• 437 Citations
  • 11 h-Index
20052017

Research output per year

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Research Output

  • 437 Citations
  • 11 h-Index
  • 19 Article
  • 2 Book
  • 1 Review article
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Article
2017

Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain

Vardanyan, R. S., Cain, J. P., Haghighi, S. M., Kumirov, V. K., McIntosh, M. I., Sandweiss, A. J., Porreca, F. & Hruby, V. J., Jan 1 2017, In : Journal of Heterocyclic Chemistry. 54, 2, p. 1228-1235 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands

Bird, M. F., Vardanyan, R. S., Hruby, V. J., Caló, G., Guerrini, R., Salvadori, S., Trapella, C., McDonald, J., Rowbotham, D. J. & Lambert, D. G., Apr 1 2015, In : British Journal of Anaesthesia. 114, 4, p. 646-656 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

Chiral effect of a Phe residue in position 3 of the Dmt1-l (or d)-Tic2 analogues on opioid functional activities

Lee, Y. S., Qu, H., Davis, P., Ma, S. W., Vardanyan, R., Lai, J., Porreca, F. & Hruby, V. J., Jul 11 2013, In : ACS Medicinal Chemistry Letters. 4, 7, p. 656-659 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Effect of anchoring 4-anilidopiperidines to opioid peptides

Petrov, R. R., Lee, Y. S., Vardanyan, R. S., Liu, L., Ma, S. W., Davis, P., Lai, J., Porreca, F., Vanderah, T. W. & Hruby, V. J., Jun 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 11, p. 3434-3437 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain

Podolsky, A. T., Sandweiss, A., Hu, J., Bilsky, E. J., Cain, J. P., Kumirov, V. K., Lee, Y. S., Hruby, V. J., Vardanyan, R. S. & Vanderah, T. W., Dec 18 2013, In : Life Sciences. 93, 25-26, p. 1010-1016 7 p.

Research output: Contribution to journalArticle

27 Scopus citations
2011

Development of potent μ and δ opioid agonists with high lipophilicity

Lee, Y. S., Kulkarani, V., Cowell, S. M., Ma, S. W., Davis, P., Hanlon, K. E., Vanderah, T. W., Lai, J., Porreca, F., Vardanyan, R. & Hruby, V. J., Jan 13 2011, In : Journal of Medicinal Chemistry. 54, 1, p. 382-386 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Improved synthesis of d,l-fluorocitric acid

Vardanyan, R., Kumirov, V. K. & Hruby, V. J., Nov 1 2011, In : Journal of Fluorine Chemistry. 132, 11, p. 920-924 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Recyclization reactions of 1-alkylpyrimidinium salts

Vardanyan, R. S., Danagulyan, G. G., Mkrtchyan, A. D. & Hruby, V. J., Sep 1 2011, In : Heterocyclic Communications. 17, 3-4, p. 129-133 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands

Vardanyan, R., Kumirov, V. K., Nichol, G. S., Davis, P., Liktor-Busa, E., Rankin, D., Varga, E., Vanderah, T., Porreca, F., Lai, J. & Hruby, V. J., Oct 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 20, p. 6135-6142 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
2010

Proton sharing and transfer in some zwitterionic compounds based on 4-oxo-4-((1-phenethylpiperidin-4-yl)(phenyl)amino)alcanoic acids

Nichol, G. S., Kumirov, V. K., Vardanyan, R. & Hruby, V. J., Nov 1 2010, In : CrystEngComm. 12, 11, p. 3651-3657 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Synthesis and crystallographic study of N'-(1-benzylpiperidin-4-yl) acetohydrazide

Nichol, G. S., Vardanyan, R. & Hruby, V. J., Nov 1 2010, In : Journal of Chemical Crystallography. 40, 11, p. 961-964 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2009

Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety.

Lee, Y. S., Petrov, R., Kulkarni, V., Min, B. J., Ma, S. W., Davis, P., Oyarzo, J., Vanderah, T., Lai, J., Porreca, F., Vardanyan, R. & Hruby, V. J., 2009, In : Advances in experimental medicine and biology. 611, p. 517-518 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain

Vardanyan, R., Vijay, G., Nichol, G. S., Liu, L., Kumarasinghe, I., Davis, P., Vanderah, T., Porreca, F., Lai, J. & Hruby, V. J., Jul 15 2009, In : Bioorganic and Medicinal Chemistry. 17, 14, p. 5044-5053 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2008

Opioid and melanocortin receptors: Do they have overlapping pharmacophores?

Lee, Y. S., Agnes, R. S., Cain, J. P., Kulkarni, V., Cai, M., Salibay, C., Ciano, K., Petrov, R., Mayorov, A., Vagner, J., Trivedi, D., Davis, P., Ma, S. W., Lai, J., Porreca, F., Vardanyan, R. & Hruby, V. J., Oct 6 2008, In : Biopolymers - Peptide Science Section. 90, 3, p. 433-438 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
2007

Development of novel enkephalin analogues that have enhanced opioid activities at both μ and δ opioid receptors

Yeon, S. L., Petrov, R., Park, C. K., Ma, S. W., Davis, P., Lai, J., Porreca, F., Vardanyan, R. & Hruby, V. J., Nov 1 2007, In : Journal of Medicinal Chemistry. 50, 22, p. 5528-5532 5 p.

Research output: Contribution to journalArticle

31 Scopus citations

Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at μ and δ opioid receptors

Lee, Y. S., Nyberg, J., Moye, S., Agnes, R. S., Davis, P., Ma, S. W., Lai, J., Porreca, F., Vardanyan, R. & Hruby, V. J., Apr 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 8, p. 2161-2165 5 p.

Research output: Contribution to journalArticle

22 Scopus citations
2006

4-{N-[2-(1,3-Dioxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl]anilino} -1-phenethylpiperidinium chloride methanol disolvate

Petrov, R. R., Vardanyan, R. S., Nichol, G. S., Carducci, M. D., Ma, S. W., Lai, J. Y. & Hruby, V. J., Jul 1 2006, In : Acta Crystallographica Section E: Structure Reports Online. 62, 7, p. o2815-o2816

Research output: Contribution to journalArticle

2 Scopus citations

Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity

Petrov, R. R., Vardanyan, R. S., Lee, Y. S., Ma, S. W., Davis, P., Begay, L. J., Lai, J. Y., Porreca, F. & Hruby, V. J., Sep 15 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 18, p. 4946-4950 5 p.

Research output: Contribution to journalArticle

22 Scopus citations
2005

Isomerization/recyclization of some 5-ethoxycarbonyl-pyrimidines

Vardanyan, R. S., Hruby, V. J., Danagulyan, G. G. & Mkrtchyan, A. D., Jan 1 2005, In : Journal of Heterocyclic Chemistry. 42, 4, p. 557-562 6 p.

Research output: Contribution to journalArticle

18 Scopus citations