Thomas P Davis

  • 10892 Citations
  • 55 h-Index
1978 …2021
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Research Output 1978 2019

  • 10892 Citations
  • 55 h-Index
  • 252 Article
  • 10 Chapter
  • 2 Review article
  • 1 Short survey
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Article
2019
1 Citation (Scopus)

Distribution of insulin in trigeminal nerve and brain after intranasal administration

Lochhead, J. J., Kellohen, K. L., Ronaldson, P. T. & Davis, T. P., Dec 1 2019, In : Scientific reports. 9, 1, 2621.

Research output: Contribution to journalArticle

Open Access
Intranasal Administration
Trigeminal Nerve
Insulin
Brain
Central Nervous System
2018
2 Citations (Scopus)

Acute pain alters P-glycoprotein-containing protein complexes in rat cerebral microvessels: Implications for P-glycoprotein trafficking

Tome, M. E., Jarvis, C. K., Schaefer, C. P., Jacobs, L. M., Herndon, J. M., Hunn, K. C., Arkwright, N. B., Kellohen, K. L., Mierau, P. C. & Davis, T. P., Dec 1 2018, In : Journal of Cerebral Blood Flow and Metabolism. 38, 12, p. 2209-2222 14 p.

Research output: Contribution to journalArticle

Acute Pain
P-Glycoprotein
Microvessels
Proteins
Pain
4 Citations (Scopus)

Chronic morphine exposure potentiates p-glycoprotein trafficking from nuclear reservoirs in cortical rat brain microvessels

Schaefer, C. P., Arkwright, N. B., Jacobs, L. M., Jarvis, C. K., Hunn, K. C., Largent-Milnes, T. M., Tome, M. E. & Davis, T. P., Feb 1 2018, In : PLoS One. 13, 2, e0192340.

Research output: Contribution to journalArticle

morphine
Microvessels
Morphine
Rats
glycoproteins
3 Citations (Scopus)

Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery

Cottier, K. E., Galloway, E. A., Calabrese, E. C., Tome, M. E., Liktor-Busa, E., Kim, J., Davis, T. P., Vanderah, T. W. & Largent-Milnes, T. M., Jul 1 2018, In : eNeuro. 5, 4

Research output: Contribution to journalArticle

Cortical Spreading Depression
Blood-Brain Barrier
Headache
Sumatriptan
Permeability
2017
2 Citations (Scopus)

17-β-Estradiol induces spreading depression and pain behavior in alert female rats

Sandweiss, A. J., Cottier, K. E., McIntosh, M. I., Dussor, G., Davis, T. P., Vanderah, T. W. & Largent-Milnes, T. M., Jan 1 2017, In : Oncotarget. 8, 69, p. 114109-114122 14 p.

Research output: Contribution to journalArticle

Estradiol
Pain
Estrogens
Migraine Disorders
Sumatriptan
3 Citations (Scopus)
Growth Differentiation Factor 2
Activin Receptors
Anions
Peptides
Central Nervous System Agents
9 Citations (Scopus)
Central Nervous System Agents
P-Glycoprotein
Blood-Brain Barrier
Anions
Peptides
13 Citations (Scopus)

Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System

Lochhead, J. J., Ronaldson, P. T. & Davis, T. P., Mar 28 2017, (Accepted/In press) In : AAPS Journal. p. 1-11 11 p.

Research output: Contribution to journalArticle

Tight Junctions
Blood-Brain Barrier
Central Nervous System
Central Nervous System Diseases
Pain
2016
9 Citations (Scopus)

P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain

Tome, M. E., Herndon, J. M., Schaefer, C. P., Jacobs, L. M., Zhang, Y., Jarvis, C. K. & Davis, T. P., Nov 1 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 11, p. 1913-1928 16 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Endothelium
Cell Membrane
Pain
Central Nervous System Agents
19 Citations (Scopus)

"Small Blood Vessels: Big Health Problems?": Scientific Recommendations of the National Institutes of Health Workshop

on behalf of the "Small Blood Vessels: Big Health Problems" Workshop Participants, Nov 1 2016, In : Journal of the American Heart Association. 5, 11, e004389.

Research output: Contribution to journalArticle

2015
12 Citations (Scopus)

Identification of P-glycoprotein co-fractionating proteins and specific binding partners in rat brain microvessels

Tome, M. E., Schaefer, C. P., Jacobs, L. M., Zhang, Y., Herndon, J. M., Matty, F. O. & Davis, T. P., Jul 1 2015, In : Journal of Neurochemistry. 134, 2, p. 200-210 11 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Microvessels
Protein Binding
Rats
Brain
3 Citations (Scopus)

Peptides at the blood brain barrier: Knowing me knowing you

Davis, T. P., Abbruscato, T. J. & Egleton, R. D., Apr 10 2015, In : Peptides. 72, p. 50-56 7 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Peptides
Research
Research Personnel
Students
25 Citations (Scopus)

Targeting transporters: Promoting blood-brain barrier repair in response to oxidative stress injury

Ronaldson, P. T. & Davis, T. P., Oct 14 2015, In : Brain Research. 1623, p. 39-52 14 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Oxidative Stress
Wounds and Injuries
Cell Communication
Brain Hypoxia-Ischemia
2014
24 Citations (Scopus)

P-glycoprotein modulates morphine uptake into the CNS: A role for the non-steroidal anti-inflammatory drug diclofenac

Sanchez-Covarrubias, L., Slosky, L. M., Thompson, B. J., Zhang, Y., Laracuente, M. L., DeMarco, K. M., Ronaldson, P. T. & Davis, T. P., Feb 10 2014, In : PLoS One. 9, 2, e88516.

Research output: Contribution to journalArticle

morphine
Diclofenac
nonsteroidal anti-inflammatory agents
P-Glycoprotein
Morphine
19 Citations (Scopus)

P-glycoprotein trafficking as a therapeutic target to optimize CNS drug delivery

Davis, T. P., Sanchez-Covarubias, L. & Tome, M. E., 2014, In : Advances in Pharmacology. 71, p. 25-44 20 p.

Research output: Contribution to journalArticle

Central Nervous System Agents
P-Glycoprotein
Protein Transport
Blood-Brain Barrier
Caveolin 1

Preface

Davis, T. P., 2014, In : Advances in Pharmacology. 71, p. xi-xii

Research output: Contribution to journalArticle

75 Citations (Scopus)

Transporters at CNS barrier sites: Obstacles or opportunities for drug delivery?

Sanchez-Covarrubias, L., Slosky, L. M., Thompson, B. J., Davis, T. P. & Ronaldson, P. T., 2014, In : Current Pharmaceutical Design. 20, 10, p. 1422-1449 28 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Cerebrospinal Fluid
Pharmaceutical Preparations
Brain
Homeostasis
2013
32 Citations (Scopus)

Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism

Slosky, L. M., Thompson, B. J., Sanchez-Covarrubias, L., Zhang, Y., Laracuente, M. L., Vanderah, T. W., Ronaldson, P. T. & Davis, T. P., Nov 2013, In : Molecular Pharmacology. 84, 5, p. 774-786 13 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Acetaminophen
Blood-Brain Barrier
Morphine
Opioid Analgesics
37 Citations (Scopus)

An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway

Guo, H., Zhao, Z., Yang, Q., Wang, M., Bell, R. D., Wang, S., Chow, N., Davis, T. P., Griffin, J. H., Goldman, S. A. & Zlokovic, B. V., Apr 3 2013, In : Journal of Neuroscience. 33, 14, p. 6181-6190 10 p.

Research output: Contribution to journalArticle

Protein C
Stem Cells
PAR-1 Receptor
Lysosphingolipid Receptors
Neural Stem Cells
4 Citations (Scopus)

Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity

Mosnier, L. O., Fernández, J. A., Davis, T. P., Zlokovic, B. V. & Griffin, J. H., Nov 2013, In : Journal of Thrombosis and Haemostasis. 11, 11, p. 2059-2062 4 p.

Research output: Contribution to journalArticle

Drug Dose Response Relationship
Partial Thromboplastin Time
Plasminogen
Thrombolytic Therapy
Blood Coagulation
38 Citations (Scopus)

Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers

Lyden, P., Levy, H., Weymer, S., Pryor, K., Kramer, W., Griffin, J. H., Davis, T. P. & Zlokovic, B., 2013, In : Current Pharmaceutical Design. 19, 42, p. 7479-7485 7 p.

Research output: Contribution to journalArticle

Protein C
Healthy Volunteers
Pharmacokinetics
Safety
PAR-1 Receptor
42 Citations (Scopus)

Targeted drug delivery to treat pain and cerebral hypoxia

Ronaldson, P. T. & Davis, T. P., Jan 1 2013, In : Pharmacological Reviews. 65, 1, p. 291-314 24 p.

Research output: Contribution to journalArticle

Brain Hypoxia
Central Nervous System Agents
Pain
Pharmaceutical Preparations
Brain
2012
51 Citations (Scopus)

An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents

Wang, Y., Zhang, Z., Chow, N., Davis, T. P., Griffin, J. H., Chopp, M. & Zlokovic, B. V., Sep 2012, In : Stroke. 43, 9, p. 2444-2449 6 p.

Research output: Contribution to journalArticle

Tissue Plasminogen Activator
Protein C
Anticoagulants
Rodentia
Stroke
82 Citations (Scopus)
Blood-Brain Barrier
Neuroglia
Stroke
Oxidative Stress
Endothelial Cells
53 Citations (Scopus)

P-glycoprotein trafficking at the blood-brain barrier altered by peripheral inflammatory hyperalgesia

McCaffrey, G., Staatz, W. D., Sanchez-Covarrubias, L., Finch, J. D., Demarco, K., Laracuente, M. L., Ronaldson, P. T. & Davis, T. P., Sep 2012, In : Journal of Neurochemistry. 122, 5, p. 962-975 14 p.

Research output: Contribution to journalArticle

Hyperalgesia
P-Glycoprotein
Blood-Brain Barrier
Pain
Caveolin 1
Central Nervous System Agents
Occludin
Physiology
P-Glycoprotein
Blood-Brain Barrier
16 Citations (Scopus)
Central Nervous System Agents
Occludin
Physiology
P-Glycoprotein
Blood-Brain Barrier
31 Citations (Scopus)

Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein c for ischemic stroke

Williams, P. D., Zlokovic, B. V., Griffin, J. H., Pryor, K. E. & Davis, T. P., 2012, In : Current Pharmaceutical Design. 18, 27, p. 4215-4222 8 p.

Research output: Contribution to journalArticle

Protein C
Pharmacokinetics
Stroke
Safety
Proteins
26 Citations (Scopus)

Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain

Lochhead, J. J., Mccaffrey, G., Sanchez-Covarrubias, L., Finch, J. D., Demarco, K. M., Quigley, C. E., Davis, T. P. & Ronaldson, P. T., Feb 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 3

Research output: Contribution to journalArticle

Occludin
Xenobiotics
Blood-Brain Barrier
Carrageenan
Permeability
2011
5 Citations (Scopus)
Cerebrovascular Circulation
Occludin
Blood-Brain Barrier
Permeability
Oxidative Stress
Neuroglia
Chronic Pain
Inflammation
45 Citations (Scopus)
Blood-Brain Barrier
Anions
Pain
Peptides
Diclofenac
30 Citations (Scopus)
Blood-Brain Barrier
Pain
Pharmaceutical Preparations
Opioid Analgesics
Tight Junction Proteins
2010
2 Citations (Scopus)

CNS delivery of peptides across the bbb using the dual-artery in situ brain perfusion model

Witt, K. A., Ronaldson, P. T., Sandoval, K. E. & Davis, T. P., 2010, In : Neuromethods. 45, p. 233-247 15 p.

Research output: Contribution to journalArticle

Brain models
Neurology
Central Nervous System
Arteries
Perfusion
137 Citations (Scopus)

Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation

Lochhead, J. J., McCaffrey, G., Quigley, C. E., Finch, J., Demarco, K. M., Nametz, N. & Davis, T. P., 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 9, p. 1625-1636 12 p.

Research output: Contribution to journalArticle

Occludin
Blood-Brain Barrier
Permeability
Oxidative Stress
Tight Junction Proteins
75 Citations (Scopus)
Tight Junction Proteins
Blood-Brain Barrier
Protein Kinase C
Permeability
Claudin-5
2009
40 Citations (Scopus)

Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity

Wang, Y., Thiyagarajan, M., Chow, N., Singh, I., Guo, H., Davis, T. P. & Zlokovic, B. V., May 1 2009, In : Stroke. 40, 5, p. 1864-1869 6 p.

Research output: Contribution to journalArticle

Protein C
Anticoagulants
Hemorrhage
Middle Cerebral Artery Infarction
Brain
55 Citations (Scopus)

Occludin oligomeric assemblies at tight junctions of the blood-brain barrier are altered by hypoxia and reoxygenation stress

McCaffrey, G., Willis, C. L., Staatz, W. D., Nametz, N., Quigley, C. A., Hom, S., Lochhead, J. J. & Davis, T. P., Jul 2009, In : Journal of Neurochemistry. 110, 1, p. 58-71 14 p.

Research output: Contribution to journalArticle

Occludin
Tight Junctions
Blood-Brain Barrier
Sodium Dodecyl Sulfate
Protein Isoforms
78 Citations (Scopus)

Transforming growth factor-Β signaling alters substrate permeability and tight junction protein expression at the blood-brain barrier during inflammatory pain

Ronaldson, P. T., Demarco, K. M., Sanchez-Covarrubias, L., Solinsky, C. M. & Davis, T. P., Jun 2009, In : Journal of Cerebral Blood Flow and Metabolism. 29, 6, p. 1084-1098 15 p.

Research output: Contribution to journalArticle

Tight Junction Proteins
Transforming Growth Factors
Blood-Brain Barrier
Permeability
Growth Factor Receptors
2008
50 Citations (Scopus)

Chronic inflammatory pain and the neurovascular unit: A central role for glia in maintaining BBB integrity?

Willis, C. L. & Davis, T. P., Jun 2008, In : Current Pharmaceutical Design. 14, 16, p. 1625-1643 19 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Neuroglia
Chronic Pain
Pain
Innate Immunity
16 Citations (Scopus)

Diclofenac attenuates the regional effect of λ-Carrageenan on blood-brain barrier function and cytoarchitecture

Brooks, T. A., Nametz, N., Charles, R. & Davis, T. P., May 2008, In : Journal of Pharmacology and Experimental Therapeutics. 325, 2, p. 665-673 9 p.

Research output: Contribution to journalArticle

Diclofenac
Carrageenan
Blood-Brain Barrier
Permeability
Claudin-5
26 Citations (Scopus)

Nociceptive inhibition prevents inflammatory pain induced changes in the blood-brain barrier

Campos, C. R., Ocheltree, S. M., Hom, S., Egleton, R. D. & Davis, T. P., Jul 24 2008, In : Brain Research. 1221, p. 6-13 8 p.

Research output: Contribution to journalArticle

Carrageenan
Blood-Brain Barrier
Pain
Nerve Block
Sucrose
53 Citations (Scopus)

Occludin oligomeric assembly at tight junctions of the blood-brain barrier is disrupted by peripheral inflammatory hyperalgesia

McCaffrey, G., Seelbach, M. J., Staatz, W. D., Nametz, N., Quigley, C., Campos, C. R., Brooks, T. A. & Davis, T. P., Sep 2008, In : Journal of Neurochemistry. 106, 6, p. 2395-2409 15 p.

Research output: Contribution to journalArticle

Occludin
Tight Junctions
Carrageenan
Hyperalgesia
Blood-Brain Barrier
37 Citations (Scopus)

Reoxygenation stress on blood-brain barrier paracellular permeability and edema in the rat

Witt, K. A., Mark, K. S., Sandoval, K. E. & Davis, T. P., Jan 2008, In : Microvascular Research. 75, 1, p. 91-96 6 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Rats
Permeability
Edema
Brain
289 Citations (Scopus)

Strategies to advance translational research into brain barriers

Neuwelt, E., Abbott, N. J., Abrey, L., Banks, W. A., Blakley, B., Davis, T. P., Engelhardt, B., Grammas, P., Nedergaard, M., Nutt, J., Pardridge, W., Rosenberg, G. A., Smith, Q. & Drewes, L. R., Jan 2008, In : The Lancet Neurology. 7, 1, p. 84-96 13 p.

Research output: Contribution to journalArticle

Translational Medical Research
Brain
Lysosomal Storage Diseases
Brain Diseases
Therapeutics
2007
45 Citations (Scopus)

Comparative changes in the blood-brain barrier and cerebral infarction of SHR and WKY rats

Hom, S., Fleegal, M. A., Egleton, R. D., Campos, C. R., Hawkins, B. T. & Davis, T. P., May 2007, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 292, 5

Research output: Contribution to journalArticle

Brain Infarction
Inbred WKY Rats
Cerebral Infarction
Inbred SHR Rats
Blood-Brain Barrier
76 Citations (Scopus)

Peripheral inflammatory hyperalgesia modulates morphine delivery to the brain: A role for P-glycoprotein

Seelbach, M. J., Brooks, T. A., Egleton, R. D. & Davis, T. P., Sep 2007, In : Journal of Neurochemistry. 102, 5, p. 1677-1690 14 p.

Research output: Contribution to journalArticle

Carrageenan
Hyperalgesia
P-Glycoprotein
Morphine
Brain
61 Citations (Scopus)

Tight junctions contain oligomeric protein assembly critical for maintaining blood-brain barrier integrity in vivo.

McCaffrey, G., Staatz, W. D., Quigley, C. A., Nametz, N., Seelbach, M. J., Campos, C. R., Brooks, T. A., Egleton, R. D. & Davis, T. P., Dec 2007, In : Journal of Neurochemistry. 103, 6, p. 2540-2555 16 p.

Research output: Contribution to journalArticle

Tight Junctions
Occludin
Tight Junction Proteins
Blood-Brain Barrier
Claudin-5
2006
60 Citations (Scopus)
Carrageenan
Intercellular Adhesion Molecule-1
Blood-Brain Barrier
Pain
Brain