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Stephen Wright

  • 5760 Citations
  • 37 h-Index
1975 …2019
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  • 2 Similar Profiles
Cations Medicine & Life Sciences
Kidney Medicine & Life Sciences
Microvilli Medicine & Life Sciences
Rabbits Medicine & Life Sciences
Proximal Kidney Tubule Medicine & Life Sciences
Tetraethylammonium Medicine & Life Sciences
Membranes Medicine & Life Sciences
Bivalvia Medicine & Life Sciences

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Projects 1983 2017

MegaTrans ? human transporter machine learning models

Wright, S.

Project: Research project

Improving In Vitro-In Vivo Extrapolation for Renal Cationic Drug Transport

Wright, S.

Project: Research project

Molecular Organization of the Organic cation-Proton Exchanger, MATE1

Wright, S. & Chang, G.

National Institutes of Health

7/17/09 → 7/31/16

Project: Research project

Cations
Protons
Kidney
Drug Interactions
Liver

Molecular Organization of Renal Organic Anion Transport

Wright, S.

National Institutes of Health

2/1/06 → 1/31/12

Project: Research project

Anions
Kidney
Proximal Kidney Tubule
Carrier Proteins
Organic Anion Transporters

Regulation of Renal Xenobiotic Transport by Estrogens

Wright, S. & Groves, C.

National Institutes of Health

9/1/03 → 8/31/08

Project: Research project

xenobiotics
anions
estrogens
kidneys
proximal tubules

Research Output 1975 2019

  • 5760 Citations
  • 37 h-Index
  • 138 Article
  • 2 Chapter

Kinetic basis of metformin-MPP interactions with organic cation transporter OCT2

Sandoval, P. J., Morales, M., Secomb, T. W. & Wright, S., Sep 1 2019, In : American journal of physiology. Renal physiology. 317, 3, p. F720-F734

Research output: Contribution to journal › Article

1-Methyl-4-phenylpyridinium
Metformin
Cations
Inhibitory Concentration 50
Cricetulus
8 Citations (Scopus)

Assessment of substrate-dependent ligand interactions at the organic cation transporter OCT2 using six model substrates s

Sandoval, P. J., Zorn, K. M., Clark, A. M., Ekins, S. & Wright, S., Sep 1 2018, In : Molecular Pharmacology. 94, 3, p. 1057-1068 12 p.

Research output: Contribution to journal › Article

Inhibitory Concentration 50
Cations
Metformin
Ligands
Drug Interactions
4 Citations (Scopus)

Correlation between apparent substrate affinity and OCT2 transport turnover

Severance, A. C., Sandoval, P. J. & Wright, S., Sep 1 2017, In : Journal of Pharmacology and Experimental Therapeutics. 362, 3, p. 405-412 8 p.

Research output: Contribution to journal › Article

Cations
Pharmacokinetics
Pharmaceutical Preparations
Kidney
Metformin
2 Citations (Scopus)

The multidrug transporter MATE1 sequesters OCs within an intracellular compartment that has no influence on OC secretion in renal proximal tubules

Martínez-Guerrero, L. J., Evans, K. K., Dantzler, W. H. & Wright, S., 2015, In : American Journal of Physiology - Renal Physiology. 310, 1, p. F57-F67

Research output: Contribution to journal › Article

Proximal Kidney Tubule
Cations
Vacuolar Proton-Translocating ATPases
Proton-Translocating ATPases
Cricetulus
10 Citations (Scopus)

Unstirred Water Layers and the Kinetics of Organic Cation Transport

Shibayama, T., Morales, M., Zhang, X., Martínez-Guerrero, L. J., Berteloot, A., Secomb, T. W. & Wright, S., Sep 8 2015, In : Pharmaceutical Research. 32, 9, p. 2937-2949 13 p., 1675.

Research output: Contribution to journal › Article

Cations
Kinetics
Water
CHO Cells
Cultured Cells