Thomas P Davis

  • 11479 Citations
  • 57 h-Index
1978 …2020

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Article
2020

Functional NHE1 expression is critical to blood brain barrier integrity and sumatriptan blood to brain uptake

Liktor-Busa, E., Blawn, K. T., Kellohen, K. L., Wiese, B. M., Verkhovsky, V., Wahl, J., Vivek, A., Palomino, S. M., Davis, T. P., Vanderah, T. W. & Largent-Milnes, T. M., May 2020, In : PloS one. 15, 5, e0227463.

Research output: Contribution to journalArticle

Open Access
2019

Distribution of insulin in trigeminal nerve and brain after intranasal administration

Lochhead, J. J., Kellohen, K. L., Ronaldson, P. T. & Davis, T. P., Dec 1 2019, In : Scientific reports. 9, 1, 2621.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2018

Acute pain alters P-glycoprotein-containing protein complexes in rat cerebral microvessels: Implications for P-glycoprotein trafficking

Tome, M. E., Jarvis, C. K., Schaefer, C. P., Jacobs, L. M., Herndon, J. M., Hunn, K. C., Arkwright, N. B., Kellohen, K. L., Mierau, P. C. & Davis, T. P., Dec 1 2018, In : Journal of Cerebral Blood Flow and Metabolism. 38, 12, p. 2209-2222 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Chronic morphine exposure potentiates p-glycoprotein trafficking from nuclear reservoirs in cortical rat brain microvessels

Schaefer, C. P., Arkwright, N. B., Jacobs, L. M., Jarvis, C. K., Hunn, K. C., Largent-Milnes, T. M., Tome, M. E. & Davis, T. P., Feb 2018, In : PloS one. 13, 2, e0192340.

Research output: Contribution to journalArticle

6 Scopus citations

Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery

Cottier, K. E., Galloway, E. A., Calabrese, E. C., Tome, M. E., Liktor-Busa, E., Kim, J., Davis, T. P., Vanderah, T. W. & Largent-Milnes, T. M., Jul 1 2018, In : eNeuro. 5, 4

Research output: Contribution to journalArticle

6 Scopus citations
2017

17-β-Estradiol induces spreading depression and pain behavior in alert female rats

Sandweiss, A. J., Cottier, K. E., McIntosh, M. I., Dussor, G., Davis, T. P., Vanderah, T. W. & Largent-Milnes, T. M., Jan 1 2017, In : Oncotarget. 8, 69, p. 114109-114122 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
5 Scopus citations
19 Scopus citations

Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System

Lochhead, J. J., Ronaldson, P. T. & Davis, T. P., Mar 28 2017, (Accepted/In press) In : AAPS Journal. p. 1-11 11 p.

Research output: Contribution to journalArticle

22 Scopus citations
2016

P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain

Tome, M. E., Herndon, J. M., Schaefer, C. P., Jacobs, L. M., Zhang, Y., Jarvis, C. K. & Davis, T. P., Nov 1 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 11, p. 1913-1928 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

"Small Blood Vessels: Big Health Problems?": Scientific Recommendations of the National Institutes of Health Workshop

on behalf of the "Small Blood Vessels: Big Health Problems" Workshop Participants, Nov 2016, In : Journal of the American Heart Association. 5, 11, e004389.

Research output: Contribution to journalArticle

30 Scopus citations
2015

Identification of P-glycoprotein co-fractionating proteins and specific binding partners in rat brain microvessels

Tome, M. E., Schaefer, C. P., Jacobs, L. M., Zhang, Y., Herndon, J. M., Matty, F. O. & Davis, T. P., Jul 1 2015, In : Journal of Neurochemistry. 134, 2, p. 200-210 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Peptides at the blood brain barrier: Knowing me knowing you

Davis, T. P., Abbruscato, T. J. & Egleton, R. D., Apr 10 2015, In : Peptides. 72, p. 50-56 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Targeting transporters: Promoting blood-brain barrier repair in response to oxidative stress injury

Ronaldson, P. T. & Davis, T. P., Oct 14 2015, In : Brain Research. 1623, p. 39-52 14 p.

Research output: Contribution to journalArticle

32 Scopus citations
2014

P-glycoprotein modulates morphine uptake into the CNS: A role for the non-steroidal anti-inflammatory drug diclofenac

Sanchez-Covarrubias, L., Slosky, L. M., Thompson, B. J., Zhang, Y., Laracuente, M. L., DeMarco, K. M., Ronaldson, P. T. & Davis, T. P., Feb 10 2014, In : PloS one. 9, 2, e88516.

Research output: Contribution to journalArticle

26 Scopus citations
2013

Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism

Slosky, L. M., Thompson, B. J., Sanchez-Covarrubias, L., Zhang, Y., Laracuente, M. L., Vanderah, T. W., Ronaldson, P. T. & Davis, T. P., Nov 1 2013, In : Molecular pharmacology. 84, 5, p. 774-786 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway

Guo, H., Zhao, Z., Yang, Q., Wang, M., Bell, R. D., Wang, S., Chow, N., Davis, T. P., Griffin, J. H., Goldman, S. A. & Zlokovic, B. V., Apr 3 2013, In : Journal of Neuroscience. 33, 14, p. 6181-6190 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers

Lyden, P., Levy, H., Weymer, S., Pryor, K., Kramer, W., Griffin, J. H., Davis, T. P. & Zlokovic, B., Dec 1 2013, In : Current Pharmaceutical Design. 19, 42, p. 7479-7485 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Targeted drug delivery to treat pain and cerebral hypoxia

Ronaldson, P. T. & Davis, T. P., Jan 1 2013, In : Pharmacological Reviews. 65, 1, p. 291-314 24 p.

Research output: Contribution to journalArticle

48 Scopus citations
2012

An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents

Wang, Y., Zhang, Z., Chow, N., Davis, T. P., Griffin, J. H., Chopp, M. & Zlokovic, B. V., Sep 1 2012, In : Stroke. 43, 9, p. 2444-2449 6 p.

Research output: Contribution to journalArticle

51 Scopus citations

P-glycoprotein trafficking at the blood-brain barrier altered by peripheral inflammatory hyperalgesia

McCaffrey, G., Staatz, W. D., Sanchez-Covarrubias, L., Finch, J. D., Demarco, K., Laracuente, M. L., Ronaldson, P. T. & Davis, T. P., Sep 1 2012, In : Journal of neurochemistry. 122, 5, p. 962-975 14 p.

Research output: Contribution to journalArticle

53 Scopus citations
19 Scopus citations

Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein c for ischemic stroke

Williams, P. D., Zlokovic, B. V., Griffin, J. H., Pryor, K. E. & Davis, T. P., Sep 21 2012, In : Current Pharmaceutical Design. 18, 27, p. 4215-4222 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain

Lochhead, J. J., Mccaffrey, G., Sanchez-Covarrubias, L., Finch, J. D., Demarco, K. M., Quigley, C. E., Davis, T. P. & Ronaldson, P. T., Feb 1 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 3, p. H582-H593

Research output: Contribution to journalArticle

27 Scopus citations
2011

Inflammatory pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier

Ronaldson, P. T., Finch, J. D., DeMarco, K. M., Quigley, C. E. & Davis, T. P., Mar 1 2011, In : Journal of Pharmacology and Experimental Therapeutics. 336, 3, p. 827-839 13 p.

Research output: Contribution to journalArticle

50 Scopus citations
2010

Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation

Lochhead, J. J., McCaffrey, G., Quigley, C. E., Finch, J., Demarco, K. M., Nametz, N. & Davis, T. P., Sep 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 9, p. 1625-1636 12 p.

Research output: Contribution to journalArticle

157 Scopus citations
79 Scopus citations
2009

Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity

Wang, Y., Thiyagarajan, M., Chow, N., Singh, I., Guo, H., Davis, T. P. & Zlokovic, B. V., May 1 2009, In : Stroke. 40, 5, p. 1864-1869 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Occludin oligomeric assemblies at tight junctions of the blood-brain barrier are altered by hypoxia and reoxygenation stress

McCaffrey, G., Willis, C. L., Staatz, W. D., Nametz, N., Quigley, C. A., Hom, S., Lochhead, J. J. & Davis, T. P., Jul 1 2009, In : Journal of neurochemistry. 110, 1, p. 58-71 14 p.

Research output: Contribution to journalArticle

57 Scopus citations

Transforming growth factor-Β signaling alters substrate permeability and tight junction protein expression at the blood-brain barrier during inflammatory pain

Ronaldson, P. T., Demarco, K. M., Sanchez-Covarrubias, L., Solinsky, C. M. & Davis, T. P., Jun 1 2009, In : Journal of Cerebral Blood Flow and Metabolism. 29, 6, p. 1084-1098 15 p.

Research output: Contribution to journalArticle

84 Scopus citations
2008

Diclofenac attenuates the regional effect of λ-Carrageenan on blood-brain barrier function and cytoarchitecture

Brooks, T. A., Nametz, N., Charles, R. & Davis, T. P., May 1 2008, In : Journal of Pharmacology and Experimental Therapeutics. 325, 2, p. 665-673 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Nociceptive inhibition prevents inflammatory pain induced changes in the blood-brain barrier

Campos, C. R., Ocheltree, S. M., Hom, S., Egleton, R. D. & Davis, T. P., Jul 24 2008, In : Brain Research. 1221, p. 6-13 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Occludin oligomeric assembly at tight junctions of the blood-brain barrier is disrupted by peripheral inflammatory hyperalgesia

McCaffrey, G., Seelbach, M. J., Staatz, W. D., Nametz, N., Quigley, C., Campos, C. R., Brooks, T. A. & Davis, T. P., Sep 1 2008, In : Journal of neurochemistry. 106, 6, p. 2395-2409 15 p.

Research output: Contribution to journalArticle

56 Scopus citations

Reoxygenation stress on blood-brain barrier paracellular permeability and edema in the rat

Witt, K. A., Mark, K. S., Sandoval, K. E. & Davis, T. P., Jan 1 2008, In : Microvascular Research. 75, 1, p. 91-96 6 p.

Research output: Contribution to journalArticle

38 Scopus citations
2007

Comparative changes in the blood-brain barrier and cerebral infarction of SHR and WKY rats

Hom, S., Fleegal, M. A., Egleton, R. D., Campos, C. R., Hawkins, B. T. & Davis, T. P., May 1 2007, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 292, 5, p. R1881-R1892

Research output: Contribution to journalArticle

45 Scopus citations

Peripheral inflammatory hyperalgesia modulates morphine delivery to the brain: A role for P-glycoprotein

Seelbach, M. J., Brooks, T. A., Egleton, R. D. & Davis, T. P., Sep 1 2007, In : Journal of neurochemistry. 102, 5, p. 1677-1690 14 p.

Research output: Contribution to journalArticle

77 Scopus citations

Tight junctions contain oligomeric protein assembly critical for maintaining blood-brain barrier integrity in vivo.

McCaffrey, G., Staatz, W. D., Quigley, C. A., Nametz, N., Seelbach, M. J., Campos, C. R., Brooks, T. A., Egleton, R. D. & Davis, T. P., Dec 1 2007, In : Journal of neurochemistry. 103, 6, p. 2540-2555 16 p.

Research output: Contribution to journalArticle

64 Scopus citations
2006
63 Scopus citations

Biphasic cytoarchitecture and functional changes in the BBB induced by chronic inflammatory pain

Brooks, T. A., Ocheltree, S. M., Seelbach, M. J., Charles, R. A., Nametz, N., Egleton, R. D. & Davis, T. P., Nov 20 2006, In : Brain Research. 1120, 1, p. 172-182 11 p.

Research output: Contribution to journalArticle

37 Scopus citations
2005
58 Scopus citations

Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations

Brooks, T. A., Hawkins, B. T., Huber, J. D., Egleton, R. D. & Davis, T. P., Aug 1 2005, In : American Journal of Physiology - Heart and Circulatory Physiology. 289, 2 58-2, p. H738-H743

Research output: Contribution to journalArticle

102 Scopus citations

Development of neuropeptide drugs that cross the blood-brain barrier

Egleton, R. D. & Davis, T. P., Jan 2005, In : NeuroRx. 2, 1, p. 44-53 10 p.

Research output: Contribution to journalArticle

109 Scopus citations

Hypoxia/aglycemia alters expression of occludin and actin in brain endothelial cells

Brown, R. C. & Davis, T. P., Feb 25 2005, In : Biochemical and Biophysical Research Communications. 327, 4, p. 1114-1123 10 p.

Research output: Contribution to journalArticle

79 Scopus citations

Hypoxia-inducible factor and nuclear factor kappa-B activation in blood-brain barrier endothelium under hypoxic/reoxygenation stress

Witt, K. A., Mark, K. S., Huber, J. & Davis, T. P., Jan 1 2005, In : Journal of neurochemistry. 92, 1, p. 203-214 12 p.

Research output: Contribution to journalArticle

43 Scopus citations

Modulation of cerebral microvascular permeability by endothelial nicotinic acetylcholine receptors

Hawkins, B. T., Egleton, R. D. & Davis, T. P., Jul 1 2005, In : American Journal of Physiology - Heart and Circulatory Physiology. 289, 1 58-1, p. H212-H219

Research output: Contribution to journalArticle

54 Scopus citations

New frontiers in translational research in neuro-oncology and the blood-brain barrier: Report of the Tenth Annual Blood-brain Barrier Disruption Consortium Meeting

Doolittle, N. D., Abrey, L. E., Bleyer, W. A., Brem, S., Davis, T. P., Dore-Duffy, P., Drewes, L. R., Hall, W. A., Hoffman, J. M., Korfel, A., Martuza, R., Muldoon, L. L., Peereboom, D., Peterson, D. R., Rabkin, S. D., Smith, Q., Stevens, G. H. J. & Neuwelt, E. A., Jan 15 2005, In : Clinical Cancer Research. 11, 2 I, p. 421-428 8 p.

Research output: Contribution to journalArticle

41 Scopus citations
2004

Effect of λ-carrageenan-induced inflammatory pain on brain uptake of codeine and antinociception

Hau, V. S., Huber, J. D., Campos, C. R., Davis, R. T. & Davis, T. P., Aug 27 2004, In : Brain Research. 1018, 2, p. 257-264 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Mannitol opening of the blood-brain barrier: Regional variation in the permeability of sucrose, but not 86Rb+ or albumin

Brown, R. C., Egleton, R. D. & Davis, T. P., Jul 16 2004, In : Brain Research. 1014, 1-2, p. 221-227 7 p.

Research output: Contribution to journalArticle

61 Scopus citations