Robert T Dorr

  • 9304 Citations
  • 50 h-Index
1976 …2016

Research output per year

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Research Output

  • 9304 Citations
  • 50 h-Index
  • 220 Article
  • 7 Letter
  • 7 Review article
  • 5 Comment/debate
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Article
2016

Magnetic resonance imaging identifies differential response to pro-oxidant chemotherapy in a xenograft model

Landowski, T. H., Guntle, G. P., Zhao, D., Jagadish, B., Mash, E. A., Dorr, R. T. & Raghunand, N., Jun 1 2016, In : Translational Oncology. 9, 3, p. 228-235 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Gemcitabine resistant pancreatic cancer cell lines acquire an invasive phenotype with collateral hypersensitivity to histone deacetylase inhibitors

Samulitis, B. K., Pond, K. W., Pond, E., Cress, A. E., Patel, H., Wisner, L., Patel, C., Dorr, R. T. & Landowski, T. H., 2015, In : Cancer biology & therapy. 16, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Synthesis and antitumor activity of heterocycles related to carbendazim

Remers, W. A., Iyengar, B. S., Dorr, R. T., Wisner, L. & Bates, R. B., Jan 2015, In : Journal of Heterocyclic Chemistry. 52, 1, p. 136-141 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
2014

Phase 2 study of imexon, a prooxidant molecule, in relapsed and refractory B-cell non-Hodgkin lymphoma

Barr, P. M., Miller, T. P., Friedberg, J. W., Peterson, D. R., Baran, A. M., Herr, M., Spier, C. M., Cui, H., Roe, D. J., Persky, D. O., Casulo, C., Littleton, J., Schwartz, M., Puvvada, S., Landowski, T. H., Rimsza, L. M., Dorr, R. T., Fisher, R. I., Bernstein, S. H. & Briehl, M. M., Aug 21 2014, In : Blood. 124, 8, p. 1259-1265 7 p.

Research output: Contribution to journalArticle

18 Scopus citations
2013

Characterization of a membrane-active anti-tumor agent, UA8967

Dorr, R. T., Samulitis, B. K., Wisner, L., Han, H., Zhao, Y., Beroza, P., Damodaran, K., Igarashi, S., Landowski, T. H. & Von Hoff, D. D., Jun 1 2013, In : Investigational New Drugs. 31, 3, p. 576-586 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo

Escalante, A. M., McGrath, R. T., Karolak, M. R., Dorr, R. T., Lynch, R. M. & Landowski, T. H., Jun 2013, In : Cancer Chemotherapy And Pharmacology. 71, 6, p. 1567-1576 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

The diaryl oxazole PC-046 is a tubulin-binding agent with experimental anti-tumor efficacy in hematologic cancers

Landowski, T. H., Samulitis, B. K. & Dorr, R. T., Dec 2013, In : Investigational New Drugs. 31, 6, p. 1616-1625 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
2012

Anti-tumor activity and mechanism of action for a cyanoaziridine- derivative, AMP423

Dorr, R. T., Wisner, L., Samulitis, B. K., Landowski, T. H. & Remers, W. A., Apr 1 2012, In : Cancer Chemotherapy And Pharmacology. 69, 4, p. 1039-1049 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Chemistry and pharmacology of imexon and related cyanoaziridines

Remers, W. A. & Dorr, R. T., Dec 24 2012, In : Current medicinal chemistry. 19, 33, p. 5745-5753 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Imexon induces an oxidative endoplasmic reticulum stress response in pancreatic cancer cells

Sheveleva, E. V., Landowski, T. H., Samulitis, B. K., Bartholomeusz, G., Powis, G. & Dorr, R. T., Mar 2012, In : Molecular Cancer Research. 10, 3, p. 392-400 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Lymphoma cells with increased anti-oxidant defenses acquire chemoresistance

Tome, M. E., Frye, J. B., Coyle, D. L., Jacobson, E. L., Samulitis, B. K., Dvorak, K., Dorr, R. T. & Briehl, M. M., May 2012, In : Experimental and Therapeutic Medicine. 3, 5, p. 845-852 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Tumor xenograft response to redox-active therapies assessed by magnetic resonance imaging using a thiol-bearing DOTA complex of gadolinium

Guntle, G. P., Jagadish, B., Mash, E. A., Powis, G., Dorr, R. T. & Raghunand, N., Jun 2012, In : Translational Oncology. 5, 3, p. 190-199 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2011

Imexon enhances gemcitabine cytotoxicity by inhibition of ribonucleotide reductase

Roman, N. O., Samulitis, B. K., Wisner, L., Landowski, T. H. & Dorr, R. T., Jan 1 2011, In : Cancer Chemotherapy And Pharmacology. 67, 1, p. 183-192 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Interaction of dacarbazine and imexon, In Vitro and In Vivo, in human A375 melanoma cells

Samulitis, B. K., Dorr, R. T. & Chow, H. H. S., Sep 2011, In : Anticancer research. 31, 9, p. 2781-2785 5 p.

Research output: Contribution to journalArticle

7 Scopus citations
2010

A phase 1-2 study of imexon plus dacarbazine in patients with unresectable metastatic melanoma

Weber, J. S., Samlowski, W. E., Gonzalez, R., Ribas, A., Stephenson, J., O'Day, S., Sato, T., Dorr, R., Grenier, K. & Hersh, E., Aug 1 2010, In : Cancer. 116, 15, p. 3683-3691 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

A phase i study of imexon plus gemcitabine as first-line therapy for advanced pancreatic cancer

Cohen, S. J., Zalupski, M. M., Modiano, M. R., Conkling, P., Patt, Y. Z., Davis, P., Dorr, R. T., Boytim, M. L. & Hersh, E. M., Jul 2010, In : Cancer Chemotherapy And Pharmacology. 66, 2, p. 287-294 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

A phase i trial of imexon, a pro-oxidant, in combination with docetaxel for the treatment of patients with advanced breast, non-small cell lung and prostate cancer

Moulder, S., Dhillon, N., Ng, C., Hong, D., Wheler, J., Naing, A., Tse, S., La Paglia, A., Dorr, R., Hersh, E., Boytim, M. & Kurzrock, R., Oct 1 2010, In : Investigational New Drugs. 28, 5, p. 634-640 7 p.

Research output: Contribution to journalArticle

23 Scopus citations
2009

Characterization of novel diaryl oxazole-based compounds as potential agents to treat pancreatic cancer

Shaw, A. Y., Henderson, M. C., Flynn, G., Samulitis, B., Han, H., Stratton, S. P., Chow, H. H. S., Hurley, L. H. & Dorr, R. T., Nov 2009, In : Journal of Pharmacology and Experimental Therapeutics. 331, 2, p. 636-647 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Inhibition of protein synthesis by imexon reduces HIF-1α expression in normoxic and hypoxic pancreatic cancer cells

Samulitis, B. K., Landowski, T. H. & Dorr, R. T., Feb 1 2009, In : Investigational New Drugs. 27, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid

Meyers, R. O., Lambert, J. D., Hajicek, N., Pourpak, A., Kalaitzis, J. A. & Dorr, R. T., Aug 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 16, p. 4752-4755 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

UA62784, a novel inhibitor of centromere protein E kinesin-like protein

Henderson, M. C., Shaw, Y. J. Y., Wang, H., Han, H., Hurley, L. H., Flynn, G., Dorr, R. T. & Von Hoff, D. D., Jan 1 2009, In : Molecular Cancer Therapeutics. 8, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2008

Phase 1 study of topical perillyl alcohol cream for chemoprevention of skin cancer

Stratton, S. P., Saboda, K. L., Myrdal, P. B., Gupta, A., McKenzie, N. E., Brooks, C., Salasche, S. J., Warneke, J. A., Ranger-Moore, J., Bozzo, P. D., Blanchard, J., Einspahr, J. G., Dorr, R. T., Levine, N. & Alberts, D. S., May 1 2008, In : Nutrition and cancer. 60, 3, p. 325-330 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Proteasomal inhibition stabilizes topoisomerase IIα protein and reverses resistance to the topoisomerase II poison ethonafide (AMP-53, 6-ethoxyazonafide)

Congdon, L. M., Pourpak, A., Escalante, A. M., Dorr, R. T. & Landowski, T. H., Feb 15 2008, In : Biochemical Pharmacology. 75, 4, p. 883-890 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
2007

Cytotoxic activity of Apomine is due to a novel membrane-mediated cytolytic mechanism independent of apoptosis in the A375 human melanoma cell line

Pourpak, A., Dorr, R. T., Meyers, R. O., Powell, M. B. & Stratton, S. P., Apr 1 2007, In : Investigational New Drugs. 25, 2, p. 107-114 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
18 Scopus citations

Imexon-based combination chemotherapy in A375 human melanoma and RPMI 8226 human myeloma cell lines

Scott, J., Dorr, R. T., Samulitis, B. & Landowski, T. H., Jun 1 2007, In : Cancer Chemotherapy And Pharmacology. 59, 6, p. 749-757 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Phase I trial of imexon in patients with advanced malignancy

Dragovich, T., Gordon, M., Mendelson, D., Wong, L., Modiano, M., Chow, H. H. S., Samulitis, B., O'Day, S., Grenier, K., Hersh, E. & Dorr, R., May 1 2007, In : Journal of Clinical Oncology. 25, 13, p. 1779-1784 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

The antitumor agent imexon activates antioxidant gene expression: Evidence for an oxidative stress response

Baker, A. F., Landowski, T., Dorr, R., Tate, W. R., Gard, J. M. C., Tavenner, B. E., Dragovich, T., Coon, A. & Powis, G., Jun 1 2007, In : Clinical Cancer Research. 13, 11, p. 3388-3394 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Therapeutic effect of anthracene-based anticancer agent ethonafide in an animal model of multiple sclerosis

Piao, W. H., Wong, R., Bai, X. F., Huang, J., Campagnolo, D. I., Dorr, R. T., Vollmer, T. L. & Shi, F. D., Dec 1 2007, In : Journal of Immunology. 179, 11, p. 7415-7423 9 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

α6 Integrin Cleavage: Sensitizing human prostate cancer to ionizing radiation

Pawar, S. C., Dougherty, S., Pennington, M. E., Demetriou, M. C., Stea, B. D., Dorr, R. T. & Cress, A. E., 2007, In : International Journal of Radiation Biology. 83, 11-12, p. 761-767 7 p.

Research output: Contribution to journalArticle

14 Scopus citations
2006

Correlates of imexon sensitivity in human multiple myeloma cell lines

Samulitis, B. K., Landowski, T. H. & Dorr, R. T., Jan 1 2006, In : Leukemia and Lymphoma. 47, 1, p. 97-109 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Glucose 6-phosphate dehydrogenase overexpression models glucose deprivation and sensitizes lymphoma cells to apoptosis

Tome, M. E., Johnson, D. B. F., Samulitis, B. K., Dorr, R. T. & Briehl, M. M., Jul 2006, In : Antioxidants and Redox Signaling. 8, 7-8, p. 1315-1327 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Preclinical antitumor activity, pharmacokinetics and pharmacodynamics of imexon in mice

Pourpak, A., Meyers, R. O., Samulitis, B. K., Sherry Chow, H. H., Kepler, C. Y., Raymond, M. A., Hersh, E. & Dorr, R. T., Nov 2006, In : Anti-cancer drugs. 17, 10, p. 1179-1184 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
2005

Cytotoxic lignans from Larrea tridentata

Lambert, J. D., Sang, S., Dougherty, A., Caldwell, C. G., Meyers, R. O., Dorr, R. T. & Timmermann, B. N., Apr 2005, In : Phytochemistry. 66, 7, p. 811-815 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Induction of apoptosis and cell cycle arrest by imexon in human pancreatic cancer cell lines

Dorr, R. T., Raymond, M. A., Landowski, T. H., Roman, N. O. & Fukushima, S., Aug 2005, In : International Journal of Gastrointestinal Cancer. 36, 1, p. 15-28 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Mitochondrial-mediated disregulation of Ca2+ is a critical determinant of velcade (PS-341/Bortezomib) cytotoxicity in myeloma cell lines

Landowski, T. H., Megli, C. J., Nullmeyer, K. D., Lynch, R. M. & Dorr, R. T., May 1 2005, In : Cancer Research. 65, 9, p. 3828-3836 9 p.

Research output: Contribution to journalArticle

173 Scopus citations

Single intratumoral injection of long-acting benzyl ester of D-penicillamine inhibits the growth of melanoma tumor in mice

Chvapil, M. & Dorr, R., Aug 1 2005, In : Anti-cancer drugs. 16, 7, p. 757-762 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Synthesis of [14C]-imexon

Jagadish, B., Iyengar, B. S., Sólyom, A. M., Remers, W. A., Dorr, R. T., Yu, J. S., Gupta, S. & Mash, E. A., Mar 2005, In : Journal of Labelled Compounds and Radiopharmaceuticals. 48, 3, p. 165-170 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
2004

Chemical Basis for the Biological Activity of Imexon and Related Cyanoaziridines

Iyengar, B. S., Dorr, R. T. & Remers, W. A., Jan 1 2004, In : Journal of Medicinal Chemistry. 47, 1, p. 218-223 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers

Dorr, R. T., Ertl, G., Levine, N., Brooks, C., Bangert, J. L., Powell, M. B., Humphrey, S. & Alberts, D. S., Jul 2004, In : Archives of Dermatology. 140, 7, p. 827-835 9 p.

Research output: Contribution to journalArticle

51 Scopus citations
2003
5 Scopus citations

Mood alterations in patients treated with chlorambucil

Hehn, S. T., Dorr, R. T. & Miller, T. P., Dec 2003, In : Clinical Lymphoma. 4, 3, p. 179-182 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals

Chow, H. H. S., Cai, Y., Hakim, I. A., Crowell, J. A., Shahi, F., Brooks, C. A., Dorr, R. T., Hara, Y. & Alberts, D. S., Sep 1 2003, In : Clinical Cancer Research. 9, 9, p. 3312-3319 8 p.

Research output: Contribution to journalArticle

513 Scopus citations
2002

Imexon activates an intrinsic apoptosis pathway in RPMI8226 myeloma cells

Dvorakova, K., Payne, C. M., Landowski, T. H., Tome, M. E., Halperin, D. S. & Dorr, R. T., Nov 2002, In : Anti-cancer drugs. 13, 10, p. 1031-1042 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Molecular and cellular characterization of imexon-resistant RPMI8226/I myeloma cells

Dvorakova, K., Payne, C. M., Tome, M. E., Briehl, M. M., Vasquez, M. A., Waltmire, C. N., Coon, A. & Dorr, R. T., Jan 1 2002, In : Molecular Cancer Therapeutics. 1, 3, p. 185-195 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Nordihydroguaiaretic acid: Hepatotoxicity and detoxification in the mouse

Lambert, J. D., Zhao, D., Meyers, R. O., Kuester, R. K., Timmermann, B. N. & Dorr, R. T., Dec 1 2002, In : Toxicon. 40, 12, p. 1701-1708 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

Pyrimidoquinazoline-based antitumor agents. Design of topoisomerase II to DNA cross-linkers with activity against protein kinases

Skibo, E. B., Huang, X., Martinez, R., Lemus, R. H., Craigo, W. A. & Dorr, R. T., Dec 5 2002, In : Journal of Medicinal Chemistry. 45, 25, p. 5543-5555 13 p.

Research output: Contribution to journalArticle

38 Scopus citations
2001

A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated L-asparaginase in patients with advanced solid tumors

Taylor, C. W., Dorr, R. T., Fanta, P., Hersh, E. M. & Salmon, S. E., Jul 31 2001, In : Cancer Chemotherapy And Pharmacology. 47, 1, p. 83-88 6 p.

Research output: Contribution to journalArticle

39 Scopus citations
86 Scopus citations

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: A Southwest Oncology Group study

List, A. F., Kopecky, K. J., Willman, C. L., Head, D. R., Persons, D. L., Slovak, M. L., Dorr, R., Karanes, C., Hynes, H. E., Doroshow, J. H., Shurafa, M. & Appelbaum, F. R., Dec 1 2001, In : Blood. 98, 12, p. 3212-3220 9 p.

Research output: Contribution to journalArticle

335 Scopus citations