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Steven D Schwartz

  • 3322 Citations
  • 28 h-Index
1982 …2020
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Enzymes Chemical Compounds
enzymes Physics & Astronomy
dehydrogenases Physics & Astronomy
Catalysis Chemical Compounds
L-Lactate Dehydrogenase Chemical Compounds
Proteins Engineering & Materials Science
Hamiltonians Chemical Compounds
Sampling Chemical Compounds

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Projects 2004 2020

A molecular study linking cTnT dynamics to genetic cardiomyopathy

Tardiff, J. C. & Schwartz, S. D.

National Institutes of Health

12/15/10 → 2/29/20

Project: Research project

Cardiomyopathies
Mutation
Familial Hypertrophic Cardiomyopathy
Phosphorylation
Biological Control Agents

A New Paradigm to Incorporate Protein Dynamics into Targeted Small Molecule Design for Sarcomeric Cardiomyopathies: A Proof of Concept for Thin Filament Therapeutics

Schwartz, S. D. & Tardiff, J. C.

Project: Research project

Rapid protein dynamics and catalysis: modulation by laboratory evolution, designed mutation, and protein control of electric field environment

Schwartz, S. D.

Project: Research project

Quantum Nuclear Dynamics and Enzyme Chemistry

Schwartz, S. D.

National Institutes of Health

9/1/12 → 6/30/15

Project: Research project

Enzymes
Alcohol Dehydrogenase
Sampling
Quantum theory
Biological systems

Protein Dynamics in Enzymatic Catalysis

Schwartz, S. D., Dyer, R. B., Schramm, V. L. & Callender, R.

National Institutes of Health

5/1/04 → 4/30/19

Project: Research project

Enzymes
Proteins
vibration
lactates
dehydrogenases

Research Output 1982 2019

  • 3322 Citations
  • 28 h-Index
  • 111 Article
  • 3 Chapter
  • 2 Review article

Optimization of the Turnover in Artificial Enzymes via Directed Evolution Results in the Coupling of Protein Dynamics to Chemistry

Schafer, J. W., Zoi, I., Antoniou, D. & Schwartz, S. D., Jan 1 2019, In : Journal of the American Chemical Society.

Research output: Contribution to journal › Article

Enzymes
Proteins
Fructose-Bisphosphate Aldolase
Aldehyde-Lyases
Trajectories

Proof of Principle that Molecular Modeling Followed by a Biophysical Experiment Can Develop Small Molecules that Restore Function to the Cardiac Thin Filament in the Presence of Cardiomyopathic Mutations

Szatkowski, L., Lynn, M. L., Holeman, T., Williams, M. R., Baldo, A. P., Tardiff, J. C. & Schwartz, S. D., Apr 9 2019, In : ACS Omega. 4, 4, p. 6492-6501 10 p.

Research output: Contribution to journal › Article

Open Access
Molecular modeling
Molecules
Experiments
Docks
Animals
2 Citations (Scopus)

Directed Evolution as a Probe of Rate Promoting Vibrations Introduced via Mutational Change

Chen, X. & Schwartz, S. D., Jun 12 2018, In : Biochemistry. 57, 23, p. 3289-3298 10 p.

Research output: Contribution to journal › Article

Vibration
Catalytic Domain
Enzymes
Sampling
Proteins
5 Citations (Scopus)

Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels

Harijan, R. K., Zoi, I., Antoniou, D., Schwartz, S. D. & Schramm, V. L., Jul 3 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 27, p. E6209-E6216

Research output: Contribution to journal › Article

Purine-Nucleoside Phosphorylase
Asparagine
Isotopes
Catalytic Domain
Enzymes
3 Citations (Scopus)

Mechanistic Insights on Human Phosphoglucomutase Revealed by Transition Path Sampling and Molecular Dynamics Calculations

Brás, N. F., Fernandes, P. A., Ramos, M. J. & Schwartz, S. D., Feb 6 2018, In : Chemistry - A European Journal. 24, 8, p. 1978-1987 10 p.

Research output: Contribution to journal › Article

Phosphoglucomutase
Glucose
Molecular dynamics
Glucose-6-Phosphate
Sampling