Thomas C Doetschman

  • 20052 Citations
  • 67 h-Index
1975 …2019

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Fibroblast growth factor 2 mediates isoproterenol-induced cardiac hypertrophy through activation of the extracellular regulated kinase

House, S. L., House, B. E., Glascock, B., Kimball, T., Nusayr, E., Schultz, J. E. J. & Doetschman, T., Nov 9 2010, In : Molecular and Cellular Pharmacology. 2, 4, p. 143-154 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Fibroblast growth factor-2 mediates pressure-induced hypertrophic response

Schultz, J. E. J., Witt, S. A., Nieman, M. L., Reiser, P. J., Engle, S. J., Zhou, M., Pawlowski, S. A., Lorenz, J. N., Kimball, T. R. & Doetschman, T., Sep 1999, In : Journal of Clinical Investigation. 104, 6, p. 709-719 11 p.

Research output: Contribution to journalArticle

Open Access
112 Scopus citations

Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway

Fei, Y., Xiao, L., Doetschman, T., Coffin, D. J. & Hurley, M. M., Nov 25 2011, In : Journal of Biological Chemistry. 286, 47, p. 40575-40583 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Flow cytometry and single nucleus sorting for Cre-based analysis of changes in transcriptional states

Samadder, P., Weng, N., Doetschman, T. C., Heimark, R. L. & Galbraith, D. W., May 1 2016, In : Cytometry Part A. 89, 5, p. 430-442 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

FLP-mediated site-specific recombination in microinjected murine zygotes

Ludwig, D. L., Stringer, J. R., Wight, D. C., Doetschman, T. C. & Duffy, J. J., Jan 1 1996, In : Transgenic Research. 5, 6, p. 385-395 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Functional changes in the gut microbiome contribute to transforming growth factor β-deficient colon cancer

Daniel, S. G., Ball, C. L., Besselsen, D. G., Doetschman, T. & Hurwitze, B. L., Sep 1 2017, In : mSystems. 2, 5, e00065.

Research output: Contribution to journalArticle

16 Scopus citations

Gastric lesions in transforming growth factor β-1 heterozygous mice

Boivin, G. P., Molina, J. R., Ormsby, I., Stemmermann, G. & Doetschman, T., Feb 1 1996, In : Laboratory Investigation. 74, 2, p. 513-518 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Generation of mice with a conditional allele for the transforming growth factor beta3 gene

Doetschman, T., Georgieva, T., Li, H., Reed, T. D., Grisham, C., Friel, J., Estabrook, M. A., Gard, C., Sanford, L. P. & Azhar, M., Jan 1 2012, In : Genesis. 50, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Generation of mice with a conditional allele for transforming growth factor beta 1 gene

Azhar, M., Yin, M., Bommireddy, R., Duffy, J. J., Yang, J., Pawlowski, S. A., Boivin, G. P., Engle, S. J., Sanford, L. P., Grisham, C., Singh, R. R., Babcock, G. F. & Doetschman, T., Sep 22 2009, In : Genesis. 47, 6, p. 423-431 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Gene targeted ablation of high molecular weight fibroblast growth factor-2

Azhar, M., Yin, M., Zhou, M., Li, H., Mustafa, M., Nusayr, E., Keenan, J. B., Chen, H., Pawlosky, S., Gard, C., Grisham, C., Sanford, L. P. & Doetschman, T., Feb 1 2009, In : Developmental Dynamics. 238, 2, p. 351-357 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
Open Access
13 Scopus citations

Germ-free and barrier-raised TGFβ1-deficient mice have similar inflammatory lesions

Boivin, G. P., Ormsby, I., Jones-Carson, J., O'Toole, B. A. & Doetschman, T., Jan 1 1997, In : Transgenic Research. 6, 3, p. 197-202 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

GI GEMs: Genetically engineered mouse models of gastrointestinal disease

Doetschman, T., Feb 2011, In : Gastroenterology. 140, 2, p. 380-385.e2

Research output: Contribution to journalArticle

3 Scopus citations

IL-4, IL-10 and IFNγ production in TGFβ1-null mice fed low doses of OVA

Barone, K. S., Tolarova, D., Ormsby, I., Doetschman, T. & Michael, J. G., Mar 20 1998, In : FASEB Journal. 12, 5, p. A881

Research output: Contribution to journalArticle

Impaired bone anabolic response to parathyroid hormone in Fgf2-/- and Fgf2+/- mice

Hurley, M. M., Okada, Y., Xiao, L., Tanaka, Y., Ito, M., Okimoto, N., Nakamura, T., Rosen, C. J., Doetschman, T. & Coffin, J. D., Mar 24 2006, In : Biochemical and Biophysical Research Communications. 341, 4, p. 989-994 6 p.

Research output: Contribution to journalArticle

70 Scopus citations

Impaired cardiac contractility in mice lacking both the AE3 Cl -/HCO3- exchanger and the NKCC1 Na +-K+-2Cl- cotransporter: Effects on Ca 2+ handling and protein phosphatases

Prasad, V., Bodi, I., Meyer, J. W., Wang, Y., Ashraf, M., Engle, S. J., Doetschman, T., Sisco, K., Nieman, M. L., Miller, M. L., Lorenz, J. N. & Shull, G. E., Nov 14 2008, In : Journal of Biological Chemistry. 283, 46, p. 31303-31314 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene

Periasamy, M., Reed, T. D., Liu, L. H., Ji, Y., Loukianov, E., Paul, R. J., Nieman, M. L., Riddle, T., Duffy, J. J., Doetschman, T., Lorenz, J. N. & Shull, G. E., Jan 22 1999, In : Journal of Biological Chemistry. 274, 4, p. 2556-2562 7 p.

Research output: Contribution to journalArticle

199 Scopus citations

Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger

Gawenis, L. R., Greeb, J. M., Prasad, V., Grisham, C., Sanford, L. P., Doetschman, T., Andringa, A., Miller, M. L. & Shull, G. E., Apr 1 2005, In : Journal of Biological Chemistry. 280, 13, p. 12781-12789 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

Impaired osteoclast formation in bone marrow cultures of Fgf2 null mice in response to parathyroid hormone

Okada, Y., Montero, A., Zhang, X., Sobue, T., Lorenzo, J., Doetschman, T., Coffin, J. D. & Hurley, M. M., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 21258-21266 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome

Lorenz, J. N., Baird, N. R., Judd, L. M., Noonan, W. T., Andringa, A., Doetschman, T., Manning, P. A., Liu, L. H., Miller, M. L. & Shull, G. E., Oct 4 2002, In : Journal of Biological Chemistry. 277, 40, p. 37871-37880 10 p.

Research output: Contribution to journalArticle

145 Scopus citations
17 Scopus citations

Incorporation of fucose and glucosamine into cell bound and medium released macromolecules

Herrmann, H., Havaranis, A. S. & Doetschman, T. C., Jun 1975, In : Journal of Cellular Physiology. 85, 3, p. 557-568 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Increased sensitivity to K+ deprivation in colonic H,K-ATPase-deficient mice

Meneton, P., Schultheis, P. J., Greeb, J., Nieman, M. L., Liu, L. H., Clarke, L. L., Duffy, J. J., Doetschman, T., Lorenz, J. N. & Shull, G. E., Feb 1 1998, In : Journal of Clinical Investigation. 101, 3, p. 536-542 7 p.

Research output: Contribution to journalArticle

Open Access
117 Scopus citations

Induction of oral tolerance in TGF-β1 null mice

Siobhan Barone, K., Tolarova, D. D., Ormsby, I., Doetschman, T. & Gabriel Michael, J., Jul 1 1998, In : Journal of Immunology. 161, 1, p. 154-160 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Initial appearance of myomesin in differentiating muscle cells

Ernst, M., Eppenberger, H. & Doetschman, T., Dec 1983, In : Cell Differentiation. 13, 4, p. 319-323 5 p.

Research output: Contribution to journalArticle

Insulin binding to cells of several tissues of the early chick embryo

Doetschman, T. C., Havaranis, A. S. & Herrmann, H., Nov 1975, In : Developmental biology. 47, 1, p. 228-232 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells

Yan, J., Mitra, A., Hu, J., Cutrera, J. J., Xia, X., Doetschman, T. C., Gagea, M., Mishra, L. & Li, S., May 1 2016, In : Journal of Hepatology. 64, 5, p. 1128-1136 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Interpretation of phenotype in genetically engineered mice

Doetschman, T., May 12 1999, In : Laboratory Animal Science. 49, 2, p. 137-143 7 p.

Research output: Contribution to journalArticle

89 Scopus citations

Intracrine and autocrine effects of basic fibroblast growth factor in vascular smooth muscle cells

Davis, M. G., Zhou, M., Ali, S., Coffin, J. D., Doetschman, T. & Dorn, G. W., Apr 1997, In : Journal of Molecular and Cellular Cardiology. 29, 4, p. 1061-1072 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Introduction of genes into mouse embryonic stem cells.

Doetschman, T., Gossler, A., Serfling, E., Schaffner, W., Marcu, K., Stanton, L. & Kemler, R., Jan 1 1986, In : Progress in clinical and biological research. 217 A, p. 47-50 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Keratin 12-deficient mice have fragile corneal epithelia

Kao, W. W. Y., Liu, C. Y., Converse, R. L., Shiraishi, A., Kao, C. W. C., Ishizaki, M., Doetschman, T. & Duffy, J., Dec 1 1996, In : Investigative Ophthalmology and Visual Science. 37, 13, p. 2572-2584 13 p.

Research output: Contribution to journalArticle

104 Scopus citations

Keratin 12 deficient mice with recurrent epithelial erosion

Kao, W. W. Y., Liu, C. Y., Shiraishi, A., Converse, R. A., Kao, C. W. C., Ishizaki, M., Doetschman, T. & Duffy, J., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3, p. S452

Research output: Contribution to journalArticle

Knockout of nuclear high molecular weight FGF2 isoforms in mice modulates bone and phosphate homeostasis

Homer-Bouthiette, C., Doetschman, T., Xiao, L. & Hurley, M. M., Dec 26 2014, In : Journal of Biological Chemistry. 289, 52, p. 36303-36314 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development

Azhar, M., Runyan, R. B., Gard, C., Sanford, L. P., Miller, M. L., Andringa, A., Pawlowski, S., Rajan, S. & Doetschman, T., Feb 1 2009, In : Developmental Dynamics. 238, 2, p. 431-442 12 p.

Research output: Contribution to journalArticle

78 Scopus citations

Liver and intestinal fatty acid binding proteins in control and TGFβ1 gene targeted deficient mice

Fontaine, R. N., Gossett, R. E., Schroeder, F., O'Toole, B. A., Doetschman, T. & Kier, A. B., Aug 15 1996, In : Molecular and Cellular Biochemistry. 159, 2, p. 149-153 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Loss of heterozygosity and point mutation at Aprt locus in T cells and fibroblasts of Pms2-/- mice

Shao, C., Yin, M., Deng, L., Stambrook, P. J., Doetschman, T. & Tischfield, J. A., Jan 1 2002, In : Oncogene. 21, 18, p. 2840-2845 6 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Loss of heterozygosity and point mutation at Aprt locus in T cells and fibroblasts of Pms2-/- mice

Shao, C., Yin, M., Deng, L., Stambrook, P. J., Doetschman, T. C. & Tischfield, J. A., Jan 1 2002, In : Oncogene. 21, 18, p. 2840-2845 6 p.

Research output: Contribution to journalArticle

Loss of the Atp2c1 Secretory Pathway Ca2+-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes

Okunade, G. W., Miller, M. L., Azhar, M., Andringa, A., Sanford, L. P., Doetschman, T., Prasad, V. & Shull, G. E., Sep 7 2007, In : Journal of Biological Chemistry. 282, 36, p. 26517-26527 11 p.

Research output: Contribution to journalArticle

80 Scopus citations

Lymphangiogenesis and angiogenesis: Concurrence and/or dependence? Studies in inbred mouse strains

Nakao, S., Maruyama, K., Zandi, S., Melhorn, M. I., Taher, M., Noda, K., Nusayr, E., Doetschman, T. & Hafezi-Moghadam, A., Feb 1 2010, In : FASEB Journal. 24, 2, p. 504-513 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf

Flagella, M., Clarke, L. L., Miller, M. L., Erway, L. C., Giannella, R. A., Andringa, A., Gawenis, L. R., Kramer, J., Duffy, J. J., Doetschman, T., Lorenz, J. N., Yamoah, E. N., Cardell, E. L. & Shull, G. E., Sep 17 1999, In : Journal of Biological Chemistry. 274, 38, p. 26946-26955 10 p.

Research output: Contribution to journalArticle

286 Scopus citations

Mice with a targeted disruption of the AE2 Cl-/HCO 3- exchanger are achlorhydric

Gawenis, L. R., Ledoussal, C., Judd, L. M., Prasad, V., Alper, S. L., Stuart-Tilley, A., Woo, A. L., Grisham, C., Sanford, L. P., Doetschman, T., Miller, M. L. & Shull, G. E., Jul 16 2004, In : Journal of Biological Chemistry. 279, 29, p. 30531-30539 9 p.

Research output: Contribution to journalArticle

107 Scopus citations

Modulating smooth muscle cell response by the release of TGFβ2 from tubular scaffolds for vascular tissue engineering

Ardila, D. C., Tamimi, E., Doetschman, T., Wagner, W. R. & Vande Geest, J. P., Apr 10 2019, In : Journal of Controlled Release. 299, p. 44-52 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro

Robbins, J., Gulick, J., Sanchez, A., Howles, P. & Doetschman, T., Aug 3 1990, In : Journal of Biological Chemistry. 265, 20, p. 11905-11909 5 p.

Research output: Contribution to journalArticle

154 Scopus citations

Mouse phospholamban gene expression during development in vivo and in vitro

Ganim, J. R., Luo, W., Ponniah, S., Grupp, I., Kim, H. W., Ferguson, D. G., Kadambi, V., Neumann, J. C., Doetschman, T. & Kranias, E. G., Nov 1992, In : Circulation research. 71, 5, p. 1021-1030 10 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations

Muscle isoactin expression during in vitro differentiation of murine embryonic stem cells

Ng, W. A., Doetschman, T., Robbins, J. & Lessard, J. L., Feb 1997, In : Pediatric Research. 41, 2, p. 285-292 8 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Myoblast Stored Myosin Heavy Chain Transcripts are Precursors to the Myotube Polysomal Myosin Heavy Chain mRNAs

DOETSCHMAN, THOMAS. C., DYM, HAVIV. P., SIEGEL, ERIC. J. & HEYWOOD, STUART. M., Jan 1 1980, In : Differentiation. 16, 1-3, p. 149-162 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Myosin heavy chain gene expression in mouse embryoid bodies. An in vitro developmental study

Sanchez, A., Jones, W. K., Gulick, J., Doetschman, T. & Robbins, J., Jan 1 1991, In : Journal of Biological Chemistry. 266, 33, p. 22419-22426 8 p.

Research output: Contribution to journalArticle

108 Scopus citations

N-6 linoleic acid induces epigenetics alterations associated with colonic inflammation and cancer

Romagnolo, D. F., Donovan, M. G., Doetschman, T. C. & Selmin, O. I., Jan 1 2019, In : Nutrients. 11, 1, 171.

Research output: Contribution to journalArticle

4 Scopus citations

Novel staining pattern of skeletal muscle M-lines upon incubation with antibodies against MM-creatine kinase

Wallimann, T., Doetschman, T. C. & Eppenberger, H. M., Jan 1 1983, In : Journal of Cell Biology. 96, 6, p. 1772-1779 8 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations