Robert T Dorr

  • 9048 Citations
  • 49 h-Index
1976 …2021
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Research Output 1976 2016

  • 9048 Citations
  • 49 h-Index
  • 236 Article
  • 3 Chapter
1991
54 Citations (Scopus)

Chemoprotectants for cancer chemotherapy

Dorr, R. T., 1991, In : Seminars in Oncology. 18, 1 SUPPL. 2, p. 48-58 11 p.

Research output: Contribution to journalArticle

Dexrazoxane
Mesna
Doxorubicin
Ifosfamide
Alkylating Agents
32 Citations (Scopus)

Comparison of cytotoxicity in heart cells and tumor cells exposed to DNA intercalating agents in vitro.

Dorr, R. T., Shipp, N. G. & Lee, K. M., Feb 1991, In : Anti-Cancer Drugs. 2, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

Intercalating Agents
Heart Neoplasms
DNA
Inhibitory Concentration 50
Anthracyclines
38 Citations (Scopus)

Cutaneous ulceration due to contrast extravasation. Experimental assessment of injury and potential antidotes

Elam, E. A., Dorr, R. T., Lagel, K. E. & Pond, G. D., 1991, In : Investigative Radiology. 26, 1, p. 13-16 4 p.

Research output: Contribution to journalArticle

Antidotes
Skin
Wounds and Injuries
Extravasation of Diagnostic and Therapeutic Materials
Ioxaglic Acid
187 Citations (Scopus)

Induction of skin tanning by subcutaneous administration of a potent synthetic melanotropin

Levine, N., Sheftel, S. N., Eytan, T., Dorr, R. T., Hadley, M. E., Weinrach, J. C., Ertl, G. A., Toth, K., McGee, D. L. & Hruby, V. J., 1991, In : Journal of the American Medical Association. 266, 19, p. 2730-2736 7 p.

Research output: Contribution to journalArticle

Tanning
Melanocyte-Stimulating Hormones
Skin
Subcutaneous Injections
Placebos
3 Citations (Scopus)

In vitro cytotoxicity against fresh human tumors and P388 leukemia predicts the differential in vivo activity of a series of anthracene anticancer drugs.

Alberts, D. S., Dorr, R. T., Wunz, T. P., Remers, W. A., Einspahr, J. G., Liu, R. & Salmon, S. E., Feb 1991, In : Anti-Cancer Drugs. 2, 1, p. 69-77 9 p.

Research output: Contribution to journalArticle

Leukemia P388
Mitoxantrone
Pharmaceutical Preparations
bisantrene
Neoplasms
11 Citations (Scopus)

Lack of ranitidine effects on cyclophosphamide bone marrow toxicity or metabolism: A placebo-controlled clinical trial

Alberts, D. S., Mason-Liddil, N., Plezia, P. M., Roe, D., Dorr, R. T., Struck, R. F. & Phillips, J. G., Dec 4 1991, In : Journal of the National Cancer Institute. 83, 23, p. 1739-1743 5 p.

Research output: Contribution to journalArticle

Ranitidine
Controlled Clinical Trials
Toxicity
Bone
Metabolism
15 Citations (Scopus)

Modulation of mitomycin C-induced multidrug resistance in vitro

Dorr, R. T. & Liddil, J. D., Jul 1991, In : Cancer Chemotherapy and Pharmacology. 27, 4, p. 290-294 5 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Mitomycin
Modulation
Quinidine
Progesterone
50 Citations (Scopus)

Structure-activity relationships for mitomycin C and mitomycin A analogues

Kunz, K. R., Iyengar, B. S., Dorr, R. T., Dorr, R. T. & Alberts, D. S., 1991, In : Journal of Medicinal Chemistry. 34, 7, p. 2281-2286 6 p.

Research output: Contribution to journalArticle

Mitomycins
Mitomycin
Structure-Activity Relationship
Leukemia P388
Assays
86 Citations (Scopus)
Benzimidazoles
Antineoplastic Agents
DNA
DNA Cleavage
Anthracyclines
1990
24 Citations (Scopus)

Alkylation of DNA by C-10 of 2,7-diaminomitosene

Iyengar, B. S., Dorr, R. T., Dorr, R. T. & Remers, W. A., 1990, In : Journal of Medicinal Chemistry. 33, 1, p. 253-257 5 p.

Research output: Contribution to journalArticle

Alkylation
Dithionite
DNA
Mitomycin
Methyl Methanesulfonate
118 Citations (Scopus)

Antidotes to vesicant chemotherapy extravasations

Dorr, R. T., 1990, In : Blood Reviews. 4, 1, p. 41-60 20 p.

Research output: Contribution to journalArticle

Antidotes
Irritants
Mitomycin
Dimethyl Sulfoxide
Drug Therapy

Mitomycin, ifosfamide, and mesna in the treatment of lung cancer

Dorr, R. T., 1990, In : Seminars in Oncology. 17, 4 SUPPL. 7, p. 2-5 4 p.

Research output: Contribution to journalArticle

Mesna
Ifosfamide
Mitomycin
Lung Neoplasms
Vinca Alkaloids

Recent advances in the management of lung and breast cancer: Introduction

Alberts, D. S. & Dorr, R. T., 1990, In : Seminars in Oncology. 17, 4 SUPPL. 7, p. 1 1 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Breast Neoplasms
61 Citations (Scopus)

The clinical relevance of multidrug resistance

Bellamy, W. T., Dalton, W. S. & Dorr, R. T., 1990, In : Cancer Investigation. 8, 5, p. 547-562 16 p.

Research output: Contribution to journalArticle

Neoplastic Gene Expression Regulation
Cultured Tumor Cells
Gene Amplification
Membrane Glycoproteins
Multiple Drug Resistance
1989
43 Citations (Scopus)

Alpha-globulins suppress human leukocyte tumor necrosis factor secretion

Scuderi, P., Dorr, R. T., Liddil, J. D., Finley, P. R., Meltzer, P., Raitano, A. B. & Rybski, J., 1989, In : European Journal of Immunology. 19, 5, p. 939-942 4 p.

Research output: Contribution to journalArticle

Alpha-Globulins
Leukocytes
Globulins
Tumor Necrosis Factor-alpha
Interferons
80 Citations (Scopus)

Antitumor activity and murine pharmacokinetics of parenteral acronycine

Dorr, R. T., Liddil, J. D., Von Hoff, D. D., Soble, M. & Osborne, C. K., 1989, In : Cancer Research. 49, 2, p. 340-344 5 p.

Research output: Contribution to journalArticle

Acronine
Pharmacokinetics
Plasmacytoma
Etoposide
Neoplasms
34 Citations (Scopus)

Association of lysosomal activity with sensitivity and resistance to tumor necrosis factor in murine L929 cells

Liddil, J. D., Dorr, R. T. & Scuderi, P., 1989, In : Cancer Research. 49, 10, p. 2722-2728 7 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor-alpha
Glutathione
Glucaric Acid
Adenosine Triphosphate
Serial Passage
12 Citations (Scopus)
Doxorubicin
Interferons
Interleukin-2
Cell Survival
Tumor Necrosis Factor-alpha
2 Citations (Scopus)

H2-Antagonists and carmustine

Dorr, R. T. & Soble, M. J., Feb 1989, In : Journal of Cancer Research and Clinical Oncology. 115, 1, p. 41-46 6 p.

Research output: Contribution to journalArticle

Carmustine
Pharmaceutical Preparations
Histamine H2 Antagonists
Inbred DBA Mouse
Injections
15 Citations (Scopus)

High levels of doxorubicin in the tissues of a patient experiencing extravasation during a 4-day infusion

Dorr, R. T., Dordal, M. S., Koenig, L. M., Taylor, C. W. & McCloskey, T. M., 1989, In : Cancer. 64, 12, p. 2462-2464 3 p.

Research output: Contribution to journalArticle

Doxorubicin
Vincristine
Debridement
Arm
Transplants
11 Citations (Scopus)

Interaction between cisplatin and mesna in mice

Dorr, R. T. & Lagel, K., Nov 1989, In : Journal of Cancer Research and Clinical Oncology. 115, 6, p. 604-605 2 p.

Research output: Contribution to journalArticle

Mesna
Cisplatin
Inbred DBA Mouse
Sulfhydryl Compounds
Leukemia
31 Citations (Scopus)

Role of glutathione and its associated enzymes in multidrug-resistant human myeloma cells

Bellamy, W. T., Dalton, W. S., Meltzer, P. & Dorr, R. T., Mar 1 1989, In : Biochemical Pharmacology. 38, 5, p. 787-793 7 p.

Research output: Contribution to journalArticle

Glutathione
Multiple Drug Resistance
Enzymes
Doxorubicin
Detoxification
1988
7 Citations (Scopus)

Cimetidine enhances cisplatin toxicity in mice

Dorr, R. T. & Soble, M. J., Feb 1988, In : Journal of Cancer Research and Clinical Oncology. 114, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle

Cimetidine
Cisplatin
Histamine H2 Antagonists
Inbred DBA Mouse
Antineoplastic Agents
7 Citations (Scopus)

Daily variation in non-protein sulfhydryl levels of human bone marrow

Bellamy, W. T., Alberts, D. S. & Dorr, R. T., 1988, In : European Journal of Cancer and Clinical Oncology. 24, 11, p. 1759-1762 4 p.

Research output: Contribution to journalArticle

Bone Marrow
Sulfhydryl Compounds
Antineoplastic Agents
Glutathione
Dithionitrobenzoic Acid
26 Citations (Scopus)

Development of a parenteral formulation for the anti-tumour agent acronycine

Dorr, R. T. & Liddil, J. D., 1988, In : Journal of Drug Development. 1, 1, p. 31-39 9 p.

Research output: Contribution to journalArticle

Acronine
Etoposide
Neoplasms
Multiple Myeloma
Rutaceae
25 Citations (Scopus)

Direct relation of DNA lesions in multidrug-resistant human myeloma cells to intracellular doxorubicin concentration

Bellamy, W. T., Dorr, R. T., Dalton, W. S. & Alberts, D. S., 1988, In : Cancer Research. 48, 22, p. 6360-6364 5 p.

Research output: Contribution to journalArticle

Doxorubicin
DNA
Pharmaceutical Preparations
DNA Damage
Double-Stranded DNA Breaks
29 Citations (Scopus)

Efficacy of sodium thiosulfate as a local antidote to mechlorethamine skin toxicity in the mouse

Dorr, R. T., Soble, M. & Alberts, D. S., Oct 1988, In : Cancer Chemotherapy and Pharmacology. 22, 4, p. 299-302 4 p.

Research output: Contribution to journalArticle

Mechlorethamine
Antidotes
Toxicity
Thiosulfates
Skin
30 Citations (Scopus)

In vitro rat myocyte cardiotoxicity model for antitumor antibiotics using adenosine triphosphate/protein ratios

Dorr, R. T., Bozak, K. A., Shipp, N. G., Hendrix, M., Alberts, D. S. & Ahmann, F. R., 1988, In : Cancer Research. 48, 18, p. 5222-5227 6 p.

Research output: Contribution to journalArticle

Doxorubicin
Muscle Cells
Adenosine Triphosphate
Anti-Bacterial Agents
Anthracyclines
4 Citations (Scopus)
Buthionine Sulfoximine
Carmustine
Melphalan
Doxorubicin
Cyclophosphamide
3 Citations (Scopus)

Mitomycin C toxicity and pharmacokinetics in mice given sulfur nucleophiles

Dorr, R. T., Alberts, D. S. & Liddil, J. D., 1988, In : Anticancer Research. 8, 4, p. 733-738 6 p.

Research output: Contribution to journalArticle

Mitomycin
Sulfur
Acetylcysteine
Pharmacokinetics
Maximum Tolerated Dose
59 Citations (Scopus)

New findings in the pharmacokinetic, metabolic, and drug-resistance aspects of mitomycin C

Dorr, R. T., 1988, In : Seminars in Oncology. 15, 3 SUPPL. 4, p. 32-41 10 p.

Research output: Contribution to journalArticle

Mitomycin
Drug Resistance
Pharmacokinetics
Half-Life
Pharmaceutical Preparations
12 Citations (Scopus)

Nucleotide derivatives of 2,7-diaminomitosene

Iyengar, B. S., Dorr, R. T., Remers, W. A. & Kowal, C. D., 1988, In : Journal of Medicinal Chemistry. 31, 8, p. 1579-1585 7 p.

Research output: Contribution to journalArticle

Mitomycin
Nucleotides
Derivatives
Pyrimidine Nucleotides
Leukemia L1210
14 Citations (Scopus)

Phase I-II trial of interferon-α(2b) by continuous subcutaneous infusion over 28 days

Dorr, R. T., Salmon, S. E., Robertone, A. & Bonnem, E., 1988, In : Journal of Interferon Research. 8, 6, p. 717-725 9 p.

Research output: Contribution to journalArticle

Subcutaneous Infusions
Interferons
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Ependymoma
Maximum Tolerated Dose
3 Citations (Scopus)
Equipment and Supplies
Neoplasms
Analysis of Variance
Thorax
Hand
22 Citations (Scopus)

Toxicologic studies of a superpotent α-melanotropin, [Nle4, D-Phe7]α-MSH

Dorr, R. T., Dawson, B. V., Al-Obeidi, F., Hadley, M. E., Levine, N. & Hruby, V. J., Dec 1988, In : Investigational New Drugs. 6, 4, p. 251-258 8 p.

Research output: Contribution to journalArticle

Melanocyte-Stimulating Hormones
Dimethyl Sulfoxide
Tanning
Vitiligo
Clinical Trials, Phase I
21 Citations (Scopus)

Transdermal delivery of a melanotropic peptide hormone analogue

Dawson, B. V., Hadley, M. E., Kreutzfeld, K., Dorr, R. T., Hruby, V. J., Al-Obeidi, F. & Don, S., 1988, In : Life Sciences. 43, 14, p. 1111-1117 7 p.

Research output: Contribution to journalArticle

Peptide Hormones
Skin
Melanocyte-Stimulating Hormones
Skin Absorption
alpha-MSH
90 Citations (Scopus)

Verapamil reversal of doxorubicin resistance in multidrug-resistant human myeloma cells and association with drug accumulation and DNA damage

Bellamy, W. T., Dalton, W. S., Kailey, J. M., Gleason, M. C., McCloskey, T. M., Dorr, R. T. & Alberts, D. S., 1988, In : Cancer Research. 48, 22, p. 6365-6370 6 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Verapamil
Doxorubicin
DNA Damage
Pharmaceutical Preparations
1987
48 Citations (Scopus)

Cisplatin nephrotoxicity: In vitro studies with precision-cut rabbit renal cortical slices

Phelps, J. S., Gandolfi, A. J., Brendel, K. & Dorr, R. T., Sep 30 1987, In : Toxicology and Applied Pharmacology. 90, 3, p. 501-512 12 p.

Research output: Contribution to journalArticle

Cisplatin
Rabbits
Kidney
Adenosine Triphosphate
Carboplatin
13 Citations (Scopus)

Dose-dependent skin ulcers in mice treated with DNA binding antitumor antibiotics

Soble, M. J., Dorr, R. T., Plezia, P. & Breckenridge, S., Aug 1987, In : Cancer Chemotherapy and Pharmacology. 20, 1, p. 33-36 4 p.

Research output: Contribution to journalArticle

Skin Ulcer
Daunorubicin
Intercalating Agents
Skin
Irritants
5 Citations (Scopus)
Antidotes
Dacarbazine
Light
Skin
Pharmaceutical Preparations
4 Citations (Scopus)

High incidence of local venous reactions to esorubicin

Lee, K. M., Dorr, R. T. & Robertone, A., Mar 1987, In : Investigational New Drugs. 5, 1, p. 31-35 5 p.

Research output: Contribution to journalArticle

Doxorubicin
Histamine Antagonists
Incidence
Clinical Trials, Phase I
Erythema
9 Citations (Scopus)
Buthionine Sulfoximine
Antineoplastic Agents
Carmustine
Doxorubicin
Assays
48 Citations (Scopus)

Mitomycin C resistant L1210 leukemia cells: Association with pleiotropic drug resistance

Dorr, R. T., Liddil, J. D., Trent, J. M. & Dalton, W. S., Oct 1 1987, In : Biochemical Pharmacology. 36, 19, p. 3115-3120 6 p.

Research output: Contribution to journalArticle

Leukemia L1210
Mitomycin
Drug Resistance
P-Glycoprotein
Pharmaceutical Preparations
35 Citations (Scopus)

New antitumor agents containing the anthracene nucleus

Wunz, T. P., Dorr, R. T., Alberts, D. S., Tunget, C. L., Einspahr, J. G., Milton, S. & Remers, W. A., 1987, In : Journal of Medicinal Chemistry. 30, 8, p. 1313-1321 9 p.

Research output: Contribution to journalArticle

bisantrene
Antineoplastic Agents
Tumors
Leukemia
Neoplasms
5 Citations (Scopus)
Melphalan
Sulfhydryl Compounds
Crosslinking
DNA
Cells
3 Citations (Scopus)

Schedule-dependent toxicity of tumor necrosis factor in rodents

Liddil, J. D. & Dorr, R. T., 1987, In : Cancer Drug Delivery. 4, 3, p. 159-167 9 p.

Research output: Contribution to journalArticle

Rodentia
Appointments and Schedules
Tumor Necrosis Factor-alpha
Granulocyte-Macrophage Progenitor Cells
Hepatocytes
15 Citations (Scopus)

VII. Topical application of a melanotropic peptide induces systemic follicular melanogenesis

Hadley, M. E., Wood, S. H., Lemus-Wilson, A. M., Dawson, B. V., Levine, N., Dorr, R. T. & Hruby, V. J., May 11 1987, In : Life Sciences. 40, 19, p. 1889-1895 7 p.

Research output: Contribution to journalArticle

Melanocyte-Stimulating Hormones
Peptide Hormones
Peptides
Skin
Melanocytes
1986
2 Citations (Scopus)

Controlled studies of a new microprocessor-based portable infusion pump

Dorr, R. T., Salmon, S. E., Marsh, M. E. & Robertone, A., 1986, In : Cancer Drug Delivery. 3, 2, p. 139-146 8 p.

Research output: Contribution to journalArticle

Parenteral Infusions
Infusion Pumps
Agammaglobulinemia
Microcomputers
Antineoplastic Agents
25 Citations (Scopus)

Cytotoxic effects of glutathione synthesis inhibition by L-buthionine-(SR)-sulfoximine on human and murine tumor cells

Dorr, R. T., Liddil, J. D. & Soble, M. J., Dec 1986, In : Investigational New Drugs. 4, 4, p. 305-313 9 p.

Research output: Contribution to journalArticle

Buthionine Sulfoximine
Glutathione
Neoplasms
Melphalan
Leukemia L1210
24 Citations (Scopus)

Interaction of cimetidine but not ranitidine with cyclophosphamide in mice

Dorr, R. T., Alberts, D. S. & Alberts, D. S., 1986, In : Cancer Research. 46, 4, p. 1795-1799 5 p.

Research output: Contribution to journalArticle

Ranitidine
Cimetidine
Cyclophosphamide
Histamine H2 Antagonists
Stem Cells