Thomas C Doetschman

  • 19943 Citations
  • 67 h-Index
1975 …2021

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2-Photon Characterization of Optical Proteolytic Beacons for Imaging Changes in Matrix-Metalloprotease Activity in a Mouse Model of Aneurysm

Haskett, D. G., Maestas, D., Howerton, S. J., Smith, T., Ardila, D. C., Doetschman, T. C., Utzinger, U., Mcgrath, D. V., McIntyre, J. O. & Vande Geest, J. P., Feb 23 2016, (Accepted/In press) In : Microscopy and Microanalysis. p. 1-12 12 p.

Research output: Contribution to journalArticle

Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection

Burt, P. M., Xiao, L., Doetschman, T. & Hurley, M. M., Apr 2019, In : Journal of Cellular Physiology. 234, 4, p. 4418-4431 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Ablation of the murine α myosin heavy chain gene leads to dosage effects and functional deficits in the heart

Jones, W. K., Grupp, I. L., Doetschman, T., Grupp, G., Osinska, H., Hewett, T. E., Boivin, G., Gulick, J., Ng, W. A. & Robbins, J., Oct 15 1996, In : Journal of Clinical Investigation. 98, 8, p. 1906-1917 12 p.

Research output: Contribution to journalArticle

Open Access
154 Scopus citations

Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice

Coffin, J. D., Florkiewicz, R. Z., Neumann, J., Mort-Hopkins, T., Dorn, G. W., Lightfoot, P., German, R., Howles, P. N., Kier, A., O'Toole, B. A., Sasse, J., Gonzalez, A. M., Baird, A. & Doetschman, T., Dec 1995, In : Molecular biology of the cell. 6, 12, p. 1861-1873 13 p.

Research output: Contribution to journalArticle

242 Scopus citations

Altered apoptosis pattern during pharyngeal arch artery remodelling is associated with aortic arch malformations in Tgfβ2 knock-out mice

Molin, D. G. M., DeRuiter, M. C., Wisse, L. J., Azhar, M., Doetschman, T., Poelmann, R. E. & Gittenberger-De Groot, A. C., Nov 1 2002, In : Cardiovascular Research. 56, 2, p. 312-322 11 p.

Research output: Contribution to journalArticle

72 Scopus citations

Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-β2 gene

Pietri, L., Bloch-Faure, M., Belair, M. F., Sanford, L. P., Doetschman, T., Ménard, J., Bruneval, P. & Meneton, P., Dec 1 2002, In : Experimental Nephrology. 10, 5-6, p. 374-382 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

A new 185,000-dalton skeletal muscle protein detected by monoclonal antibodies

Grove, B. K., Kurer, V., Lehner, C., Doetschman, T. C., Perriard, J. C. & Eppenberger, H. M., Jan 1 1984, In : Journal of Cell Biology. 98, 2, p. 518-524 7 p.

Research output: Contribution to journalArticle

Open Access
161 Scopus citations

Appearance of langerhans cells in the epidermis of Tgfb1-/- SCID mice: Paracrine and autocrine effects of transforming growth factor-β1 and -β21

Thomas, R. M., Belsito, D. V., Huang, C., Chen, L. Z., Ormsby, I., Simmons, W. J., Cowin, P., Shaw, J., Doetschman, T. & Thorbecke, G. J., Dec 2001, In : Journal of Investigative Dermatology. 117, 6, p. 1574-1580 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Association of MSX1 and TGFB3 with nonsyndromic clefting in humans

Lidral, A. C., Romitti, P. A., Basart, A. M., Doetschman, T., Leysens, N. J., Daack-Hirsch, S., Semina, E. V., Johnson, L. R., Machida, J., Burds, A., Parnell, T. J., Rubenstein, J. L. R. & Murray, J. C., Aug 1998, In : American Journal of Human Genetics. 63, 2, p. 557-568 12 p.

Research output: Contribution to journalArticle

239 Scopus citations

Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2

Kozel, P. J., Friedman, R. A., Erway, L. C., Yamoah, E. N., Liu, L. H., Riddle, T., Duffy, J. J., Doetschman, T., Miller, M. L., Cardell, E. L. & Shull, G. E., Jul 24 1998, In : Journal of Biological Chemistry. 273, 30, p. 18693-18696 4 p.

Research output: Contribution to journalArticle

231 Scopus citations

Biomechanical Comparison of Glutaraldehyde-Crosslinked Gelatin Fibrinogen Electrospun Scaffolds to Porcine Coronary Arteries

Tamimi, E., Ardila, D. C., Haskett, D. G., Doetschman, T. C., Slepian, M. J., Kellar, R. S. & Vande Geest, J. P., Jan 1 2016, In : Journal of Biomechanical Engineering. 138, 1, 011001.

Research output: Contribution to journalArticle

17 Scopus citations

Calcineurin deficiency decreases inflammatory lesions in transforming growth factor β1-deficient mice

Bommireddy, R., Bueno, O. F., Martin, J., Ormsby, I., Chen, H., Gard, C., Molkentin, J. D., Boivin, G. P., Babcock, G. F. & Doetschman, T., Dec 1 2009, In : Clinical and Experimental Immunology. 158, 3, p. 317-324 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart

Abel, E. D., Kaulbach, H. C., Tian, R., Hopkins, J. C. A., Duffy, J., Doetschman, T., Minnemann, T., Boers, M. E., Hadro, E., Oberste-Berghaus, C., Quist, W., Lowell, B. B., Ingwall, J. S. & Kahn, B. B., Dec 1999, In : Journal of Clinical Investigation. 104, 12, p. 1703-1714 12 p.

Research output: Contribution to journalArticle

236 Scopus citations

Cardiac-Specific Overexpression of Fibroblast Growth Factor-2 Protects Against Myocardial Dysfunction and Infarction in a Murine Model of Low-Flow Ischemia

House, S. L., Bolte, C., Zhou, M., Doetschman, T., Klevitsky, R., Newman, G. & Schultz, J. E. J., Dec 23 2003, In : Circulation. 108, 25, p. 3140-3148 9 p.

Research output: Contribution to journalArticle

83 Scopus citations

Cardioprotection induced by cardiac-specific overexpression of fibroblast growth factor-2 is mediated by the MAPK cascade

House, S. L., Branch, K., Newman, G., Doetschman, T. & Schultz, J. E. J., Nov 1 2005, In : American Journal of Physiology - Heart and Circulatory Physiology. 289, 5 58-5, p. H2167-H2175

Research output: Contribution to journalArticle

45 Scopus citations

Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient mice

Meneton, P., Bloch-Faure, M., Hagege, A. A., Ruetten, H., Huang, W., Bergaya, S., Ceiler, D., Gehring, D., Martins, I., Salmon, G., Boulanger, C. M., Nussberger, J., Crozatier, B., Gasc, J. M., Heudes, D., Bruneval, P., Doetschman, T., Ménard, J. & Alhenc-Gelas, F., Feb 27 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 5, p. 2634-2639 6 p.

Research output: Contribution to journalArticle

131 Scopus citations

Cell surface turnover and shedding of fucosyl-glycoprotein in L6 cells

Doetschman, T. C., Apr 1980, In : Cell Biology International Reports. 4, 4, p. 379-390 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis

Vaccarino, F. M., Schwartz, M. L., Raballo, R., Nilsen, J., Rhee, J., Zhou, M., Doetschman, T., Coffin, J. D., Wyland, J. J. & Hung, Y. T. E., Mar 1 1999, In : Nature neuroscience. 2, 3, p. 246-253 8 p.

Research output: Contribution to journalArticle

284 Scopus citations

Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na +/HCO 3 - cotransporter

Gawenis, L. R., Bradford, E. M., Prasad, V., Lorenz, J. N., Simpson, J. E., Clarke, L. L., Woo, A. L., Grisham, C., Sanford, L. P., Doetschman, T., Miller, M. L. & Shull, G. E., Mar 23 2007, In : Journal of Biological Chemistry. 282, 12, p. 9042-9052 11 p.

Research output: Contribution to journalArticle

112 Scopus citations

Comparison of M-line and other myofibril components during reversible phorbol ester treatment.

Doetschman, T. C. & Eppenberger, H. M., Mar 1 1984, In : European Journal of Cell Biology. 33, 2, p. 265-274 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Corrigendum to "Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells"

Yan, J., Mitra, A., Hu, J., Cutrera, J. J., Xia, X., Doetschman, T. C., Gagea, M., Mishra, L. & Li, S., 2016, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

1 Scopus citations

Decrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 gene

Chen, K., Ohkubo, Y., Shin, D., Doetschman, T., Sanford, L. P., Li, H. & Vaccarino, F. M., Sep 30 2008, In : BMC Neuroscience. 9, 94.

Research output: Contribution to journalArticle

8 Scopus citations

Defective endothelium-dependent relaxation of vascular smooth muscle and endothelial cell Ca2+ signaling in mice lacking sarco(endo)plasmic reticulum Ca2+-ATPase isoform

Liu, L. H., Paul, R. J., Sutliff, R. L., Miller, M. L., Lorenz, J. N., Pun, R. Y. K., Duffy, J. J., Doetschman, T., Kimura, Y., MacLennan, D. H., Hoying, J. B. & Shull, G. E., Nov 28 1997, In : Journal of Biological Chemistry. 272, 48, p. 30538-30545 8 p.

Research output: Contribution to journalArticle

90 Scopus citations

Delayed wound healing in immunodeficient TGF-β1 knockout mice

Crowe, M. J., Doetschman, T. & Greenhalgh, D. G., Jan 1 2000, In : Journal of Investigative Dermatology. 115, 1, p. 3-11 9 p.

Research output: Contribution to journalArticle

129 Scopus citations

Developmental analysis of tropomyosin gene expression in embryonic stem cells and mouse embryos

Muthuchamy, M., Pajak, L., Howles, P., Doetschman, T. & Wieczorek, D. F., Jun 1993, In : Molecular and cellular biology. 13, 6, p. 3311-3323 13 p.

Research output: Contribution to journalArticle

Open Access
100 Scopus citations

Developmental expression of the TGFβs in the mouse cochlea

Paradies, N. E., Sanford, L. P., Doetschman, T. & Friedman, R. A., Dec 1 1998, In : Mechanisms of Development. 79, 1-2, p. 165-168 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Developmental history of the two M-line proteins MM-creatine kinase and myomesin during myogenesis.

Eppenberger, H. M., Strehler, E. E., Doetschman, T. C., Rosenberg, U. B., Perriard, J. C. & Wallimann, T., Jan 1 1982, In : Progress in clinical and biological research. 85 Pt B, p. 381-389 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Differential distribution of cytokeratins after microinjection of anti-cytokeratin monoclonal antibodies.

Boller, K., Kemler, R., Baribault, H. & Doetschman, T., Jun 1 1987, In : European Journal of Cell Biology. 43, 3, p. 459-468 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells

Xiao, L., Sobue, T., Esliger, A., Kronenberg, M. S., Coffin, J. D., Doetschman, T. & Hurley, M. M., Aug 1 2010, In : Bone. 47, 2, p. 360-370 11 p.

Research output: Contribution to journalArticle

68 Scopus citations

Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation

Montero, A., Okada, Y., Tomita, M., Ito, M., Tsurukami, H., Nakamura, T., Doetschman, T., Coffin, J. D. & Hurley, M. M., Apr 2000, In : Journal of Clinical Investigation. 105, 8, p. 1085-1093 9 p.

Research output: Contribution to journalArticle

Open Access
351 Scopus citations

Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis

Doetschman, T., Sholl, A., Chen, H. D. R., Gard, C., Hildeman, D. A. & Bommireddy, R., Mar 1 2011, In : Clinical Immunology. 138, 3, p. 321-330 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping, myocardialization, endocardial cushion differentiation, and apoptosis in TGF-β2-knockout mice

Bartram, U., Molin, D. G. M., Wisse, L. J., Mohamad, A., Sanford, L. P., Doetschman, T., Speer, C. P., Poelmann, R. E. & Gittenberger-de Groot, A. C., Jun 5 2001, In : Circulation. 103, 22, p. 2745-2752 8 p.

Research output: Contribution to journalArticle

Open Access
241 Scopus citations

Dual roles of immunoregulatory cytokine TGF-β in the pathogenesis of autoimmunity-mediated organ damage

Saxena, V., Lienesch, D. W., Zhou, M., Bommireddy, R., Azhar, M., Doetschman, T. & Singh, R. R., Feb 1 2008, In : Journal of Immunology. 180, 3, p. 1903-1912 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

Early-onset multifocal inflammation in the transforming growth factor β1-null mouse is lymphocyte mediated

Diebold, R. J., Eis, M. J., Yin, M., Ormsby, I., Boivini, G. P., Darrow, B. J., Saffitz, J. E. & Doetschman, T., Dec 19 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 26, p. 12215-12219 5 p.

Research output: Contribution to journalArticle

Open Access
218 Scopus citations

Effect of transforming growth factor‐β1 and ‐β2 on Schwann cell proliferation on neurites

Guénard, V., Rosenbaum, T., Gwynn, L. A., Doetschman, T., Ratner, N. & Wood, P. M., Apr 1995, In : Glia. 13, 4, p. 309-318 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFβ1-deficient mice

Bommireddy, R., Engle, S. J., Ormsby, I., Boivin, G. P., Babcock, G. F. & Doetschman, T., Nov 1 2004, In : Cellular Immunology. 232, 1-2, p. 96-104 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice

Engle, S. J., Ormsby, I., Pawlowski, S., Boivin, G. P., Croft, J., Balish, E. & Doetschman, T., Nov 15 2002, In : Cancer Research. 62, 22, p. 6362-6366 5 p.

Research output: Contribution to journalArticle

169 Scopus citations

Embryonic stem cell model systems for vascular morphogenesis and cardiac disorders

Doetschman, T., Shull, M., Kier, A. & Coffin, J. D., Oct 1993, In : Hypertension. 22, 4, p. 618-629 12 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations

Endogenous FGF-2 is critically important in PTH anabolic effects on bone

Sabbieti, M. G., Agas, D., Xiao, L., Marchetti, L., Coffin, J. D., Doetschman, T. & Hurley, M. M., Apr 1 2009, In : Journal of Cellular Physiology. 219, 1, p. 143-151 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Endogenous transforming growth factor β1 suppresses inflammation and promotes survival in adult CNS

Makwana, M., Jones, L. L., Cuthill, D., Heuer, H., Bohatschek, M., Hristova, M., Friedrichsen, S., Ormsby, I., Bueringer, D., Koppius, A., Bauer, K., Doetschman, T. & Raivich, G., Oct 17 2007, In : Journal of Neuroscience. 27, 42, p. 11201-11213 13 p.

Research output: Contribution to journalArticle

77 Scopus citations

Endothelium-dependent vascular relaxation is defective in mice lacking (SARCO)endoplasmic reticulum CA2+ ATPase isoform 3 (SERCA3)

Liu, L. H., Sutliff, R. L., Paul, R. J., Lorenz, J. N., Miller, M. L., Duffy, J. J., Doetschman, T. & Shull, G. E., Dec 1 1997, In : FASEB Journal. 11, 3, p. A519

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Essential role of bone marrow fibroblast growth factor-2 in the effect of estradiol on reendothelialization and endothelial progenitor cell mobilization

Fontaine, V., Filipe, C., Werner, N., Gourdy, P., Billon, A., Garmy-Susini, B., Brouchet, L., Bayard, F., Prats, H., Doetschman, T., Nickenig, G. & Arnal, J. F., Nov 2006, In : American Journal of Pathology. 169, 5, p. 1855-1862 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

Establishment of hamster blastocyst-derived embryonic stem (ES) cells

Doetschman, T., Williams, P. & Maeda, N., May 1988, In : Developmental biology. 127, 1, p. 224-227 4 p.

Research output: Contribution to journalArticle

158 Scopus citations

Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice

Xiao, L., Liu, P., Li, X., Doetschman, T., Coffin, J. D., Drissi, H. & Hurley, M. M., Jan 30 2009, In : Journal of Biological Chemistry. 284, 5, p. 3170-3182 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Expression of the lacZ gene targeted to the HPRT locus in embryonic stem cells and their derivatives

Shaw-white, J. R., Denko, N., Albers, L., Doetschman, T. C. & Stringer, J. R., Jan 1 1993, In : Transgenic Research. 2, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Faulty aiib/,33 activation in response to adp but not thrombin in platelets from transforming growth factor-b1 knockout mice

Hoying, J. B., Yin, M. & Doetschman, T., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1167

Research output: Contribution to journalArticle

Fibroblast growth factor 2: Roles of regulation of lens cell proliferation and epithelial-mesenchymal transition in response to injury

Tanaka, T., Saika, S., Ohnishi, Y., Ooshima, A., McAvoy, J. W., Liu, C. Y., Azhar, M., Doetschman, T. & Kao, W. W. Y., Jul 15 2004, In : Molecular Vision. 10, p. 462-467 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Fibroblast growth factor 2 control of vascular tone

Zhou, M., Sutliff, R. L., Paul, R. J., Lorenz, J. N., Hoying, J. B., Haudenschild, C. C., Yin, M., Coffin, J. D., Kong, L., Kranias, E. G., Luo, W., Boivin, G. P., Duffy, J. J., Pawlowski, S. A. & Doetschman, T., Apr 7 1998, In : Nature Medicine. 4, 2, p. 201-207 7 p.

Research output: Contribution to journalArticle

276 Scopus citations

Fibroblast growth factor-2-induced cardioprotection against myocardial infarction occurs via the interplay between nitric oxide, protein kinase signaling, and ATP-sensitive potassium channels

Manning, J. R., Carpenter, G., Porter, D. R., House, S. L., Pietras, D. A., Doetschman, T. & Schultz, J. E. J., Apr 2012, In : Growth Factors. 30, 2, p. 124-139 16 p.

Research output: Contribution to journalArticle

10 Scopus citations