• 1746 Citations
  • 23 h-Index
1991 …2020

Research output per year

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Research Output

  • 1746 Citations
  • 23 h-Index
  • 43 Article
  • 3 Review article
  • 1 Editorial
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Article
2020

A novel “cut and paste” method for in situ replacement of cMYBP-C reveals a new role for cMYBP-C in the regulation of contractile oscillations

Napierski, N. C., Granger, K., Langlais, P. R., Moran, H. R., Strom, J., Touma, K. & Harris, S. P., Mar 13 2020, In : Circulation research. p. 737-749 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Cardiac effects of a single dose of pimobendan in cats with hypertrophic cardiomyopathy; A randomized, placebo-controlled, crossover study

Oldach, M. S., Ueda, Y., Ontiveros, E. S., Fousse, S. L., Harris, S. P. & Stern, J. A., Feb 4 2019, In : Frontiers in Veterinary Science. 6, FEB, 15.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
1 Scopus citations
2018

N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament

Risi, C., Belknap, B., Forgacs-Lonart, E., Harris, S. P., Schröder, G. F., White, H. D. & Galkin, V. E., Dec 4 2018, In : Structure. 26, 12, p. 1604-1611.e4

Research output: Contribution to journalArticle

13 Scopus citations

Point mutations in the tri-helix bundle of the M-domain of cardiac myosin binding protein-C influence systolic duration and delay cardiac relaxation

van Dijk, S. J., Kooiker, K. B., Napierski, N. C., Touma, K. D., Mazzalupo, S. & Harris, S. P., Jun 2018, In : Journal of Molecular and Cellular Cardiology. 119, p. 116-124 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy

McNamara, J. W., Li, A., Lal, S., Bos, J. M., Harris, S. P., Van Der Velden, J., Ackerman, M. J., Cooke, R. & Dos Remedios, C. G., Jun 2017, In : PloS one. 12, 6, e0180064.

Research output: Contribution to journalArticle

33 Scopus citations
2016

Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes

McNamara, J. W., Li, A., Smith, N. J., Lal, S., Graham, R. M., Kooiker, K. B., van Dijk, S. J., Remedios, C. G. D., Harris, S. P. & Cooke, R., May 1 2016, In : Journal of Molecular and Cellular Cardiology. 94, p. 65-71 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

A small molecule inhibitor of sarcomere contractility acutely relieves left ventricular outflow tract obstruction in feline hypertrophic cardiomyopathy

Stern, J. A., Markova, S., Ueda, Y., Kim, J. B., Pascoe, P. J., Evanchik, M. J., Green, E. M. & Harris, S. P., Dec 2016, In : PloS one. 11, 12, e0168407.

Research output: Contribution to journalArticle

25 Scopus citations

C0 and C1 N-terminal Ig domains of myosin binding protein C exert different effects on thin filament activation

Harris, S. P., Belknap, B., Van Sciver, R. E., White, H. D. & Galkin, V. E., Feb 9 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 6, p. 1558-1563 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Platelet Activation and Clopidogrel Effects on ADP-Induced Platelet Activation in Cats with or without the A31P Mutation in MYBPC3

Li, R. H. L., Stern, J. A., Ho, V., Tablin, F. & Harris, S. P., Sep 1 2016, In : Journal of Veterinary Internal Medicine. 30, 5, p. 1619-1629 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

The A31P missense mutation in cardiac myosin binding protein C alters protein structure but does not cause haploinsufficiency

Van Dijk, S. J., Bezold Kooiker, K., Mazzalupo, S., Yang, Y., Kostyukova, A. S., Mustacich, D. J., Hoye, E. R., Stern, J. A., Kittleson, M. D. & Harris, S. P., Jul 1 2016, In : Archives of Biochemistry and Biophysics. 601, p. 133-140 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

The cMyBP-C HCM variant L348P enhances thin filament activation through an increased shift in tropomyosin position

Mun, J. Y., Kensler, R. W., Harris, S. P. & Craig, R., Feb 1 2016, In : Journal of Molecular and Cellular Cardiology. 91, p. 141-147 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin

Kolb, J., Li, F., Methawasin, M., Adler, M., Escobar, Y. N., Nedrud, J., Pappas, C. T., Harris, S. P. & Granzier, H., Aug 1 2016, In : Journal of Molecular and Cellular Cardiology. 97, p. 286-294 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Effects of cardiac myosin binding protein-C on actin motility are explained with a drag-activation-competition model

Walcott, S., Docken, S. & Harris, S. P., Jan 6 2015, In : Biophysical Journal. 108, 1, p. 10-13 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Normal cardiac contraction in mice lacking the proline-alanine rich region and C1 domain of cardiac myosin binding protein C

van Dijk, S. J., Witt, C. C. & Harris, S. P., Nov 1 2015, In : Journal of Molecular and Cellular Cardiology. 88, p. 124-132 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Orientation of myosin binding protein C in the cardiac muscle sarcomere determined by domain-specific immuno-EM

Lee, K., Harris, S. P., Sadayappan, S. & Craig, R., Jan 30 2015, In : Journal of Molecular Biology. 427, 2, p. 274-286 13 p.

Research output: Contribution to journalArticle

18 Scopus citations
2014

Altered interactions between cardiac myosin binding protein-c and α-cardiac actin variants associated with cardiomyopathies

Chow, M. L., Shaffer, J. F., Harris, S. P. & Dawson, J. F., May 15 2014, In : Archives of Biochemistry and Biophysics. 550-551, p. 28-32 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Modulation of thin filament activation of myosin ATP hydrolysis by N-terminal domains of cardiac myosin binding protein-C

Belknap, B., Harris, S. P. & White, H. D., Oct 28 2014, In : Biochemistry. 53, 42, p. 6717-6724 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
2013

A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin

Bezold, K. L., Shaffer, J. F., Khosa, J. K., Hoye, E. R. & Harris, S. P., Jul 26 2013, In : Journal of Biological Chemistry. 288, 30, p. 21496-21505 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Cross-species mechanical fingerprinting of cardiac myosin binding protein-C

Karsai, Á., Kellermayer, M. S. Z. & Harris, S. P., Jun 4 2013, In : Biophysical Journal. 104, 11, p. 2465-2475 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
2011

Binding of the N-terminal fragment C0-C2 of cardiac MyBP-C to cardiac F-actin

Kensler, R. W., Shaffer, J. F. & Harris, S. P., Apr 1 2011, In : Journal of Structural Biology. 174, 1, p. 44-51 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

In the thick of it: HCM-causing mutations in myosin binding proteins of the thick filament

Harris, S. P., Lyons, R. G. & Bezold, K. L., Mar 18 2011, In : Circulation research. 108, 6, p. 751-764 14 p.

Research output: Contribution to journalArticle

121 Scopus citations

Mechanical unfolding of cardiac myosin binding protein-C by atomic force microscopy

Karsai, Á., Kellermayer, M. S. Z. & Harris, S. P., Oct 19 2011, In : Biophysical Journal. 101, 8, p. 1968-1977 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Translational medicine: To the rescue of the failing heart

Bers, D. M. & Harris, S. P., May 5 2011, In : Nature. 473, 7345, p. 36-39 4 p.

Research output: Contribution to journalArticle

12 Scopus citations
2010

Functional differences between the N-terminal domains of mouse and human myosin binding protein-C

Harris, S. P., Shaffer, J. F., Wong, P. & Bezold, K. L., 2010, In : Journal of Biomedicine and Biotechnology. 2010, 789798.

Research output: Contribution to journalArticle

23 Scopus citations
44 Scopus citations
2009

The myosin-binding protein C motif binds to F-actin in a phosphorylation-sensitive manner

Shaffer, J. F., Kensler, R. W. & Harris, S. P., May 1 2009, In : Journal of Biological Chemistry. 284, 18, p. 12318-12327 10 p.

Research output: Contribution to journalArticle

130 Scopus citations
2008

Cardiac myosin-binding protein C decorates F-actin: Implications for cardiac function

Whitten, A. E., Jeffries, C. M., Harris, S. P. & Trewhella, J., Nov 25 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 47, p. 18360-18365 6 p.

Research output: Contribution to journalArticle

89 Scopus citations

Contribution of the myosin binding protein c motif to functional effects in permeabilized rat trabeculae

Razumova, M. V., Bezold, K. L., Tu, A. Y., Regnier, M. & Harris, S. P., Nov 1 2008, In : Journal of General Physiology. 132, 5, p. 575-585 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Small-Angle X-ray Scattering Reveals the N-Terminal Domain Organization of Cardiac Myosin Binding Protein C

Jeffries, C. M., Whitten, A. E., Harris, S. P. & Trewhella, J., Apr 4 2008, In : Journal of Molecular Biology. 377, 4, p. 1186-1199 14 p.

Research output: Contribution to journalArticle

57 Scopus citations

The structure of isolated cardiac myosin thick filaments from cardiac myosin binding protein-C knockout mice

Kensler, R. W. & Harris, S. P., Mar 1 2008, In : Biophysical Journal. 94, 5, p. 1707-1718 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Understanding the Organisation and Role of Myosin Binding Protein C in Normal Striated Muscle by Comparison with MyBP-C Knockout Cardiac Muscle

Luther, P. K., Bennett, P. M., Knupp, C., Craig, R., Padrón, R., Harris, S. P., Patel, J. & Moss, R. L., Dec 5 2008, In : Journal of Molecular Biology. 384, 1, p. 60-72 13 p.

Research output: Contribution to journalArticle

81 Scopus citations
2007

Myosin S2 is not required for effects of myosin binding protein-C on motility

Shaffer, J. F., Razumova, M. V., Tu, A. Y., Regnier, M. & Harris, S. P., Apr 3 2007, In : FEBS Letters. 581, 7, p. 1501-1504 4 p.

Research output: Contribution to journalArticle

21 Scopus citations
2006

Effects of the N-terminal domains of myosin binding protein-C in an in vitro motility assay: Evidence for long-lived cross-bridges

Razumova, M. V., Shaffer, J. F., Tu, A. Y., Flint, G. V., Regnier, M. & Harris, S. P., Nov 24 2006, In : Journal of Biological Chemistry. 281, 47, p. 35846-35854 9 p.

Research output: Contribution to journalArticle

86 Scopus citations
2004

Binding of myosin binding protein-C to myosin subfragment S2 affects contractility independent of a tether mechanism

Harris, S. P., Rostkova, E., Gautel, M. & Moss, R. L., Oct 29 2004, In : Circulation research. 95, 9, p. 930-936 7 p.

Research output: Contribution to journalArticle

54 Scopus citations

Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening

Palmer, B. M., Georgakopoulos, D., Janssen, P. M., Wang, Y., Alpert, N. R., Belardi, D. F., Harris, S. P., Moss, R. L., Burgon, P. G., Seidman, C. E., Seidman, J. G., Maughan, D. W. & Kass, D. A., May 14 2004, In : Circulation research. 94, 9, p. 1249-1255 7 p.

Research output: Contribution to journalArticle

88 Scopus citations
2003

Loaded Shortening, Power Output, and Rate of Force Redevelopment Are Increased With Knockout of Cardiac Myosin Binding Protein-C

Korte, F. S., McDonald, K. S., Harris, S. P. & Moss, R. L., Oct 17 2003, In : Circulation research. 93, 8, p. 752-758 7 p.

Research output: Contribution to journalArticle

122 Scopus citations

Solution structure of heavy meromyosin by small-angle scattering

Harris, S. P., Heller, W. T., Greaser, M. L., Moss, R. L. & Trewhella, J., Feb 21 2003, In : Journal of Biological Chemistry. 278, 8, p. 6034-6040 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
2002

Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice

Harris, S. P., Bartley, C. R., Hacker, T. A., McDonald, K. S., Douglas, P. S., Greaser, M. L., Powers, P. A. & Moss, R. L., Mar 22 2002, In : Circulation research. 90, 5, p. 594-601 8 p.

Research output: Contribution to journalArticle

237 Scopus citations
2000

Polyamines decrease Ca2+ sensitivity of tension and increase rates of activation in skinned cardiac myocytes

Harris, S. P., Patel, J. R., Marton, L. J. & Moss, R. L., 2000, In : American Journal of Physiology - Heart and Circulatory Physiology. 279, 3 48-3, p. H1383-H1391

Research output: Contribution to journalArticle

10 Scopus citations
1999

A mechanism for branchial acid excretion in marine fish: Identification of multiple Na+/H+ antiporter (NHE) isoforms in gills of two seawater teleosts

Claiborne, J. B., Blackston, C. R., Choe, K. P., Dawson, D. C., Harris, S. P., Mackenzie, L. A. & Morrison-Shetlar, A. I., Feb 1 1999, In : Journal of Experimental Biology. 202, 3, p. 315-324 10 p.

Research output: Contribution to journalArticle

71 Scopus citations
1997

Epithelial localization of a reptilian Na+/H+ exchanger homologous to NHE-1

Harris, S. P., Strong, T. V., Wys, N., Richards, N. W., Pouysségur, J., Ernst, S. A. & Dawson, D. C., Jun 1997, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 272, 6 35-6, p. G1594-G1606

Research output: Contribution to journalArticle

7 Scopus citations
1991

Plasma profiles of IL-6-like and TNF-like activities in brain-dead dogs

Huber, T. S., Kluger, M. J., Harris, S. P. & D'Alecy, L. G., 1991, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 261, 5 30-5, p. R1133-R1140

Research output: Contribution to journalArticle

15 Scopus citations