Thomas C Doetschman

  • 20112 Citations
  • 68 h-Index
1975 …2019

Research output per year

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Research Output

2019

Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection

Burt, P. M., Xiao, L., Doetschman, T. & Hurley, M. M., Apr 2019, In : Journal of Cellular Physiology. 234, 4, p. 4418-4431 14 p.

Research output: Contribution to journalArticle

2 Scopus citations
Open Access
5 Scopus citations

Modulating smooth muscle cell response by the release of TGFβ2 from tubular scaffolds for vascular tissue engineering

Ardila, D. C., Tamimi, E., Doetschman, T., Wagner, W. R. & Vande Geest, J. P., Apr 10 2019, In : Journal of Controlled Release. 299, p. 44-52 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

N-6 linoleic acid induces epigenetics alterations associated with colonic inflammation and cancer

Romagnolo, D. F., Donovan, M. G., Doetschman, T. C. & Selmin, O. I., Jan 1 2019, In : Nutrients. 11, 1, 171.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Functional changes in the gut microbiome contribute to transforming growth factor β-deficient colon cancer

Daniel, S. G., Ball, C. L., Besselsen, D. G., Doetschman, T. & Hurwitze, B. L., Sep 1 2017, In : mSystems. 2, 5, e00065.

Research output: Contribution to journalArticle

16 Scopus citations

Gene Editing with CRISPR/Cas9 RNA-Directed Nuclease

Doetschman, T. & Georgieva, T., Mar 3 2017, In : Circulation research. 120, 5, p. 876-894 19 p.

Research output: Contribution to journalReview article

35 Scopus citations
Open Access
13 Scopus citations

Mediterranean Diet: Prevention of Colorectal Cancer

Donovan, M. G., Selmin, O. I., Doetschman, T. C. & Romagnolo, D. F., Dec 5 2017, In : Frontiers in Nutrition. 4, 59.

Research output: Contribution to journalReview article

Open Access
25 Scopus citations
2016

2-Photon Characterization of Optical Proteolytic Beacons for Imaging Changes in Matrix-Metalloprotease Activity in a Mouse Model of Aneurysm

Haskett, D. G., Maestas, D., Howerton, S. J., Smith, T., Ardila, D. C., Doetschman, T. C., Utzinger, U., Mcgrath, D. V., McIntyre, J. O. & Vande Geest, J. P., Feb 23 2016, (Accepted/In press) In : Microscopy and Microanalysis. p. 1-12 12 p.

Research output: Contribution to journalArticle

Biomechanical Comparison of Glutaraldehyde-Crosslinked Gelatin Fibrinogen Electrospun Scaffolds to Porcine Coronary Arteries

Tamimi, E., Ardila, D. C., Haskett, D. G., Doetschman, T. C., Slepian, M. J., Kellar, R. S. & Vande Geest, J. P., Jan 1 2016, In : Journal of Biomechanical Engineering. 138, 1, 011001.

Research output: Contribution to journalArticle

19 Scopus citations

Corrigendum to "Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells"

Yan, J., Mitra, A., Hu, J., Cutrera, J. J., Xia, X., Doetschman, T. C., Gagea, M., Mishra, L. & Li, S., 2016, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

1 Scopus citations

Flow cytometry and single nucleus sorting for Cre-based analysis of changes in transcriptional states

Samadder, P., Weng, N., Doetschman, T. C., Heimark, R. L. & Galbraith, D. W., May 1 2016, In : Cytometry Part A. 89, 5, p. 430-442 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
17 Scopus citations

Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells

Yan, J., Mitra, A., Hu, J., Cutrera, J. J., Xia, X., Doetschman, T. C., Gagea, M., Mishra, L. & Li, S., May 1 2016, In : Journal of Hepatology. 64, 5, p. 1128-1136 9 p.

Research output: Contribution to journalArticle

12 Scopus citations
2015

TGFβ2 differentially modulates smooth muscle cell proliferation andmigration in electrospun gelatin-fibrinogen constructs

Ardila, D. C., Tamimi, E., Danford, F. L., Haskett, D. G., Kellar, R. S., Doetschman, T. & Vande Geest, J. P., Jan 1 2015, In : Biomaterials. 37, p. 164-173 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
2014

Erratum to: FGF2 modulates cardiac remodeling in an isoform-and sex-specific manner(Physiol Rep, (2013), 1, 4, e00088, 10.1002/phy2.88)

Nusayr, E., Sadideen, D. T. & Doetschman, T. C., 2014, In : Physiological Reports. 2, 6, e12024.

Research output: Contribution to journalComment/debate

Gene Targeting in Embryonic Stem Cells, I: History and Methodology

Sanford, L. P. & Doetschman, T. C., Jun 23 2014, Transgenic Animal Technology: A Laboratory Handbook: Third Edition. Elsevier Inc., p. 109-139 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Knockout of nuclear high molecular weight FGF2 isoforms in mice modulates bone and phosphate homeostasis

Homer-Bouthiette, C., Doetschman, T., Xiao, L. & Hurley, M. M., Dec 26 2014, In : Journal of Biological Chemistry. 289, 52, p. 36303-36314 12 p.

Research output: Contribution to journalArticle

14 Scopus citations
2012

Cardiac-specific inducible and conditional gene targeting in mice

Doetschman, T. & Azhar, M., May 25 2012, In : Circulation research. 110, 11, p. 1498-1512 15 p.

Research output: Contribution to journalReview article

36 Scopus citations

Fibroblast growth factor-2-induced cardioprotection against myocardial infarction occurs via the interplay between nitric oxide, protein kinase signaling, and ATP-sensitive potassium channels

Manning, J. R., Carpenter, G., Porter, D. R., House, S. L., Pietras, D. A., Doetschman, T. & Schultz, J. E. J., Apr 2012, In : Growth Factors. 30, 2, p. 124-139 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Generation of mice with a conditional allele for the transforming growth factor beta3 gene

Doetschman, T., Georgieva, T., Li, H., Reed, T. D., Grisham, C., Friel, J., Estabrook, M. A., Gard, C., Sanford, L. P. & Azhar, M., Jan 1 2012, In : Genesis. 50, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Overview of designing genetically engineered mouse (GEM) models

Doetschman, T. C. & Sanford, L. P., Jan 1 2012, Genetically Engineered Mice for Cancer Research: Design, Analysis, Pathways, Validation and Pre-Clinical Testing. Springer New York, p. 1-15 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Transforming growth factor beta signaling in adult cardiovascular diseases and repair

Doetschman, T., Barnett, J. V., Runyan, R. B., Camenisch, T. D., Heimark, R. L., Granzier, H. L., Conway, S. J. & Azhar, M., Jan 1 2012, In : Cell and Tissue Research. 347, 1, p. 203-223 21 p.

Research output: Contribution to journalReview article

57 Scopus citations
2011

Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis

Doetschman, T., Sholl, A., Chen, H. D. R., Gard, C., Hildeman, D. A. & Bommireddy, R., Mar 1 2011, In : Clinical Immunology. 138, 3, p. 321-330 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway

Fei, Y., Xiao, L., Doetschman, T., Coffin, D. J. & Hurley, M. M., Nov 25 2011, In : Journal of Biological Chemistry. 286, 47, p. 40575-40583 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

GI GEMs: Genetically engineered mouse models of gastrointestinal disease

Doetschman, T., Feb 2011, In : Gastroenterology. 140, 2, p. 380-385.e2

Research output: Contribution to journalArticle

3 Scopus citations

The inter-relationship of periostin, TGFβ, and BMP in heart valve development and valvular heart diseases

Conway, S. J., Doetschman, T. & Azhar, M., Jul 28 2011, In : TheScientificWorldJournal. 11, p. 1509-1524 16 p.

Research output: Contribution to journalReview article

42 Scopus citations

Transforming growth factor Beta2 is required for valve remodeling during heart development

Azhar, M., Brown, K., Gard, C., Chen, H., Rajan, S., Elliott, D. A., Stevens, M. V., Camenisch, T. D., Conway, S. J. & Doetschman, T., Sep 1 2011, In : Developmental Dynamics. 240, 9, p. 2127-2141 15 p.

Research output: Contribution to journalArticle

43 Scopus citations
2010

Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells

Xiao, L., Sobue, T., Esliger, A., Kronenberg, M. S., Coffin, J. D., Doetschman, T. & Hurley, M. M., Aug 1 2010, In : Bone. 47, 2, p. 360-370 11 p.

Research output: Contribution to journalArticle

69 Scopus citations

Fibroblast growth factor 2 mediates isoproterenol-induced cardiac hypertrophy through activation of the extracellular regulated kinase

House, S. L., House, B. E., Glascock, B., Kimball, T., Nusayr, E., Schultz, J. E. J. & Doetschman, T., Nov 9 2010, In : Molecular and Cellular Pharmacology. 2, 4, p. 143-154 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Lymphangiogenesis and angiogenesis: Concurrence and/or dependence? Studies in inbred mouse strains

Nakao, S., Maruyama, K., Zandi, S., Melhorn, M. I., Taher, M., Noda, K., Nusayr, E., Doetschman, T. & Hafezi-Moghadam, A., Feb 2010, In : FASEB Journal. 24, 2, p. 504-513 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

The influence of FGF2 high molecular weight (HMW) isoforms in the development of cardiac ischemia-reperfusion injury

Liao, S., Bodmer, J. R., Azhar, M., Newman, G., Coffin, J. D., Doetschman, T. & Schultz, J. E. J., Jun 1 2010, In : Journal of Molecular and Cellular Cardiology. 48, 6, p. 1245-1254 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2009

Biological functions of the low and high molecular weight protein isoforms of fibroblast growth factor-2 in cardiovascular development and disease

Liao, S., Bodmer, J., Pietras, D., Azhar, M., Doetschman, T. & Schultz, J. E. J., Feb 1 2009, In : Developmental Dynamics. 238, 2, p. 249-264 16 p.

Research output: Contribution to journalReview article

48 Scopus citations

Calcineurin deficiency decreases inflammatory lesions in transforming growth factor β1-deficient mice

Bommireddy, R., Bueno, O. F., Martin, J., Ormsby, I., Chen, H., Gard, C., Molkentin, J. D., Boivin, G. P., Babcock, G. F. & Doetschman, T., Dec 1 2009, In : Clinical and Experimental Immunology. 158, 3, p. 317-324 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Endogenous FGF-2 is critically important in PTH anabolic effects on bone

Sabbieti, M. G., Agas, D., Xiao, L., Marchetti, L., Coffin, J. D., Doetschman, T. & Hurley, M. M., Apr 1 2009, In : Journal of Cellular Physiology. 219, 1, p. 143-151 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice

Xiao, L., Liu, P., Li, X., Doetschman, T., Coffin, J. D., Drissi, H. & Hurley, M. M., Jan 30 2009, In : Journal of Biological Chemistry. 284, 5, p. 3170-3182 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Generation of mice with a conditional allele for transforming growth factor beta 1 gene

Azhar, M., Yin, M., Bommireddy, R., Duffy, J. J., Yang, J., Pawlowski, S. A., Boivin, G. P., Engle, S. J., Sanford, L. P., Grisham, C., Singh, R. R., Babcock, G. F. & Doetschman, T., Sep 22 2009, In : Genesis. 47, 6, p. 423-431 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Gene targeted ablation of high molecular weight fibroblast growth factor-2

Azhar, M., Yin, M., Zhou, M., Li, H., Mustafa, M., Nusayr, E., Keenan, J. B., Chen, H., Pawlosky, S., Gard, C., Grisham, C., Sanford, L. P. & Doetschman, T., Feb 1 2009, In : Developmental Dynamics. 238, 2, p. 351-357 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Influence of genetic background on genetically engineered mouse phenotypes

Doetschman, T., Dec 1 2009, Gene Knockout Protocols: Second Edition. Kuhn, R. & Wurst, W. (eds.). p. 423-433 11 p. (Methods in Molecular Biology; vol. 530).

Research output: Chapter in Book/Report/Conference proceedingChapter

117 Scopus citations

Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development

Azhar, M., Runyan, R. B., Gard, C., Sanford, L. P., Miller, M. L., Andringa, A., Pawlowski, S., Rajan, S. & Doetschman, T., Feb 1 2009, In : Developmental Dynamics. 238, 2, p. 431-442 12 p.

Research output: Contribution to journalArticle

79 Scopus citations

Origin of cardiac fibroblasts and the role of periostin

Snider, P., Standley, K. N., Wang, J., Azhar, M., Doetschman, T. & Conway, S. J., Nov 1 2009, In : Circulation research. 105, 10, p. 934-947 14 p.

Research output: Contribution to journalReview article

166 Scopus citations
2008

Decrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 gene

Chen, K., Ohkubo, Y., Shin, D., Doetschman, T., Sanford, L. P., Li, H. & Vaccarino, F. M., Sep 30 2008, In : BMC Neuroscience. 9, 94.

Research output: Contribution to journalArticle

8 Scopus citations

Dual roles of immunoregulatory cytokine TGF-β in the pathogenesis of autoimmunity-mediated organ damage

Saxena, V., Lienesch, D. W., Zhou, M., Bommireddy, R., Azhar, M., Doetschman, T. & Singh, R. R., Feb 1 2008, In : Journal of Immunology. 180, 3, p. 1903-1912 10 p.

Research output: Contribution to journalArticle

Open Access
79 Scopus citations

Impaired cardiac contractility in mice lacking both the AE3 Cl -/HCO3- exchanger and the NKCC1 Na +-K+-2Cl- cotransporter: Effects on Ca 2+ handling and protein phosphatases

Prasad, V., Bodi, I., Meyer, J. W., Wang, Y., Ashraf, M., Engle, S. J., Doetschman, T., Sisco, K., Nieman, M. L., Miller, M. L., Lorenz, J. N. & Shull, G. E., Nov 14 2008, In : Journal of Biological Chemistry. 283, 46, p. 31303-31314 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Reduced expression and function of bone morphogenetic protein-2 in bones of Fgf2 null mice

Naganawa, T., Xiao, L., Coffin, J. D., Doetschman, T., Sabbieti, M. G., Agas, D. & Hurley, M. M., Apr 15 2008, In : Journal of Cellular Biochemistry. 103, 6, p. 1975-1988 14 p.

Research output: Contribution to journalArticle

57 Scopus citations

Sevoflurane protects against renal ischemia and reperfusion injury in mice via the transforming growth factor-β1 pathway

Lee, H. T., Chen, S. W. C., Doetschman, T. C., Deng, C., D'Agati, V. D. & Kim, M., Jul 1 2008, In : American Journal of Physiology - Renal Physiology. 295, 1, p. F128-F136

Research output: Contribution to journalArticle

50 Scopus citations

TGFβ1 deficiency does not affect the generation and maintenance of CD4+CD25+FOXP3+ putative Treg cells, but causes their numerical inadequacy and loss of regulatory function

Bommireddy, R., Babcock, G. F., Singh, R. R. & Doetschman, T., May 1 2008, In : Clinical Immunology. 127, 2, p. 206-213 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2007

Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na +/HCO 3 - cotransporter

Gawenis, L. R., Bradford, E. M., Prasad, V., Lorenz, J. N., Simpson, J. E., Clarke, L. L., Woo, A. L., Grisham, C., Sanford, L. P., Doetschman, T., Miller, M. L. & Shull, G. E., Mar 23 2007, In : Journal of Biological Chemistry. 282, 12, p. 9042-9052 11 p.

Research output: Contribution to journalArticle

112 Scopus citations

Endogenous transforming growth factor β1 suppresses inflammation and promotes survival in adult CNS

Makwana, M., Jones, L. L., Cuthill, D., Heuer, H., Bohatschek, M., Hristova, M., Friedrichsen, S., Ormsby, I., Bueringer, D., Koppius, A., Bauer, K., Doetschman, T. & Raivich, G., Oct 17 2007, In : Journal of Neuroscience. 27, 42, p. 11201-11213 13 p.

Research output: Contribution to journalArticle

78 Scopus citations

Loss of the Atp2c1 Secretory Pathway Ca2+-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes

Okunade, G. W., Miller, M. L., Azhar, M., Andringa, A., Sanford, L. P., Doetschman, T., Prasad, V. & Shull, G. E., Sep 7 2007, In : Journal of Biological Chemistry. 282, 36, p. 26517-26527 11 p.

Research output: Contribution to journalArticle

81 Scopus citations