• 1618 Citations
  • 26 h-Index
1992 …2020
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Research Output 1992 2019

  • 1618 Citations
  • 26 h-Index
  • 68 Article
  • 2 Chapter
  • 1 Foreword/postscript
2019

Crystal structure of AdoMet radical enzyme 7-carboxy-7-deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe–4S] cluster engender flavodoxin specificity

Grell, T. A. J., Bell, B. N., Nguyen, C., Dowling, D. P., Bruender, N. A., Bandarian, V. & Drennan, C. L., Jan 1 2019, In : Protein Science. 28, 1, p. 202-215 14 p.

Research output: Contribution to journalArticle

Flavodoxin
Methionine
Escherichia coli
Crystal structure
Enzymes
2018

A Radical Clock Probe Uncouples H-atom Abstraction from Thi-oether Crosslink Formation by the Radical SAM Enzyme SkfB

Kincannon, W., Bruender, N. A. & Bandarian, V., May 10 2018, (Accepted/In press) In : Biochemistry.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Clocks
Sulfides
Atoms
Enzymes
3 Citations (Scopus)

A radical intermediate in bacillus subtilis quee during turnover with the substrate analogue 6-Carboxypterin

Wilcoxen, J., Bruender, N. A., Bandarian, V. & Britt, R. D., Feb 7 2018, In : Journal of the American Chemical Society. 140, 5, p. 1753-1759 7 p.

Research output: Contribution to journalArticle

Bacilli
Bacillus subtilis
Methionine
Substrates
Metabolites
1 Citation (Scopus)

Biochemical and Structural Characterization of a Schiff Base in the Radical-Mediated Biosynthesis of 4-Demethylwyosine by TYW1

Grell, T. A. J., Young, A. P., Drennan, C. L. & Bandarian, V., Jun 6 2018, In : Journal of the American Chemical Society. 140, 22, p. 6842-6852 11 p.

Research output: Contribution to journalArticle

Schiff Bases
Biosynthesis
Pyruvic Acid
Methionine
Lysine
1 Citation (Scopus)

Deconvoluting the Reduction Potentials for the Three [4Fe-4S] Clusters in an AdoMet Radical SCIFF Maturase

Walker, L. M., Kincannon, W. M., Bandarian, V. & Elliott, S. J., Oct 23 2018, In : Biochemistry. 57, 42, p. 6050-6053 4 p.

Research output: Contribution to journalArticle

Methionine
Enzymes
Sulfides
Electrochemical properties
Cysteine

Preface

Bandarian, V., Jan 1 2018, Methods in Enzymology. Academic Press Inc., p. xv-xvi (Methods in Enzymology; vol. 606).

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

QueE: A Radical SAM Enzyme Involved in the Biosynthesis of 7-Deazapurine Containing Natural Products

Lewis, J. K., Bruender, N. A. & Bandarian, V., Jan 1 2018, (Accepted/In press) In : Methods in Enzymology.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Biosynthesis
Biological Products
Enzymes
GTP Cyclohydrolase

Structural and spectroscopic analyses of the sporulation killing factor biosynthetic enzyme SkfB, a bacterial AdoMet radical sactisynthase

Grell, T. A. J., Kincannon, W. M., Bruender, N. A., Blaesi, E. J., Krebs, C., Bandarian, V. & Drennan, C. L., Nov 9 2018, In : The Journal of biological chemistry. 293, 45, p. 17349-17361 13 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Enzymes
Bacillus subtilis
Sulfur
PQQ Cofactor

TYW1: A Radical SAM Enzyme Involved in the Biosynthesis of Wybutosine Bases

Young, A. P. & Bandarian, V., Jan 1 2018, (Accepted/In press) In : Methods in Enzymology.

Research output: Contribution to journalArticle

Biosynthesis
RNA, Transfer, Phe
S-Adenosylmethionine
Enzymes
Transfer RNA
2017
10 Citations (Scopus)

7-Carboxy-7-deazaguanine synthase: A radical S-adenosyl-L-methionine enzyme with polar tendencies

Bruender, N. A., Grell, T. A. J., Dowling, D. P., McCarty, R. M., Drennan, C. L. & Bandarian, V., Feb 8 2017, In : Journal of the American Chemical Society. 139, 5, p. 1912-1920 9 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Esters
Enzymes
Biosynthesis
Substrates
4 Citations (Scopus)

Human Viperin Causes Radical SAM-Dependent Elongation of Escherichia coli, Hinting at Its Physiological Role

Nelp, M. T., Young, A. P., Stepanski, B. M. & Bandarian, V., Aug 1 2017, In : Biochemistry. 56, 30, p. 3874-3876 3 p.

Research output: Contribution to journalArticle

Viruses
Endoplasmic Reticulum
Methionine
Escherichia coli
Interferons
5 Citations (Scopus)
creatininase
Mycobacterium smegmatis
Biosynthesis
Peptides
Biological Products
2016
28 Citations (Scopus)

An informatic framework for decoding protein complexes by top-down mass spectrometry

Skinner, O. S., Havugimana, P. C., Haverland, N. A., Fornelli, L., Early, B. P., Greer, J. B., Fellers, R. T., Durbin, K. R., Do Vale, L. H. F., Melani, R. D., Seckler, H. S., Nelp, M. T., Belov, M. E., Horning, S. R., Makarov, A. A., LeDuc, R. D., Bandarian, V., Compton, P. D. & Kelleher, N. L., Feb 25 2016, In : Nature Methods. 13, 3, p. 237-240 4 p.

Research output: Contribution to journalArticle

Informatics
Mass spectrometry
Decoding
Mass Spectrometry
Protein Subunits
3 Citations (Scopus)

A protein-derived oxygen is the source of the amide oxygen of nitrile hydratases

Nelp, M. T., Song, Y., Wysocki, V. H. & Bandarian, V., Apr 8 2016, In : Journal of Biological Chemistry. 291, 15, p. 7822-7829 8 p.

Research output: Contribution to journalArticle

Amides
Nitriles
Oxygen
Nucleophiles
Proteins
19 Citations (Scopus)

Biochemical and Spectroscopic Characterization of a Radical S-Adenosyl- l -methionine Enzyme Involved in the Formation of a Peptide Thioether Cross-Link

Bruender, N. A., Wilcoxen, J., Britt, R. D. & Bandarian, V., Apr 26 2016, In : Biochemistry. 55, 14, p. 2122-2134 13 p.

Research output: Contribution to journalArticle

Sulfides
Methionine
Peptides
Enzymes
Biological Products
1 Citation (Scopus)
Biochemistry
Enzymes
7-deazaguanine
11 Citations (Scopus)

Molecular basis of cobalamin-dependent RNA modification

Dowling, D. P., Miles, Z. D., Köhrer, C., Maiocco, S. J., Elliott, S. J., Bandarian, V. & Drennan, C. L., 2016, In : Nucleic Acids Research. 44, 20, p. 9965-9976 12 p.

Research output: Contribution to journalArticle

Vitamin B 12
RNA
Nucleoside Q
Transfer RNA
Anticodon
11 Citations (Scopus)

SkfB Abstracts a Hydrogen Atom from Cα on SkfA to Initiate Thioether Cross-Link Formation

Bruender, N. A. & Bandarian, V., Aug 2 2016, In : Biochemistry. 55, 30, p. 4131-4134 4 p.

Research output: Contribution to journalArticle

Sulfides
Methionine
Hydrogen
Atoms
Peptides
20 Citations (Scopus)

The Radical S-Adenosyl- l -methionine Enzyme MftC Catalyzes an Oxidative Decarboxylation of the C-Terminus of the MftA Peptide

Bruender, N. A. & Bandarian, V., May 24 2016, In : Biochemistry. 55, 20, p. 2813-2816 4 p.

Research output: Contribution to journalArticle

Decarboxylation
Methionine
Peptides
Enzymes
Accessories
2015
12 Citations (Scopus)

A Single Enzyme Transforms a Carboxylic Acid into a Nitrile through an Amide Intermediate

Nelp, M. T. & Bandarian, V., Sep 1 2015, In : Angewandte Chemie - International Edition. 54, 36, p. 10627-10629 3 p.

Research output: Contribution to journalArticle

Nitriles
Carboxylic Acids
Carboxylic acids
Amides
Enzymes
13 Citations (Scopus)

Biochemical and Spectroscopic Studies of Epoxyqueuosine Reductase: A Novel Iron-Sulfur Cluster- and Cobalamin-Containing Protein Involved in the Biosynthesis of Queuosine

Miles, Z. D., Myers, W. K., Kincannon, W. M., Britt, R. D. & Bandarian, V., Aug 11 2015, In : Biochemistry. 54, 31, p. 4927-4935 9 p.

Research output: Contribution to journalArticle

Nucleoside Q
Biosynthesis
Vitamin B 12
Sulfur
Oxidoreductases
14 Citations (Scopus)

Chemical and biological reduction of the radical SAM enzyme CPH<inf>4</inf> synthase

Bruender, N. A., Young, A. P. & Bandarian, V., May 12 2015, In : Biochemistry. 54, 18, p. 2903-2910 8 p.

Research output: Contribution to journalArticle

Flavodoxin
Dithionite
Methionine
Enzymes
Chemical activation
7 Citations (Scopus)

Mechanistic Studies of the Radical S- Adenosyl- l -methionine Enzyme 4-Demethylwyosine Synthase Reveal the Site of Hydrogen Atom Abstraction

Young, A. P. & Bandarian, V., Jun 16 2015, In : Biochemistry. 54, 23, p. 3569-3572 4 p.

Research output: Contribution to journalArticle

Pyruvic Acid
Methionine
Hydrogen
Atoms
Enzymes
6 Citations (Scopus)

Radical-mediated ring contraction in the biosynthesis of 7-deazapurines

Bandarian, V. & Drennan, C. L., Dec 1 2015, In : Current Opinion in Structural Biology. 35, p. 116-124 9 p.

Research output: Contribution to journalArticle

Biosynthetic Pathways
Biological Products
pyrrolopyrimidine
7-deazapurine
26 Citations (Scopus)

Refining the structural model of a heterohexameric protein complex: Surface induced dissociation and ion mobility provide key connectivity and topology information

Song, Y., Nelp, M. T., Bandarian, V. & Wysocki, V. H., Dec 23 2015, In : ACS Central Science. 1, 9, p. 477-487 11 p.

Research output: Contribution to journalArticle

Toyocamycin
Refining
Mass spectrometry
Topology
Ions
11 Citations (Scopus)

Variable substrate preference among phospholipase D toxins from sicariid spiders

Lajoie, D. M., Roberts, S. A., Zobel-Thropp, P. A., Delahaye, J. L., Bandarian, V., Binford, G. J. & Cordes, M. H., Apr 24 2015, In : Journal of Biological Chemistry. 290, 17, p. 10994-11007 14 p.

Research output: Contribution to journalArticle

Phospholipase D
Sphingolipids
Spiders
Choline
Ethanolamine
2014
9 Citations (Scopus)
Tunnels
Catalytic Domain
Enzymes
Bacterial Structures
Mammals
33 Citations (Scopus)

Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism.

Dowling, D. P., Bruender, N. A., Young, A. P., McCarty, R. M., Bandarian, V. & Drennan, C. L., 2014, Nature chemical biology. 2 ed. Vol. 10. p. 106-112 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

S-Adenosylmethionine
Metals
Enzymes
Burkholderia
Biosynthetic Pathways
10 Citations (Scopus)

The alpha subunit of nitrile hydratase is sufficient for catalytic activity and post-translational modification

Nelp, M. T., Astashkin, A. V., Breci, L. A., McCarty, R. M. & Bandarian, V., Jun 24 2014, In : Biochemistry. 53, 24, p. 3990-3994 5 p.

Research output: Contribution to journalArticle

Toyocamycin
Post Translational Protein Processing
Catalyst activity
Streptomyces rimosus
Catalytic Domain
2013

B12-Containing Enzymes

Bandarian, V. & Matthews, R. G., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 155-160 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Vitamin B 12
Enzymes
Organometallics
Liver Extracts
Pernicious Anemia
16 Citations (Scopus)

Phospholipase D Toxins of Brown Spider Venom Convert Lysophosphatidylcholine and Sphingomyelin to Cyclic Phosphates

Lajoie, D. M., Zobel-Thropp, P. A., Kumirov, V. K., Bandarian, V., Binford, G. J. & Cordes, M. H., Aug 29 2013, In : PLoS One. 8, 8, e72372.

Research output: Contribution to journalArticle

Spider Venoms
lysophosphatidylcholine
Phospholipase D
phospholipase D
sphingomyelins
17 Citations (Scopus)

Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine

Young, A. P. & Bandarian, V., Aug 2013, In : Current Opinion in Chemical Biology. 17, 4, p. 613-618 6 p.

Research output: Contribution to journalArticle

RNA, Transfer, Phe
Biosynthesis
Archaea
Transfer RNA
Eukaryota
32 Citations (Scopus)
Cyclization
Biosynthesis
Methionine
Kinetics
Enzymes
2012
38 Citations (Scopus)

Biosynthesis of pyrrolopyrimidines

McCarty, R. M. & Bandarian, V., Aug 2012, In : Bioorganic Chemistry. 43, p. 15-25 11 p.

Research output: Contribution to journalArticle

Biosynthesis
Secondary Metabolism
Biosynthetic Pathways
Metabolites
RNA
13 Citations (Scopus)
Biosynthesis
Biological Products
Methionine
Enzymes
Transfer RNA
2011
59 Citations (Scopus)

Comparison of a PreQ1 riboswitch aptamer in metabolite-bound and free states with implications for gene regulation

Jenkins, J. L., Krucinska, J., McCarty, R. M., Bandarian, V. & Wedekind, J. E., Jul 15 2011, In : Journal of Biological Chemistry. 286, 28, p. 24626-24637 12 p.

Research output: Contribution to journalArticle

Riboswitch
Metabolites
Gene expression
Ligands
Genes
44 Citations (Scopus)

Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification

Miles, Z. D., McCarty, R. M., Molnar, G. & Bandarian, V., May 3 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 18, p. 7368-7372 5 p.

Research output: Contribution to journalArticle

Transfer RNA
Oxidoreductases
Biosynthetic Pathways
Nucleoside Q
RNA, Transfer, Asn
23 Citations (Scopus)

Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine

Young, A. P. & Bandarian, V., Dec 13 2011, In : Biochemistry. 50, 49, p. 10573-10575 3 p.

Research output: Contribution to journalArticle

Imidazolines
Pyruvic Acid
Carbon
Biosynthesis
Substrates
55 Citations (Scopus)

Revealing the quaternary structure of a heterogeneous noncovalent protein complex through surface-induced dissociation

Blackwell, A. E., Dodds, E. D., Bandarian, V. & Wysocki, V. H., Apr 15 2011, In : Analytical Chemistry. 83, 8, p. 2862-2865 4 p.

Research output: Contribution to journalArticle

Toyocamycin
Mass spectrometry
Proteins
Chemical activation
Topology
2009
32 Citations (Scopus)

Escherichia coli QueD Is a 6-Carboxy-5,6,7,8-tetrahydropterin synthase

McCarty, R. M., Somogyi, Á. & Bandarian, V., Mar 24 2009, In : Biochemistry. 48, 11, p. 2301-2303 3 p.

Research output: Contribution to journalArticle

Biosynthesis
Escherichia coli
Nucleoside Q
Biopterin
Biological Products
54 Citations (Scopus)

The deazapurine biosynthetic pathway revealed: In vitro enzymatic synthesis of PreQ0 from guanosine 5′-triphosphate in four steps

McCarty, R. M., Somogyi, Á., Lin, G., Jacobsen, N. E. & Bandarian, V., May 12 2009, In : Biochemistry. 48, 18, p. 3847-3852 6 p.

Research output: Contribution to journalArticle

Guanosine
Biosynthetic Pathways
Guanosine Triphosphate
Bacillus subtilis
Nucleoside Q
64 Citations (Scopus)

The structural basis for recognition of the preQ0 metabolite by an unusually small riboswitch aptamer domain

Spitale, R. C., Torelli, A. T., Krucinska, J., Bandarian, V. & Wedekind, J. E., Apr 24 2009, In : Journal of Biological Chemistry. 284, 17, p. 11012-11016 5 p.

Research output: Contribution to journalArticle

Riboswitch
Metabolites
Ribosomes
Binding Sites
RNA
2008
8 Citations (Scopus)
Methanocaldococcus
GTP Cyclohydrolase
Guanosine Triphosphate
Metal ions
Crystal structure
52 Citations (Scopus)

Deciphering Deazapurine Biosynthesis: Pathway for Pyrrolopyrimidine Nucleosides Toyocamycin and Sangivamycin

McCarty, R. M. & Bandarian, V., Aug 25 2008, In : Chemistry and Biology. 15, 8, p. 790-798 9 p.

Research output: Contribution to journalArticle

sangivamycin
Toyocamycin
Biosynthesis
Nucleosides
Genes

Delivery of tailor-made cobalamin to methylmalonyl-CoA mutase

Bandarian, V., Mar 2008, In : Nature Chemical Biology. 4, 3, p. 158-159 2 p.

Research output: Contribution to journalArticle

Methylmalonyl-CoA Mutase
Vitamin B 12
Intramolecular Transferases
Enzymes
methylmalonyl-coenzyme A
2 Citations (Scopus)
Streptomyces coelicolor
Catalytic Domain
activity (biology)
Pterins
metal ions
6 Citations (Scopus)

Understanding functional divergence in proteins by studying intragenomic homologues

Spoonamore, J. E. & Bandarian, V., Feb 26 2008, In : Biochemistry. 47, 8, p. 2592-2600 9 p.

Research output: Contribution to journalArticle

Guanosine Triphosphate
Streptomyces coelicolor
Catalytic Domain
Genes
GTP Cyclohydrolase
2007
23 Citations (Scopus)

The copper-inducible cin operon encodes an unusual methionine-rich azurin-like protein and a pre-Q0 reductase in Pseudomonas putida KT2440

Quaranta, D., McCarty, R., Bandarian, V. & Rensing, C., Jul 2007, In : Journal of Bacteriology. 189, 14, p. 5361-5371 11 p.

Research output: Contribution to journalArticle

Azurin
Pseudomonas putida
Operon
Methionine
Copper
2006
15 Citations (Scopus)

Evolution of new function in the GTP cyclohydrolase II proteins of Streptomyces coelicolor

Spoonamore, J. E., Dahlgran, A. L., Jacobsen, N. E. & Bandarian, V., Oct 3 2006, In : Biochemistry. 45, 39, p. 12144-12155 12 p.

Research output: Contribution to journalArticle

Streptomyces coelicolor
Guanosine
Guanosine Triphosphate
GTP Cyclohydrolase
Proteins
12 Citations (Scopus)

Probing nitrogen-sensitive steps in the free-radical-mediated deamination of amino alcohols by ethanolamine ammonia-lyase

Poyner, R. R., Anderson, M. A., Bandarian, V., Cleland, W. W. & Reed, G. H., Jun 7 2006, In : Journal of the American Chemical Society. 128, 22, p. 7120-7121 2 p.

Research output: Contribution to journalArticle

Ethanolamine Ammonia-Lyase
Amino alcohols
Amino Alcohols
Ethanolamines
Deamination