• 1692 Citations
  • 22 h-Index
1991 …2019
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Research Output 1991 2019

  • 1692 Citations
  • 22 h-Index
  • 45 Article
  • 1 Editorial
2019
1 Citation (Scopus)

Cardiac effects of a single dose of pimobendan in cats with hypertrophic cardiomyopathy; A randomized, placebo-controlled, crossover study

Oldach, M. S., Ueda, Y., Ontiveros, E. S., Fousse, S. L., Harris, S. P. & Stern, J. A., Feb 4 2019, In : Frontiers in Veterinary Science. 6, FEB, 15.

Research output: Contribution to journalArticle

Open Access
Hypertrophic Cardiomyopathy
cardiomyopathy
Cross-Over Studies
placebos
Cats

Sarcomeric mutations in cardiac diseases

Harris, S. P. & de Tombe, P. P., May 1 2019, In : Pflugers Archiv European Journal of Physiology. 471, 5, p. 659-660 2 p.

Research output: Contribution to journalEditorial

Open Access
Heart Diseases
Mutation
2018
11 Citations (Scopus)

N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament

Risi, C., Belknap, B., Forgacs-Lonart, E., Harris, S. P., Schröder, G. F., White, H. D. & Galkin, V. E., Dec 4 2018, In : Structure. 26, 12, p. 1604-1611.e4

Research output: Contribution to journalArticle

Cardiac Myosins
Actomyosin
Tropomyosin
Myosins
Muscle Contraction
4 Citations (Scopus)

Point mutations in the tri-helix bundle of the M-domain of cardiac myosin binding protein-C influence systolic duration and delay cardiac relaxation

van Dijk, S. J., Kooiker, K. B., Napierski, N. C., Touma, K. D., Mazzalupo, S. & Harris, S. P., Jun 1 2018, In : Journal of Molecular and Cellular Cardiology. 119, p. 116-124 9 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Point Mutation
Actins
Protein Binding
Systole
Precision Medicine
Hypertrophic Cardiomyopathy
cardiomyopathy
medicine
Cats
2017
27 Citations (Scopus)

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy

McNamara, J. W., Li, A., Lal, S., Bos, J. M., Harris, S. P., Van Der Velden, J., Ackerman, M. J., Cooke, R. & Dos Remedios, C. G., Jun 1 2017, In : PLoS One. 12, 6, e0180064.

Research output: Contribution to journalArticle

Cardiac Myosins
Hypertrophic Cardiomyopathy
cardiomyopathy
Myosins
myosin
2016
32 Citations (Scopus)

Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes

McNamara, J. W., Li, A., Smith, N. J., Lal, S., Graham, R. M., Kooiker, K. B., van Dijk, S. J., Remedios, C. G. D., Harris, S. P. & Cooke, R., May 1 2016, In : Journal of Molecular and Cellular Cardiology. 94, p. 65-71 7 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Myosins
Cardiac Myocytes
Knockout Mice
Adenosine Triphosphate
20 Citations (Scopus)

A small molecule inhibitor of sarcomere contractility acutely relieves left ventricular outflow tract obstruction in feline hypertrophic cardiomyopathy

Stern, J. A., Markova, S., Ueda, Y., Kim, J. B., Pascoe, P. J., Evanchik, M. J., Green, E. M. & Harris, S. P., Dec 1 2016, In : PLoS One. 11, 12, e0168407.

Research output: Contribution to journalArticle

Ventricular Outflow Obstruction
Sarcomeres
sarcomeres
Hypertrophic Cardiomyopathy
cardiomyopathy
22 Citations (Scopus)

C0 and C1 N-terminal Ig domains of myosin binding protein C exert different effects on thin filament activation

Harris, S. P., Belknap, B., Van Sciver, R. E., White, H. D. & Galkin, V. E., Feb 9 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 6, p. 1558-1563 6 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Tropomyosin
Actins
Sarcomeres
Myosins
8 Citations (Scopus)

Platelet Activation and Clopidogrel Effects on ADP-Induced Platelet Activation in Cats with or without the A31P Mutation in MYBPC3

Li, R. H. L., Stern, J. A., Ho, V., Tablin, F. & Harris, S. P., Sep 1 2016, In : Journal of Veterinary Internal Medicine. 30, 5, p. 1619-1629 11 p.

Research output: Contribution to journalArticle

clopidogrel
adenosine diphosphate
platelet activation
Platelet Activation
Adenosine Diphosphate
8 Citations (Scopus)

The cMyBP-C HCM variant L348P enhances thin filament activation through an increased shift in tropomyosin position

Mun, J. Y., Kensler, R. W., Harris, S. P. & Craig, R., Feb 1 2016, In : Journal of Molecular and Cellular Cardiology. 91, p. 141-147 7 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Tropomyosin
Hypertrophic Cardiomyopathy
Phosphorylation
Mutation
13 Citations (Scopus)

Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin

Kolb, J., Li, F., Methawasin, M., Adler, M., Escobar, Y. N., Nedrud, J., Pappas, C. T., Harris, S. P. & Granzier, H., Aug 1 2016, In : Journal of Molecular and Cellular Cardiology. 97, p. 286-294 9 p.

Research output: Contribution to journalArticle

Connectin
Sarcomeres
Tropomodulin
Heart Atria
Muscle Cells
2015
15 Citations (Scopus)

Effects of cardiac myosin binding protein-C on actin motility are explained with a drag-activation-competition model

Walcott, S., Docken, S. & Harris, S. P., Jan 6 2015, In : Biophysical Journal. 108, 1, p. 10-13 4 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Actins
Contractile Proteins
Tropomyosin
Myosins
6 Citations (Scopus)

Normal cardiac contraction in mice lacking the proline-alanine rich region and C1 domain of cardiac myosin binding protein C

van Dijk, S. J., Witt, C. C. & Harris, S. P., Nov 1 2015, In : Journal of Molecular and Cellular Cardiology. 88, p. 124-132 9 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Proline
Alanine
Calcium
myosin-binding protein C
17 Citations (Scopus)

Orientation of myosin binding protein C in the cardiac muscle sarcomere determined by domain-specific immuno-EM

Lee, K., Harris, S. P., Sadayappan, S. & Craig, R., Jan 30 2015, In : Journal of Molecular Biology. 427, 2, p. 274-286 13 p.

Research output: Contribution to journalArticle

Sarcomeres
Cardiac Myosins
Myocardium
Antibodies
Striated Muscle
6 Citations (Scopus)

The A31P missense mutation in cardiac myosin binding protein C alters protein structure but does not cause haploinsufficiency

van Dijk, S. J., Bezold Kooiker, K., Mazzalupo, S., Yang, Y., Kostyukova, A. S., Mustacich, D. J., Hoye, E. R., Stern, J. A., Kittleson, M. D. & Harris, S. P., Nov 27 2015, (Accepted/In press) In : Archives of Biochemistry and Biophysics.

Research output: Contribution to journalArticle

Cardiac Myosins
Haploinsufficiency
Missense Mutation
Mutation
Hypertrophic Cardiomyopathy
9 Citations (Scopus)

The genetic basis of hypertrophic cardiomyopathy in cats and humans

Kittleson, M. D., Meurs, K. M. & Harris, S. P., Dec 1 2015, In : Journal of Veterinary Cardiology. 17, p. S53-S73

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
cardiomyopathy
Cats
cats
Genes
2014
9 Citations (Scopus)

Altered interactions between cardiac myosin binding protein-c and α-cardiac actin variants associated with cardiomyopathies

Chow, M. L., Shaffer, J. F., Harris, S. P. & Dawson, J. F., May 15 2014, In : Archives of Biochemistry and Biophysics. 550-551, p. 28-32 5 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Cardiomyopathies
Actins
Carrier Proteins
Proteins
29 Citations (Scopus)

Earning stripes: Myosin binding protein-C interactions with actin

Van Dijk, S. J., Bezold, K. L. & Harris, S. P., Mar 2014, In : Pflugers Archiv European Journal of Physiology. 466, 3, p. 445-450 6 p.

Research output: Contribution to journalArticle

Actins
Myosins
myosin-binding protein C
Skeletal Muscle Myosins
Actomyosin
13 Citations (Scopus)

Modulation of thin filament activation of myosin ATP hydrolysis by N-terminal domains of cardiac myosin binding protein-C

Belknap, B., Harris, S. P. & White, H. D., Oct 28 2014, In : Biochemistry. 53, 42, p. 6717-6724 8 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Myosins
Hydrolysis
Adenosine Triphosphate
Chemical activation
2013
19 Citations (Scopus)

A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin

Bezold, K. L., Shaffer, J. F., Khosa, J. K., Hoye, E. R. & Harris, S. P., Jul 26 2013, In : Journal of Biological Chemistry. 288, 30, p. 21496-21505 10 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Actins
Amino Acids
Actomyosin
Mutation
3 Citations (Scopus)

Cross-species mechanical fingerprinting of cardiac myosin binding protein-C

Karsai, Á., Kellermayer, M. S. Z. & Harris, S. P., Jun 4 2013, In : Biophysical Journal. 104, 11, p. 2465-2475 11 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Atomic Force Microscopy
Immunoglobulins
myosin-binding protein C
Baculoviridae
2011
54 Citations (Scopus)

Binding of the N-terminal fragment C0-C2 of cardiac MyBP-C to cardiac F-actin

Kensler, R. W., Shaffer, J. F. & Harris, S. P., Apr 2011, In : Journal of Structural Biology. 174, 1, p. 44-51 8 p.

Research output: Contribution to journalArticle

Actins
Cardiac Myosins
Electron Microscopy
Myocardial Contraction
Negative Staining
118 Citations (Scopus)

In the thick of it: HCM-causing mutations in myosin binding proteins of the thick filament

Harris, S. P., Lyons, R. G. & Bezold, K. L., Mar 18 2011, In : Circulation Research. 108, 6, p. 751-764 14 p.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Myosins
Carrier Proteins
Mutation
Cardiac Myosins
24 Citations (Scopus)

Mechanical unfolding of cardiac myosin binding protein-C by atomic force microscopy

Karsai, Á., Kellermayer, M. S. Z. & Harris, S. P., Oct 19 2011, In : Biophysical Journal. 101, 8, p. 1968-1977 10 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Atomic Force Microscopy
Myosins
Immunoglobulins
Actins
12 Citations (Scopus)

Translational medicine: To the rescue of the failing heart

Bers, D. M. & Harris, S. P., May 5 2011, In : Nature. 473, 7345, p. 36-39 4 p.

Research output: Contribution to journalArticle

Cardiotonic Agents
Translational Medical Research
cardiovascular disease
medicine
urea
2010
23 Citations (Scopus)

Functional differences between the N-terminal domains of mouse and human myosin binding protein-C

Harris, S. P., Shaffer, J. F., Wong, P. & Bezold, K. L., 2010, In : Journal of Biomedicine and Biotechnology. 2010, 789798.

Research output: Contribution to journalArticle

Actomyosin
Protein Isoforms
Rats
Fusion reactions
Amino Acids
44 Citations (Scopus)
Cardiac Myosins
Phosphorylation
Protein Kinases
Cyclic AMP-Dependent Protein Kinases
Mass spectrometry
2009
28 Citations (Scopus)

Species-specific differences in the Pro-Ala rich region of cardiac myosin binding protein-C

Shaffer, J. F. & Harris, S. P., Dec 2009, In : Journal of Muscle Research and Cell Motility. 30, 7-8, p. 303-306 4 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Alanine
Protein Isoforms
Familial Hypertrophic Cardiomyopathy
Sarcomeres
128 Citations (Scopus)

The myosin-binding protein C motif binds to F-actin in a phosphorylation-sensitive manner

Shaffer, J. F., Kensler, R. W. & Harris, S. P., May 1 2009, In : Journal of Biological Chemistry. 284, 18, p. 12318-12327 10 p.

Research output: Contribution to journalArticle

Amino Acid Motifs
Phosphorylation
Actins
Cardiac Myosins
Connectin
2008
88 Citations (Scopus)

Cardiac myosin-binding protein C decorates F-actin: Implications for cardiac function

Whitten, A. E., Jeffries, C. M., Harris, S. P. & Trewhella, J., Nov 25 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 47, p. 18360-18365 6 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Actins
Myosins
Contractile Proteins
Sarcomeres
31 Citations (Scopus)

Contribution of the myosin binding protein c motif to functional effects in permeabilized rat trabeculae

Razumova, M. V., Bezold, K. L., Tu, A. Y., Regnier, M. & Harris, S. P., Nov 2008, In : Journal of General Physiology. 132, 5, p. 575-585 11 p.

Research output: Contribution to journalArticle

Amino Acid Motifs
Myosins
Carrier Proteins
Recombinant Proteins
Cardiac Myosins
57 Citations (Scopus)

Small-Angle X-ray Scattering Reveals the N-Terminal Domain Organization of Cardiac Myosin Binding Protein C

Jeffries, C. M., Whitten, A. E., Harris, S. P. & Trewhella, J., Apr 4 2008, In : Journal of Molecular Biology. 377, 4, p. 1186-1199 14 p.

Research output: Contribution to journalArticle

Cardiac Myosins
X-Rays
Immunoglobulins
Protein Isoforms
Actomyosin
23 Citations (Scopus)

The structure of isolated cardiac myosin thick filaments from cardiac myosin binding protein-C knockout mice

Kensler, R. W. & Harris, S. P., Mar 1 2008, In : Biophysical Journal. 94, 5, p. 1707-1718 12 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Knockout Mice
Myosins
Familial Hypertrophic Cardiomyopathy
myosin-binding protein C
79 Citations (Scopus)

Understanding the Organisation and Role of Myosin Binding Protein C in Normal Striated Muscle by Comparison with MyBP-C Knockout Cardiac Muscle

Luther, P. K., Bennett, P. M., Knupp, C., Craig, R., Padrón, R., Harris, S. P., Patel, J. & Moss, R. L., Dec 5 2008, In : Journal of Molecular Biology. 384, 1, p. 60-72 13 p.

Research output: Contribution to journalArticle

Striated Muscle
Myocardium
Myosins
Skeletal Muscle
Familial Hypertrophic Cardiomyopathy
2007
21 Citations (Scopus)

Myosin S2 is not required for effects of myosin binding protein-C on motility

Shaffer, J. F., Razumova, M. V., Tu, A. Y., Regnier, M. & Harris, S. P., Apr 3 2007, In : FEBS Letters. 581, 7, p. 1501-1504 4 p.

Research output: Contribution to journalArticle

Myosins
Amino Acid Motifs
Assays
Myosin Subfragments
Recombinant Proteins
2006
85 Citations (Scopus)

Effects of the N-terminal domains of myosin binding protein-C in an in vitro motility assay: Evidence for long-lived cross-bridges

Razumova, M. V., Shaffer, J. F., Tu, A. Y., Flint, G. V., Regnier, M. & Harris, S. P., Nov 24 2006, In : Journal of Biological Chemistry. 281, 47, p. 35846-35854 9 p.

Research output: Contribution to journalArticle

Assays
Myosin Subfragments
Actins
Tropomyosin
Amino Acid Motifs
2004
54 Citations (Scopus)

Binding of myosin binding protein-C to myosin subfragment S2 affects contractility independent of a tether mechanism

Harris, S. P., Rostkova, E., Gautel, M. & Moss, R. L., Oct 29 2004, In : Circulation Research. 95, 9, p. 930-936 7 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Myosin Subfragments
Myosins
Muscle Cells
Gene Knockout Techniques
87 Citations (Scopus)

Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening

Palmer, B. M., Georgakopoulos, D., Janssen, P. M., Wang, Y., Alpert, N. R., Belardi, D. F., Harris, S. P., Moss, R. L., Burgon, P. G., Seidman, C. E., Seidman, J. G., Maughan, D. W. & Kass, D. A., May 14 2004, In : Circulation Research. 94, 9, p. 1249-1255 7 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Muscles
Sarcomeres
Myofibrils
Muscle Contraction
2003
121 Citations (Scopus)

Loaded Shortening, Power Output, and Rate of Force Redevelopment Are Increased With Knockout of Cardiac Myosin Binding Protein-C

Korte, F. S., McDonald, K. S., Harris, S. P. & Moss, R. L., Oct 17 2003, In : Circulation Research. 93, 8, p. 752-758 7 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Muscle Cells
Cardiac Myocytes
myosin-binding protein C
Familial Hypertrophic Cardiomyopathy
9 Citations (Scopus)

Solution structure of heavy meromyosin by small-angle scattering

Harris, S. P., Heller, W. T., Greaser, M. L., Moss, R. L. & Trewhella, J., Feb 21 2003, In : Journal of Biological Chemistry. 278, 8, p. 6034-6040 7 p.

Research output: Contribution to journalArticle

Small Angle Scattering
Myosin Subfragments
Myosins
Head
Scattering
2002
233 Citations (Scopus)

Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice

Harris, S. P., Bartley, C. R., Hacker, T. A., McDonald, K. S., Douglas, P. S., Greaser, M. L., Powers, P. A. & Moss, R. L., Mar 22 2002, In : Circulation Research. 90, 5, p. 594-601 8 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Hypertrophic Cardiomyopathy
Knockout Mice
Familial Hypertrophic Cardiomyopathy
Mutation
2000
10 Citations (Scopus)
Spermine
Polyamines
Cardiac Myocytes
Putrescine
Spermidine
1999
69 Citations (Scopus)

A mechanism for branchial acid excretion in marine fish: Identification of multiple Na+/H+ antiporter (NHE) isoforms in gills of two seawater teleosts

Claiborne, J. B., Blackston, C. R., Choe, K. P., Dawson, D. C., Harris, S. P., Mackenzie, L. A. & Morrison-Shetlar, A. I., Feb 1999, In : Journal of Experimental Biology. 202, 3, p. 315-324 10 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Seawater
teleost
homology
excretion
1997
7 Citations (Scopus)

Epithelial localization of a reptilian Na+/H+ exchanger homologous to NHE-1

Harris, S. P., Strong, T. V., Wys, N., Richards, N. W., Pouysségur, J., Ernst, S. A. & Dawson, D. C., Jun 1997, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 272, 6 35-6

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Turtles
Colon
Epithelial Cells
Stomach
1991
15 Citations (Scopus)

Plasma profiles of IL-6-like and TNF-like activities in brain-dead dogs

Huber, T. S., Kluger, M. J., Harris, S. P. & D'Alecy, L. G., 1991, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 261, 5 30-5

Research output: Contribution to journalArticle

Brain Death
Interleukin-6
Tumor Necrosis Factor-alpha
Dogs
Lipopolysaccharides