Thomas C Doetschman

  • 20052 Citations
  • 67 h-Index
1975 …2019

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Onset and progression of pathological lesions in transforming growth factor-β1-deficient mice

Boivin, G. P., O'Toole, B. A., Orsmby, I. E., Diebold, R. J., Eis, M. J., Doetschman, T. & Kier, A. B., Jan 1 1995, In : American Journal of Pathology. 146, 1, p. 276-288 13 p.

Research output: Contribution to journalArticle

91 Scopus citations

Ontogenetic limb bone scaling in basic fibroblast growth factor (FGF-2) transgenic mice

Lightfoot, P. S., Swisher, R., Coffin, J. D., Doetschman, T. C. & German, R. Z., Dec 1 1997, In : Growth, Development and Aging. 61, 3-4, p. 127-139 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule

Schultheis, P. J., Lorenz, J. N., Meneton, P., Nieman, M. L., Riddle, T. M., Flagella, M., Duffy, J. J., Doetschman, T., Miller, M. L. & Shull, G. E., Oct 30 1998, In : Journal of Biological Chemistry. 273, 44, p. 29150-29155 6 p.

Research output: Contribution to journalArticle

232 Scopus citations

Phospholamban gene dosage effects in the mammalian heart

Luo, W., Wolska, B. M., Grupp, I. L., Harrer, J. M., Haghighi, K., Ferguson, D. G., Slack, J. P., Grupp, G., Doetschman, T., Solaro, R. J. & Kranias, E. G., May 1996, In : Circulation research. 78, 5, p. 839-847 9 p.

Research output: Contribution to journalArticle

99 Scopus citations

Protein tyrosine phosphatase alpha (PTPα) knockout mice show deficits in Morris water maze learning, decreased locomotor activity, and decreases in anxiety

Skelton, M. R., Ponniah, S., Wang, D. Z. M., Doetschman, T., Vorhees, C. V. & Pallen, C. J., Sep 12 2003, In : Brain Research. 984, 1-2, p. 1-10 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Reduced expression and function of bone morphogenetic protein-2 in bones of Fgf2 null mice

Naganawa, T., Xiao, L., Coffin, J. D., Doetschman, T., Sabbieti, M. G., Agas, D. & Hurley, M. M., Apr 15 2008, In : Journal of Cellular Biochemistry. 103, 6, p. 1975-1988 14 p.

Research output: Contribution to journalArticle

57 Scopus citations

Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger

Schultheis, P. J., Clarke, L. L., Meneton, P., Miller, M. L., Soleimani, M., Gawenis, L. R., Riddle, T. M., Duffy, J. J., Doetschman, T., Wang, T., Giebisch, G., Aronson, P. S., Lorenz, J. N. & Shull, G. E., Jul 15 1998, In : Nature Genetics. 19, 3, p. 282-285 4 p.

Research output: Contribution to journalArticle

620 Scopus citations

Rescue of cardiac α-actin-deficient mice by enteric smooth muscle γ-actin

Kumar, A., Crawford, K., Close, L., Madison, M., Lorenz, J., Doetschman, T., Pawlowski, S., Duffy, J., Neumann, J., Robbins, J., Boivin, G. P., O'Toole, B. A. & Lessard, J. L., Apr 29 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 9, p. 4406-4411 6 p.

Research output: Contribution to journalArticle

167 Scopus citations

Role of fibroblast growth factor-2 isoforms in the effect of estradiol on endothelial cell migration and proliferation

Garmy-Susini, B., Delmas, E., Gourdy, P., Zhou, M., Bossard, C., Bugler, B., Bayard, F., Krust, A., Prats, A. C., Doetschman, T., Prats, H. & Arnal, J. F., May 28 2004, In : Circulation research. 94, 10, p. 1301-1309 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Salivary Acinar Cells from Aquaporin 5-deficient Mice Have Decreased Membrane Water Permeability and Altered Cell Volume Regulation

Krane, C. M., Melvin, J. E., Nguyen, H. V., Richardson, L., Towne, J. E., Doetschman, T. & Menon, A. G., Jun 29 2001, In : Journal of Biological Chemistry. 276, 26, p. 23413-23420 8 p.

Research output: Contribution to journalArticle

220 Scopus citations

Self-antigen recognition by TGFβ1-deficient T cells causes their activation and systemic inflammation

Bommireddy, R., Pathak, L. J., Martin, J., Ormsby, I., Engle, S. J., Boivin, G. P., Babcock, G. F., Eriksson, A. U., Singh, R. R. & Doetschman, T., Oct 7 2006, In : Laboratory Investigation. 86, 10, p. 1008-1019 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Sevoflurane protects against renal ischemia and reperfusion injury in mice via the transforming growth factor-β1 pathway

Lee, H. T., Chen, S. W. C., Doetschman, T. C., Deng, C., D'Agati, V. D. & Kim, M., Jul 1 2008, In : American Journal of Physiology - Renal Physiology. 295, 1, p. F128-F136

Research output: Contribution to journalArticle

50 Scopus citations

Site-directed point mutations in embryonic stem cells: A gene-targeting tag-and-exchange strategy

Askew, G. R., Doetschman, T. & Lingrel, J. B., Jul 1993, In : Molecular and cellular biology. 13, 7, p. 4115-4124 10 p.

Research output: Contribution to journalArticle

Open Access
119 Scopus citations

Stomachs of mice lacking the gastric H,K-ATPase α-subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia

Spicer, Z., Miller, M. L., Andringa, A., Riddle, T. M., Duffy, J. J., Doetschman, T. & Shull, G. E., Jul 14 2000, In : Journal of Biological Chemistry. 275, 28, p. 21555-21565 11 p.

Research output: Contribution to journalArticle

140 Scopus citations

Strain dependency of TGFβ1 function during embryogenesis

Kallapur, S., Ormsby, I. & Doetschman, T., Jan 1 1999, In : Molecular Reproduction and Development. 52, 4, p. 341-349 9 p.

Research output: Contribution to journalArticle

73 Scopus citations

Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4

Okunade, G. W., Miller, M. L., Pyne, G. J., Sutliff, R. L., O'Connor, K. T., Neumann, J. C., Andringa, A., Miller, D. A., Prasad, V., Doetschman, T., Paul, R. J. & Shull, G. E., Aug 6 2004, In : Journal of Biological Chemistry. 279, 32, p. 33742-33750 9 p.

Research output: Contribution to journalArticle

231 Scopus citations

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of β-agonist stimulation

Luo, W., Grupp, I. L., Harrer, J., Ponniah, S., Grupp, G., Duffy, J. J., Doetschman, T. & Kranias, E. G., Jan 1 1994, In : Circulation research. 75, 3, p. 401-409 9 p.

Research output: Contribution to journalArticle

Open Access
595 Scopus citations

Targeted disruption of the Fgf2 gene does not affect vascular growth in the mouse ischemic hindlimb

Sullivan, C. J., Doetschman, T. & Hoying, J. B., Dec 2002, In : Journal of Applied Physiology. 93, 6, p. 2009-2017 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease [14]

Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., Annunziata, N. & Doetschman, T., Jan 1 1992, In : Nature. 359, 6397, p. 693-699 7 p.

Research output: Contribution to journalArticle

2429 Scopus citations

Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion

Schultheis, P. J., Clarke, L. L., Meneton, P., Harline, M., Boivin, G. P., Stemmermann, G., Duffy, J. J., Doetschman, T., Miller, M. L. & Shull, G. E., Mar 15 1998, In : Journal of Clinical Investigation. 101, 6, p. 1243-1253 11 p.

Research output: Contribution to journalArticle

Open Access
196 Scopus citations

Targeted mutation of the Hprt gene in mouse embryonic stem cells

Doetschman, T., Maeda, N. & Smithies, O., Jan 1 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, 22, p. 8583-8587 5 p.

Research output: Contribution to journalArticle

Open Access
175 Scopus citations

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

Doetschman, T., Gregg, R. G., Maeda, N., Hooper, M. L., Melton, D. W., Thompson, S. & Smithies, O., Jan 1 1987, In : Nature. 330, 6148, p. 576-578 3 p.

Research output: Contribution to journalArticle

510 Scopus citations

TGFβ1 deficiency does not affect the generation and maintenance of CD4+CD25+FOXP3+ putative Treg cells, but causes their numerical inadequacy and loss of regulatory function

Bommireddy, R., Babcock, G. F., Singh, R. R. & Doetschman, T., May 1 2008, In : Clinical Immunology. 127, 2, p. 206-213 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

TGFβ1 inhibits Ca2+-calcineurin-mediated activation in thymocytes

Bommireddy, R., Ormsby, I., Yin, M., Boivin, G. P., Babcock, G. F. & Doetschman, T., Apr 1 2003, In : Journal of Immunology. 170, 7, p. 3645-3652 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

TGF-β1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II

Schultz, J. E. J., Witt, S. A., Glascock, B. J., Nieman, M. L., Reiser, P. J., Nix, S. L., Kimballand, T. R. & Doetschman, T. C., Jan 1 2002, In : Journal of Clinical Investigation. 109, 6, p. 787-796 10 p.

Research output: Contribution to journalArticle

342 Scopus citations

TGF-β1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes

Bommireddy, R., Saxena, V., Ormsby, I., Yin, M., Boivin, G. P., Babcock, G. F., Singh, R. R. & Doetschman, T., May 1 2003, In : Journal of Immunology. 170, 9, p. 4612-4622 11 p.

Research output: Contribution to journalArticle

57 Scopus citations

TGFβ2 differentially modulates smooth muscle cell proliferation andmigration in electrospun gelatin-fibrinogen constructs

Ardila, D. C., Tamimi, E., Danford, F. L., Haskett, D. G., Kellar, R. S., Doetschman, T. & Vande Geest, J. P., Jan 1 2015, In : Biomaterials. 37, p. 164-173 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Tgfβ2 in corneal morphogenesis during mouse embryonic development

Saika, S., Saika, S., Liu, C. Y., Azhar, M., Sanford, L. P., Doetschman, T., Gendron, R. L., Kao, C. W. C. & Kao, W. W. Y., Dec 15 2001, In : Developmental biology. 240, 2, p. 419-432 14 p.

Research output: Contribution to journalArticle

123 Scopus citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

Sanford, L. P., Ormsby, I., Gittenberger-de Groot, A. C., Sariola, H., Friedman, R., Boivin, G. P., Cardell, E. L. & Doetschman, T., Jul 1 1997, In : Development. 124, 13, p. 2659-2670 12 p.

Research output: Contribution to journalArticle

1073 Scopus citations

TGF-β3, but not TGF-β1, protects keratinocytes against 12-O- tetradecanoylphorbol-13-acetate-induced cell death in vitro and in vivo

Li, J., Foitzik, K., Calautti, E., Baden, H., Doetschman, T. & Dotto, G. P., Feb 12 1999, In : Journal of Biological Chemistry. 274, 7, p. 4213-4219 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: The role of JNK signaling

Liao, S., Porter, D., Scott, A., Newman, G., Doetschman, T. & Schultz, J. E. J., Jan 1 2007, In : Journal of Molecular and Cellular Cardiology. 42, 1, p. 106-120 15 p.

Research output: Contribution to journalArticle

43 Scopus citations

The contribution of cell death to medium-released fractions of cell cultures

Doetschman, T. C. & Jewett, J., Feb 1981, In : In Vitro. 17, 2, p. 178-184 7 p.

Research output: Contribution to journalArticle

The effects of Con A on cell surface shedding in cell cultures

Doetschman, T. C., Jan 1 1980, In : Journal of Cell Science. VOL.46, p. 221-234 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

The influence of FGF2 high molecular weight (HMW) isoforms in the development of cardiac ischemia-reperfusion injury

Liao, S., Bodmer, J. R., Azhar, M., Newman, G., Coffin, J. D., Doetschman, T. & Schultz, J. E. J., Jun 1 2010, In : Journal of Molecular and Cellular Cardiology. 48, 6, p. 1245-1254 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
1662 Scopus citations

The neural crest is contiguous with the cardiac conduction system in the mouse embryo: A role in induction?

Poelmann, R. E., Jongbloed, M. R. M., Molin, D. G. M., Fekkes, M. L., Wang, Z., Fishman, G. I., Doetschman, T., Azhar, M. & Gittenberger-De Groot, A. C., Aug 1 2004, In : Anatomy and Embryology. 208, 5, p. 389-393 5 p.

Research output: Contribution to journalArticle

45 Scopus citations

The protein kinase C pathway mediates cardioprotection induced by cardiac-specific overexpression of fibroblast growth factor-2

House, S. L., Melhorn, S. J., Newman, G., Doetschman, T. & Schultz, J. E. J., Jul 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 293, 1, p. H354-H365

Research output: Contribution to journalArticle

22 Scopus citations

The TGF-β2 isoform is both a required and sufficient inducer of murine hair follicle morphogenesis

Foitzik, K., Paus, R., Doetschman, T. & Paolo Dotto, G., Aug 15 1999, In : Developmental biology. 212, 2, p. 278-289 12 p.

Research output: Contribution to journalArticle

110 Scopus citations

Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer

Kaiser, S., Park, Y. K., Franklin, J. L., Halberg, R. B., Yu, M., Jessen, W. J., Freudenberg, J., Chen, X., Haigis, K., Jegga, A. G., Kong, S., Sakthivel, B., Xu, H., Reichling, T., Azhar, M., Boivin, G. P., Roberts, R. B., Bissahoyo, A. C., Gonzales, F., Bloom, G. C. & 17 others, Eschrich, S., Carter, S. L., Aronow, J. E., Kleimeyer, J., Kleimeyer, M., Ramaswamy, V., Settle, S. H., Boone, B., Levy, S., Graff, J. M., Doetschman, T., Groden, J., Dove, W. F., Threadgill, D. W., Yeatman, T. J., Coffey, R. J. & Aronow, B. J., Jul 5 2007, In : Genome biology. 8, 7, R131.

Research output: Contribution to journalArticle

219 Scopus citations

Transforming growth factor Beta2 is required for valve remodeling during heart development

Azhar, M., Brown, K., Gard, C., Chen, H., Rajan, S., Elliott, D. A., Stevens, M. V., Camenisch, T. D., Conway, S. J. & Doetschman, T., Sep 1 2011, In : Developmental Dynamics. 240, 9, p. 2127-2141 15 p.

Research output: Contribution to journalArticle

43 Scopus citations

Transforming growth factor β1 enhances platelet aggregation through a non-transcriptional effect on the fibrinogen receptor

Hoying, J. B., Yin, M., Diebold, R., Ormsby, I., Becker, A. & Doetschman, T., Oct 22 1999, In : Journal of Biological Chemistry. 274, 43, p. 31008-31013 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

Transforming growth factor β1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis

Engle, S. J., Hoying, J. B., Boivin, G. P., Ormsby, I., Gartside, P. S. & Doetschman, T., Jul 15 1999, In : Cancer Research. 59, 14, p. 3379-3386 8 p.

Research output: Contribution to journalArticle

189 Scopus citations

Transforming growth factor–β3 is required for secondary palate fusion

Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., Ding, J., Ferguson, M. W. J. & Doetschman, T., Dec 1995, In : Nature Genetics. 11, 4, p. 409-414 6 p.

Research output: Contribution to journalArticle

710 Scopus citations

Transforming growth factor β-SMAD2 signaling regulates aortic arch innervation and development

Molin, D. G. M., Poelmann, R. E., DeRuiter, M. C., Azhar, M., Doetschman, T. & Gittenberger-de Groot, A. C., Nov 26 2004, In : Circulation research. 95, 11, p. 1109-1117 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Transgenesis by means of blastocyst-derived embryonic stem cell lines

Gossler, A., Doetschman, T., Korn, R., Serfling, E. & Kemler, R., Jan 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 23, p. 9065-9069 5 p.

Research output: Contribution to journalArticle

Open Access
319 Scopus citations

Tubedown-1 in remodeling of the developing vitreal vasculature in vivo and regulation of capillary outgrowth in vitro

Paradis, H., Liu, C. Y., Saika, S., Azhar, M., Doetschman, T., Good, W. V., Nayak, R., Laver, N., Kao, C. C., Kao, W. Y. & Gendron, R. L., Jan 1 2002, In : Developmental biology. 249, 1, p. 140-155 16 p.

Research output: Contribution to journalArticle

19 Scopus citations

Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies

Risau, W., Sariola, H., Zerwes, H. G., Sasse, J., Ekblom, P., Kemler, R. & Doetschman, T., Jan 1 1988, In : Development. 102, 3, p. 471-478 8 p.

Research output: Contribution to journalArticle

521 Scopus citations

Wound healing in the transforming growth factor‐β1—deficient mouse

Brown, R. L., Ormsby, I., Doetschman, T. C. & Greenhalgh, D. G., 1995, In : Wound Repair and Regeneration. 3, 1, p. 25-36 12 p.

Research output: Contribution to journalArticle

58 Scopus citations