• 399 Citations
  • 11 h-Index
20052017
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Research Output 2005 2017

  • 399 Citations
  • 11 h-Index
  • 20 Article
  • 2 Book
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Article
2016
2 Citations (Scopus)

Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain

Vardanyan, R. S., Cain, J. P., Haghighi, S. M., Kumirov, V. K., Mcintosh, M. I., Sandweiss, A. J., Porreca, F. & Hruby, V. J., 2016, (Accepted/In press) In : Journal of Heterocyclic Chemistry.

Research output: Contribution to journalArticle

Opioid Receptors
Opioid Analgesics
Analgesics
Ligands
Enkephalins
2015
5 Citations (Scopus)

Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands

Bird, M. F., Vardanyan, R. S., Hruby, V. J., Caló, G., Guerrini, R., Salvadori, S., Trapella, C., McDonald, J., Rowbotham, D. J. & Lambert, D. G., Apr 1 2015, In : British Journal of Anaesthesia. 114, 4, p. 646-656 11 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Opioid Peptides
Narcotic Antagonists
Fentanyl
Ligands
2014
76 Citations (Scopus)
Fentanyl
Neurokinin-1 Receptors
delta Opioid Receptor
mu Opioid Receptor
Structure-Activity Relationship
2013
1 Citation (Scopus)

Chiral effect of a Phe residue in position 3 of the Dmt1-l (or d)-Tic2 analogues on opioid functional activities

Lee, Y. S., Qu, H., Davis, P., Ma, S. W., Vardanyan, R. S., Lai, J., Porreca, F. & Hruby, V. J., Jul 11 2013, In : ACS Medicinal Chemistry Letters. 4, 7, p. 656-659 4 p.

Research output: Contribution to journalArticle

Chirality
Opioid Receptors
Opioid Analgesics
Structure-Activity Relationship
Ligands
7 Citations (Scopus)

Effect of anchoring 4-anilidopiperidines to opioid peptides

Petrov, R. R., Lee, Y. S., Vardanyan, R. S., Liu, L., Ma, S. W., Davis, P., Lai, J., Porreca, F., Vanderah, T. W. & Hruby, V. J., Jun 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 11, p. 3434-3437 4 p.

Research output: Contribution to journalArticle

Opioid Peptides
Opioid Analgesics
Fentanyl
Scaffolds
Light
24 Citations (Scopus)

Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain

Podolsky, A. T., Sandweiss, A., Hu, J., Bilsky, E. J., Cain, J. P., Kumirov, V. K., Lee, Y. S., Hruby, V. J., Vardanyan, R. S. & Vanderah, T. W., Dec 18 2013, In : Life Sciences. 93, 25-26, p. 1010-1016 7 p.

Research output: Contribution to journalArticle

Acute Pain
Fentanyl
Chronic Pain
Opioid Analgesics
delta Opioid Receptor
2011
34 Citations (Scopus)

Development of potent μ and δ opioid agonists with high lipophilicity

Lee, Y. S., Kulkarani, V., Cowell, S. M., Ma, S. W., Davis, P., Hanlon, K. E., Vanderah, T. W., Lai, J., Porreca, F., Vardanyan, R. S. & Hruby, V. J., Jan 13 2011, In : Journal of Medicinal Chemistry. 54, 1, p. 382-386 5 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Ligands
Enkephalins
Halogenation
Opioid Receptors
4 Citations (Scopus)

Improved synthesis of d,l-fluorocitric acid

Vardanyan, R. S., Kumirov, V. K. & Hruby, V. J., Nov 2011, In : Journal of Fluorine Chemistry. 132, 11, p. 920-924 5 p.

Research output: Contribution to journalArticle

Oxaloacetates
Fluoroacetates
Esters
hydrogenolysis
Hydrogenolysis
1 Citation (Scopus)

Recyclization reactions of 1-alkylpyrimidinium salts

Vardanyan, R. S., Danagulyan, G. G., Mkrtchyan, A. D. & Hruby, V. J., Sep 2011, In : Heterocyclic Communications. 17, 3-4, p. 129-133 5 p.

Research output: Contribution to journalArticle

Iodides
Salts
Heating
3-phenylpyridine
benzylamine
18 Citations (Scopus)

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands

Vardanyan, R. S., Kumirov, V. K., Nichol, G. S., Davis, P., Liktor-Busa, E., Rankin, D., Varga, E., Vanderah, T. W., Porreca, F., Lai, J. & Hruby, V. J., Oct 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 20, p. 6135-6142 8 p.

Research output: Contribution to journalArticle

Perchlorates
Opioid Analgesics
Ligands
Hydrazines
Lead compounds
2010
3 Citations (Scopus)

Proton sharing and transfer in some zwitterionic compounds based on 4-oxo-4-((1-phenethylpiperidin-4-yl)(phenyl)amino)alcanoic acids

Nichol, G. S., Kumirov, V. K., Vardanyan, R. S. & Hruby, V. J., Nov 2010, In : CrystEngComm. 12, 11, p. 3651-3657 7 p.

Research output: Contribution to journalArticle

zwitterions
amino acids
Protons
Amino acids
Dimers
1 Citation (Scopus)

Synthesis and crystallographic study of N'-(1-benzylpiperidin-4-yl) acetohydrazide

Nichol, G. S., Vardanyan, R. S. & Hruby, V. J., Nov 2010, In : Journal of Chemical Crystallography. 40, 11, p. 961-964 4 p.

Research output: Contribution to journalArticle

Molecules
synthesis
molecules
Conformations
symmetry
2009
2 Citations (Scopus)

Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety.

Lee, Y., Petrov, R., Kulkarni, V., Min, B. J., Ma, S. W., Davis, P., Oyarzo, J., Vanderah, T. W., Lai, J., Porreca, F., Vardanyan, R. S. & Hruby, V. J., 2009, In : Advances in Experimental Medicine and Biology. 611, p. 517-518 2 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Enkephalins
mu Opioid Receptor
Opioid Analgesics
Rats
16 Citations (Scopus)

Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain

Vardanyan, R. S., Gokhale, V., Nichol, G. S., Liu, L., Kumarasinghe, I., Davis, P., Vanderah, T. W., Porreca, F., Lai, J. & Hruby, V. J., Jul 15 2009, In : Bioorganic and Medicinal Chemistry. 17, 14, p. 5044-5053 10 p.

Research output: Contribution to journalArticle

Neuralgia
Fentanyl
Indomethacin
Chronic Pain
Opioid Analgesics
2008
7 Citations (Scopus)

Opioid and melanocortin receptors: Do they have overlapping pharmacophores?

Lee, Y. S., Agnes, R. S., Cain, J. P., Kulkarni, V., Cai, M., Salibay, C., Ciano, K., Petrov, R., Mayorov, A., Vagner, J., Trivedi, D., Davis, P., Ma, S. W., Lai, J., Porreca, F., Vardanyan, R. S. & Hruby, V. J., 2008, In : Biopolymers - Peptide Science Section. 90, 3, p. 433-438 6 p.

Research output: Contribution to journalArticle

Melanocortin Receptors
Opioid Receptors
Receptor, Melanocortin, Type 1
Carboxylic acids
Ligands
2007
29 Citations (Scopus)

Development of novel enkephalin analogues that have enhanced opioid activities at both μ and δ opioid receptors

Yeon, S. L., Petrov, R., Park, C. K., Ma, S. W., Davis, P., Lai, J., Porreca, F., Vardanyan, R. S. & Hruby, V. J., Nov 1 2007, In : Journal of Medicinal Chemistry. 50, 22, p. 5528-5532 5 p.

Research output: Contribution to journalArticle

Enkephalins
Opioid Receptors
Opioid Analgesics
Lead compounds
Hydrophobicity
21 Citations (Scopus)

Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at μ and δ opioid receptors

Lee, Y. S., Nyberg, J., Moye, S., Agnes, R. S., Davis, P., Ma, S. W., Lai, J., Porreca, F., Vardanyan, R. S. & Hruby, V. J., Apr 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 8, p. 2161-2165 5 p.

Research output: Contribution to journalArticle

Opioid Receptors
Bioactivity
Fentanyl
Amino Acids
Acids
2006
2 Citations (Scopus)

4-{N-[2-(1,3-Dioxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl]anilino} -1-phenethylpiperidinium chloride methanol disolvate

Petrov, R. R., Vardanyan, R. S., Nichol, G. S., Carducci, M. D., Ma, S. W., Lai, J. Y. & Hruby, V. J., Jul 2006, In : Acta Crystallographica Section E: Structure Reports Online. 62, 7

Research output: Contribution to journalArticle

Fentanyl
Hydrogen Bonding
Methanol
Conformations
Cations
21 Citations (Scopus)

Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity

Petrov, R. R., Vardanyan, R. S., Lee, Y. S., Ma, S. W., Davis, P., Begay, L. J., Lai, J. Y., Porreca, F. & Hruby, V. J., Sep 15 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 18, p. 4946-4950 5 p.

Research output: Contribution to journalArticle

hydrazine
Opioid Receptors
Fentanyl
Opioid Analgesics
Bioactivity
2005
16 Citations (Scopus)

Isomerization/recyclization of some 5-ethoxycarbonyl-pyrimidines

Vardanyan, R. S., Hruby, V. J., Danagulyan, G. G. & Mkrtchyan, A. D., May 2005, In : Journal of Heterocyclic Chemistry. 42, 4, p. 557-562 6 p.

Research output: Contribution to journalArticle

Pyrimidines
Isomerization
Hydrazones
Nucleophiles
Cyclization