Thomas C Doetschman

  • 19542 Citations
  • 65 h-Index
1975 …2021
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Research Output 1975 2019

  • 19542 Citations
  • 65 h-Index
  • 164 Article
  • 5 Chapter
  • 1 Comment/debate
  • 1 Review article
2019
Open Access
Triple Negative Breast Neoplasms
Aryl Hydrocarbon Receptors
Genistein
genistein
Epigenomics

Modulating smooth muscle cell response by the release of TGFβ2 from tubular scaffolds for vascular tissue engineering

Ardila, D. C., Tamimi, E., Doetschman, T. C., Wagner, W. R. & Vande Geest, J. P., Apr 10 2019, In : Journal of Controlled Release. 299, p. 44-52 9 p.

Research output: Contribution to journalArticle

Gelatin
Tissue Engineering
Smooth Muscle Myocytes
Blood Vessels
Blood Vessel Prosthesis
1 Citation (Scopus)

N-6 linoleic acid induces epigenetics alterations associated with colonic inflammation and cancer

Romagnolo, D., Donovan, M. G., Doetschman, T. C. & Selmin, O., Jan 1 2019, In : Nutrients. 11, 1, 171.

Research output: Contribution to journalArticle

Adenomatous Polyposis Coli
bile acids
Linoleic Acid
Epigenomics
epigenetics
2018

Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection

Burt, P. M., Xiao, L., Doetschman, T. C. & Hurley, M. M., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Ablation
Osteoarthritis
Protein Isoforms
Cartilage
Molecular Weight
2017
10 Citations (Scopus)

Functional changes in the gut microbiome contribute to transforming growth factor β-deficient colon cancer

Daniel, S. G., Ball, C. L., Besselsen, D. G., Doetschman, T. C. & Hurwitze, B. L., Sep 1 2017, In : mSystems. 2, 5, e00065.

Research output: Contribution to journalArticle

Helicobacter hepaticus
functional change
transforming growth factors
Microbiota
Growth Factors
22 Citations (Scopus)

Gene Editing with CRISPR/Cas9 RNA-Directed Nuclease

Doetschman, T. C. & Georgieva, T., Mar 3 2017, In : Circulation Research. 120, 5, p. 876-894 19 p.

Research output: Contribution to journalReview article

Ribonucleases
Long Noncoding RNA
Therapeutic Human Experimentation
Dystrophin
Genetic Engineering
8 Citations (Scopus)
Open Access
Aromatic Hydrocarbons
aromatic hydrocarbons
Genistein
cytosine
Cytosine
2016

2-Photon Characterization of Optical Proteolytic Beacons for Imaging Changes in Matrix-Metalloprotease Activity in a Mouse Model of Aneurysm

Haskett, D. G., Maestas, D., Howerton, S. J., Smith, T., Ardila, D. C., Doetschman, T. C., Utzinger, U., Mcgrath, D. V., McIntyre, J. O. & Vande Geest, J. P., Feb 23 2016, (Accepted/In press) In : Microscopy and Microanalysis. p. 1-12 12 p.

Research output: Contribution to journalArticle

beacons
mice
Photons
Imaging techniques
photons
12 Citations (Scopus)

Biomechanical Comparison of Glutaraldehyde-Crosslinked Gelatin Fibrinogen Electrospun Scaffolds to Porcine Coronary Arteries

Tamimi, E., Ardila, D. C., Haskett, D. G., Doetschman, T. C., Slepian, M. J., Kellar, R. S. & Vande Geest, J. P., Jan 1 2016, In : Journal of Biomechanical Engineering. 138, 1, 011001.

Research output: Contribution to journalArticle

Glutaral
Gelatin
Grafts
Scaffolds
Fibrinogen
1 Citation (Scopus)

Corrigendum to "Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells"

Yan, J., Mitra, A., Hu, J., Cutrera, J. J., Xia, X., Doetschman, T. C., Gagea, M., Mishra, L. & Li, S., 2016, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Natural Killer T-Cells
Interleukins
Gastroenterology
Sepsis
Cytokines
2 Citations (Scopus)

Flow cytometry and single nucleus sorting for Cre-based analysis of changes in transcriptional states

Samadder, P., Weng, N., Doetschman, T. C., Heimark, R. L. & Galbraith, D. W., May 1 2016, In : Cytometry Part A. 89, 5, p. 430-442 13 p.

Research output: Contribution to journalArticle

Flow Cytometry
Green Fluorescent Proteins
Carcinogenesis
Histones
Transgenic Mice
14 Citations (Scopus)
Adenomatous Polyposis Coli
Bile Acids and Salts
Colonic Neoplasms
Colon
Mucous Membrane
8 Citations (Scopus)

Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells

Yan, J., Mitra, A., Hu, J., Cutrera, J. J., Xia, X., Doetschman, T. C., Gagea, M., Mishra, L. & Li, S., May 1 2016, In : Journal of Hepatology. 64, 5, p. 1128-1136 9 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
Interleukins
Sepsis
Cytokines
Interleukin-10
2015
13 Citations (Scopus)

TGFβ2 differentially modulates smooth muscle cell proliferation andmigration in electrospun gelatin-fibrinogen constructs

Ardila, D. C., Tamimi, E., Danford, F. L., Haskett, D. G., Kellar, R. S., Doetschman, T. C. & Vande Geest, J. P., Jan 1 2015, In : Biomaterials. 37, p. 164-173 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factor beta2
Cell proliferation
Gelatin
Scaffolds
Fibrinogen
2014

Erratum to: FGF2 modulates cardiac remodeling in an isoform-and sex-specific manner(Physiol Rep, (2013), 1, 4, e00088, 10.1002/phy2.88)

Nusayr, E., Sadideen, D. T. & Doetschman, T. C., 2014, In : Physiological Reports. 2, 6, e12024.

Research output: Contribution to journalComment/debate

Fibroblast Growth Factor 2
Protein Isoforms

Gene Targeting in Embryonic Stem Cells, I: History and Methodology

Sanford, L. P. & Doetschman, T. C., Jun 23 2014, Transgenic Animal Technology: A Laboratory Handbook: Third Edition. Elsevier Inc., p. 109-139 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gene Targeting
Embryonic Stem Cells
Stem cells
Stem Cells
Genes
12 Citations (Scopus)

Knockout of nuclear high molecular weight FGF2 isoforms in mice modulates bone and phosphate homeostasis

Homer-Bouthiette, C., Doetschman, T. C., Xiao, L. & Hurley, M. M., Dec 26 2014, In : Journal of Biological Chemistry. 289, 52, p. 36303-36314 12 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Protein Isoforms
Bone
Homeostasis
Molecular Weight
2012
32 Citations (Scopus)

Cardiac-specific inducible and conditional gene targeting in mice

Doetschman, T. C. & Azhar, M., May 25 2012, In : Circulation Research. 110, 11, p. 1498-1512 15 p.

Research output: Contribution to journalArticle

Gene Targeting
Heart Diseases
Technology
Genetic Engineering
Molecular Biology
10 Citations (Scopus)

Fibroblast growth factor-2-induced cardioprotection against myocardial infarction occurs via the interplay between nitric oxide, protein kinase signaling, and ATP-sensitive potassium channels

Manning, J. R., Carpenter, G., Porter, D. R., House, S. L., Pietras, D. A., Doetschman, T. C. & Schultz, J. E. J., Apr 2012, In : Growth Factors. 30, 2, p. 124-139 16 p.

Research output: Contribution to journalArticle

KATP Channels
Fibroblast Growth Factor 2
Protein Kinases
Nitric Oxide
Myocardial Infarction
13 Citations (Scopus)

Generation of mice with a conditional allele for the transforming growth factor beta3 gene

Doetschman, T. C., Georgieva, T., Li, H., Reed, T. D., Grisham, C., Friel, J., Estabrook, M. A., Gard, C., Sanford, L. P. & Azhar, M., Jan 2012, In : Genesis. 50, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

Transforming Growth Factor beta3
Alleles
Genes
Cleft Palate
Embryonic Development
2 Citations (Scopus)

Gene Targeting in Embryonic Stem Cells: I. History and Methodology

Doetschman, T. C., Dec 2 2012, Transgenic Animal Technology: A Laboratory Handbook: Second Edition. Elsevier Inc., p. 113-141 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Stem cells
Genes

Overview of designing genetically engineered mouse (GEM) models

Doetschman, T. C. & Sanford, L. P., Jan 1 2012, Genetically Engineered Mice for Cancer Research: Design, Analysis, Pathways, Validation and Pre-Clinical Testing. Springer New York, p. 1-15 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Research Personnel
Genetically Modified Animals
Gene Targeting
Research Design
Research
49 Citations (Scopus)

Transforming growth factor beta signaling in adult cardiovascular diseases and repair

Doetschman, T. C., Barnett, J. V., Runyan, R. B., Camenisch, T. D., Heimark, R. L., Granzier, H. H., Conway, S. J. & Azhar, M., Jan 2012, In : Cell & Tissue Research. 347, 1, p. 203-223 21 p.

Research output: Contribution to journalArticle

Transforming Growth Factor beta
Cardiovascular Diseases
Heart Diseases
Transforming Growth Factor beta Receptors
Genes
2011
5 Citations (Scopus)

Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis

Doetschman, T. C., Sholl, A., Chen, H. D. R., Gard, C., Hildeman, D. A. & Bommireddy, R., Mar 2011, In : Clinical Immunology. 138, 3, p. 321-330 10 p.

Research output: Contribution to journalArticle

Calcineurin
Regulatory T-Lymphocytes
Homeostasis
T-Lymphocytes
Catalytic Domain
54 Citations (Scopus)

Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway

Fei, Y., Xiao, L., Doetschman, T. C., Coffin, D. J. & Hurley, M. M., Nov 25 2011, In : Journal of Biological Chemistry. 286, 47, p. 40575-40583 9 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Osteoblasts
Fibroblast Growth Factor 2
Osteogenesis
Catenins
3 Citations (Scopus)

GI GEMs: Genetically engineered mouse models of gastrointestinal disease

Doetschman, T. C., Feb 2011, In : Gastroenterology. 140, 2, p. 380-385 6 p.

Research output: Contribution to journalArticle

Animal Disease Models
Gastrointestinal Neoplasms
Genetic Engineering
Gene Targeting
Gastrointestinal Diseases
37 Citations (Scopus)

The inter-relationship of periostin, TGFβ, and BMP in heart valve development and valvular heart diseases

Conway, S. J., Doetschman, T. C. & Azhar, M., Jul 28 2011, In : TheScientificWorldJournal [electronic resource]. 11, p. 1509-1524 16 p.

Research output: Contribution to journalArticle

Heart Valve Diseases
Bone Morphogenetic Proteins
Heart Valves
cardiovascular disease
Transforming Growth Factor beta
42 Citations (Scopus)

Transforming growth factor Beta2 is required for valve remodeling during heart development

Azhar, M., Pogreba-Brown, K. M., Gard, C., Chen, H. D. R., Rajan, S., Elliott, D. A., Stevens, M. V., Camenisch, T. D., Conway, S. J. & Doetschman, T. C., Sep 2011, In : Developmental Dynamics. 240, 9, p. 2127-2141 15 p.

Research output: Contribution to journalArticle

Transforming Growth Factor beta2
Embryonic Structures
Cell Lineage
Mesoderm
Cartilage
2010
63 Citations (Scopus)

Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells

Xiao, L., Sobue, T., Esliger, A., Kronenberg, M. S., Coffin, J. D., Doetschman, T. C. & Hurley, M. M., Aug 2010, In : Bone. 47, 2, p. 360-370 11 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Stromal Cells
Stem Cells
Bone Marrow
Mesenchymal Stromal Cells
31 Citations (Scopus)

Fibroblast growth factor 2 mediates isoproterenol-induced cardiac hypertrophy through activation of the extracellular regulated kinase

House, S. L., House, B. E., Glascock, B., Kimball, T., Nusayr, E., Schultz, J. E. J. & Doetschman, T. C., 2010, In : Molecular and Cellular Pharmacology. 2, 4, p. 143-154 12 p.

Research output: Contribution to journalArticle

Cardiomegaly
Fibroblast Growth Factor 2
Isoproterenol
Phosphotransferases
Transgenic Mice
35 Citations (Scopus)

Lymphangiogenesis and angiogenesis: Concurrence and/or dependence? Studies in inbred mouse strains

Nakao, S., Maruyama, K., Zandi, S., Melhorn, M. I., Taher, M., Noda, K., Nusayr, E., Doetschman, T. C. & Hafezi-Moghadam, A., Feb 2010, In : FASEB Journal. 24, 2, p. 504-513 10 p.

Research output: Contribution to journalArticle

Lymphangiogenesis
Inbred Strains Mice
Intercellular Signaling Peptides and Proteins
Blood vessels
Fibroblast Growth Factor 2
13 Citations (Scopus)

The influence of FGF2 high molecular weight (HMW) isoforms in the development of cardiac ischemia-reperfusion injury

Liao, S., Bodmer, J. R., Azhar, M., Newman, G., Coffin, J. D., Doetschman, T. C. & Schultz, J. E. J., Jun 2010, In : Journal of Molecular and Cellular Cardiology. 48, 6, p. 1245-1254 10 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Reperfusion Injury
Protein Isoforms
Molecular Weight
Fibroblast Growth Factor Receptors
2009
45 Citations (Scopus)

Biological functions of the low and high molecular weight protein isoforms of fibroblast growth factor-2 in cardiovascular development and disease

Liao, S., Bodmer, J., Pietras, D., Azhar, M., Doetschman, T. C. & Schultz, J. E. J., Feb 2009, In : Developmental Dynamics. 238, 2, p. 249-264 16 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Protein Isoforms
Cardiovascular Diseases
Molecular Weight
Cardiomegaly
5 Citations (Scopus)

Calcineurin deficiency decreases inflammatory lesions in transforming growth factor β1-deficient mice

Bommireddy, R., Bueno, O. F., Martin, J., Ormsby, I., Chen, H. D. R., Gard, C., Molkentin, J. D., Boivin, G. P., Babcock, G. F. & Doetschman, T. C., Dec 2009, In : Clinical and Experimental Immunology. 158, 3, p. 317-324 8 p.

Research output: Contribution to journalArticle

Calcineurin
Transforming Growth Factors
T-Lymphocytes
Inflammation
Knockout Mice
48 Citations (Scopus)

Endogenous FGF-2 is critically important in PTH anabolic effects on bone

Sabbieti, M. G., Agas, D., Xiao, L., Marchetti, L., Coffin, J. D., Doetschman, T. C. & Hurley, M. M., Apr 2009, In : Journal of Cellular Physiology. 219, 1, p. 143-151 9 p.

Research output: Contribution to journalArticle

Anabolic Agents
Fibroblast Growth Factor 2
Parathyroid Hormone
Osteoblasts
Bone
40 Citations (Scopus)

Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice

Xiao, L., Liu, P., Li, X., Doetschman, T. C., Coffin, J. D., Drissi, H. & Hurley, M. M., Jan 30 2009, In : Journal of Biological Chemistry. 284, 5, p. 3170-3182 13 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Protein Isoforms
Bone
Bone and Bones
Frizzled Receptors
22 Citations (Scopus)

Generation of mice with a conditional allele for transforming growth factor beta 1 gene

Azhar, M., Yin, M., Bommireddy, R., Duffy, J. J., Yang, J., Pawlowski, S. A., Boivin, G. P., Engle, S. J., Sanford, L. P., Grisham, C., Singh, R. R., Babcock, G. F. & Doetschman, T. C., 2009, In : Genesis. 47, 6, p. 423-431 9 p.

Research output: Contribution to journalArticle

Transforming Growth Factor beta
Alleles
T-Lymphocytes
Transforming Growth Factors
Genes
16 Citations (Scopus)

Gene targeted ablation of high molecular weight fibroblast growth factor-2

Azhar, M., Yin, M., Zhou, M., Li, H., Mustafa, M., Nusayr, E., Keenan, J. B., Chen, H. D. R., Pawlosky, S., Gard, C., Grisham, C., Sanford, L. P. & Doetschman, T. C., Feb 2009, In : Developmental Dynamics. 238, 2, p. 351-357 7 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Protein Isoforms
Molecular Weight
Genes
Gene Targeting
111 Citations (Scopus)

Influence of genetic background on genetically engineered mouse phenotypes

Doetschman, T. C., 2009, Methods in Molecular Biology. Vol. 530. p. 423-433 11 p. (Methods in Molecular Biology; vol. 530).

Research output: Chapter in Book/Report/Conference proceedingChapter

Phenotype
Genes
Alleles
Modifier Genes
Gene Targeting
72 Citations (Scopus)

Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development

Azhar, M., Runyan, R. B., Gard, C., Sanford, L. P., Miller, M. L., Andringa, A., Pawlowski, S., Rajan, S. & Doetschman, T. C., Feb 2009, In : Developmental Dynamics. 238, 2, p. 431-442 12 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Transforming Growth Factor beta
Ligands
Embryonic Structures
Collagen
158 Citations (Scopus)

Origin of cardiac fibroblasts and the role of periostin

Snider, P., Standley, K. N., Wang, J., Azhar, M., Doetschman, T. C. & Conway, S. J., Nov 2009, In : Circulation Research. 105, 10, p. 934-947 14 p.

Research output: Contribution to journalArticle

Fibroblasts
Epithelial-Mesenchymal Transition
Cell Lineage
Morphogenesis
Cardiac Myocytes
2008
8 Citations (Scopus)

Decrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 gene

Chen, K., Ohkubo, Y., Shin, D., Doetschman, T. C., Sanford, L. P., Li, H. & Vaccarino, F. M., Sep 30 2008, In : BMC Neuroscience. 9, 94.

Research output: Contribution to journalArticle

Astrocytes
Cerebral Cortex
Exons
Neurons
Genes
70 Citations (Scopus)

Dual roles of immunoregulatory cytokine TGF-β in the pathogenesis of autoimmunity-mediated organ damage

Saxena, V., Lienesch, D. W., Zhou, M., Bommireddy, R., Azhar, M., Doetschman, T. C. & Singh, R. R., Feb 1 2008, In : Journal of Immunology. 180, 3, p. 1903-1912 10 p.

Research output: Contribution to journalArticle

Autoimmunity
Autoantibodies
Cytokines
Autoimmune Diseases
Inflammation
23 Citations (Scopus)

Impaired cardiac contractility in mice lacking both the AE3 Cl -/HCO3- exchanger and the NKCC1 Na +-K+-2Cl- cotransporter: Effects on Ca 2+ handling and protein phosphatases

Prasad, V., Bodi, I., Meyer, J. W., Wang, Y., Ashraf, M., Engle, S. J., Doetschman, T. C., Sisco, K., Nieman, M. L., Miller, M. L., Lorenz, J. N. & Shull, G. E., Nov 14 2008, In : Journal of Biological Chemistry. 283, 46, p. 31303-31314 12 p.

Research output: Contribution to journalArticle

Chloride-Bicarbonate Antiporters
Protein Phosphatase 2
Null Lymphocytes
Muscle Cells
Protein Phosphatase 1
53 Citations (Scopus)

Reduced expression and function of bone morphogenetic protein-2 in bones of Fgf2 null mice

Naganawa, T., Xiao, L., Coffin, J. D., Doetschman, T. C., Sabbieti, M. G., Agas, D. & Hurley, M. M., Apr 15 2008, In : Journal of Cellular Biochemistry. 103, 6, p. 1975-1988 14 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 2
Bone
Bone and Bones
Fibroblast Growth Factor 2
Proteins
46 Citations (Scopus)

Sevoflurane protects against renal ischemia and reperfusion injury in mice via the transforming growth factor-β1 pathway

Lee, H. T., Chen, S. W. C., Doetschman, T. C., Deng, C., D'Agati, V. D. & Kim, M., Jul 2008, In : American Journal of Physiology - Renal Physiology. 295, 1

Research output: Contribution to journalArticle

Transforming Growth Factors
Reperfusion Injury
Kidney
Anesthetics
Necrosis
6 Citations (Scopus)
Regulatory T-Lymphocytes
Maintenance
T-Lymphocytes
Spleen
Autoantigens
2007
111 Citations (Scopus)

Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na +/HCO 3 - cotransporter

Gawenis, L. R., Bradford, E. M., Prasad, V., Lorenz, J. N., Simpson, J. E., Clarke, L. L., Woo, A. L., Grisham, C., Sanford, L. P., Doetschman, T. C., Miller, M. L. & Shull, G. E., Mar 23 2007, In : Journal of Biological Chemistry. 282, 12, p. 9042-9052 11 p.

Research output: Contribution to journalArticle

Acidosis
Anions
Colon
Defects
Intestinal Mucosa
75 Citations (Scopus)

Endogenous transforming growth factor β1 suppresses inflammation and promotes survival in adult CNS

Makwana, M., Jones, L. L., Cuthill, D., Heuer, H., Bohatschek, M., Hristova, M., Friedrichsen, S., Ormsby, I., Bueringer, D., Koppius, A., Bauer, K., Doetschman, T. C. & Raivich, G., Oct 17 2007, In : Journal of Neuroscience. 27, 42, p. 11201-11213 13 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Inflammation
Microglia
Brain
Cytokines
76 Citations (Scopus)

Loss of the Atp2c1 Secretory Pathway Ca2+-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes

Okunade, G. W., Miller, M. L., Azhar, M., Andringa, A., Sanford, L. P., Doetschman, T. C., Prasad, V. & Shull, G. E., Sep 7 2007, In : Journal of Biological Chemistry. 282, 36, p. 26517-26527 11 p.

Research output: Contribution to journalArticle

Calcium-Transporting ATPases
Secretory Pathway
Heterozygote
Tumors
Skin