Thomas C Doetschman

  • 19802 Citations
  • 67 h-Index
1975 …2021

Research output per year

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Research Output

  • 19802 Citations
  • 67 h-Index
  • 164 Article
  • 5 Chapter
  • 1 Comment/debate
  • 1 Review article
1975

Incorporation of fucose and glucosamine into cell bound and medium released macromolecules

Herrmann, H., Havaranis, A. S. & Doetschman, T. C., 1975, In : Journal of Cellular Physiology. 85, 3, p. 557-568 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Insulin binding to cells of several tissues of the early chick embryo

Doetschman, T. C., Havaranis, A. S. & Herrmann, H., 1975, In : Developmental Biology. 47, 1, p. 228-232 5 p.

Research output: Contribution to journalArticle

5 Scopus citations
1980

Cell surface turnover and shedding of fucosyl-glycoprotein in L6 cells

Doetschman, T. C., 1980, In : Cell Biology International Reports. 4, 4, p. 379-390 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Myoblast stored myosin heavy chain transcripts are precursors to the myotube polysomal myosin heavy chain mRNAs

Doetschman, T. C., Dym, H. P., Siegel, E. J. & Heywood, S. M., 1980, In : Differentiation. 16, 3, p. 149-162 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

The effects of Con A on cell surface shedding in cell cultures

Doetschman, T. C., 1980, In : Journal of Cell Science. VOL.46, p. 221-234 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
1981

The contribution of cell death to medium-released fractions of cell cultures

Doetschman, T. C. & Jewett, J., 1981, In : In Vitro. 17, 2, p. 178-184 7 p.

Research output: Contribution to journalArticle

1982

Developmental history of the two M-line proteins MM-creatine kinase and myomesin during myogenesis.

Eppenberger, H. M., Strehler, E. E., Doetschman, T. C., Rosenberg, U. B., Perriard, J. C. & Wallimann, T., 1982, In : Progress in Clinical and Biological Research. 85 Pt B, p. 381-389 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
1983

Initial appearance of myomesin in differentiating muscle cells

Ernst, M., Eppenberger, H. & Doetschman, T. C., 1983, In : Cell Differentiation. 13, 4, p. 319-323 5 p.

Research output: Contribution to journalArticle

Novel staining pattern of skeletal muscle M-lines upon incubation with antibodies against MM-creatine kinase

Wallimann, T., Doetschman, T. C. & Eppenberger, H. M., 1983, In : Journal of Cell Biology. 96, 6, p. 1772-1779 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
1984

A new 185,000-dalton skeletal muscle protein detected by monoclonal antibodies

Grove, B. K., Kurer, V., Lehner, C., Doetschman, T. C., Perriard, J. C. & Eppenberger, H. M., 1984, In : Journal of Cell Biology. 98, 2, p. 518-524 7 p.

Research output: Contribution to journalArticle

161 Scopus citations

Comparison of M-line and other myofibril components during reversible phorbol ester treatment.

Doetschman, T. C. & Eppenberger, H. M., Mar 1984, In : European Journal of Cell Biology. 33, 2, p. 265-274 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
1985
1653 Scopus citations
1986

Introduction of genes into mouse embryonic stem cells.

Doetschman, T. C., Gossler, A., Serfling, E., Schaffner, W., Marcu, K., Stanton, L. & Kemler, R., 1986, In : Progress in Clinical and Biological Research. 217 A, p. 47-50 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Transgenesis by means of blastocyst-derived embryonic stem cell lines

Gossler, A., Doetschman, T. C., Korn, R., Serfling, E. & Kemler, R., 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 23, p. 9065-9069 5 p.

Research output: Contribution to journalArticle

317 Scopus citations
1987

Differential distribution of cytokeratins after microinjection of anti-cytokeratin monoclonal antibodies.

Boller, K., Kemler, R., Baribault, H. & Doetschman, T. C., Jun 1987, In : European Journal of Cell Biology. 43, 3, p. 459-468 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

Doetschman, T. C., Gregg, R. G., Maeda, N., Hooper, M. L., Melton, D. W., Thompson, S. & Smithies, O., 1987, In : Nature. 330, 6148, p. 576-578 3 p.

Research output: Contribution to journalArticle

506 Scopus citations
1988

Establishment of hamster blastocyst-derived embryonic stem (ES) cells

Doetschman, T. C., Williams, P. & Maeda, N., 1988, In : Developmental Biology. 127, 1, p. 224-227 4 p.

Research output: Contribution to journalArticle

158 Scopus citations

Targeted mutation of the Hprt gene in mouse embryonic stem cells

Doetschman, T. C., Maeda, N. & Smithies, O., 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, 22, p. 8583-8587 5 p.

Research output: Contribution to journalArticle

173 Scopus citations

Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies

Risau, W., Sariola, H., Zerwes, H. G., Sasse, J., Ekblom, P., Kemler, R. & Doetschman, T. C., 1988, In : Development. 102, 3, p. 471-478 8 p.

Research output: Contribution to journalArticle

518 Scopus citations
1990

Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro

Robbins, J., Gulick, J., Sanchez, A., Howles, P. & Doetschman, T. C., Jul 15 1990, In : Journal of Biological Chemistry. 265, 20, p. 11905-11909 5 p.

Research output: Contribution to journalArticle

154 Scopus citations
1991

Gene targeting in embryonic stem cells.

Doetschman, T. C., 1991, In : Biotechnology (Reading, Mass.). 16, p. 89-101 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Myosin heavy chain gene expression in mouse embryoid bodies: An in vitro developmental study

Sánchez, A., Jones, W. K., Gulick, J., Doetschman, T. C. & Robbins, J., 1991, In : Journal of Biological Chemistry. 266, 33, p. 22419-22426 8 p.

Research output: Contribution to journalArticle

108 Scopus citations
1992

Embryonic stem cells as a model for cardiogenesis

Robbins, J., Doetschman, T. C., Jones, W. K. & Sánchez, A., 1992, In : Trends in Cardiovascular Medicine. 2, 2, p. 44-50 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mouse phospholamban gene expression during development in vivo and in vitro

Ganim, J. R., Luo, W., Ponniah, S., Grupp, I., Kim, H. W., Ferguson, D. G., Kadambi, V., Neumann, J. C., Doetschman, T. C. & Kranias, E. G., Nov 1992, In : Circulation Research. 71, 5, p. 1021-1030 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., Annunziata, N. & Doetschman, T. C., Oct 22 1992, In : Nature. 359, 6397, p. 693-699 7 p.

Research output: Contribution to journalArticle

2405 Scopus citations
1993

Developmental analysis of tropomyosin gene expression in embryonic stem cells and mouse embryos

Muthuchamy, M., Pajak, L., Howles, P., Doetschman, T. C. & Wieczorek, D. F., Jun 1993, In : Molecular and Cellular Biology. 13, 6, p. 3311-3323 13 p.

Research output: Contribution to journalArticle

100 Scopus citations

Embryonic stem cell model systems for vascular morphogenesis and cardiac disorders

Doetschman, T. C., Shull, M., Kier, A. & Coffin, J. D., Oct 1993, In : Hypertension. 22, 4, p. 618-629 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Expression of the lacZ gene targeted to the HPRT locus in embryonic stem cells and their derivatives

Shaw-white, J. R., Denko, N., Albers, L., Doetschman, T. C. & Stringer, J. R., Jan 1993, In : Transgenic Research. 2, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Site-directed point mutations in embryonic stem cells: A gene-targeting tag-and-exchange strategy

Askew, G. R., Doetschman, T. C. & Lingrel, J. B., Jul 1993, In : Molecular and Cellular Biology. 13, 7, p. 4115-4124 10 p.

Research output: Contribution to journalArticle

119 Scopus citations
1994

Targeted ablation of the phospholainban gene is associated with markedly enhanced myocardial contractility and loss of β-agonist stimulation

Luo, W., Grupp, I. L., Harrer, J., Ponniah, S., Grupp, G., Duffy, J. J., Doetschman, T. C. & Kranias, E. G., Sep 1994, In : Circulation Research. 75, 3, p. 401-409 9 p.

Research output: Contribution to journalArticle

592 Scopus citations

Transforming growth factor-β1 in reproduction and development

Shull, M. M. & Doetschman, T. C., 1994, In : Molecular Reproduction and Development. 39, 2, p. 239-246 8 p.

Research output: Contribution to journalArticle

62 Scopus citations
1995

Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice

Coffin, J. D., Florkiewicz, R. Z., Neumann, J., Mort-Hopkins, T., Dorn, G. W., Lightfoot, P., German, R., Howles, P. N., Kier, A., O'Toole, B. A., Sasse, J., Gonzalez, A. M., Baird, A. & Doetschman, T. C., 1995, In : Molecular Biology of the Cell. 6, 12, p. 1861-1873 13 p.

Research output: Contribution to journalArticle

242 Scopus citations

Early-onset multifocal inflammation in the transforming growth factor β1-null mouse is lymphocyte mediated

Diebold, R. J., Eis, M. J., Yin, M., Ormsby, I., Boivini, G. P., Darrow, B. J., Saffitz, J. E. & Doetschman, T. C., Dec 19 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 26, p. 12215-12219 5 p.

Research output: Contribution to journalArticle

218 Scopus citations

Effect of transforming growth factor-beta1 and -beta2 on Schwann cell proliferation on neurites

Guenard, V., Rosenbaum, T., Gwynn, L. A., Doetschman, T. C., Ratner, N. & Wood, P. M., Apr 1995, In : GLIA. 13, 4, p. 309-318 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Onset and progression of pathological lesions in transforming growth factor-β1-deficient mice

Boivin, G. P., O'Toole, B. A., Orsmby, I. E., Diebold, R. J., Eis, M. J., Doetschman, T. C. & Kier, A. B., 1995, In : American Journal of Pathology. 146, 1, p. 276-288 13 p.

Research output: Contribution to journalArticle

90 Scopus citations

Transforming growth factor-β3 is required for secondary palate fusion

Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., Ding, J., Ferguson, M. W. J. & Doetschman, T. C., 1995, In : Nature Genetics. 11, 4, p. 409-414 6 p.

Research output: Contribution to journalArticle

706 Scopus citations

Wound healing in the transforming growth factor‐β1—deficient mouse

Brown, R. L., Ormsby, I., Doetschman, T. C. & Greenhalgh, D. G., 1995, In : Wound Repair and Regeneration. 3, 1, p. 25-36 12 p.

Research output: Contribution to journalArticle

57 Scopus citations
1996

Ablation of the murine α myosin heavy chain gene leads to dosage effects and functional deficits in the heart

Jones, W. K., Grupp, I. L., Doetschman, T. C., Grupp, G., Osinska, H., Hewett, T. E., Boivin, G., Gulick, J., Ng, W. A. & Robbins, J., Oct 15 1996, In : Journal of Clinical Investigation. 98, 8, p. 1906-1917 12 p.

Research output: Contribution to journalArticle

153 Scopus citations

FLP-mediated site-specific recombination in microinjected murine zygotes

Ludwig, D. L., Stringer, J. R., Wight, D. C., Doetschman, T. C. & Duffy, J. J., Nov 1996, In : Transgenic Research. 5, 6, p. 385-395 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Gastric lesions in transforming growth factor β-1 heterozygous mice

Boivin, G. P., Molina, J. R., Ormsby, I., Stemmermann, G. & Doetschman, T. C., Feb 1996, In : Laboratory Investigation. 74, 2, p. 513-518 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Keratin 12-deficient mice have fragile corneal epithelia

Kao, W. W. Y., Liu, C. Y., Converse, R. L., Shiraishi, A., Kao, C. W. C., Ishizaki, M., Doetschman, T. C. & Duffy, J., Dec 1996, In : Investigative Ophthalmology and Visual Science. 37, 13, p. 2572-2584 13 p.

Research output: Contribution to journalArticle

104 Scopus citations

Keratin 12 deficient mice with recurrent epithelial erosion

Kao, W. W. Y., Liu, C. Y., Shiraishi, A., Converse, R. A., Kao, C. W. C., Ishizaki, M., Doetschman, T. C. & Duffy, J., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3

Research output: Contribution to journalArticle

Liver and intestinal fatty acid binding proteins in control and TGFβ1 gene targeted deficient mice

Fontaine, R. N., Gossett, R. E., Schroeder, F., O'Toole, B. A., Doetschman, T. C. & Kier, A. B., 1996, In : Molecular and Cellular Biochemistry. 159, 2, p. 149-153 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Phospholamban gene dosage effects in the mammalian heart

Luo, W., Wolska, B. M., Grupp, I. L., Harrer, J. M., Haghighi, K., Ferguson, D. G., Slack, J. P., Grupp, G., Doetschman, T. C., Solaro, R. J. & Kranias, E. G., May 1996, In : Circulation Research. 78, 5, p. 839-847 9 p.

Research output: Contribution to journalArticle

99 Scopus citations
1997

Defective endothelium-dependent relaxation of vascular smooth muscle and endothelial cell Ca2+ signaling in mice lacking sarco(endo)plasmic reticulum Ca2+-ATPase isoform

Liu, L. H., Paul, R. J., Sutliff, R. L., Miller, M. L., Lorenz, J. N., Pun, R. Y. K., Duffy, J. J., Doetschman, T. C., Kimura, Y., MacLennan, D. H., Hoying, J. B. & Shull, G. E., Nov 28 1997, In : Journal of Biological Chemistry. 272, 48, p. 30538-30545 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

Endothelium-dependent vascular relaxation is defective in mice lacking (SARCO)endoplasmic reticulum CA2+ ATPase isoform 3 (SERCA3)

Liu, L. H., Sutliff, R. L., Paul, R. J., Lorenz, J. N., Miller, M. L., Duffy, J. J., Doetschman, T. C. & Shull, G. E., 1997, In : FASEB Journal. 11, 3

Research output: Contribution to journalArticle

Germ-free and barrier-raised TGFβ1-deficient mice have similar inflammatory lesions

Boivin, G. P., Ormsby, I., Jones-Carson, J., O'Toole, B. A. & Doetschman, T. C., May 1997, In : Transgenic Research. 6, 3, p. 197-202 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Intracrine and autocrine effects of basic fibroblast growth factor in vascular smooth muscle cells

Davis, M. G., Zhou, M., Ali, S., Coffin, J. D., Doetschman, T. C. & Dorn, G. W., Apr 1997, In : Journal of Molecular and Cellular Cardiology. 29, 4, p. 1061-1072 12 p.

Research output: Contribution to journalArticle

35 Scopus citations