]

Zhou, Q., Duan, W., Simmons, D., Shayo, Y., Raymond, M. A., Dorr, R. T. & Hurley, L. H., Oct 6 2001, In : Journal of the American Chemical Society. 123, 20, p. 4865-4866 2 p.

Research output: Contribution to journalLetter

38 Scopus citations

Drug interactions with the taxanes: Clinical implications

Baker, A. F. & Dorr, R. T., Jan 1 2001, In : Cancer Treatment Reviews. 27, 4, p. 221-233 13 p.

Research output: Contribution to journalArticle

48 Scopus citations

Induction of mitochondrial changes in myeloma cells by imexon

Dvorakova, K., Waltmire, C. N., Payne, C. M., Tome, M. E., Briehl, M. M. & Dorr, R. T., Jun 1 2001, In : Blood. 97, 11, p. 3544-3551 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

Pharmacokinetic analysis by high-performance liquid chromatography of intravenous nordihydroguaiaretic acid in the mouse

Lambert, J. D., Meyers, R. O., Timmermann, B. N. & Dorr, R. T., Apr 15 2001, In : Journal of Chromatography B: Biomedical Sciences and Applications. 754, 1, p. 85-90 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia

Dorr, R., Karanes, C., Spier, C., Grogan, T., Greer, J., Moore, J., Weinberger, B., Schiller, G., Pearce, T., Litchman, M., Dalton, W., Roe, D. & List, A. F., Mar 15 2001, In : Journal of Clinical Oncology. 19, 6, p. 1589-1599 11 p.

Research output: Contribution to journalArticle

76 Scopus citations

Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and Polyphenon E

Chow, H. H. S., Cai, Y., Alberts, D. S., Hakim, I., Dorr, R., Shahi, F., Crowell, J. A., Yang, C. S. & Hara, Y., Jan 1 2001, In : Cancer Epidemiology Biomarkers and Prevention. 10, 1, p. 53-58 6 p.

Research output: Contribution to journalArticle

354 Scopus citations

Preclinical antitumor activity of the azonafide series of anthracene-based DNA intercalators

Dorr, R. T., Liddil, J. D., Sami, S. M., Remers, W., Hersh, E. M. & Alberts, D. S., Apr 17 2001, In : Anti-cancer drugs. 12, 3, p. 213-220 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
5 Scopus citations

tetra-O-Methylnordihydroguaiaretic acid inhibits melanoma in vivo

Lambert, J. D., Meyers, R. O., Timmermann, B. N. & Dorr, R. T., Aug 28 2001, In : Cancer Letters. 171, 1, p. 47-56 10 p.

Research output: Contribution to journalArticle

54 Scopus citations
2000

Analogues of amonafide and azonafide with novel ring systems

Sami, S. M., Dorr, R. T., Alberts, D. S., Solyom, A. M. & Remers, W. A., Aug 10 2000, In : Journal of Medicinal Chemistry. 43, 16, p. 3067-3073 7 p.

Research output: Contribution to journalArticle

60 Scopus citations

A phase I trial of AUC-directed carboplatin with infusional doxorubicin and ifosfamide plus G-CSF in patients with advanced gynecologic malignancies

Lopez, A. M., Ketchum, M., Nichols, H., Xu, M. J., Peng, Y. M., Dorr, R. & Alberts, D. S., Jan 1 2000, In : Cancer Chemotherapy And Pharmacology. 46, 5, p. 411-415 5 p.

Research output: Contribution to journalArticle

Approaches to reducing toxicity of parenteral anticancer drug formulations using cyclodextrins

Bhardwaj, R., Dorr, R. T. & Blanchard, J., May 1 2000, In : PDA Journal of Pharmaceutical Science and Technology. 54, 3, p. 233-239 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Chemoprevention of human actinic keratoses by topical 2-(Difluoromethyl)-dl-ornithine

Alberts, D. S., Dorr, R. T., Einspahr, J. G., Aickin, M., Saboda, K., Xu, M. J., Peng, Y. M., Goldman, R., Foote, J. A., Warneke, J. A., Salasche, S., Roe, D. J. & Bowden, G. T., Dec 1 2000, In : Cancer Epidemiology Biomarkers and Prevention. 9, 12, p. 1281-1286 6 p.

Research output: Contribution to journalArticle

79 Scopus citations
6 Scopus citations

Dermal toxicity of topical (-)epigallocatechin-3-gallate in BALB/c and SKH1 mice

Stratton, S. P., Bangert, J. L., Alberts, D. S. & Dorr, R. T., Sep 29 2000, In : Cancer Letters. 158, 1, p. 47-52 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Design of cancer-specific antitumor agents based on aziridinylcyclopent[b]indoloquinones

Xing, C., Wu, P., Skibo, E. B. & Dorr, R. T., Feb 10 2000, In : Journal of Medicinal Chemistry. 43, 3, p. 457-466 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Development and testing of an improved parenteral formulation of phenytoin using 2-hydroxypropyl-β-cyclodextrin

Blanchard, J., Ugwu, S. O., Bhardwaj, R. & Dorr, R. T., Aug 15 2000, In : Pharmaceutical Development and Technology. 5, 3, p. 333-338 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction

Wessells, H., Gralnek, D., Dorr, R., Hruby, V. J., Hadley, M. E. & Levine, N., Oct 1 2000, In : Urology. 56, 4, p. 641-646 6 p.

Research output: Contribution to journalArticle

126 Scopus citations

Increased eumelanin expression and tanning is induced by a superpotent melanotropin [Nle4-D-Phe7]-α-MSH in humans

Dorr, R. T., Dvorakova, K., Brooks, C., Lines, R., Levine, N., Schram, K., Miketova, P., Hruby, V. & Alberts, D. S., Oct 1 2000, In : Photochemistry and Photobiology. 72, 4, p. 526-532 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon

Dvorakova, K., Payne, C. M., Tome, M. E., Briehl, M. M., McClure, T. & Dorr, R. T., Sep 15 2000, In : Biochemical Pharmacology. 60, 6, p. 749-758 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

Melanocortin receptor agonists, penile erection, and sexual motivation: Human studies with Melanotan II

Wessells, H., Levine, N., Hadley, M. E., Dorr, R. & Hruby, V., Oct 1 2000, In : International Journal of Impotence Research. 12, p. S74-S79

Research output: Contribution to journalArticle

Open Access
89 Scopus citations

Pharmacologic response of a controlled-release PLGA formulation for the alpha-melanocyte stimulating hormone analog, Melanotan-I

Bhardwaj, R., Hadley, M. E., Dorr, R. T., Dvorakova, K., Brooks, C. & Blanchard, J., Jul 10 2000, In : Pharmaceutical Research. 17, 5, p. 593-599 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

The state-of-the-art in chemoprevention of skin cancer

Stratton, S. P., Dorr, R. T. & Alberts, D. S., Jun 1 2000, In : European Journal of Cancer. 36, 10, p. 1292-1297 6 p.

Research output: Contribution to journalArticle

85 Scopus citations
1999

Dosing considerations with amifostine: A review of the literature and clinical experience

Dorr, R. T. & Holmes, B. C., Jun 7 1999, In : Seminars in Oncology. 26, 2 SUPPL. 7, p. 108-119 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Effects of a potent synthetic melanotropin, Nle4-D-Phe7-α-MSH (Melanotan-I) on tanning: A dose-ranging study

Levine, N., Dorr, R. T., Ertl, G. A., Brooks, C. & Alberts, D. S., Jan 1 1999, In : Journal of Dermatological Treatment. 10, 2, p. 127-132 6 p.

Research output: Contribution to journalArticle

14 Scopus citations
3 Scopus citations

Novel antitumor 2-cyanoaziridine-1-carboxamides

Iyengar, B. S., Dorr, R. T., Alberts, D. S., Hersh, E. M., Salmon, S. E. & Remers, W. A., Feb 24 1999, In : Journal of Medicinal Chemistry. 42, 3, p. 510-514 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Pharmacokinetics of the green tea derivative, EGCG, by the topical route of administration in mouse and human skin

Dvorakova, K., Dorr, R. T., Valcic, S., Timmermann, B. & Alberts, D. S., Feb 17 1999, In : Cancer Chemotherapy And Pharmacology. 43, 4, p. 331-335 5 p.

Research output: Contribution to journalArticle

84 Scopus citations

Topical DMSO treatment for pegylated liposomal doxorubicin-induced palmar-plantar erythrodysesthesia

Lopez, A. M., Wallace, L., Dorr, R. T., Koff, M., Hersh, E. M. & Alberts, D. S., Sep 2 1999, In : Cancer Chemotherapy And Pharmacology. 44, 4, p. 303-306 4 p.

Research output: Contribution to journalArticle

98 Scopus citations
1998

Analytical and biological inequivalence of two commercial formulations of the antitumor agent bleomycin

Dorr, R. T., Meyers, R., Snead, K. & Liddil, J. D., Jun 22 1998, In : Cancer Chemotherapy And Pharmacology. 42, 2, p. 149-154 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

A phase I/II trial of paclitaxel for non-Hodgkin's lymphoma followed by paclitaxel plus quinine in drug-resistant disease

Miller, T. P., Chase, E. M., Dorr, R., Dalton, W. S., Lam, K. S. & Salmon, S. E., Jan 1 1998, In : Anti-cancer drugs. 9, 2, p. 135-140 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Correlation of cytotoxicity and protein-associated DNA strand breaks for 2-(arylmethylamino)-1,3-propanediols

Dorr, R. T., Bellamy, W., Liddil, J. D., Baker, A. & Bair, K. W., Oct 1 1998, In : Anti-Cancer Drug Design. 13, 7, p. 825-835 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Discovery and development of novel melanogenic drugs. Melanotan-I and -II.

Hadley, M. E., Hruby, V. J., Blanchard, J., Dorr, R. T., Levine, N., Dawson, B. V., al-Obeidi, F. & Sawyer, T. K., 1998, In : Pharmaceutical biotechnology. 11, p. 575-595 21 p.

Research output: Contribution to journalReview article

27 Scopus citations

Identification and characterization of in vitro metabolites of 2-[2'- (dimethylamino)ethyl]-1,2-dihydro-3h-dibenz[de,h]isoquinoline-1,3-dione (azonafide)

Mayr, C. A., Sami, S. M., Remers, W. A. & Dorr, R. T., Feb 1 1998, In : Drug Metabolism and Disposition. 26, 2, p. 105-109 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

New perspectives on an old friend: Optimizing carboplatin for the treatment of solid tumors

Alberts, D. S. & Dorr, R. T., 1998, In : Oncologist. 3, 1, p. 15-34 20 p.

Research output: Contribution to journalArticle

Open Access
57 Scopus citations

Radioprotectants: Pharmacology and clinical applications of amifostine

Dorr, R. T., Nov 5 1998, In : Seminars in Radiation Oncology. 8, 4 SUPPL. 1, p. 10-13 4 p.

Research output: Contribution to journalArticle

40 Scopus citations

Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: Double-blind, placebo controlled crossover study

Wessells, H., Fuciarelli, K., Hansen, J., Hadley, M. E., Hruby, V. J., Dorr, R. & Levine, N., Aug 1998, In : Journal of Urology. 160, 2, p. 389-393 5 p.

Research output: Contribution to journalArticle

162 Scopus citations
1997

1,4-disubstituted anthracene antitumor agents

Iyengar, B. S., Dorr, R. T., Alberts, D. S., Sólyom, A. M., Krutzsch, M. & Remers, W. A., Nov 20 1997, In : Journal of Medicinal Chemistry. 40, 23, p. 3734-3738 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Clinical pharmacology of taxanes as radiosensitizers and the thiol- based radioprotectant amifostine

Dorr, R. T., Jan 1 1997, In : Seminars in Radiation Oncology. 7, 3 SUPPL. 2, p. 66-76 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Combination chemotherapy with cyclophosphamide, vincristine, adriamycin, and dexamethasone (CVAD) plus oral quinine and verapamil in patients with advanced breast cancer

Taylor, C. W., Dalton, W. S., Mosley, K., Dorr, R. T. & Salmon, S. E., Feb 11 1997, In : Breast Cancer Research and Treatment. 42, 1, p. 7-14 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Human tumor models in the severe combined immune deficient (scid) mouse

Paine-Murrieta, G. D., Taylor, C. W., Curtis, R. A., Lopez, M. H. A., Dorr, R. T., Johnson, C. S., Funk, C. Y., Thompson, F. & Hersh, E. M., Jul 1 1997, In : Cancer Chemotherapy And Pharmacology. 40, 3, p. 209-214 6 p.

Research output: Contribution to journalArticle

61 Scopus citations

Inhibition of intracellular Ca2+ signalling, cytotoxicity and antitumor activity of the herbicide oryzalin and its analogues

Powis, G., Gallegos, A., Abraham, R. T., Ashendel, C. L., Zalkow, L. H., Dorr, R., Dvorakova, K., Salmon, S., Harrison, S. & Worzalla, J., Dec 1 1997, In : Cancer Chemotherapy And Pharmacology. 41, 1, p. 22-28 7 p.

Research output: Contribution to journalArticle

8 Scopus citations
13 Scopus citations

Pharmacokinetic studies of the herbicide and antitumor compound oryzalin in mice

Dvorakova, K., Dorr, R. T., Gallegos, A., McClure, T. & Powis, G., Aug 29 1997, In : Journal of Chromatography B: Biomedical Applications. 696, 2, p. 275-281 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pharmacology of the taxanes

Dorr, R. T., Sep 1 1997, In : Pharmacotherapy. 17, 5 II SUPPL., p. 96S-104S

Research output: Contribution to journalArticle

36 Scopus citations

Skin pigmentation and pharmacokinetics of melanotan-I in humans

Ugwu, S. O., Blanchard, J., Dorr, R. T., Levine, N., Brooks, C., Hadley, M. E., Aickin, M. & Hruby, V. J., Apr 1997, In : Biopharmaceutics and Drug Disposition. 18, 3, p. 259-269 11 p.

Research output: Contribution to journalArticle

32 Scopus citations