• 3414 Citations
  • 29 h-Index
1982 …2020
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Fingerprint Dive into the research topics where Steven D Schwartz is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Enzymes Chemical Compounds
enzymes Physics & Astronomy
dehydrogenases Physics & Astronomy
Catalysis Chemical Compounds
L-Lactate Dehydrogenase Chemical Compounds
Proteins Engineering & Materials Science
Hamiltonians Chemical Compounds
Sampling Chemical Compounds

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Projects 2004 2020

Cardiomyopathies
Mutation
Familial Hypertrophic Cardiomyopathy
Phosphorylation
Biological Control Agents
Enzymes
Alcohol Dehydrogenase
Sampling
Quantum theory
Biological systems

Protein Dynamics in Enzymatic Catalysis

Schwartz, S. D., Dyer, R. B., Schramm, V. L. & Callender, R.

National Institutes of Health

5/1/044/30/19

Project: Research project

Enzymes
Proteins
vibration
lactates
dehydrogenases

Research Output 1982 2019

  • 3414 Citations
  • 29 h-Index
  • 112 Article
  • 3 Chapter
  • 2 Review article

Examining the origin of catalytic power of Catechol O-Methyltransferase

Chen, X. & Schwartz, S. D., Jan 1 2019, (Accepted/In press) In : ACS Catalysis.

Research output: Contribution to journalArticle

Catechol O-Methyltransferase
Enzymes
Computational chemistry
Electrostatics
Electric fields

FRET-based analysis of the cardiac troponin T linker region reveals the structural basis of the hypertrophic cardiomyopathy-causing Δ160E mutation

Abdullah, S., Lynn, M. L., McConnell, M. T., Klass, M. M., Baldo, A. P., Schwartz, S. D. & Tardiff, J. C., Jan 1 2019, In : Journal of Biological Chemistry. 294, 40, p. 14634-14647 14 p.

Research output: Contribution to journalArticle

Troponin T
Hypertrophic Cardiomyopathy
Actomyosin
Tropomyosin
Mutation
1 Citation (Scopus)
Enzymes
Proteins
Fructose-Bisphosphate Aldolase
Aldehyde-Lyases
Trajectories
1 Citation (Scopus)

Proof of Principle that Molecular Modeling Followed by a Biophysical Experiment Can Develop Small Molecules that Restore Function to the Cardiac Thin Filament in the Presence of Cardiomyopathic Mutations

Szatkowski, L., Lynn, M. L., Holeman, T., Williams, M. R., Baldo, A. P., Tardiff, J. C. & Schwartz, S. D., Apr 9 2019, In : ACS Omega. 4, 4, p. 6492-6501 10 p.

Research output: Contribution to journalArticle

Open Access
Molecular modeling
Molecules
Experiments
Docks
Animals
3 Citations (Scopus)

Directed Evolution as a Probe of Rate Promoting Vibrations Introduced via Mutational Change

Chen, X. & Schwartz, S. D., Jun 12 2018, In : Biochemistry. 57, 23, p. 3289-3298 10 p.

Research output: Contribution to journalArticle

Vibration
Catalytic Domain
Enzymes
Sampling
Proteins