Thomas C Doetschman

  • 19802 Citations
  • 67 h-Index
1975 …2021

Research output per year

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Research Output

  • 19802 Citations
  • 67 h-Index
  • 164 Article
  • 5 Chapter
  • 1 Comment/debate
  • 1 Review article
1999

Interpretation of phenotype in genetically engineered mice

Doetschman, T. C., 1999, In : Laboratory Animal Science. 49, 2, p. 137-143 7 p.

Research output: Contribution to journalArticle

89 Scopus citations

Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf

Flagella, M., Clarke, L. L., Miller, M. L., Erway, L. C., Giannella, R. A., Andringa, A., Gawenis, L. R., Kramer, J., Duffy, J. J., Doetschman, T. C., Lorenz, J. N., Yamoah, E. N., Cardell, E. L. & Shull, G. E., Sep 17 1999, In : Journal of Biological Chemistry. 274, 38, p. 26946-26955 10 p.

Research output: Contribution to journalArticle

284 Scopus citations

Strain dependency of TGFβ1 function during embryogenesis

Kallapur, S., Ormsby, I. & Doetschman, T. C., 1999, In : Molecular Reproduction and Development. 52, 4, p. 341-349 9 p.

Research output: Contribution to journalArticle

73 Scopus citations

TGF-β3, but not TGF-β1, protects keratinocytes against 12-O- tetradecanoylphorbol-13-acetate-induced cell death in vitro and in vivo

Li, J., Foitzik, K., Calautti, E., Baden, H., Doetschman, T. C. & Dotto, G. P., Feb 12 1999, In : Journal of Biological Chemistry. 274, 7, p. 4213-4219 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

The TGF-β2 isoform is both a required and sufficient inducer of murine hair follicle morphogenesis

Foitzik, K., Paus, R., Doetschman, T. C. & Paolo Dotto, G., Aug 15 1999, In : Developmental Biology. 212, 2, p. 278-289 12 p.

Research output: Contribution to journalArticle

109 Scopus citations

Transforming growth factor β1 enhances platelet aggregation through a non-transcriptional effect on the fibrinogen receptor

Hoying, J. B., Yin, M., Diebold, R., Ormsby, I., Becker, A. & Doetschman, T. C., Oct 22 1999, In : Journal of Biological Chemistry. 274, 43, p. 31008-31013 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Transforming growth factor β1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis

Engle, S. J., Hoying, J. B., Boivin, G. P., Ormsby, I., Gartside, P. S. & Doetschman, T. C., Jul 15 1999, In : Cancer Research. 59, 14, p. 3379-3386 8 p.

Research output: Contribution to journalArticle

186 Scopus citations
1998

Association of MSX1 and TGFB3 with nonsyndromic clefting in humans

Lidral, A. C., Romitti, P. A., Basart, A. M., Doetschman, T. C., Leysens, N. J., Daack-Hirsch, S., Semina, E. V., Johnson, L. R., Machida, J., Burds, A., Parnell, T. J., Rubenstein, J. L. R. & Murray, J. C., Aug 1998, In : American Journal of Human Genetics. 63, 2, p. 557-568 12 p.

Research output: Contribution to journalArticle

239 Scopus citations

Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2

Kozel, P. J., Friedman, R. A., Erway, L. C., Yamoah, E. N., Liu, L. H., Riddle, T., Duffy, J. J., Doetschman, T. C., Miller, M. L., Cardell, E. L. & Shull, G. E., Jul 24 1998, In : Journal of Biological Chemistry. 273, 30, p. 18693-18696 4 p.

Research output: Contribution to journalArticle

231 Scopus citations

Developmental expression of the TGFβs in the mouse cochlea

Paradies, N. E., Sanford, L. P., Doetschman, T. C. & Friedman, R. A., 1998, In : Mechanisms of Development. 79, 1-2, p. 165-168 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Fibroblast growth factor 2 control of vascular tone

Zhou, M., Sutliff, R. L., Paul, R. J., Lorenz, J. N., Hoying, J. B., Haudenschild, C. C., Yin, M., Coffin, J. D., Kong, L., Kranias, E. G., Luo, W., Boivin, G. P., Duffy, J. J., Pawlowski, S. A. & Doetschman, T. C., 1998, In : Nature Medicine. 4, 2, p. 201-207 7 p.

Research output: Contribution to journalArticle

274 Scopus citations

IL-4, IL-10 and IFNγ production in TGFβ1-null mice fed low doses of OVA

Barone, K. S., Tolarova, D., Ormsby, I., Doetschman, T. C. & Michael, J. G., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

Increased sensitivity to K+ deprivation in colonic H,K-ATPase-deficient mice

Meneton, P., Schultheis, P. J., Greeb, J., Nieman, M. L., Liu, L. H., Clarke, L. L., Duffy, J. J., Doetschman, T. C., Lorenz, J. N. & Shull, G. E., Feb 1 1998, In : Journal of Clinical Investigation. 101, 3, p. 536-542 7 p.

Research output: Contribution to journalArticle

117 Scopus citations

Induction of oral tolerance in TGF-β1 null mice

Siobhan Barone, K., Tolarova, D. D., Ormsby, I., Doetschman, T. C. & Gabriel Michael, J., 1998, In : Journal of Immunology. 161, 1, p. 154-160 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule

Schultheis, P. J., Lorenz, J. N., Meneton, P., Nieman, M. L., Riddle, T. M., Flagella, M., Duffy, J. J., Doetschman, T. C., Miller, M. L. & Shull, G. E., Oct 30 1998, In : Journal of Biological Chemistry. 273, 44, p. 29150-29155 6 p.

Research output: Contribution to journalArticle

228 Scopus citations

Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger

Schultheis, P. J., Clarke, L. L., Meneton, P., Miller, M. L., Soleimani, M., Gawenis, L. R., Riddle, T. M., Duffy, J. J., Doetschman, T. C., Wang, T., Giebisch, G., Aronson, P. S., Lorenz, J. N. & Shull, G. E., 1998, In : Nature Genetics. 19, 3, p. 282-285 4 p.

Research output: Contribution to journalArticle

617 Scopus citations

Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion

Schultheis, P. J., Clarke, L. L., Meneton, P., Harline, M., Boivin, G. P., Stemmermann, G., Duffy, J. J., Doetschman, T. C., Miller, M. L. & Shull, G. E., Mar 15 1998, In : Journal of Clinical Investigation. 101, 6, p. 1243-1253 11 p.

Research output: Contribution to journalArticle

195 Scopus citations
1997

Defective endothelium-dependent relaxation of vascular smooth muscle and endothelial cell Ca2+ signaling in mice lacking sarco(endo)plasmic reticulum Ca2+-ATPase isoform

Liu, L. H., Paul, R. J., Sutliff, R. L., Miller, M. L., Lorenz, J. N., Pun, R. Y. K., Duffy, J. J., Doetschman, T. C., Kimura, Y., MacLennan, D. H., Hoying, J. B. & Shull, G. E., Nov 28 1997, In : Journal of Biological Chemistry. 272, 48, p. 30538-30545 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

Endothelium-dependent vascular relaxation is defective in mice lacking (SARCO)endoplasmic reticulum CA2+ ATPase isoform 3 (SERCA3)

Liu, L. H., Sutliff, R. L., Paul, R. J., Lorenz, J. N., Miller, M. L., Duffy, J. J., Doetschman, T. C. & Shull, G. E., 1997, In : FASEB Journal. 11, 3

Research output: Contribution to journalArticle

Germ-free and barrier-raised TGFβ1-deficient mice have similar inflammatory lesions

Boivin, G. P., Ormsby, I., Jones-Carson, J., O'Toole, B. A. & Doetschman, T. C., May 1997, In : Transgenic Research. 6, 3, p. 197-202 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Intracrine and autocrine effects of basic fibroblast growth factor in vascular smooth muscle cells

Davis, M. G., Zhou, M., Ali, S., Coffin, J. D., Doetschman, T. C. & Dorn, G. W., Apr 1997, In : Journal of Molecular and Cellular Cardiology. 29, 4, p. 1061-1072 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Muscle isoactin expression during in vitro differentiation of murine embryonic stem cells

Ng, W. A., Doetschman, T. C., Robbins, J. & Lessard, J. L., Feb 1997, In : Pediatric Research. 41, 2, p. 285-292 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Ontogenetic limb bone scaling in basic fibroblast growth factor (FGF-2) transgenic mice

Lightfoot, P. S., Swisher, R., Coffin, J. D., Doetschman, T. C. & German, R. Z., 1997, In : Growth, Development and Aging. 61, 3-4, p. 127-139 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Rescue of cardiac α-actin-deficient mice by enteric smooth muscle γ- actin

Kumar, A., Crawford, K., Close, L., Madison, M., Lorenz, J., Doetschman, T. C., Pawlowski, S., Duffy, J., Neumann, J., Robbins, J., Boivin, G. P., O'Toole, B. A. & Lessard, J. L., 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 9, p. 4406-4411 6 p.

Research output: Contribution to journalArticle

166 Scopus citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

Sanford, L. P., Ormsby, I., Gittenberger-de Groot, A. C., Sariola, H., Friedman, R., Boivin, G. P., Cardell, E. L. & Doetschman, T. C., Jul 1997, In : Development. 124, 13, p. 2659-2670 12 p.

Research output: Contribution to journalArticle

1056 Scopus citations
1996

Ablation of the murine α myosin heavy chain gene leads to dosage effects and functional deficits in the heart

Jones, W. K., Grupp, I. L., Doetschman, T. C., Grupp, G., Osinska, H., Hewett, T. E., Boivin, G., Gulick, J., Ng, W. A. & Robbins, J., Oct 15 1996, In : Journal of Clinical Investigation. 98, 8, p. 1906-1917 12 p.

Research output: Contribution to journalArticle

153 Scopus citations

FLP-mediated site-specific recombination in microinjected murine zygotes

Ludwig, D. L., Stringer, J. R., Wight, D. C., Doetschman, T. C. & Duffy, J. J., Nov 1996, In : Transgenic Research. 5, 6, p. 385-395 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Gastric lesions in transforming growth factor β-1 heterozygous mice

Boivin, G. P., Molina, J. R., Ormsby, I., Stemmermann, G. & Doetschman, T. C., Feb 1996, In : Laboratory Investigation. 74, 2, p. 513-518 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Keratin 12-deficient mice have fragile corneal epithelia

Kao, W. W. Y., Liu, C. Y., Converse, R. L., Shiraishi, A., Kao, C. W. C., Ishizaki, M., Doetschman, T. C. & Duffy, J., Dec 1996, In : Investigative Ophthalmology and Visual Science. 37, 13, p. 2572-2584 13 p.

Research output: Contribution to journalArticle

104 Scopus citations

Keratin 12 deficient mice with recurrent epithelial erosion

Kao, W. W. Y., Liu, C. Y., Shiraishi, A., Converse, R. A., Kao, C. W. C., Ishizaki, M., Doetschman, T. C. & Duffy, J., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3

Research output: Contribution to journalArticle

Liver and intestinal fatty acid binding proteins in control and TGFβ1 gene targeted deficient mice

Fontaine, R. N., Gossett, R. E., Schroeder, F., O'Toole, B. A., Doetschman, T. C. & Kier, A. B., 1996, In : Molecular and Cellular Biochemistry. 159, 2, p. 149-153 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Phospholamban gene dosage effects in the mammalian heart

Luo, W., Wolska, B. M., Grupp, I. L., Harrer, J. M., Haghighi, K., Ferguson, D. G., Slack, J. P., Grupp, G., Doetschman, T. C., Solaro, R. J. & Kranias, E. G., May 1996, In : Circulation Research. 78, 5, p. 839-847 9 p.

Research output: Contribution to journalArticle

99 Scopus citations
1995

Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice

Coffin, J. D., Florkiewicz, R. Z., Neumann, J., Mort-Hopkins, T., Dorn, G. W., Lightfoot, P., German, R., Howles, P. N., Kier, A., O'Toole, B. A., Sasse, J., Gonzalez, A. M., Baird, A. & Doetschman, T. C., 1995, In : Molecular Biology of the Cell. 6, 12, p. 1861-1873 13 p.

Research output: Contribution to journalArticle

242 Scopus citations

Early-onset multifocal inflammation in the transforming growth factor β1-null mouse is lymphocyte mediated

Diebold, R. J., Eis, M. J., Yin, M., Ormsby, I., Boivini, G. P., Darrow, B. J., Saffitz, J. E. & Doetschman, T. C., Dec 19 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 26, p. 12215-12219 5 p.

Research output: Contribution to journalArticle

218 Scopus citations

Effect of transforming growth factor-beta1 and -beta2 on Schwann cell proliferation on neurites

Guenard, V., Rosenbaum, T., Gwynn, L. A., Doetschman, T. C., Ratner, N. & Wood, P. M., Apr 1995, In : GLIA. 13, 4, p. 309-318 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Onset and progression of pathological lesions in transforming growth factor-β1-deficient mice

Boivin, G. P., O'Toole, B. A., Orsmby, I. E., Diebold, R. J., Eis, M. J., Doetschman, T. C. & Kier, A. B., 1995, In : American Journal of Pathology. 146, 1, p. 276-288 13 p.

Research output: Contribution to journalArticle

90 Scopus citations

Transforming growth factor-β3 is required for secondary palate fusion

Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., Ding, J., Ferguson, M. W. J. & Doetschman, T. C., 1995, In : Nature Genetics. 11, 4, p. 409-414 6 p.

Research output: Contribution to journalArticle

706 Scopus citations

Wound healing in the transforming growth factor‐β1—deficient mouse

Brown, R. L., Ormsby, I., Doetschman, T. C. & Greenhalgh, D. G., 1995, In : Wound Repair and Regeneration. 3, 1, p. 25-36 12 p.

Research output: Contribution to journalArticle

57 Scopus citations
1994

Targeted ablation of the phospholainban gene is associated with markedly enhanced myocardial contractility and loss of β-agonist stimulation

Luo, W., Grupp, I. L., Harrer, J., Ponniah, S., Grupp, G., Duffy, J. J., Doetschman, T. C. & Kranias, E. G., Sep 1994, In : Circulation Research. 75, 3, p. 401-409 9 p.

Research output: Contribution to journalArticle

592 Scopus citations

Transforming growth factor-β1 in reproduction and development

Shull, M. M. & Doetschman, T. C., 1994, In : Molecular Reproduction and Development. 39, 2, p. 239-246 8 p.

Research output: Contribution to journalArticle

62 Scopus citations
1993

Developmental analysis of tropomyosin gene expression in embryonic stem cells and mouse embryos

Muthuchamy, M., Pajak, L., Howles, P., Doetschman, T. C. & Wieczorek, D. F., Jun 1993, In : Molecular and Cellular Biology. 13, 6, p. 3311-3323 13 p.

Research output: Contribution to journalArticle

100 Scopus citations

Embryonic stem cell model systems for vascular morphogenesis and cardiac disorders

Doetschman, T. C., Shull, M., Kier, A. & Coffin, J. D., Oct 1993, In : Hypertension. 22, 4, p. 618-629 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Expression of the lacZ gene targeted to the HPRT locus in embryonic stem cells and their derivatives

Shaw-white, J. R., Denko, N., Albers, L., Doetschman, T. C. & Stringer, J. R., Jan 1993, In : Transgenic Research. 2, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Site-directed point mutations in embryonic stem cells: A gene-targeting tag-and-exchange strategy

Askew, G. R., Doetschman, T. C. & Lingrel, J. B., Jul 1993, In : Molecular and Cellular Biology. 13, 7, p. 4115-4124 10 p.

Research output: Contribution to journalArticle

119 Scopus citations
1992

Embryonic stem cells as a model for cardiogenesis

Robbins, J., Doetschman, T. C., Jones, W. K. & Sánchez, A., 1992, In : Trends in Cardiovascular Medicine. 2, 2, p. 44-50 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mouse phospholamban gene expression during development in vivo and in vitro

Ganim, J. R., Luo, W., Ponniah, S., Grupp, I., Kim, H. W., Ferguson, D. G., Kadambi, V., Neumann, J. C., Doetschman, T. C. & Kranias, E. G., Nov 1992, In : Circulation Research. 71, 5, p. 1021-1030 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., Annunziata, N. & Doetschman, T. C., Oct 22 1992, In : Nature. 359, 6397, p. 693-699 7 p.

Research output: Contribution to journalArticle

2405 Scopus citations
1991

Gene targeting in embryonic stem cells.

Doetschman, T. C., 1991, In : Biotechnology (Reading, Mass.). 16, p. 89-101 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Myosin heavy chain gene expression in mouse embryoid bodies: An in vitro developmental study

Sánchez, A., Jones, W. K., Gulick, J., Doetschman, T. C. & Robbins, J., 1991, In : Journal of Biological Chemistry. 266, 33, p. 22419-22426 8 p.

Research output: Contribution to journalArticle

108 Scopus citations