Robert T Dorr

  • 9048 Citations
  • 49 h-Index
1976 …2021
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Research Output 1976 2016

  • 9048 Citations
  • 49 h-Index
  • 236 Article
  • 3 Chapter
1997
16 Citations (Scopus)

Skin ulceration potential of paclitaxel in a mouse skin model in vivo [3]

Bertelli, G., Cafferata, M. A., Ardizzoni, A., Gozza, A., Rosso, R., Dini, D. & Dorr, R. T., 1997, In : Cancer. 79, 11, p. 2266-2269 4 p.

Research output: Contribution to journalArticle

Phytogenic Antineoplastic Agents
Extravasation of Diagnostic and Therapeutic Materials
Skin Ulcer
Taxoids
Hyaluronoglucosaminidase
1996
35 Citations (Scopus)
Quantitative Structure-Activity Relationship
Tumors
Cells
Leukemia L1210
Cytotoxicity
29 Citations (Scopus)
Quantitative Structure-Activity Relationship
Cells
Tumors
Leukemia L1210
Mitoxantrone
59 Citations (Scopus)

Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor

Dorr, R. T., Dvorakova, K., Snead, K., Alberts, D. S., Salmon, S. E. & Pettit, G. R., 1996, In : Investigational New Drugs. 14, 2, p. 131-137 7 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Biological Products
Inhibitory Concentration 50
Melanoma
Neoplasms
39 Citations (Scopus)

Cardioprotection of rat heart myocytes with amifostine (Ethyol®) and its free thiol, WR-1065, in vitro

Dorr, R. T., Lagel, K. & McLean, S., 1996, In : European Journal of Cancer. 32, SUPPL. 4

Research output: Contribution to journalArticle

Amifostine
Sulfhydryl Compounds
Muscle Cells
Doxorubicin
In Vitro Techniques
130 Citations (Scopus)

Cytoprotective agents for anthracyclines

Dorr, R. T., 1996, In : Seminars in Oncology. 23, 4 SUPPL. 8, p. 23-34 12 p.

Research output: Contribution to journalArticle

Amifostine
Anthracyclines
Doxorubicin
Dexrazoxane
Superoxides
50 Citations (Scopus)
Oxidants
Dexamethasone
Catalase
Antioxidants
Apoptosis
53 Citations (Scopus)

Disposition and metabolism of topically administered α-tocopherol acetate: A common ingredient of commercially available sunscreens and cosmetics

Alberts, D. S., Goldman, R., Xu, M. J., Dorr, R. T., Quinn, J., Welch, K., Guillen-Rodriguez, J., Aickin, M., Peng, Y. M., Loescher, L. J. & Gensler, H., 1996, In : Nutrition and Cancer. 26, 2, p. 193-201 9 p.

Research output: Contribution to journalArticle

Sunscreening Agents
alpha-Tocopherol
cosmetics
tocopherols
Cosmetics
107 Citations (Scopus)

Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study

Dorr, R. T., Lines, R., Levine, N., Brooks, C., Xiang, L., Hruby, V. J. & Hadley, M. E., Apr 12 1996, In : Life Sciences. 58, 20, p. 1777-1784 8 p.

Research output: Contribution to journalArticle

Cyclic Peptides
Subcutaneous Injections
melanotan-II
Clinical Studies
Yawning
22 Citations (Scopus)

Liposomal amikacin: Improved treatment of Mycobacterium avium complex infection in the beige mouse model

Petersen, E. A., Grayson, J. B., Hersh, E. M., Dorr, R. T., Chiang, S. M., Oka, M. & Proffitt, R. T., 1996, In : Journal of Antimicrobial Chemotherapy. 38, 5, p. 819-828 10 p.

Research output: Contribution to journalArticle

Mycobacterium avium Complex
Amikacin
Infection
Mycobacterium avium
Therapeutics
116 Citations (Scopus)

Prevention of photocarcinogenesis by topical administration of pure epigallocatechin gallate isolated from green tea

Gensler, H. L., Timmermann, B. N., Valcic, S., Wächter, G. A., Dorr, R. T., Dvorakova, K. & Alberts, D. S., 1996, In : Nutrition and Cancer. 26, 3, p. 325-335 11 p.

Research output: Contribution to journalArticle

Topical Administration
epigallocatechin
green tea
Tea
mice
101 Citations (Scopus)

Safety of autotransplants with high-dose melphalan in renal failure: A pharmacokinetic and toxicity study

Tricot, G., Alberts, D. S., Johnson, C., Roe, D., Dorr, R. T., Bracy, D., Vesole, D. H., Jagannath, S., Meyers, R. & Barlogie, B., Jun 1996, In : Clinical Cancer Research. 2, 6, p. 947-952 6 p.

Research output: Contribution to journalArticle

Melphalan
Autografts
Renal Insufficiency
Pharmacokinetics
Safety
28 Citations (Scopus)

Skin ulceration potential of paclitaxel in a mouse skin model in vivo

Dorr, R. T., Snead, K. & Liddil, J. D., Jul 1 1996, In : Cancer. 78, 1, p. 152-156 5 p.

Research output: Contribution to journalArticle

Paclitaxel
Skin
Skin Ulcer
Hyaluronoglucosaminidase
Antidotes
1995
6 Citations (Scopus)

Absorption enhancement of melanotan-l: Comparison of the caco-2 and rat in situ models

Surendran, N., Ugwu, S. O., Nguyen, L. D., Sterling, E. J., Dorr, R. T. & Blanchard, J., 1995, In : Drug Delivery. 2, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

Aprotinin
Cyclodextrins
Biological Availability
Sodium
Protease Inhibitors
47 Citations (Scopus)
Quantitative Structure-Activity Relationship
amonafide
Tumors
Anthracenes
Leukemia P388
278 Citations (Scopus)

Anticancer drug renal toxicity and elimination: dosing guidelines for altered renal function

Kintzel, P. E. & Dorr, R. T., 1995, In : Cancer Treatment Reviews. 21, 1, p. 33-64 32 p.

Research output: Contribution to journalArticle

Drug-Related Side Effects and Adverse Reactions
Guidelines
Kidney
Pharmaceutical Preparations
Renal Elimination
13 Citations (Scopus)

Antidote studies of vinorelbine-induced skin ulceration in the mouse

Dorr, R. T. & Bool, K. L., Jul 1995, In : Cancer Chemotherapy and Pharmacology. 36, 4, p. 290-292 3 p.

Research output: Contribution to journalArticle

Antidotes
Skin
Hyaluronoglucosaminidase
hyaluronate lyase
Vinca Alkaloids
17 Citations (Scopus)

Preclinical pharmacokinetics and antitumor activity of imexon

Dorr, R. T., Liddil, J. D., Klein, M. K. & Hersh, E. M., Jun 1995, In : Investigational New Drugs. 13, 2, p. 113-116 4 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Pharmaceutical Preparations
Dogs
Leukemia L1210
Neoplasms
Mitomycin
Heparin
Glucose
Injections
Plastics
1994
7 Citations (Scopus)

A comparison of HPLC and bioassay methods for plasma melanotan-II (MT-II) determination: Application to a pharmacokinetic study in rats

Ugwu, S. O., Blanchard, J., Nguyen, L. D., Hadley, M. E. & Dorr, R. T., 1994, In : Biopharmaceutics and Drug Disposition. 15, 5, p. 383-390 8 p.

Research output: Contribution to journalArticle

Biological Assay
Pharmacokinetics
High Pressure Liquid Chromatography
Area Under Curve
Regression Analysis
8 Citations (Scopus)

Adult rat myocardial slices: A tool for studies of comparative cardiotoxicity

Parrish, A. R., Dorr, R. T., Gandolfi, A. J. & Brendel, K., 1994, In : Toxicology in Vitro. 8, 6, p. 1233-1237 5 p.

Research output: Contribution to journalArticle

Allylamine
Doxorubicin
Rats
Lipid Peroxidation
Adenosine Triphosphate
2 Citations (Scopus)

Biologic activity of a nucleotide conjugate between mitomycin C and cytarabine monophosphate

Dorr, R. T., Liddil, J. D., Iyengar, B. S., List, A. F. & Remers, W. A., 1994, In : Nucleosides and Nucleotides. 13, 8, p. 1655-1667 13 p.

Research output: Contribution to journalArticle

Cytarabine
Mitomycin
Bearings (structural)
Nucleotides
Antimetabolites
8 Citations (Scopus)

Coat color darkening in a dog in response to a potent melanotropic peptide.

Johnson, P. D., Dawson, B. V., Dorr, R. T., Hadley, M. E., Levine, N. & Hruby, V. J., Nov 1994, In : American Journal of Veterinary Research. 55, 11, p. 1593-1596 4 p.

Research output: Contribution to journalArticle

Hair
hairs
Color
melanocyte-stimulating hormone
Dogs
9 Citations (Scopus)
Allylamine
Coculture Techniques
Liver
Rabbits
Alcohols

Correction to cancer therapy protocols [4]

Dorr, R. T., 1994, In : American Journal of Hospital Pharmacy. 51, 21, p. 2727 1 p.

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Methylprednisolone
Etoposide
Non-Hodgkin's Lymphoma

Dosing error in protocol book [7]

Dorr, R. T. & Lauper, D., 1994, In : Journal of Clinical Oncology. 12, 11, p. 2520 1 p.

Research output: Contribution to journalArticle

Drug Dose Response Relationship
Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Methylprednisolone
Etoposide
20 Citations (Scopus)

Effect of doxorubicin on glutathione and glutathione-dependent enzymes in cultured rat heart cells

Paranka, N. S. & Dorr, R. T., 1994, In : Anticancer Research. 14, 5 A, p. 2047-2052 6 p.

Research output: Contribution to journalArticle

Doxorubicin
Glutathione
Enzymes
Carmustine
Glutathione Transferase
23 Citations (Scopus)
perfosfamide
Acrolein
Sulfhydryl Compounds
Muscle Cells
Glutathione
223 Citations (Scopus)

Enhancement of regression of cervical intraepithelial neoplasia II (moderate dysplasia) with topically applied all-/trans-retinoic Acid: A randomized trial

Meyskens, F. L., Surwit, E., Moon, T. E., Childers, J. M., Davis, J. R., Dorr, R. T., Johnson, C. S. & Alberts, D. S., Apr 6 1994, In : Journal of the National Cancer Institute. 86, 7, p. 539-543 5 p.

Research output: Contribution to journalArticle

Randomized Trial
Cervical Intraepithelial Neoplasia
Tretinoin
Fisher's Exact Test
Enhancement
3 Citations (Scopus)

Introduction

Koeller, J. M. & Dorr, R. T., 1994, In : Annals of Pharmacotherapy. 28, 5 SUPPL.

Research output: Contribution to journalArticle

225 Citations (Scopus)

Pharmacology and toxicology of Cremophor EL diluent

Dorr, R. T., 1994, In : Annals of Pharmacotherapy. 28, 5 SUPPL.

Research output: Contribution to journalArticle

Drug Hypersensitivity
Paclitaxel
Surface-Active Agents
Glycerol
Toxicology
1 Citation (Scopus)

Summary

Koeller, J. M. & Dorr, R. T., 1994, In : Annals of Pharmacotherapy. 28, 5 SUPPL.

Research output: Contribution to journalArticle

1993
64 Citations (Scopus)

2-Substituted 1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones. A new class of antitumor agent

Sami, S. M., Dorr, R. T., Alberts, D. S. & Remers, W. A., 1993, In : Journal of Medicinal Chemistry. 36, 6, p. 765-770 6 p.

Research output: Contribution to journalArticle

amonafide
Antineoplastic Agents
Nitrogen
lissamine rhodamine B
Cells
5 Citations (Scopus)

Administration of melanotropic peptides during gestation in the rodent

Dawson, B. V., Ford, C. A., Holloway, H., Dorr, R. T. & Johnson, P., Jan 29 1993, In : Toxicology. 77, 1-2, p. 91-101 11 p.

Research output: Contribution to journalArticle

Melanocyte-Stimulating Hormones
Rodentia
Pregnancy
Peptides
Fetal Development
31 Citations (Scopus)

Characterization of experimental mitoxantrone cardiotoxicity and its partial inhibition by ICRF-187 in cultured neonatal rat heart cells

Shipp, N. G., Dorr, R. T., Alberts, D. S., Dawson, B. V. & Hendrix, M., Feb 1 1993, In : Cancer Research. 53, 3, p. 550-556 7 p.

Research output: Contribution to journalArticle

Dexrazoxane
Mitoxantrone
Muscle Cells
Metals
Cardiotoxicity
70 Citations (Scopus)
Granulocyte-Macrophage Colony-Stimulating Factor
Yeasts
Escherichia coli
Pharmacokinetics
Bacteria
35 Citations (Scopus)

Extravasation injury with nonionic contrast material [1]

Memolo, M., Dyer, R., Zagoria, R. J., Pond, G. D. & Dorr, R. T., 1993, In : American Journal of Roentgenology. 160, 1, p. 203-204 2 p.

Research output: Contribution to journalArticle

Extravasation of Diagnostic and Therapeutic Materials
Iohexol
Forearm
Contrast Media
Wounds and Injuries
136 Citations (Scopus)

Interferon-α in malignant and viral diseases: A review

Dorr, R. T., Feb 1993, In : Drugs. 45, 2, p. 177-211 35 p.

Research output: Contribution to journalArticle

Virus Diseases
Interferons
Renal Cell Carcinoma
Antiviral Agents
Hepatitis C
33 Citations (Scopus)

Melanotropic peptides for therapeutic and cosmetic tanning of the skin

Hadley, M. E., Sharma, S. D., Hruby, V. J., Levine, N. & Dorr, R. T., 1993, In : Annals of the New York Academy of Sciences. 680, p. 424-439 16 p.

Research output: Contribution to journalArticle

Tanning
Melanocyte-Stimulating Hormones
Cosmetics
Skin
Peptides
291 Citations (Scopus)

Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia

List, A. F., Perry, C. S., Greer, J., Wolff, S., Hutter, J., Dorr, R. T., Salmon, S., Futscher, B. W., Baier, M. & Dalton, W., 1993, In : Journal of Clinical Oncology. 11, 9, p. 1652-1660 9 p.

Research output: Contribution to journalArticle

Cyclosporine
Leukemia
Drug Therapy
Daunorubicin
Hyperbilirubinemia
23 Citations (Scopus)

The effect of anticancer drug sequence in experimental combination chemotherapy

Adel, A. L., Dorr, R. T. & Liddil, J. D., 1993, In : Cancer Investigation. 11, 1, p. 15-24 10 p.

Research output: Contribution to journalArticle

Drug Combinations
Combination Drug Therapy
Pharmaceutical Preparations
Bleomycin
Etoposide
1992
33 Citations (Scopus)

Antiproliferative and antitumor activity of the 2-cyanoaziridine compound imexon on tumor cell lines and fresh tumor cells in vitro

Hersh, E. M., Gschwind, C. R., Taylor, C. W., Dorr, R. T., Taetle, R. & Salmon, S. E., Aug 19 1992, In : Journal of the National Cancer Institute. 84, 16, p. 1238-1244 7 p.

Research output: Contribution to journalArticle

Tumor Cell Line
Tumors
Tumor
Cells
Line
77 Citations (Scopus)

Bleomycin pharmacology: Mechanism of action and resistance, and clinical pharmacokinetics

Dorr, R. T., 1992, In : Seminars in Oncology. 19, 2 SUPPL. 5, p. 3-8 6 p.

Research output: Contribution to journalArticle

Bleomycin
Iron
Pharmacokinetics
Pharmacology
Free Radicals
4 Citations (Scopus)

Cardiotoxicity of mitomycin A, mitomycin C, and seven N7 analogs in vitro

Dorr, R. T., Shipp, N. G., Liddil, J. D., Iyengar, B. S., Kunz, K. R. & Remers, W. A., Jan 1992, In : Cancer Chemotherapy and Pharmacology. 31, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Mitomycin
Mitomycins
Doxorubicin
Tumors
Cardiotoxins
11 Citations (Scopus)

Organ culture of rat myocardial slices: An alternative in vitro tool in organ-specific toxicology

Parrish, A. R., Shipp, N. G., Spall, R. D., Dorr, R. T., Krumdieck, C. L., Gandolfi, A. J. & Brendel, K., 1992, In : Toxicology Mechanisms and Methods. 2, 2, p. 101-111 11 p.

Research output: Contribution to journalArticle

Organ Culture Techniques
Toxicology
Rats
Tissue
Leucine
20 Citations (Scopus)

Skin ulceration from extravasation of low-osmolality contrast medium: A complication of automation [1]

Pond, G. D., Dorr, R. T. & McAleese, K. A., 1992, In : American Journal of Roentgenology. 158, 4, p. 915-916 2 p.

Research output: Contribution to journalArticle

Extravasation of Diagnostic and Therapeutic Materials
Skin Ulcer
Automation
Osmolar Concentration
Contrast Media
6 Citations (Scopus)

Topical absorption and inactivation of cytotoxic anticancer agents in vitro

Dorr, R. T. & Alberts, D. S., 1992, In : Cancer. 70, 4 SUPPL., p. 983-987 5 p.

Research output: Contribution to journalArticle

Cytotoxins
Antineoplastic Agents
Daunorubicin
Melphalan
Pharmaceutical Preparations
1991
10 Citations (Scopus)

Additional nucleotide derivatives of mitosenes. Synthesis and activity against parental and multidrug resistant L1210 leukemia

Iyengar, B. S., Dorr, R. T. & Dorr, R. T., 1991, In : Journal of Medicinal Chemistry. 34, 7, p. 1947-1951 5 p.

Research output: Contribution to journalArticle

Leukemia L1210
Mitomycin
Nucleotides
Derivatives
Ribonucleosides
6 Citations (Scopus)

Biochemical effects and toxicity of mitoxantrone in cultured heart cells

Shipp, N. G. & Dorr, R. T., 1991, In : Advances in Experimental Medicine and Biology. 283, p. 821-825 5 p.

Research output: Contribution to journalArticle

Razoxane
Mitoxantrone
Malondialdehyde
Lipid Peroxidation
Toxicity
37 Citations (Scopus)

Case report: topical DMSO for mitomycin-C-induced skin ulceration.

Alberts, D. S. & Dorr, R. T., May 1991, In : Oncology Nursing Forum. 18, 4, p. 693-695 3 p.

Research output: Contribution to journalArticle

Mitomycin
Dimethyl Sulfoxide
Skin
Antidotes
Skin Transplantation