Ron Lynch

  • 3456 Citations
  • 32 h-Index
1978 …2020

Research output per year

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Research Output

2020

Lower oxygen consumption and Complex I activity in mitochondria isolated from skeletal muscle of fetal sheep with intrauterine growth restriction

Pendleton, A. L., Antolic, A. T., Kelly, A. C., Davis, M. A., Camacho, L. E., Doubleday, K., Anderson, M. J., Langlais, P. R., Lynch, R. M. & Limesand, S. W., Jul 2020, In : American Journal of Physiology - Endocrinology and Metabolism. 319, 1, p. E67-E80

Research output: Contribution to journalArticle

1 Scopus citations
2019

Oxygen Perfusion (Persufflation) of Human Pancreata Enhances Insulin Secretion and Attenuates Islet Proinflammatory Signaling

Kelly, A. C., Smith, K. E., Purvis, W. G., Min, C. G., Weber, C. S., Cooksey, A. M., Hasilo, C., Paraskevas, S., Suszynski, T. M., Weegman, B. P., Anderson, M. J., Camacho, L. E., Harland, R. C., Loudovaris, T., Jandova, J., Molano, DI. S., Price, N. D., Georgiev, I. G., Scott, W. E., Manas, D. M. D. & 12 others, Shaw, J. A. M., O'Gorman, D., Kin, T., McCarthy, F. M., Szot, G. L., Posselt, A. M., Stock, P. G., Karatzas, T., Shapiro, A. M. J., Lynch, R. M., Limesand, S. W. & Papas, K. K., Jan 1 2019, In : Transplantation. 103, 1, p. 160-167 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Permeability of epithelial/endothelial barriers in transwells and microfluidic bilayer devices

Frost, T. S., Jiang, L., Lynch, R. M. & Zohar, Y., Aug 1 2019, In : Micromachines. 10, 8, 533.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

Adrenergic receptor stimulation suppresses oxidative metabolism in isolated rat islets and Min6 cells

Kelly, A. C., Camacho, L. E., Pendarvis, K., Davenport, H. M., Steffens, N. R., Smith, K. E., Weber, C. S., Lynch, R. M., Papas, K. K. & Limesand, S. W., Sep 15 2018, In : Molecular and Cellular Endocrinology. 473, p. 136-145 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Functional compartmentation of carbohydrate metabolism

Lynch, R. & Paul, R. J., Jan 1 2018, Microcompartmentation. CRC Press, p. 17-35 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

In vitro characterization of neonatal, juvenile, and adult porcine islet oxygen demand, β-cell function, and transcriptomes

Smith, K. E., Purvis, W. G., Davis, M. A., Min, C. G., Cooksey, A. M., Weber, C. S., Jandova, J., Price, N. D., Molano, D. S., Stanton, J. B., Kelly, A. C., Steyn, L. V., Lynch, R., Limesand, S. W., Alexander, M., Lakey, J. R. T., Seeberger, K., Korbutt, G. S., Mueller, K. R., Hering, B. J. & 2 others, McCarthy, F. M. & Papas, K. K., Jan 1 2018, (Accepted/In press) In : Xenotransplantation.

Research output: Contribution to journalArticle

7 Scopus citations
2017

Acute Ischemia Induced by High-Density Culture Increases Cytokine Expression and Diminishes the Function and Viability of Highly Purified Human Islets of Langerhans

Smith, K. E., Kelly, A. C., Min, C. G., Weber, C. S., McCarthy, F. M., Steyn, L. V., Badarinarayana, V., Stanton, J. B., Kitzmann, J. P., Strop, P., Gruessner, A. C., Lynch, R. M., Limesand, S. W. & Papas, K. K., Nov 1 2017, In : Transplantation. 101, 11, p. 2705-2712 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine

Chen, X., Kelly, A. C., Yates, D. T., Macko, A. R., Lynch, R. M. & Limesand, S. W., 2017, In : Journal of Endocrinology. 232, 2, p. 285-295 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2015

A Synthetic Heterobivalent Ligand Composed of Glucagon-Like Peptide 1 and Yohimbine Specifically Targets β Cells Within the Pancreas

Steyn, L. V., Ananthakrishnan, K., Anderson, M. J., Patek, R., Kelly, A., Vagner, J., Lynch, R. & Limesand, S. W., Jan 21 2015, In : Molecular Imaging and Biology. 17, 4, p. 461-470 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Bestrophin-1 influences transepithelial electrical properties and Ca2+signaling in human retinal pigment epithelium

Marmorstein, A. D., Kinnick, T. R., Stanton, J. B., Johnson, A. A., Lynch, R. M. & Marmorstein, L. Y., Apr 1 2015, In : Molecular Vision. 21, p. 347-359 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Development of a time-resolved fluorescence probe for evaluation of competitive binding to the cholecystokinin 2 receptor

Elshan, N. G. R. D., Jayasundera, T., Weber, C. S., Lynch, R. M. & Mash, E. A., Apr 15 2015, In : Bioorganic and Medicinal Chemistry. 23, 8, p. 1841-1848 8 p.

Research output: Contribution to journalArticle

Linear scaffolds for multivalent targeting of melanocortin receptors

Dehigaspitiya, D. C., Anglin, B. L., Smith, K. R., Weber, C. S., Lynch, R. M. & Mash, E. A., 2015, In : Organic and Biomolecular Chemistry. 13, 47, p. 11507-11517 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Pyruvate sensitizes pancreatic tumors to a hypoxia activated pro-drug TH-302.

Wojtkowiak, J. W., Cornell, H. C., Matsumoto, S., Saito, K., Takakusagi, Y., Dutta, P., Kim, M., Zhang, X., Leo, R., Bailey, K. M., Martinez, G., Lloyd, M. C., Lynch, R. M., Baker, A., Gatenby, R. A., Rejniak, K., Hart, C., Krishna, M. C. & Gillies, R. J., Jan 29 2015, In : Cancer Metab.. 3, p. 2-15

Research output: Contribution to journalArticle

Synthesis and bioactivity of MSH4 oligomers prepared by an A<inf>2</inf> + B<inf>2</inf> strategy

Dehigaspitiya, D. C., Navath, S., Weber, C. S., Lynch, R. & Mash, E. A., Jul 3 2015, In : Tetrahedron Letters. 56, 23, p. 3060-3065 6 p., 45546.

Research output: Contribution to journalArticle

4 Scopus citations

Trigonal scaffolds for multivalent targeting of melanocortin receptors

Elshan, N. G. R. D., Jayasundera, T., Anglin, B. L., Weber, C. S., Lynch, R. M. & Mash, E. A., Feb 14 2015, In : Organic and Biomolecular Chemistry. 13, 6, p. 1778-1791 14 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Function and expression of sulfonylurea, adrenergic, and glucagon-like peptide 1 receptors in isolated porcine islets

Kelly, A. C., Steyn, L. V., Kitzmann, J. P., Anderson, M. J., Mueller, K. R., Hart, N. J., Lynch, R. M., Papas, K. K. & Limesand, S. W., Jan 1 2014, In : Xenotransplantation. 21, 4, p. 385-391 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Glucagon-like peptide-1 modulation of calcium homeostasis in human coronary microvascular endothelial cells after ischemia and reperfusion.

Dokken, B. B., Weber, C. S., Mitchell, J. L., Gold, J. M. & Lynch, R. M., Feb 2014, In : J. Endocrinol. Diabetes Obes.. 2, p. 1025-1032

Research output: Contribution to journalArticle

Hetero-bivalent GLP-1/glibenclamide for targeting pancreatic β-cells

Hart, N. J., Chung, W. J., Weber, C., Ananthakrishnan, K., Anderson, M., Patek, R., Zhang, Z., Limesand, S. W., Vagner, J. & Lynch, R. M., Jan 3 2014, In : ChemBioChem. 15, 1, p. 135-145 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2013

Increased redox-sensitive green fluorescent protein reduction potential in the endoplasmic reticulum following glutathione-mediated dimerization

Sarkar, D. D., Edwards, S. K., Mauser, J. A., Suarez, A. M., Serowoky, M. A., Hudok, N. L., Hudok, P. L., Nuñez, M., Weber, C. S., Lynch, R. M., Miyashita, O. & Tsao, T. S., May 14 2013, In : Biochemistry. 52, 19, p. 3332-3345 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Multivalent interactions: Synthesis and evaluation of melanotropin multimers - Tools for melanoma targeting

Brabez, N., Saunders, K., Nguyen, K. L., Jayasundera, T., Weber, C., Lynch, R. M., Chassaing, G., Lavielle, S. & Hruby, V. J., Jan 10 2013, In : ACS Medicinal Chemistry Letters. 4, 1, p. 98-102 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo

Escalante, A. M., McGrath, R. T., Karolak, M. R., Dorr, R. T., Lynch, R. M. & Landowski, T. H., Jun 2013, In : Cancer Chemotherapy And Pharmacology. 71, 6, p. 1567-1576 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Simultaneous analysis of intracellular pH and Ca<sup>2+</sup> from cell populations

Martinez-Zaguilan, R., Tompkins, L. S., Gillies, R. J. & Lynch, R., 2013, Methods in Molecular Biology. Humana Press Inc., Vol. 937. p. 253-271 19 p. (Methods in Molecular Biology; vol. 937).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Simultaneous analysis of intracellular pH and Ca2+ from cell populations.

Martinez-Zaguilan, R., Tompkins, L. S., Gillies, R. J. & Lynch, R., 2013, In : Methods in molecular biology (Clifton, N.J.). 937, p. 253-271 19 p.

Research output: Contribution to journalArticle

Synthesis and characterization of time-resolved fluorescence probes for evaluation of competitive binding to melanocortin receptors

Alleti, R., Vagner, J., Dehigaspitiya, D. C., Moberg, V. E., Elshan, N. G. R. D., Tafreshi, N. K., Brabez, N., Weber, C. S., Lynch, R. M., Hruby, V. J., Gillies, R. J., Morse, D. L. & Mash, E. A., Sep 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 17, p. 5029-5038 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Synthesis and evaluation of cholecystokinin trimers: A multivalent approach to pancreatic cancer detection and treatment

Brabez, N., Nguyen, K. L., Saunders, K., Lacy, R., Xu, L., Gillies, R. J., Lynch, R. M., Chassaing, G., Lavielle, S. & Hruby, V. J., Apr 15 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 8, p. 2422-2425 4 p.

Research output: Contribution to journalArticle

7 Scopus citations
2012

Chronic pulsatile hyperglycemia reduces insulin secretion and increases accumulation of reactive oxygen species in fetal sheep islets

Green, A. S., Chen, X., Macko, A. R., Anderson, M. J., Kelly, A. C., Hart, N. J., Lynch, R. M. & Limesand, S. W., Mar 1 2012, In : Journal of Endocrinology. 212, 3, p. 327-342 16 p.

Research output: Contribution to journalArticle

12 Scopus citations

Heterobivalent ligands target cell-surface receptor combinations in vivo

Xu, L., Josan, J. S., Vagner, J., Caplan, M. R., Hruby, V. J., Mash, E. A., Lynch, R. M., Morse, D. L. & Gillies, R. J., Dec 26 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 52, p. 21295-21300 6 p.

Research output: Contribution to journalArticle

48 Scopus citations
2011

Cell-specific targeting by heterobivalent ligands

Josan, J. S., Handl, H. L., Sankaranarayanan, R., Xu, L., Lynch, R. M., Vagner, J., Mash, E. A., Hruby, V. J. & Gillies, R. J., Jul 20 2011, In : Bioconjugate Chemistry. 22, 7, p. 1270-1278 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Design, synthesis, and biological studies of efficient multivalent melanotropin ligands: Tools toward melanoma diagnosis and treatment

Brabez, N., Lynch, R. M., Xu, L., Gillies, R. J., Chassaing, G., Lavielle, S. & Hruby, V. J., Oct 27 2011, In : Journal of Medicinal Chemistry. 54, 20, p. 7375-7384 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Fluorescent and lanthanide labeling for ligand screens, assays, and imaging.

Josan, J. S., De Silva, C. R., Yoo, B., Lynch, R. M., Pagel, M. D., Vagner, J. & Hruby, V. J., 2011, In : Methods in molecular biology (Clifton, N.J.). 716, p. 89-126 38 p.

Research output: Contribution to journalArticle

18 Scopus citations
2010

Changes in APS sectional programming for EB2011

Carmines, P. & Lynch, R. M., Oct 1 2010, Physiologist, 53, 5, p. 137+140.

Research output: Contribution to specialist publicationArticle

Na+-K+-ATPase and Ca2+ clearance proteins in smooth muscle: A functional unit

Pritchard, T. J., Bowman, P. S., Jefferson, A., Tosun, M., Lynch, R. M. & Paul, R. J., Aug 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 299, 2, p. H548-H556

Research output: Contribution to journalArticle

23 Scopus citations
16 Scopus citations
2009

Enhanced targeting with heterobivalent ligands

Xu, L., Vagner, J., Josan, J., Lynch, R. M., Morse, D. L., Baggett, B., Han, H., Mash, E. A., Hruby, V. J. & Gillies, R. J., Aug 1 2009, In : Molecular Cancer Therapeutics. 8, 8, p. 2356-2365 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Heterobivalent ligands crosslink multiple receptors for targeting pancreatic beta-cells to monitor beta-cell mass.

Vagner, J., Chung, W. J., Weber, C. S., Limesand, S. W., De Silva, C. R. & Lynch, R. M., Apr 2009, In : J. Am. Peptide Soc.. 21, p. 32-34

Research output: Contribution to journalArticle

2008

Clearance of store-released Ca2+ by the Na+-Ca 2+ exchanger is diminished in aortic smooth muscle from Na +-K+-ATPase α2-isoform gene-ablated mice

Lynch, R. M., Weber, C. S., Nullmeyer, K. D., Moore, E. D. W. & Paul, R. J., Mar 1 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 294, 3, p. H1407-H1416

Research output: Contribution to journalArticle

30 Scopus citations
46 Scopus citations

Image acquisition for colocalization using optical microscopy

Scriven, D. R. L., Lynch, R. M. & Moore, E. D. W., May 1 2008, In : American Journal of Physiology - Cell Physiology. 294, 5, p. C1119-C1122

Research output: Contribution to journalReview article

25 Scopus citations

L-DOPA is an endogenous ligand for OA1

Lopez, V. M., Decatur, C. L., Stamer, W. D., Lynch, R. M. & McKay, B. S., Sep 2008, In : PLoS biology. 6, 9, p. 1861-1869 9 p., e236.

Research output: Contribution to journalArticle

101 Scopus citations
2007

Comparison of the contributions of the nuclear and cytoplasmic compartments to global gene expression in human cells

Barthelson, R. A., Lambert, G. M., Vanier, C., Lynch, R. M. & Galbraith, D. W., Sep 25 2007, In : BMC genomics. 8, 340.

Research output: Contribution to journalArticle

47 Scopus citations

Peptide-labeled quantum dots for imaging GPCRs in whole cells and as single molecules

Zhou, M., Nakatani, E., Gronenberg, L. S., Tokimoto, T., Wirth, M. J., Hruby, V. J., Roberts, A., Lynch, R. M. & Ghosh, I., Mar 1 2007, In : Bioconjugate Chemistry. 18, 2, p. 323-332 10 p.

Research output: Contribution to journalArticle

91 Scopus citations

Transgenic mice expressing Na+-K+-ATPase in smooth muscle decreases blood pressure

Pritchard, T. J., Parvatiyar, M., Bullard, D. P., Lynch, R. M., Lorenz, J. N. & Paul, R. J., Aug 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 293, 2, p. H1172-H1182

Research output: Contribution to journalArticle

33 Scopus citations
2006

Regulation of Na+/H+ exchanger-NHE3 by angiotensin-II in OKP cells

Xu, L., Dixit, M. P., Nullmeyer, K. D., Xu, H., Kiela, P. R., Lynch, R. M. & Ghishan, F. K., Apr 1 2006, In : Biochimica et Biophysica Acta - Biomembranes. 1758, 4, p. 519-526 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Simultaneous analysis of intracellular pH and Ca2+ from cell populations

Martinez-Zaguilan, R., Tompkins, L. S., Gillies, R. J. & Lynch, R. M., Dec 1 2006, Calcium Signaling Protocols. Lambert, D. (ed.). p. 269-287 19 p. (Methods in Molecular Biology; vol. 312).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2005

Developmental expression of glucokinase in rat hypothalamus

Sutherland, V. L., McReynolds, M., Tompkins, L. S., Brooks, H. L. & Lynch, R. M., Feb 8 2005, In : Developmental Brain Research. 154, 2, p. 255-258 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mitochondrial-mediated disregulation of Ca2+ is a critical determinant of velcade (PS-341/Bortezomib) cytotoxicity in myeloma cell lines

Landowski, T. H., Megli, C. J., Nullmeyer, K. D., Lynch, R. M. & Dorr, R. T., May 1 2005, In : Cancer Research. 65, 9, p. 3828-3836 9 p.

Research output: Contribution to journalArticle

173 Scopus citations
2004

In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI

Aoki, I., Wu, Y. J. L., Silva, A. C., Lynch, R. M. & Koretsky, A. P., Jul 1 2004, In : NeuroImage. 22, 3, p. 1046-1059 14 p.

Research output: Contribution to journalArticle

220 Scopus citations