Thomas P Davis

  • 11479 Citations
  • 57 h-Index
1978 …2020

Research output per year

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Research Output

2020

Functional NHE1 expression is critical to blood brain barrier integrity and sumatriptan blood to brain uptake

Liktor-Busa, E., Blawn, K. T., Kellohen, K. L., Wiese, B. M., Verkhovsky, V., Wahl, J., Vivek, A., Palomino, S. M., Davis, T. P., Vanderah, T. W. & Largent-Milnes, T. M., May 2020, In : PloS one. 15, 5, e0227463.

Research output: Contribution to journalArticle

Open Access
Open Access
2019

Distribution of insulin in trigeminal nerve and brain after intranasal administration

Lochhead, J. J., Kellohen, K. L., Ronaldson, P. T. & Davis, T. P., Dec 1 2019, In : Scientific reports. 9, 1, 2621.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Perivascular and perineural pathways involved in brain delivery and distribution of drugs after intranasal administration

Lochhead, J. J. & Davis, T. P., Nov 2019, In : Pharmaceutics. 11, 11, 598.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations

Vascular dysfunction—The disregarded partner of Alzheimer's disease

Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., Jacobs, R. E., Doubal, F. N., Ramirez, J., Black, S. E., Nedergaard, M., Benveniste, H., Dichgans, M., Iadecola, C., Love, S., Bath, P. M. & 49 others, Markus, H. S., Salman, R. A., Allan, S. M., Quinn, T. J., Kalaria, R. N., Werring, D. J., Carare, R. O., Touyz, R. M., Williams, S. C. R., Moskowitz, M. A., Katusic, Z. S., Lutz, S. E., Lazarov, O., Minshall, R. D., Rehman, J., Davis, T. P., Wellington, C. L., González, H. M., Yuan, C., Lockhart, S. N., Hughes, T. M., Chen, C. L. H., Sachdev, P., O'Brien, J. T., Skoog, I., Pantoni, L., Gustafson, D. R., Biessels, G. J., Wallin, A., Smith, E. E., Mok, V., Wong, A., Passmore, P., Barkof, F., Muller, M., Breteler, M. M. B., Román, G. C., Hamel, E., Seshadri, S., Gottesman, R. F., van Buchem, M. A., Arvanitakis, Z., Schneider, J. A., Drewes, L. R., Hachinski, V., Finch, C. E., Toga, A. W., Wardlaw, J. M. & Zlokovic, B. V., Jan 2019, In : Alzheimer's and Dementia. 15, 1, p. 158-167 10 p.

Research output: Contribution to journalShort survey

Open Access
76 Scopus citations
2018

Acute pain alters P-glycoprotein-containing protein complexes in rat cerebral microvessels: Implications for P-glycoprotein trafficking

Tome, M. E., Jarvis, C. K., Schaefer, C. P., Jacobs, L. M., Herndon, J. M., Hunn, K. C., Arkwright, N. B., Kellohen, K. L., Mierau, P. C. & Davis, T. P., Dec 1 2018, In : Journal of Cerebral Blood Flow and Metabolism. 38, 12, p. 2209-2222 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Chronic morphine exposure potentiates p-glycoprotein trafficking from nuclear reservoirs in cortical rat brain microvessels

Schaefer, C. P., Arkwright, N. B., Jacobs, L. M., Jarvis, C. K., Hunn, K. C., Largent-Milnes, T. M., Tome, M. E. & Davis, T. P., Feb 2018, In : PloS one. 13, 2, e0192340.

Research output: Contribution to journalArticle

6 Scopus citations

Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery

Cottier, K. E., Galloway, E. A., Calabrese, E. C., Tome, M. E., Liktor-Busa, E., Kim, J., Davis, T. P., Vanderah, T. W. & Largent-Milnes, T. M., Jul 1 2018, In : eNeuro. 5, 4

Research output: Contribution to journalArticle

6 Scopus citations

Modulation of opioid transport at the blood-brain barrier by altered atp-binding cassette (ABC) transporter expression and activity

Yang, J., Reilly, B. G., Davis, T. P. & Ronaldson, P. T., Dec 1 2018, In : Pharmaceutics. 10, 4, 192.

Research output: Contribution to journalReview article

3 Scopus citations
2017

17-β-Estradiol induces spreading depression and pain behavior in alert female rats

Sandweiss, A. J., Cottier, K. E., McIntosh, M. I., Dussor, G., Davis, T. P., Vanderah, T. W. & Largent-Milnes, T. M., Jan 1 2017, In : Oncotarget. 8, 69, p. 114109-114122 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
5 Scopus citations

Development and Maintenance of the Blood-Brain Barrier

Herndon, J. M., Tome, M. E. & Davis, T. P., Mar 7 2017, Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc., p. 51-56 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations
19 Scopus citations

Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System

Lochhead, J. J., Ronaldson, P. T. & Davis, T. P., Mar 28 2017, (Accepted/In press) In : AAPS Journal. p. 1-11 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Mechanisms of Endothelial Injury and Blood-Brain Barrier Dysfunction in Stroke

Ronaldson, P. T. & Davis, T. P., Mar 7 2017, Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc., p. 220-226 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

The opioid epidemic: A central role for the blood brain barrier in opioid analgesia and abuse

Schaefer, C. P., Tome, M. E. & Davis, T. P., Nov 29 2017, In : Fluids and Barriers of the CNS. 14, 1, 32.

Research output: Contribution to journalReview article

10 Scopus citations
2016

P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain

Tome, M. E., Herndon, J. M., Schaefer, C. P., Jacobs, L. M., Zhang, Y., Jarvis, C. K. & Davis, T. P., Nov 1 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 11, p. 1913-1928 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

"Small Blood Vessels: Big Health Problems?": Scientific Recommendations of the National Institutes of Health Workshop

on behalf of the "Small Blood Vessels: Big Health Problems" Workshop Participants, Nov 2016, In : Journal of the American Heart Association. 5, 11, e004389.

Research output: Contribution to journalArticle

30 Scopus citations
2015

Identification of P-glycoprotein co-fractionating proteins and specific binding partners in rat brain microvessels

Tome, M. E., Schaefer, C. P., Jacobs, L. M., Zhang, Y., Herndon, J. M., Matty, F. O. & Davis, T. P., Jul 1 2015, In : Journal of Neurochemistry. 134, 2, p. 200-210 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Peptides at the blood brain barrier: Knowing me knowing you

Davis, T. P., Abbruscato, T. J. & Egleton, R. D., Apr 10 2015, In : Peptides. 72, p. 50-56 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Targeting transporters: Promoting blood-brain barrier repair in response to oxidative stress injury

Ronaldson, P. T. & Davis, T. P., Oct 14 2015, In : Brain Research. 1623, p. 39-52 14 p.

Research output: Contribution to journalArticle

32 Scopus citations
2014

P-glycoprotein modulates morphine uptake into the CNS: A role for the non-steroidal anti-inflammatory drug diclofenac

Sanchez-Covarrubias, L., Slosky, L. M., Thompson, B. J., Zhang, Y., Laracuente, M. L., DeMarco, K. M., Ronaldson, P. T. & Davis, T. P., Feb 10 2014, In : PloS one. 9, 2, e88516.

Research output: Contribution to journalArticle

26 Scopus citations

P-glycoprotein trafficking as a therapeutic target to optimize CNS drug delivery

Davis, T. P., Sanchez-Covarubias, L. & Tome, M. E., Jan 1 2014, Advances in Pharmacology. Academic Press Inc., p. 25-44 20 p. (Advances in Pharmacology; vol. 71).

Research output: Chapter in Book/Report/Conference proceedingChapter

25 Scopus citations

Preface

Davis, T. P., Jan 1 2014, In : Advances in Pharmacology. 71, p. xi-xii

Research output: Contribution to journalEditorial

Transporters at CNS barrier sites: Obstacles or opportunities for drug delivery?

Sanchez-Covarrubias, L., Slosky, L. M., Thompson, B. J., Davis, T. P. & Ronaldson, P. T., Jan 1 2014, In : Current Pharmaceutical Design. 20, 10, p. 1422-1449 28 p.

Research output: Contribution to journalReview article

98 Scopus citations
2013

Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism

Slosky, L. M., Thompson, B. J., Sanchez-Covarrubias, L., Zhang, Y., Laracuente, M. L., Vanderah, T. W., Ronaldson, P. T. & Davis, T. P., Nov 1 2013, In : Molecular pharmacology. 84, 5, p. 774-786 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway

Guo, H., Zhao, Z., Yang, Q., Wang, M., Bell, R. D., Wang, S., Chow, N., Davis, T. P., Griffin, J. H., Goldman, S. A. & Zlokovic, B. V., Apr 3 2013, In : Journal of Neuroscience. 33, 14, p. 6181-6190 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity

Mosnier, L. O., Fernández, J. A., Davis, T. P., Zlokovic, B. V. & Griffin, J. H., Nov 1 2013, In : Journal of Thrombosis and Haemostasis. 11, 11, p. 2059-2062 4 p.

Research output: Contribution to journalLetter

5 Scopus citations

Opioid Peptides

Egleton, R. D., Witt, K. A. & Davis, T. P., Aug 29 2013, Handbook of Biologically Active Peptides. Elsevier Inc., p. 1696-1701 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers

Lyden, P., Levy, H., Weymer, S., Pryor, K., Kramer, W., Griffin, J. H., Davis, T. P. & Zlokovic, B., Dec 1 2013, In : Current Pharmaceutical Design. 19, 42, p. 7479-7485 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Targeted drug delivery to treat pain and cerebral hypoxia

Ronaldson, P. T. & Davis, T. P., Jan 1 2013, In : Pharmacological Reviews. 65, 1, p. 291-314 24 p.

Research output: Contribution to journalArticle

48 Scopus citations
2012

An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents

Wang, Y., Zhang, Z., Chow, N., Davis, T. P., Griffin, J. H., Chopp, M. & Zlokovic, B. V., Sep 1 2012, In : Stroke. 43, 9, p. 2444-2449 6 p.

Research output: Contribution to journalArticle

51 Scopus citations
91 Scopus citations

P-glycoprotein trafficking at the blood-brain barrier altered by peripheral inflammatory hyperalgesia

McCaffrey, G., Staatz, W. D., Sanchez-Covarrubias, L., Finch, J. D., Demarco, K., Laracuente, M. L., Ronaldson, P. T. & Davis, T. P., Sep 1 2012, In : Journal of neurochemistry. 122, 5, p. 962-975 14 p.

Research output: Contribution to journalArticle

53 Scopus citations
19 Scopus citations

Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein c for ischemic stroke

Williams, P. D., Zlokovic, B. V., Griffin, J. H., Pryor, K. E. & Davis, T. P., Sep 21 2012, In : Current Pharmaceutical Design. 18, 27, p. 4215-4222 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain

Lochhead, J. J., Mccaffrey, G., Sanchez-Covarrubias, L., Finch, J. D., Demarco, K. M., Quigley, C. E., Davis, T. P. & Ronaldson, P. T., Feb 1 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 3, p. H582-H593

Research output: Contribution to journalArticle

27 Scopus citations
2011
6 Scopus citations

Inflammatory pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier

Ronaldson, P. T., Finch, J. D., DeMarco, K. M., Quigley, C. E. & Davis, T. P., Mar 1 2011, In : Journal of Pharmacology and Experimental Therapeutics. 336, 3, p. 827-839 13 p.

Research output: Contribution to journalArticle

50 Scopus citations
31 Scopus citations
2010

CNS delivery of peptides across the bbb using the dual-artery in situ brain perfusion model

Witt, K. A., Ronaldson, P. T., Sandoval, K. E. & Davis, T. P., Jan 15 2010, Drug Delivery to the Central Nervous System. Jain, K. K. (ed.). p. 233-247 15 p. (Neuromethods; vol. 45).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation

Lochhead, J. J., McCaffrey, G., Quigley, C. E., Finch, J., Demarco, K. M., Nametz, N. & Davis, T. P., Sep 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 9, p. 1625-1636 12 p.

Research output: Contribution to journalArticle

157 Scopus citations
79 Scopus citations
2009

Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity

Wang, Y., Thiyagarajan, M., Chow, N., Singh, I., Guo, H., Davis, T. P. & Zlokovic, B. V., May 1 2009, In : Stroke. 40, 5, p. 1864-1869 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Occludin oligomeric assemblies at tight junctions of the blood-brain barrier are altered by hypoxia and reoxygenation stress

McCaffrey, G., Willis, C. L., Staatz, W. D., Nametz, N., Quigley, C. A., Hom, S., Lochhead, J. J. & Davis, T. P., Jul 1 2009, In : Journal of neurochemistry. 110, 1, p. 58-71 14 p.

Research output: Contribution to journalArticle

57 Scopus citations

Transforming growth factor-Β signaling alters substrate permeability and tight junction protein expression at the blood-brain barrier during inflammatory pain

Ronaldson, P. T., Demarco, K. M., Sanchez-Covarrubias, L., Solinsky, C. M. & Davis, T. P., Jun 1 2009, In : Journal of Cerebral Blood Flow and Metabolism. 29, 6, p. 1084-1098 15 p.

Research output: Contribution to journalArticle

84 Scopus citations
2008

Chronic inflammatory pain and the neurovascular unit: A central role for glia in maintaining BBB integrity?

Willis, C. L. & Davis, T. P., Jun 1 2008, In : Current Pharmaceutical Design. 14, 16, p. 1625-1643 19 p.

Research output: Contribution to journalReview article

51 Scopus citations