Thomas C Doetschman

  • 19802 Citations
  • 67 h-Index
1975 …2021

Research output per year

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Research Output

  • 19802 Citations
  • 67 h-Index
  • 164 Article
  • 5 Chapter
  • 1 Comment/debate
  • 1 Review article
2007

TGFβ1 and Treg cells: alliance for tolerance

Bommireddy, R. & Doetschman, T. C., Nov 2007, In : Trends in Molecular Medicine. 13, 11, p. 492-501 10 p.

Research output: Contribution to journalArticle

67 Scopus citations

TGF-β2 does not affect Neural Crest Cell Migration but is a Key Player in Vascular Remodeling During Embryogenesis

Molin, D. G. M., Deruiter, M. C., Doetschman, T. C., Sucov, H. M., Poelmann, R. E. & Gittenberger-de Groot, A. C., Nov 16 2007, Cardiovascular Development and Congenital Malformations: Molecular & Genetic Mechanisms. Blackwell Publishing Ltd, p. 148-149 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: The role of JNK signaling

Liao, S., Porter, D., Scott, A., Newman, G., Doetschman, T. C. & Schultz, J. E. J., Jan 2007, In : Journal of Molecular and Cellular Cardiology. 42, 1, p. 106-120 15 p.

Research output: Contribution to journalArticle

41 Scopus citations
21 Scopus citations

Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer

Kaiser, S., Park, Y. K., Franklin, J. L., Halberg, R. B., Yu, M., Jessen, W. J., Freudenberg, J., Chen, X., Haigis, K., Jegga, A. G., Kong, S., Sakthivel, B., Xu, H., Reichling, T., Azhar, M., Boivin, G. P., Roberts, R. B., Bissahoyo, A. C., Gonzales, F., Bloom, G. C. & 17 others, Eschrich, S., Carter, S. L., Aronow, J. E., Kleimeyer, J., Kleimeyer, M., Ramaswamy, V., Settle, S. H., Boone, B., Levy, S., Graff, J. M., Doetschman, T. C., Groden, J., Dove, W. F., Threadgill, D. W., Yeatman, T. J., Coffey, R. J. & Aronow, B. J., Jul 5 2007, In : Genome Biology. 8, 7, R131.

Research output: Contribution to journalArticle

212 Scopus citations
2006

Essential role of bone marrow fibroblast growth factor-2 in the effect of estradiol on reendothelialization and endothelial progenitor cell mobilization

Fontaine, V., Filipe, C., Werner, N., Gourdy, P., Billon, A., Garmy-Susini, B., Brouchet, L., Bayard, F., Prats, H., Doetschman, T. C., Nickenig, G. & Arnal, J. F., Nov 2006, In : American Journal of Pathology. 169, 5, p. 1855-1862 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

Impaired bone anabolic response to parathyroid hormone in Fgf2-/- and Fgf2+/- mice

Hurley, M. M., Okada, Y., Xiao, L., Tanaka, Y., Ito, M., Okimoto, N., Nakamura, T., Rosen, C. J., Doetschman, T. C. & Coffin, J. D., Mar 24 2006, In : Biochemical and Biophysical Research Communications. 341, 4, p. 989-994 6 p.

Research output: Contribution to journalArticle

67 Scopus citations

Self-antigen recognition by TGFβ1-deficient T cells causes their activation and systemic inflammation

Bommireddy, R., Pathak, L. J., Martin, J., Ormsby, I., Engle, S. J., Boivin, G. P., Babcock, G. F., Eriksson, A. U., Singh, R. R. & Doetschman, T. C., Oct 7 2006, In : Laboratory Investigation. 86, 10, p. 1008-1019 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2005

Cardioprotection induced by cardiac-specific overexpression of fibroblast growth factor-2 is mediated by the MAPK cascade

House, S. L., Branch, K., Newman, G., Doetschman, T. C. & Schultz, J. E. J., Nov 2005, In : American Journal of Physiology - Heart and Circulatory Physiology. 289, 5 58-5

Research output: Contribution to journalArticle

42 Scopus citations

Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger

Gawenis, L. R., Greeb, J. M., Prasad, V., Grisham, C., Sanford, L. P., Doetschman, T. C., Andringa, A., Miller, M. L. & Shull, G. E., Apr 1 2005, In : Journal of Biological Chemistry. 280, 13, p. 12781-12789 9 p.

Research output: Contribution to journalArticle

67 Scopus citations
2004

Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFβ1-deficient mice

Bommireddy, R., Engle, S. J., Ormsby, I., Boivin, G. P., Babcock, G. F. & Doetschman, T. C., Nov 2004, In : Cellular Immunology. 232, 1-2, p. 96-104 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Fibroblast growth factor 2: Roles of regulation of lens cell proliferation and epithelial-mesenchymal transition in response to injury

Tanaka, T., Saika, S., Ohnishi, Y., Ooshima, A., McAvoy, J. W., Liu, C. Y., Azhar, M., Doetschman, T. C. & Kao, W. W. Y., Jul 15 2004, In : Molecular Vision. 10, p. 462-467 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Mice with a targeted disruption of the AE2 Cl-/HCO 3- exchanger are achlorhydric

Gawenis, L. R., Ledoussal, C., Judd, L. M., Prasad, V., Alper, S. L., Stuart-Tilley, A., Woo, A. L., Grisham, C., Sanford, L. P., Doetschman, T. C., Miller, M. L. & Shull, G. E., Jul 16 2004, In : Journal of Biological Chemistry. 279, 29, p. 30531-30539 9 p.

Research output: Contribution to journalArticle

107 Scopus citations

Role of fibroblast growth factor-2 isoforms in the effect of estradiol on endothelial cell migration and proliferation

Garmy-Susini, B., Delmas, E., Gourdy, P., Zhou, M., Bossard, C., Bugler, B., Bayard, F., Krust, A., Prats, A. C., Doetschman, T. C., Prats, H. & Arnal, J. F., May 28 2004, In : Circulation Research. 94, 10, p. 1301-1309 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4

Okunade, G. W., Miller, M. L., Pyne, G. J., Sutliff, R. L., O'Connor, K. T., Neumann, J. C., Andringa, A., Miller, D. A., Prasad, V., Doetschman, T. C., Paul, R. J. & Shull, G. E., Aug 6 2004, In : Journal of Biological Chemistry. 279, 32, p. 33742-33750 9 p.

Research output: Contribution to journalArticle

231 Scopus citations

TGF-β, T-cell tolerance and anti-CD3 therapy

Bommireddy, R. & Doetschman, T. C., Jan 2004, In : Trends in Molecular Medicine. 10, 1, p. 3-9 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

The neural crest is contiguous with the cardiac conduction system in the mouse embryo: A role in induction?

Poelmann, R. E., Jongbloed, M. R. M., Molin, D. G. M., Fekkes, M. L., Wang, Z., Fishman, G. I., Doetschman, T. C., Azhar, M. & Gittenberger-De Groot, A. C., Aug 2004, In : Anatomy and Embryology. 208, 5, p. 389-393 5 p.

Research output: Contribution to journalArticle

45 Scopus citations

Transforming growth factor β-SMAD2 signaling regulates aortic arch innervation and development

Molin, D. G. M., Poelmann, R. E., DeRuiter, M. C., Azhar, M., Doetschman, T. C. & Gittenberger-de Groot, A. C., Nov 26 2004, In : Circulation Research. 95, 11, p. 1109-1117 9 p.

Research output: Contribution to journalArticle

41 Scopus citations
2003

Cardiac-Specific Overexpression of Fibroblast Growth Factor-2 Protects Against Myocardial Dysfunction and Infarction in a Murine Model of Low-Flow Ischemia

House, S. L., Bolte, C., Zhou, M., Doetschman, T. C., Klevitsky, R., Newman, G. & Schultz, J. E. J., Dec 23 2003, In : Circulation. 108, 25, p. 3140-3148 9 p.

Research output: Contribution to journalArticle

80 Scopus citations

Impaired osteoclast formation in bone marrow cultures of Fgf2 null mice in response to parathyroid hormone

Okada, Y., Montero, A., Zhang, X., Sobue, T., Lorenzo, J., Doetschman, T. C., Coffin, J. D. & Hurley, M. M., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 21258-21266 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Pathology of mouse models of intestinal cancer: Consensus report and recommendations

Boivin, G. P., Washington, K., Yang, K., Ward, J. M., Pretlow, T. P., Russell, R., Besselsen, D. G., Godfrey, V. L., Doetschman, T. C., Dove, W. F., Pitot, H. C., Halberg, R. B., Itzkowltz, S. H., Groden, J. & Coffey, R. J., Mar 1 2003, In : Gastroenterology. 124, 3, p. 762-777 16 p.

Research output: Contribution to journalArticle

373 Scopus citations

Protein tyrosine phosphatase alpha (PTPα) knockout mice show deficits in Morris water maze learning, decreased locomotor activity, and decreases in anxiety

Skelton, M. R., Ponniah, S., Wang, D. Z. M., Doetschman, T. C., Vorhees, C. V. & Pallen, C. J., Sep 12 2003, In : Brain Research. 984, 1-2, p. 1-10 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

TGFβ1 inhibits Ca2+-calcineurin-mediated activation in thymocytes

Bommireddy, R., Ormsby, I., Yin, M., Boivin, G. P., Babcock, G. F. & Doetschman, T. C., Apr 1 2003, In : Journal of Immunology. 170, 7, p. 3645-3652 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

TGF-β1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes

Bommireddy, R., Saxena, V., Ormsby, I., Yin, M., Boivin, G. P., Babcock, G. F., Singh, R. R. & Doetschman, T. C., May 1 2003, In : Journal of Immunology. 170, 9, p. 4612-4622 11 p.

Research output: Contribution to journalArticle

56 Scopus citations

Transforming growth factor beta in cardiovascular development and function

Azhar, M., Schultz, J. E. J., Grupp, I., Dorn, G. W., Meneton, P., Molin, D. G. M., Gittenberger-de Groot, A. C. & Doetschman, T. C., Oct 2003, In : Cytokine and Growth Factor Reviews. 14, 5, p. 391-407 17 p.

Research output: Contribution to journalArticle

154 Scopus citations
2002

Altered apoptosis pattern during pharyngeal arch artery remodelling is associated with aortic arch malformations in Tgfβ2 knock-out mice

Molin, D. G. M., DeRuiter, M. C., Wisse, L. J., Azhar, M., Doetschman, T. C., Poelmann, R. E. & Gittenberger-De Groot, A. C., Nov 2002, In : Cardiovascular Research. 56, 2, p. 312-322 11 p.

Research output: Contribution to journalArticle

72 Scopus citations

Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-β2 gene

Pietri, L., Bloch-Faure, M., Belair, M. F., Sanford, L. P., Doetschman, T. C., Ménard, J., Bruneval, P. & Meneton, P., 2002, In : Experimental Nephrology. 10, 5-6, p. 374-382 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice

Engle, S. J., Ormsby, I., Pawlowski, S., Boivin, G. P., Croft, J., Balish, E. & Doetschman, T. C., Nov 15 2002, In : Cancer Research. 62, 22, p. 6362-6366 5 p.

Research output: Contribution to journalArticle

169 Scopus citations

Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome

Lorenz, J. N., Baird, N. R., Judd, L. M., Noonan, W. T., Andringa, A., Doetschman, T. C., Manning, P. A., Liu, L. H., Miller, M. L. & Shull, G. E., Oct 4 2002, In : Journal of Biological Chemistry. 277, 40, p. 37871-37880 10 p.

Research output: Contribution to journalArticle

145 Scopus citations

Loss of heterozygosity and point mutation at Aprt locus in T cells and fibroblasts of Pms2-/- mice

Shao, C., Yin, M., Deng, L., Stambrook, P. J., Doetschman, T. C. & Tischfield, J. A., Jan 1 2002, In : Oncogene. 21, 18, p. 2840-2845 6 p.

Research output: Contribution to journalArticle

Loss of heterozygosity and point mutation at Aprt locus in T cells and fibroblasts of Pms2-/- mice

Shao, C., Yin, M., Deng, L., Stambrook, P. J., Doetschman, T. C. & Tischfield, J. A., Apr 25 2002, In : Oncogene. 21, 18, p. 2840-2845 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Targeted disruption of the Fgf2 gene does not affect vascular growth in the mouse ischemic hindlimb

Sullivan, C. J., Doetschman, T. C. & Hoying, J. B., Dec 2002, In : Journal of Applied Physiology. 93, 6, p. 2009-2017 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

TGF-β1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II

Schultz, J. E. J., Witt, S. A., Glascock, B. J., Nieman, M. L., Reiser, P. J., Nix, S. L., Kimballand, T. R. & Doetschman, T. C., Jan 1 2002, In : Journal of Clinical Investigation. 109, 6, p. 787-796 10 p.

Research output: Contribution to journalArticle

336 Scopus citations

TGFβ2 mediates the effects of Hedgehog on hypertrophic differentiation and PTHrP expression

Alvarez, J., Sohn, P., Zeng, X., Doetschman, T. C., Robbins, D. J. & Serra, R., 2002, In : Development. 129, 8, p. 1913-1924 12 p.

Research output: Contribution to journalArticle

121 Scopus citations

Tubedown-1 in remodeling of the developing vitreal vasculature in vivo and regulation of capillary outgrowth in vitro

Paradis, H., Liu, C. Y., Saika, S., Azhar, M., Doetschman, T. C., Good, W. V., Nayak, R., Laver, N., Kao, C. C., Kao, W. Y. & Gendron, R. L., 2002, In : Developmental Biology. 249, 1, p. 140-155 16 p.

Research output: Contribution to journalArticle

19 Scopus citations
2001

Appearance of langerhans cells in the epidermis of Tgfb1-/- SCID mice: Paracrine and autocrine effects of transforming growth factor-β1 and -β21

Thomas, R. M., Belsito, D. V., Huang, C., Chen, L. Z., Ormsby, I., Simmons, W. J., Cowin, P., Shaw, J., Doetschman, T. C. & Thorbecke, G. J., 2001, In : Journal of Investigative Dermatology. 117, 6, p. 1574-1580 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient mice

Meneton, P., Bloch-Faure, M., Hagege, A. A., Ruetten, H., Huang, W., Bergaya, S., Ceiler, D., Gehring, D., Martins, I., Salmon, G., Boulanger, C. M., Nussberger, J., Crozatier, B., Gasc, J. M., Heudes, D., Bruneval, P., Doetschman, T. C., Ménard, J. & Alhenc-Gelas, F., Feb 27 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 5, p. 2634-2639 6 p.

Research output: Contribution to journalArticle

131 Scopus citations

Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping, myocardialization, endocardial cushion differentiation, and apoptosis in TGF-β2-knockout mice

Bartram, U., Molin, D. G. M., Wisse, L. J., Mohamad, A., Sanford, L. P., Doetschman, T. C., Speer, C. P., Poelmann, R. E. & Gittenberger-de Groot, A. C., Jun 5 2001, In : Circulation. 103, 22, p. 2745-2752 8 p.

Research output: Contribution to journalArticle

240 Scopus citations

Influence of genetic background on knockout mouse phenotypes.

Sanford, L. P., Kallapur, S., Ormsby, I. & Doetschman, T. C., 2001, In : Methods in molecular biology (Clifton, N.J.). 158, p. 217-225 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Salivary Acinar Cells from Aquaporin 5-deficient Mice Have Decreased Membrane Water Permeability and Altered Cell Volume Regulation

Krane, C. M., Melvin, J. E., Nguyen, H. V., Richardson, L., Towne, J. E., Doetschman, T. C. & Menon, A. G., Jun 29 2001, In : Journal of Biological Chemistry. 276, 26, p. 23413-23420 8 p.

Research output: Contribution to journalArticle

218 Scopus citations

Tgfβ2 in corneal morphogenesis during mouse embryonic development

Saika, S., Saika, S., Liu, C. Y., Azhar, M., Sanford, L. P., Doetschman, T. C., Gendron, R. L., Kao, C. W. C. & Kao, W. W. Y., Dec 15 2001, In : Developmental Biology. 240, 2, p. 419-432 14 p.

Research output: Contribution to journalArticle

119 Scopus citations
2000

Delayed wound healing in immunodeficient TGF-β1 knockout mice

Crowe, M. J., Doetschman, T. C. & Greenhalgh, D. G., 2000, In : Journal of Investigative Dermatology. 115, 1, p. 3-11 9 p.

Research output: Contribution to journalArticle

128 Scopus citations

Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation

Montero, A., Okada, Y., Tomita, M., Ito, M., Tsurukami, H., Nakamura, T., Doetschman, T. C., Coffin, J. D. & Hurley, M. M., Apr 2000, In : Journal of Clinical Investigation. 105, 8, p. 1085-1093 9 p.

Research output: Contribution to journalArticle

347 Scopus citations

Stomachs of mice lacking the gastric H,K-ATPase α-subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia

Spicer, Z., Miller, M. L., Andringa, A., Riddle, T. M., Duffy, J. J., Doetschman, T. C. & Shull, G. E., Jul 14 2000, In : Journal of Biological Chemistry. 275, 28, p. 21555-21565 11 p.

Research output: Contribution to journalArticle

139 Scopus citations
1999

Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart

Abel, E. D., Kaulbach, H. C., Tian, R., Hopkins, J. C. A., Duffy, J., Doetschman, T. C., Minnemann, T., Boers, M. E., Hadro, E., Oberste-Berghaus, C., Quist, W., Lowell, B. B., Ingwall, J. S. & Kahn, B. B., Dec 1999, In : Journal of Clinical Investigation. 104, 12, p. 1703-1714 12 p.

Research output: Contribution to journalArticle

234 Scopus citations

Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis

Vaccarino, F. M., Schwartz, M. L., Raballo, R., Nilsen, J., Rhee, J., Zhou, M., Doetschman, T. C., Coffin, J. D., Wyland, J. J. & Hung, Y. T. E., Mar 1999, In : Nature Neuroscience. 2, 3, p. 246-253 8 p.

Research output: Contribution to journalArticle

282 Scopus citations

Erratum: Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis (Nature Neuroscience (1999) 2 (246-253))

Vaccarino, F. M., Schwartz, M. L., Raballo, R., Nilsen, J., Rhee, J., Zhou, M., Doetschman, T. C., Coffin, J. D., Wyland, J. J. & Hung, Y. T. E., 1999, In : Nature Neuroscience. 2, 5, p. 485 1 p.

Research output: Contribution to journalArticle

Erratum: Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis (Nature Neuroscience (1999) 2 (246-253))

Vaccarino, F. M., Schwartz, M. L., Raballo, R., Nilsen, J., Rhee, J., Zhou, M., Doetschman, T. C., Coffin, J. D., Wyland, J. J. & Hung, Y. U. E., 1999, In : Nature Neuroscience. 2, 9, p. 848 1 p.

Research output: Contribution to journalArticle

36 Scopus citations

Fibroblast growth factor-2 mediates pressure-induced hypertrophic response

Schultz, J. E. J., Witt, S. A., Nieman, M. L., Reiser, P. J., Engle, S. J., Zhou, M., Pawlowski, S. A., Lorenz, J. N., Kimball, T. R. & Doetschman, T. C., Sep 1999, In : Journal of Clinical Investigation. 104, 6, p. 709-719 11 p.

Research output: Contribution to journalArticle

111 Scopus citations

Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene

Periasamy, M., Reed, T. D., Liu, L. H., Ji, Y., Loukianov, E., Paul, R. J., Nieman, M. L., Riddle, T., Duffy, J. J., Doetschman, T. C., Lorenz, J. N. & Shull, G. E., Jan 22 1999, In : Journal of Biological Chemistry. 274, 4, p. 2556-2562 7 p.

Research output: Contribution to journalArticle

198 Scopus citations