Robert T Dorr

  • 9048 Citations
  • 49 h-Index
1976 …2021
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Research Output 1976 2016

  • 9048 Citations
  • 49 h-Index
  • 236 Article
  • 3 Chapter
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Article
2016
3 Citations (Scopus)

Magnetic resonance imaging identifies differential response to pro-oxidant chemotherapy in a xenograft model

Landowski, T. H., Guntle, G. P., Zhao, D., Jagadish, B., Mash, E. A., Dorr, R. T. & Raghunand, N., Jun 1 2016, In : Translational Oncology. 9, 3, p. 228-235 8 p.

Research output: Contribution to journalArticle

Heterografts
Reactive Oxygen Species
Magnetic Resonance Imaging
Drug Therapy
Neoplasms
2015
16 Citations (Scopus)

Gemcitabine resistant pancreatic cancer cell lines acquire an invasive phenotype with collateral hypersensitivity to histone deacetylase inhibitors

Samulitis, B. K., Pond, K. W., Pond, E., Cress, A. E., Patel, H., Wisner, L., Patel, C., Dorr, R. T. & Landowski, T. H., 2015, In : Cancer biology & therapy. 16, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

gemcitabine
Histone Deacetylase Inhibitors
Pancreatic Neoplasms
Hypersensitivity
Phenotype
3 Citations (Scopus)

Synthesis and antitumor activity of heterocycles related to carbendazim

Remers, W. A., Iyengar, B. S., Dorr, R. T., Wisner, L. & Bates, R. B., 2015, In : Journal of Heterocyclic Chemistry. 52, 1, p. 136-141 6 p.

Research output: Contribution to journalArticle

Esters
Tumors
Triazines
Derivatives
Bearings (structural)
2014
15 Citations (Scopus)

Phase 2 study of imexon, a prooxidant molecule, in relapsed and refractory B-cell non-Hodgkin lymphoma

Barr, P. M., Miller, T. P., Friedberg, J. W., Peterson, D. R., Baran, A. M., Herr, M., Perry, C. S., Cui, H., Roe, D., Persky, D. O., Casulo, C., Littleton, J., Schwartz, M., Puvvada, S. D., Landowski, T. H., Rimsza, L. M., Dorr, R. T., Fisher, R. I., Bernstein, S. H. & Briehl, M. M., Aug 21 2014, In : Blood. 124, 8, p. 1259-1265 7 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
Refractory materials
Non-Hodgkin's Lymphoma
Oxidation-Reduction
Cells
2013
1 Citation (Scopus)

Characterization of a membrane-active anti-tumor agent, UA8967

Dorr, R. T., Samulitis, B. K., Wisner, L., Han, H., Zhao, Y., Beroza, P., Damodaran, K., Igarashi, S., Landowski, T. H. & Von Hoff, D. D., Jun 2013, In : Investigational New Drugs. 31, 3, p. 576-586 11 p.

Research output: Contribution to journalArticle

Membranes
Colonic Neoplasms
Neoplasms
Trypan Blue
Cell Membrane
17 Citations (Scopus)

Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo

Escalante, A. M., McGrath, R. T., Karolak, M. R., Dorr, R. T., Lynch, R. & Landowski, T. H., Jun 2013, In : Cancer Chemotherapy and Pharmacology. 71, 6, p. 1567-1576 10 p.

Research output: Contribution to journalArticle

Calpain
Cell death
Cell Death
Cytotoxicity
HIV Protease Inhibitors
3 Citations (Scopus)

The diaryl oxazole PC-046 is a tubulin-binding agent with experimental anti-tumor efficacy in hematologic cancers

Landowski, T. H., Samulitis, B. K. & Dorr, R. T., Dec 2013, In : Investigational New Drugs. 31, 6, p. 1616-1625 10 p.

Research output: Contribution to journalArticle

Oxazoles
Tubulin
Microtubules
SCID Mice
Biological Availability
2012
7 Citations (Scopus)

Anti-tumor activity and mechanism of action for a cyanoaziridine- derivative, AMP423

Dorr, R. T., Wisner, L., Samulitis, B. K., Landowski, T. H. & Remers, W. A., Apr 2012, In : Cancer Chemotherapy and Pharmacology. 69, 4, p. 1039-1049 11 p.

Research output: Contribution to journalArticle

Tumors
Bearings (structural)
Derivatives
Cells
Neoplasms
4 Citations (Scopus)

Chemistry and pharmacology of imexon and related cyanoaziridines

Remers, W. A. & Dorr, R. T., 2012, In : Current Medicinal Chemistry. 19, 33, p. 5745-5753 9 p.

Research output: Contribution to journalArticle

gemcitabine
Pharmacology
Tumors
Cell culture
Sulfhydryl Compounds
13 Citations (Scopus)

Imexon induces an oxidative endoplasmic reticulum stress response in pancreatic cancer cells

Sheveleva, E. V., Landowski, T. H., Samulitis, B. K., Bartholomeusz, G., Powis, G. & Dorr, R. T., Mar 2012, In : Molecular Cancer Research. 10, 3, p. 392-400 9 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Pancreatic Neoplasms
Oxidation-Reduction
Sulfhydryl Compounds
Endoplasmic Reticulum
18 Citations (Scopus)

Lymphoma cells with increased anti-oxidant defenses acquire chemoresistance

Tome, M. E., Frye, J. B., Coyle, D. L., Jacobson, E. L., Samulitis, B. K., Dvorak, K., Dorr, R. T. & Briehl, M. M., May 2012, In : Experimental and Therapeutic Medicine. 3, 5, p. 845-852 8 p.

Research output: Contribution to journalArticle

Oxidants
Lymphoma
Oxidation-Reduction
Reactive Oxygen Species
Enzymes
9 Citations (Scopus)

Tumor xenograft response to redox-active therapies assessed by magnetic resonance imaging using a thiol-bearing DOTA complex of gadolinium

Guntle, G. P., Jagadish, B., Mash, E. A., Powis, G., Dorr, R. T. & Raghunand, N., Jun 2012, In : Translational Oncology. 5, 3, p. 190-199 10 p.

Research output: Contribution to journalArticle

Gadolinium
Heterografts
Oxidation-Reduction
Magnetic Resonance Imaging
Neoplasms
2011
7 Citations (Scopus)

Imexon enhances gemcitabine cytotoxicity by inhibition of ribonucleotide reductase

Roman, N. O., Samulitis, B. K., Wisner, L., Landowski, T. H. & Dorr, R. T., Jan 2011, In : Cancer Chemotherapy and Pharmacology. 67, 1, p. 183-192 10 p.

Research output: Contribution to journalArticle

gemcitabine
Ribonucleotide Reductases
Cytotoxicity
Pancreatic Neoplasms
Pharmacokinetics
5 Citations (Scopus)

Interaction of dacarbazine and imexon, In Vitro and In Vivo, in human A375 melanoma cells

Samulitis, B. K., Dorr, R. T. & Chow, H-H., Sep 2011, In : Anticancer Research. 31, 9, p. 2781-2785 5 p.

Research output: Contribution to journalArticle

Dacarbazine
Melanoma
DNA Breaks
Pharmaceutical Preparations
Comet Assay
2010
16 Citations (Scopus)

A phase 1-2 study of imexon plus dacarbazine in patients with unresectable metastatic melanoma

Weber, J. S., Samlowski, W. E., Gonzalez, R., Ribas, A., Stephenson, J., O'Day, S., Sato, T., Dorr, R. T., Grenier, K. & Hersh, E. M., Aug 1 2010, In : Cancer. 116, 15, p. 3683-3691 9 p.

Research output: Contribution to journalArticle

Dacarbazine
Melanoma
Maximum Tolerated Dose
Pharmacokinetics
Survival
18 Citations (Scopus)

A phase i study of imexon plus gemcitabine as first-line therapy for advanced pancreatic cancer

Cohen, S. J., Zalupski, M. M., Modiano, M. R., Conkling, P., Patt, Y. Z., Davis, P., Dorr, R. T., Boytim, M. L. & Hersh, E. M., Jul 2010, In : Cancer Chemotherapy and Pharmacology. 66, 2, p. 287-294 8 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Toxicity
Maximum Tolerated Dose
Abdominal Pain
20 Citations (Scopus)

A phase i trial of imexon, a pro-oxidant, in combination with docetaxel for the treatment of patients with advanced breast, non-small cell lung and prostate cancer

Moulder, S., Dhillon, N., Ng, C., Hong, D., Wheler, J., Naing, A., Tse, S., La Paglia, A., Dorr, R. T., Hersh, E. M., Boytim, M. & Kurzrock, R., Oct 2010, In : Investigational New Drugs. 28, 5, p. 634-640 7 p.

Research output: Contribution to journalArticle

docetaxel
Non-Small Cell Lung Carcinoma
Reactive Oxygen Species
Prostatic Neoplasms
Breast
2009
23 Citations (Scopus)

Characterization of novel diaryl oxazole-based compounds as potential agents to treat pancreatic cancer

Shaw, A. Y., Henderson, M. C., Flynn, G., Samulitis, B., Han, H., Stratton, S. P., Chow, H-H., Hurley, L. & Dorr, R. T., Nov 2009, In : Journal of Pharmacology and Experimental Therapeutics. 331, 2, p. 636-647 12 p.

Research output: Contribution to journalArticle

Oxazoles
Pancreatic Neoplasms
Kinesin
Cell Line
Protein Kinases
10 Citations (Scopus)
Pancreatic Neoplasms
Proteins
Protein Biosynthesis
Proteasome Endopeptidase Complex
gemcitabine
16 Citations (Scopus)

Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid

Meyers, R. O., Lambert, J. D., Hajicek, N., Pourpak, A., Kalaitzis, J. A. & Dorr, R. T., Aug 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 16, p. 4752-4755 4 p.

Research output: Contribution to journalArticle

Masoprocol
Carbonates
Cytotoxicity
Heterografts
Sulfates
30 Citations (Scopus)

UA62784, a novel inhibitor of centromere protein E kinesin-like protein

Henderson, M. C., Shaw, Y. J. Y., Wang, H., Han, H., Hurley, L., Flynn, G., Dorr, R. T. & Von Hoff, D. D., Jan 1 2009, In : Molecular Cancer Therapeutics. 8, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

Kinesin
Proteins
Antimitotic Agents
Kinetochores
Gene Deletion
2008
18 Citations (Scopus)

Phase 1 study of topical perillyl alcohol cream for chemoprevention of skin cancer

Stratton, S. P., Saboda, K. L., Myrdal, P. B., Gupta, A., McKenzie, N. E., Brooks, C., Salasche, S. J., Warneke, J. A., Ranger-Moore, J., Bozzo, P. D., Blanchard, J., Einspahr, J. G., Dorr, R. T., Levine, N. & Alberts, D. S., May 2008, In : Nutrition and Cancer. 60, 3, p. 325-330 6 p.

Research output: Contribution to journalArticle

perilla alcohol
chemoprevention
Chemoprevention
Skin Neoplasms
cream
13 Citations (Scopus)

Proteasomal inhibition stabilizes topoisomerase IIα protein and reverses resistance to the topoisomerase II poison ethonafide (AMP-53, 6-ethoxyazonafide)

Congdon, L. M., Pourpak, A., Escalante, A. M., Dorr, R. T. & Landowski, T. H., Feb 15 2008, In : Biochemical Pharmacology. 75, 4, p. 883-890 8 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
Poisons
Cytotoxicity
Proteins
Drug Resistance
2007
6 Citations (Scopus)

Cytotoxic activity of Apomine is due to a novel membrane-mediated cytolytic mechanism independent of apoptosis in the A375 human melanoma cell line

Pourpak, A., Dorr, R. T., Meyers, R. O., Powell, M. B. & Stratton, S. P., Apr 2007, In : Investigational New Drugs. 25, 2, p. 107-114 8 p.

Research output: Contribution to journalArticle

Melanoma
Apoptosis
Cell Line
Membranes
Cell Death
18 Citations (Scopus)
Type II DNA Topoisomerase
Prostatic Neoplasms
Cell Line
amonafide
Antineoplastic Agents
13 Citations (Scopus)

Imexon-based combination chemotherapy in A375 human melanoma and RPMI 8226 human myeloma cell lines

Scott, J., Dorr, R. T., Samulitis, B. & Landowski, T. H., Jun 2007, In : Cancer Chemotherapy and Pharmacology. 59, 6, p. 749-757 9 p.

Research output: Contribution to journalArticle

Chemotherapy
Combination Drug Therapy
Melanoma
Cells
Cell Line
40 Citations (Scopus)

Phase I trial of imexon in patients with advanced malignancy

Dragovich, T., Gordon, M., Mendelson, D., Wong, L., Modiano, M., Chow, H-H., Samulitis, B., O'Day, S., Grenier, K., Hersh, E. M. & Dorr, R. T., May 1 2007, In : Journal of Clinical Oncology. 25, 13, p. 1779-1784 6 p.

Research output: Contribution to journalArticle

Sulfhydryl Compounds
Neoplasms
Maximum Tolerated Dose
Reactive Oxygen Species
Pharmacokinetics
15 Citations (Scopus)

The antitumor agent imexon activates antioxidant gene expression: Evidence for an oxidative stress response

Baker, A. F., Landowski, T. H., Dorr, R. T., Tate, W. R., Gard, J. M. C., Tavenner, B. E., Dragovich, T., Coon, A. & Powis, G., Jun 1 2007, In : Clinical Cancer Research. 13, 11, p. 3388-3394 7 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Oxidative Stress
Antioxidants
Gene Expression
GATA1 Transcription Factor
15 Citations (Scopus)

Therapeutic effect of anthracene-based anticancer agent ethonafide in an animal model of multiple sclerosis

Piao, W. H., Wong, R., Bai, X. F., Huang, J., Campagnolo, D. I., Dorr, R. T., Vollmer, T. L. & Shi, F. D., Dec 1 2007, In : Journal of Immunology. 179, 11, p. 7415-7423 9 p.

Research output: Contribution to journalArticle

Therapeutic Uses
Antineoplastic Agents
Mitoxantrone
Multiple Sclerosis
Animal Models
13 Citations (Scopus)

α6 Integrin Cleavage: Sensitizing human prostate cancer to ionizing radiation

Pawar, S. C., Dougherty, S., Pennington, M. E., Demetriou, M. C., Stea, B., Dorr, R. T. & Cress, A. E., 2007, In : International Journal of Radiation Biology. 83, 11-12, p. 761-767 7 p.

Research output: Contribution to journalArticle

sensitizing
Ionizing radiation
integrins
prostatic neoplasms
Ionizing Radiation
2006
13 Citations (Scopus)

Correlates of imexon sensitivity in human multiple myeloma cell lines

Samulitis, B. K., Landowski, T. H. & Dorr, R. T., Jan 2006, In : Leukemia and Lymphoma. 47, 1, p. 97-109 13 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Cell Line
Mitochondrial Membrane Potential
Sulfhydryl Compounds
Pharmaceutical Preparations
18 Citations (Scopus)

Glucose 6-phosphate dehydrogenase overexpression models glucose deprivation and sensitizes lymphoma cells to apoptosis

Tome, M. E., Johnson, D. B. F., Samulitis, B. K., Dorr, R. T. & Briehl, M. M., Jul 2006, In : Antioxidants and Redox Signaling. 8, 7-8, p. 1315-1327 13 p.

Research output: Contribution to journalArticle

Glucosephosphate Dehydrogenase
Lymphoma
Apoptosis
Glucocorticoids
Glucose
76 Citations (Scopus)

Melanocortin peptide therapeutics: Historical milestones, clinical studies and commercialization

Hadley, M. E. & Dorr, R. T., Apr 2006, In : Peptides. 27, 4, p. 921-930 10 p.

Research output: Contribution to journalArticle

Melanocortins
Skin
Melanocortin Receptors
Tanning
Cyclic Peptides
12 Citations (Scopus)

Preclinical antitumor activity, pharmacokinetics and pharmacodynamics of imexon in mice

Pourpak, A., Meyers, R. O., Samulitis, B. K., Chow, H-H., Kepler, C. Y., Raymond, M. A., Hersh, E. M. & Dorr, R. T., Nov 2006, In : Anti-Cancer Drugs. 17, 10, p. 1179-1184 6 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Sulfhydryl Compounds
Cystine
Maximum Tolerated Dose
Biomarkers
2005
17 Citations (Scopus)

Cytotoxic lignans from Larrea tridentata

Lambert, J. D., Sang, S., Dougherty, A., Caldwell, C. G., Meyers, R. O., Dorr, R. T. & Timmermann, B. N., Apr 2005, In : Phytochemistry. 66, 7, p. 811-815 5 p.

Research output: Contribution to journalArticle

Larrea
Larrea tridentata
Lignans
lignans
Colonic Neoplasms
20 Citations (Scopus)

Induction of apoptosis and cell cycle arrest by imexon in human pancreatic cancer cell lines

Dorr, R. T., Raymond, M. A., Landowski, T. H., Roman, N. O. & Fukushima, S., Aug 2005, In : International Journal of Gastrointestinal Cancer. 36, 1, p. 15-28 14 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Pancreatic Neoplasms
Apoptosis
Cell Line
Growth
166 Citations (Scopus)

Mitochondrial-mediated disregulation of Ca2+ is a critical determinant of velcade (PS-341/Bortezomib) cytotoxicity in myeloma cell lines

Landowski, T. H., Megli, C. J., Nullmeyer, K. D., Lynch, R. & Dorr, R. T., May 1 2005, In : Cancer Research. 65, 9, p. 3828-3836 9 p.

Research output: Contribution to journalArticle

Cell Line
Cell Death
Caspases
Multiple Myeloma
Ruthenium Compounds
6 Citations (Scopus)

Single intratumoral injection of long-acting benzyl ester of D-penicillamine inhibits the growth of melanoma tumor in mice

Chvapil, M. & Dorr, R. T., Aug 2005, In : Anti-Cancer Drugs. 16, 7, p. 757-762 6 p.

Research output: Contribution to journalArticle

Melanoma
Injections
Growth
Neoplasms
Polymers
3 Citations (Scopus)

Synthesis of [14C]-imexon

Jagadish, B., Iyengar, B. S., Sólyom, A. M., Remers, W. A., Dorr, R. T., Yu, J. S., Gupta, S. & Mash, E. A., Mar 2005, In : Journal of Labelled Compounds and Radiopharmaceuticals. 48, 3, p. 165-170 6 p.

Research output: Contribution to journalArticle

Phosgene
4-imino-1,3-diazabicyclo(3.1.0)hexan-2-one
2004
47 Citations (Scopus)

Chemical Basis for the Biological Activity of Imexon and Related Cyanoaziridines

Iyengar, B. S., Dorr, R. T. & Remers, W. A., Jan 1 2004, In : Journal of Medicinal Chemistry. 47, 1, p. 218-223 6 p.

Research output: Contribution to journalArticle

Bioactivity
Sulfhydryl Compounds
Oxidative stress
Cytotoxicity
Lysine
47 Citations (Scopus)

Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers

Dorr, R. T., Ertl, G., Levine, N., Brooks, C., Bangert, J. L., Powell, M. B., Humphrey, S. & Alberts, D. S., Jul 2004, In : Archives of Dermatology. 140, 7, p. 827-835 9 p.

Research output: Contribution to journalArticle

Tanning
Sunlight
Volunteers
Radiation
Skin
23 Citations (Scopus)

Nordihydroguaiaretic acid: A review of its numerous and varied biological activities

Lambert, J. D., Dorr, R. T. & Timmermann, B. N., Apr 2004, In : Pharmaceutical Biology. 42, 2, p. 149-158 10 p.

Research output: Contribution to journalArticle

nordihydroguaiaretic acid
Masoprocol
Bioactivity
bioactive properties
Zygophyllaceae
2003
5 Citations (Scopus)

Comparative pharmacokinetic study of high-dose etoposide and etoposide phosphate in patients with lymphoid malignancy receiving autologous stem cell transplantation

Dorr, R. T., Briggs, A., Kintzel, P., Meyers, R., Chow, H-H. & List, A., Apr 2003, In : Bone Marrow Transplantation. 31, 8, p. 643-649 7 p.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Etoposide
Pharmacokinetics
Mucositis
Hematologic Neoplasms
15 Citations (Scopus)

Effects of chronic intrathecal infusion of a ∂ opioid agonist in dogs

Horais, K., Hruby, V. J., Rossi, S., Cizkova, D., Meschter, C., Dorr, R. T. & Yaksh, T. L., Feb 1 2003, In : Toxicological Sciences. 71, 2, p. 263-275 13 p.

Research output: Contribution to journalArticle

Enkephalins
Opioid Analgesics
Dogs
Catheters
Cerebrospinal fluid
4 Citations (Scopus)

Mood alterations in patients treated with chlorambucil

Hehn, S. T., Dorr, R. T. & Miller, T. P., Dec 2003, In : Clinical Lymphoma. 4, 3, p. 179-182 4 p.

Research output: Contribution to journalArticle

Chlorambucil
Psychomotor Agitation
Alkylating Agents
Lymphoma
Appointments and Schedules
494 Citations (Scopus)

Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals

Chow, H-H., Cai, Y., Hakim, I. A., Crowell, J. A., Shahi, F., Brooks, C. A., Dorr, R. T., Hara, Y. & Alberts, D. S., Sep 1 2003, In : Clinical Cancer Research. 9, 9, p. 3312-3319 8 p.

Research output: Contribution to journalArticle

Polyphenols
Tea
Pharmacokinetics
Safety
polyphenon E
2002
19 Citations (Scopus)

Imexon activates an intrinsic apoptosis pathway in RPMI8226 myeloma cells

Dvorakova, K., Payne, C. M., Landowski, T. H., Tome, M. E., Halperin, D. S. & Dorr, R. T., Nov 2002, In : Anti-Cancer Drugs. 13, 10, p. 1031-1042 12 p.

Research output: Contribution to journalArticle

Apoptosis
Caspase 9
Caspase 3
Caspase 8
4-imino-1,3-diazabicyclo(3.1.0)hexan-2-one
31 Citations (Scopus)

Molecular and cellular characterization of imexon-resistant RPMI8226/I myeloma cells

Dvorakova, K., Payne, C. M., Tome, M. E., Briehl, M. M., Vasquez, M. A., Waltmire, C. N., Coon, A. & Dorr, R. T., Jan 2002, In : Molecular Cancer Therapeutics. 1, 3, p. 185-195 11 p.

Research output: Contribution to journalArticle

irinotecan
Glutathione
Mitochondria
Oxidative Stress
4-imino-1,3-diazabicyclo(3.1.0)hexan-2-one
60 Citations (Scopus)

Nordihydroguaiaretic acid: Hepatotoxicity and detoxification in the mouse

Lambert, J. D., Zhao, D., Meyers, R. O., Kuester, R. K., Timmermann, B. N. & Dorr, R. T., Dec 1 2002, In : Toxicon. 40, 12, p. 1701-1708 8 p.

Research output: Contribution to journalArticle

Masoprocol
Detoxification
Larrea
Acids
Metabolism
38 Citations (Scopus)

Pyrimidoquinazoline-based antitumor agents. Design of topoisomerase II to DNA cross-linkers with activity against protein kinases

Skibo, E. B., Huang, X., Martinez, R., Lemus, R. H., Craigo, W. A. & Dorr, R. T., Dec 5 2002, In : Journal of Medicinal Chemistry. 45, 25, p. 5543-5555 13 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
Antineoplastic Agents
Protein Kinases
DNA
Anthraquinones