Thomas C Doetschman

  • 19943 Citations
  • 67 h-Index
1975 …2021

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1997

Germ-free and barrier-raised TGFβ1-deficient mice have similar inflammatory lesions

Boivin, G. P., Ormsby, I., Jones-Carson, J., O'Toole, B. A. & Doetschman, T., Jan 1 1997, In : Transgenic Research. 6, 3, p. 197-202 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Intracrine and autocrine effects of basic fibroblast growth factor in vascular smooth muscle cells

Davis, M. G., Zhou, M., Ali, S., Coffin, J. D., Doetschman, T. & Dorn, G. W., Apr 1997, In : Journal of Molecular and Cellular Cardiology. 29, 4, p. 1061-1072 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Muscle isoactin expression during in vitro differentiation of murine embryonic stem cells

Ng, W. A., Doetschman, T., Robbins, J. & Lessard, J. L., Feb 1997, In : Pediatric Research. 41, 2, p. 285-292 8 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Ontogenetic limb bone scaling in basic fibroblast growth factor (FGF-2) transgenic mice

Lightfoot, P. S., Swisher, R., Coffin, J. D., Doetschman, T. C. & German, R. Z., Dec 1 1997, In : Growth, Development and Aging. 61, 3-4, p. 127-139 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Rescue of cardiac α-actin-deficient mice by enteric smooth muscle γ-actin

Kumar, A., Crawford, K., Close, L., Madison, M., Lorenz, J., Doetschman, T., Pawlowski, S., Duffy, J., Neumann, J., Robbins, J., Boivin, G. P., O'Toole, B. A. & Lessard, J. L., Apr 29 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 9, p. 4406-4411 6 p.

Research output: Contribution to journalArticle

166 Scopus citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

Sanford, L. P., Ormsby, I., Gittenberger-de Groot, A. C., Sariola, H., Friedman, R., Boivin, G. P., Cardell, E. L. & Doetschman, T., Jul 1 1997, In : Development. 124, 13, p. 2659-2670 12 p.

Research output: Contribution to journalArticle

1068 Scopus citations
1996

Ablation of the murine α myosin heavy chain gene leads to dosage effects and functional deficits in the heart

Jones, W. K., Grupp, I. L., Doetschman, T., Grupp, G., Osinska, H., Hewett, T. E., Boivin, G., Gulick, J., Ng, W. A. & Robbins, J., Oct 15 1996, In : Journal of Clinical Investigation. 98, 8, p. 1906-1917 12 p.

Research output: Contribution to journalArticle

Open Access
154 Scopus citations

FLP-mediated site-specific recombination in microinjected murine zygotes

Ludwig, D. L., Stringer, J. R., Wight, D. C., Doetschman, T. C. & Duffy, J. J., Jan 1 1996, In : Transgenic Research. 5, 6, p. 385-395 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Gastric lesions in transforming growth factor β-1 heterozygous mice

Boivin, G. P., Molina, J. R., Ormsby, I., Stemmermann, G. & Doetschman, T., Feb 1 1996, In : Laboratory Investigation. 74, 2, p. 513-518 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Keratin 12-deficient mice have fragile corneal epithelia

Kao, W. W. Y., Liu, C. Y., Converse, R. L., Shiraishi, A., Kao, C. W. C., Ishizaki, M., Doetschman, T. & Duffy, J., Dec 1 1996, In : Investigative Ophthalmology and Visual Science. 37, 13, p. 2572-2584 13 p.

Research output: Contribution to journalArticle

104 Scopus citations

Keratin 12 deficient mice with recurrent epithelial erosion

Kao, W. W. Y., Liu, C. Y., Shiraishi, A., Converse, R. A., Kao, C. W. C., Ishizaki, M., Doetschman, T. & Duffy, J., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3, p. S452

Research output: Contribution to journalArticle

Liver and intestinal fatty acid binding proteins in control and TGFβ1 gene targeted deficient mice

Fontaine, R. N., Gossett, R. E., Schroeder, F., O'Toole, B. A., Doetschman, T. & Kier, A. B., Aug 15 1996, In : Molecular and Cellular Biochemistry. 159, 2, p. 149-153 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Phospholamban gene dosage effects in the mammalian heart

Luo, W., Wolska, B. M., Grupp, I. L., Harrer, J. M., Haghighi, K., Ferguson, D. G., Slack, J. P., Grupp, G., Doetschman, T., Solaro, R. J. & Kranias, E. G., May 1996, In : Circulation research. 78, 5, p. 839-847 9 p.

Research output: Contribution to journalArticle

99 Scopus citations
1995

Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice

Coffin, J. D., Florkiewicz, R. Z., Neumann, J., Mort-Hopkins, T., Dorn, G. W., Lightfoot, P., German, R., Howles, P. N., Kier, A., O'Toole, B. A., Sasse, J., Gonzalez, A. M., Baird, A. & Doetschman, T., Dec 1995, In : Molecular biology of the cell. 6, 12, p. 1861-1873 13 p.

Research output: Contribution to journalArticle

242 Scopus citations

Early-onset multifocal inflammation in the transforming growth factor β1-null mouse is lymphocyte mediated

Diebold, R. J., Eis, M. J., Yin, M., Ormsby, I., Boivini, G. P., Darrow, B. J., Saffitz, J. E. & Doetschman, T., Dec 19 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 26, p. 12215-12219 5 p.

Research output: Contribution to journalArticle

Open Access
218 Scopus citations

Effect of transforming growth factor‐β1 and ‐β2 on Schwann cell proliferation on neurites

Guénard, V., Rosenbaum, T., Gwynn, L. A., Doetschman, T., Ratner, N. & Wood, P. M., Apr 1995, In : Glia. 13, 4, p. 309-318 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Onset and progression of pathological lesions in transforming growth factor-β1-deficient mice

Boivin, G. P., O'Toole, B. A., Orsmby, I. E., Diebold, R. J., Eis, M. J., Doetschman, T. & Kier, A. B., Jan 1 1995, In : American Journal of Pathology. 146, 1, p. 276-288 13 p.

Research output: Contribution to journalArticle

90 Scopus citations

Transforming growth factor–β3 is required for secondary palate fusion

Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., Ding, J., Ferguson, M. W. J. & Doetschman, T., Dec 1995, In : Nature Genetics. 11, 4, p. 409-414 6 p.

Research output: Contribution to journalArticle

709 Scopus citations

Wound healing in the transforming growth factor‐β1—deficient mouse

Brown, R. L., Ormsby, I., Doetschman, T. C. & Greenhalgh, D. G., 1995, In : Wound Repair and Regeneration. 3, 1, p. 25-36 12 p.

Research output: Contribution to journalArticle

58 Scopus citations
1994

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of β-agonist stimulation

Luo, W., Grupp, I. L., Harrer, J., Ponniah, S., Grupp, G., Duffy, J. J., Doetschman, T. & Kranias, E. G., Jan 1 1994, In : Circulation research. 75, 3, p. 401-409 9 p.

Research output: Contribution to journalArticle

Open Access
595 Scopus citations
1993

Developmental analysis of tropomyosin gene expression in embryonic stem cells and mouse embryos

Muthuchamy, M., Pajak, L., Howles, P., Doetschman, T. & Wieczorek, D. F., Jun 1993, In : Molecular and cellular biology. 13, 6, p. 3311-3323 13 p.

Research output: Contribution to journalArticle

Open Access
100 Scopus citations

Embryonic stem cell model systems for vascular morphogenesis and cardiac disorders

Doetschman, T., Shull, M., Kier, A. & Coffin, J. D., Oct 1993, In : Hypertension. 22, 4, p. 618-629 12 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations

Expression of the lacZ gene targeted to the HPRT locus in embryonic stem cells and their derivatives

Shaw-white, J. R., Denko, N., Albers, L., Doetschman, T. C. & Stringer, J. R., Jan 1 1993, In : Transgenic Research. 2, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Site-directed point mutations in embryonic stem cells: A gene-targeting tag-and-exchange strategy

Askew, G. R., Doetschman, T. & Lingrel, J. B., Jul 1993, In : Molecular and cellular biology. 13, 7, p. 4115-4124 10 p.

Research output: Contribution to journalArticle

Open Access
119 Scopus citations
1992

Mouse phospholamban gene expression during development in vivo and in vitro

Ganim, J. R., Luo, W., Ponniah, S., Grupp, I., Kim, H. W., Ferguson, D. G., Kadambi, V., Neumann, J. C., Doetschman, T. & Kranias, E. G., Nov 1992, In : Circulation research. 71, 5, p. 1021-1030 10 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease [14]

Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., Annunziata, N. & Doetschman, T., Jan 1 1992, In : Nature. 359, 6397, p. 693-699 7 p.

Research output: Contribution to journalArticle

2415 Scopus citations
1991

Myosin heavy chain gene expression in mouse embryoid bodies. An in vitro developmental study

Sanchez, A., Jones, W. K., Gulick, J., Doetschman, T. & Robbins, J., Jan 1 1991, In : Journal of Biological Chemistry. 266, 33, p. 22419-22426 8 p.

Research output: Contribution to journalArticle

108 Scopus citations
1990

Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro

Robbins, J., Gulick, J., Sanchez, A., Howles, P. & Doetschman, T., Aug 3 1990, In : Journal of Biological Chemistry. 265, 20, p. 11905-11909 5 p.

Research output: Contribution to journalArticle

154 Scopus citations
1988

Establishment of hamster blastocyst-derived embryonic stem (ES) cells

Doetschman, T., Williams, P. & Maeda, N., May 1988, In : Developmental biology. 127, 1, p. 224-227 4 p.

Research output: Contribution to journalArticle

158 Scopus citations

Targeted mutation of the Hprt gene in mouse embryonic stem cells

Doetschman, T., Maeda, N. & Smithies, O., Jan 1 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, 22, p. 8583-8587 5 p.

Research output: Contribution to journalArticle

Open Access
173 Scopus citations

Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies

Risau, W., Sariola, H., Zerwes, H. G., Sasse, J., Ekblom, P., Kemler, R. & Doetschman, T., Jan 1 1988, In : Development. 102, 3, p. 471-478 8 p.

Research output: Contribution to journalArticle

518 Scopus citations
1987

Differential distribution of cytokeratins after microinjection of anti-cytokeratin monoclonal antibodies.

Boller, K., Kemler, R., Baribault, H. & Doetschman, T., Jun 1 1987, In : European Journal of Cell Biology. 43, 3, p. 459-468 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

Doetschman, T., Gregg, R. G., Maeda, N., Hooper, M. L., Melton, D. W., Thompson, S. & Smithies, O., Jan 1 1987, In : Nature. 330, 6148, p. 576-578 3 p.

Research output: Contribution to journalArticle

508 Scopus citations
1986

Introduction of genes into mouse embryonic stem cells.

Doetschman, T., Gossler, A., Serfling, E., Schaffner, W., Marcu, K., Stanton, L. & Kemler, R., Jan 1 1986, In : Progress in clinical and biological research. 217 A, p. 47-50 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Transgenesis by means of blastocyst-derived embryonic stem cell lines

Gossler, A., Doetschman, T., Korn, R., Serfling, E. & Kemler, R., Jan 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 23, p. 9065-9069 5 p.

Research output: Contribution to journalArticle

Open Access
317 Scopus citations
1985
1657 Scopus citations
1984

A new 185,000-dalton skeletal muscle protein detected by monoclonal antibodies

Grove, B. K., Kurer, V., Lehner, C., Doetschman, T. C., Perriard, J. C. & Eppenberger, H. M., Jan 1 1984, In : Journal of Cell Biology. 98, 2, p. 518-524 7 p.

Research output: Contribution to journalArticle

Open Access
161 Scopus citations

Comparison of M-line and other myofibril components during reversible phorbol ester treatment.

Doetschman, T. C. & Eppenberger, H. M., Mar 1 1984, In : European Journal of Cell Biology. 33, 2, p. 265-274 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
1983

Initial appearance of myomesin in differentiating muscle cells

Ernst, M., Eppenberger, H. & Doetschman, T., Dec 1983, In : Cell Differentiation. 13, 4, p. 319-323 5 p.

Research output: Contribution to journalArticle

Novel staining pattern of skeletal muscle M-lines upon incubation with antibodies against MM-creatine kinase

Wallimann, T., Doetschman, T. C. & Eppenberger, H. M., Jan 1 1983, In : Journal of Cell Biology. 96, 6, p. 1772-1779 8 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations
1982

Developmental history of the two M-line proteins MM-creatine kinase and myomesin during myogenesis.

Eppenberger, H. M., Strehler, E. E., Doetschman, T. C., Rosenberg, U. B., Perriard, J. C. & Wallimann, T., Jan 1 1982, In : Progress in clinical and biological research. 85 Pt B, p. 381-389 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
1981

The contribution of cell death to medium-released fractions of cell cultures

Doetschman, T. C. & Jewett, J., Feb 1981, In : In Vitro. 17, 2, p. 178-184 7 p.

Research output: Contribution to journalArticle

1980

Cell surface turnover and shedding of fucosyl-glycoprotein in L6 cells

Doetschman, T. C., Apr 1980, In : Cell Biology International Reports. 4, 4, p. 379-390 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Myoblast Stored Myosin Heavy Chain Transcripts are Precursors to the Myotube Polysomal Myosin Heavy Chain mRNAs

DOETSCHMAN, THOMAS. C., DYM, HAVIV. P., SIEGEL, ERIC. J. & HEYWOOD, STUART. M., Jan 1 1980, In : Differentiation. 16, 1-3, p. 149-162 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

The effects of Con A on cell surface shedding in cell cultures

Doetschman, T. C., Jan 1 1980, In : Journal of Cell Science. VOL.46, p. 221-234 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
1975

Incorporation of fucose and glucosamine into cell bound and medium released macromolecules

Herrmann, H., Havaranis, A. S. & Doetschman, T. C., Jun 1975, In : Journal of Cellular Physiology. 85, 3, p. 557-568 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Insulin binding to cells of several tissues of the early chick embryo

Doetschman, T. C., Havaranis, A. S. & Herrmann, H., Nov 1975, In : Developmental biology. 47, 1, p. 228-232 5 p.

Research output: Contribution to journalArticle

5 Scopus citations