• 1460 Citations
  • 24 h-Index
1992 …2020
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Research Output 1992 2018

  • 1460 Citations
  • 24 h-Index
  • 63 Article
  • 2 Chapter
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Article
2018

A radical intermediate in bacillus subtilis quee during turnover with the substrate analogue 6-Carboxypterin

Wilcoxen, J., Bruender, N. A., Bandarian, V. & Britt, R. D. Feb 7 2018 In : Journal of the American Chemical Society. 140, 5, p. 1753-1759 7 p.

Research output: Contribution to journalArticle

Bacilli
Bacillus subtilis
Methionine
Substrates
Metabolites

Biochemical and Structural Characterization of a Schiff Base in the Radical-Mediated Biosynthesis of 4-Demethylwyosine by TYW1

Grell, T. A. J., Young, A. P., Drennan, C. L. & Bandarian, V. Jun 6 2018 In : Journal of the American Chemical Society. 140, 22, p. 6842-6852 11 p.

Research output: Contribution to journalArticle

Schiff Bases
Biosynthesis
Pyruvic Acid
Methionine
Lysine

TYW1: A Radical SAM Enzyme Involved in the Biosynthesis of Wybutosine Bases

Young, A. P. & Bandarian, V. Jan 1 2018 (Accepted/In press) In : Methods in enzymology.

Research output: Contribution to journalArticle

Cracks
S-Adenosylmethionine
Nitrobenzene
Enzymes
Transfer RNA
2017
6 Citations

7-Carboxy-7-deazaguanine synthase: A radical S-adenosyl-L-methionine enzyme with polar tendencies

Bruender, N. A., Grell, T. A. J., Dowling, D. P., McCarty, R. M., Drennan, C. L. & Bandarian, V. Feb 8 2017 In : Journal of the American Chemical Society. 139, 5, p. 1912-1920 9 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Esters
Enzymes
Biosynthesis
Substrates
3 Citations

Human Viperin Causes Radical SAM-Dependent Elongation of Escherichia coli, Hinting at Its Physiological Role

Nelp, M. T., Young, A. P., Stepanski, B. M. & Bandarian, V. Aug 1 2017 In : Biochemistry. 56, 30, p. 3874-3876 3 p.

Research output: Contribution to journalArticle

Methionine
Escherichia coli
Elongation
Viruses
Bacteria
2 Citations
creatininase
Mycobacterium smegmatis
Biosynthesis
Peptides
Biological Products
2016
20 Citations

An informatic framework for decoding protein complexes by top-down mass spectrometry

Skinner, O. S., Havugimana, P. C., Haverland, N. A., Fornelli, L., Early, B. P., Greer, J. B., Fellers, R. T., Durbin, K. R., Do Vale, L. H. F., Melani, R. D., Seckler, H. S., Nelp, M. T., Belov, M. E., Horning, S. R., Makarov, A. A., LeDuc, R. D., Bandarian, V., Compton, P. D. & Kelleher, N. L. Feb 25 2016 In : Nature Methods. 13, 3, p. 237-240 4 p.

Research output: Contribution to journalArticle

Informatics
Mass spectrometry
Decoding
Mass Spectrometry
Protein Subunits
2 Citations

A protein-derived oxygen is the source of the amide oxygen of nitrile hydratases

Nelp, M. T., Song, Y., Wysocki, V. H. & Bandarian, V. Apr 8 2016 In : Journal of Biological Chemistry. 291, 15, p. 7822-7829 8 p.

Research output: Contribution to journalArticle

Amides
Nitriles
Oxygen
Nucleophiles
Proteins
11 Citations

Biochemical and Spectroscopic Characterization of a Radical S-Adenosyl- l -methionine Enzyme Involved in the Formation of a Peptide Thioether Cross-Link

Bruender, N. A., Wilcoxen, J., Britt, R. D. & Bandarian, V. Apr 26 2016 In : Biochemistry. 55, 14, p. 2122-2134 13 p.

Research output: Contribution to journalArticle

Sulfides
Methionine
Peptides
Enzymes
Biological Products
Biochemistry
Cracks
Enzymes
7-deazaguanine
8 Citations

Molecular basis of cobalamin-dependent RNA modification

Dowling, D. P., Miles, Z. D., Köhrer, C., Maiocco, S. J., Elliott, S. J., Bandarian, V. & Drennan, C. L. 2016 In : Nucleic Acids Research. 44, 20, p. 9965-9976 12 p.

Research output: Contribution to journalArticle

Vitamin B 12
RNA
Nucleoside Q
Transfer RNA
Anticodon
9 Citations

SkfB Abstracts a Hydrogen Atom from Cα on SkfA to Initiate Thioether Cross-Link Formation

Bruender, N. A. & Bandarian, V. Aug 2 2016 In : Biochemistry. 55, 30, p. 4131-4134 4 p.

Research output: Contribution to journalArticle

Sulfides
Methionine
Hydrogen
Atoms
Peptides
12 Citations

The Radical S-Adenosyl- l -methionine Enzyme MftC Catalyzes an Oxidative Decarboxylation of the C-Terminus of the MftA Peptide

Bruender, N. A. & Bandarian, V. May 24 2016 In : Biochemistry. 55, 20, p. 2813-2816 4 p.

Research output: Contribution to journalArticle

Decarboxylation
Methionine
Peptides
Enzymes
Accessories
2015
7 Citations

A Single Enzyme Transforms a Carboxylic Acid into a Nitrile through an Amide Intermediate

Nelp, M. T. & Bandarian, V. Sep 1 2015 In : Angewandte Chemie - International Edition. 54, 36, p. 10627-10629 3 p.

Research output: Contribution to journalArticle

Nitriles
Carboxylic Acids
Carboxylic acids
Amides
Enzymes
11 Citations

Biochemical and Spectroscopic Studies of Epoxyqueuosine Reductase: A Novel Iron-Sulfur Cluster- and Cobalamin-Containing Protein Involved in the Biosynthesis of Queuosine

Miles, Z. D., Myers, W. K., Kincannon, W. M., Britt, R. D. & Bandarian, V. Aug 11 2015 In : Biochemistry. 54, 31, p. 4927-4935 9 p.

Research output: Contribution to journalArticle

Nucleoside Q
Biosynthesis
Vitamin B 12
Sulfur
Oxidoreductases
9 Citations

Chemical and biological reduction of the radical SAM enzyme CPH<inf>4</inf> synthase

Bruender, N. A., Young, A. P. & Bandarian, V. May 12 2015 In : Biochemistry. 54, 18, p. 2903-2910 8 p.

Research output: Contribution to journalArticle

Flavodoxin
Dithionite
Methionine
Enzymes
Chemical activation
6 Citations

Mechanistic Studies of the Radical S- Adenosyl- l -methionine Enzyme 4-Demethylwyosine Synthase Reveal the Site of Hydrogen Atom Abstraction

Young, A. P. & Bandarian, V. Jun 16 2015 In : Biochemistry. 54, 23, p. 3569-3572 4 p.

Research output: Contribution to journalArticle

Pyruvic Acid
Methionine
Hydrogen
Atoms
Enzymes
4 Citations

Radical-mediated ring contraction in the biosynthesis of 7-deazapurines

Bandarian, V. & Drennan, C. L. Dec 1 2015 In : Current Opinion in Structural Biology. 35, p. 116-124 9 p.

Research output: Contribution to journalArticle

Biosynthetic Pathways
Biological Products
pyrrolopyrimidine
7-deazapurine
17 Citations

Refining the structural model of a heterohexameric protein complex: Surface induced dissociation and ion mobility provide key connectivity and topology information

Song, Y., Nelp, M. T., Bandarian, V. & Wysocki, V. H. Dec 23 2015 In : ACS Central Science. 1, 9, p. 477-487 11 p.

Research output: Contribution to journalArticle

Toyocamycin
Refining
Mass spectrometry
Topology
Ions
8 Citations

Variable substrate preference among phospholipase D toxins from sicariid spiders

Lajoie, D. M., Roberts, S. A., Zobel-Thropp, P. A., Delahaye, J. L., Bandarian, V., Binford, G. J. & Cordes, M. H. J. Apr 24 2015 In : Journal of Biological Chemistry. 290, 17, p. 10994-11007 14 p.

Research output: Contribution to journalArticle

Phospholipase D
Sphingolipids
Spiders
Choline
Ethanolamine
2014
8 Citations
Tunnels
Catalytic Domain
Enzymes
Bacterial Structures
Mammals
8 Citations

The alpha subunit of nitrile hydratase is sufficient for catalytic activity and post-translational modification

Nelp, M. T., Astashkin, A. V., Breci, L. A., McCarty, R. M. & Bandarian, V. Jun 24 2014 In : Biochemistry. 53, 24, p. 3990-3994 5 p.

Research output: Contribution to journalArticle

Toyocamycin
Post Translational Protein Processing
Catalyst activity
Streptomyces rimosus
Catalytic Domain
2013
14 Citations

Phospholipase D Toxins of Brown Spider Venom Convert Lysophosphatidylcholine and Sphingomyelin to Cyclic Phosphates

Lajoie, D. M., Zobel-Thropp, P. A., Kumirov, V. K., Bandarian, V., Binford, G. J. & Cordes, M. H. J. Aug 29 2013 In : PLoS One. 8, 8, e72372

Research output: Contribution to journalArticle

Spider Venoms
lysophosphatidylcholine
Phospholipase D
phospholipase D
sphingomyelins
15 Citations

Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine

Young, A. P. & Bandarian, V. Aug 2013 In : Current Opinion in Chemical Biology. 17, 4, p. 613-618 6 p.

Research output: Contribution to journalArticle

RNA, Transfer, Phe
Biosynthesis
Archaea
Transfer RNA
Eukaryota
26 Citations
Cyclization
Biosynthesis
Methionine
Kinetics
Enzymes
2012
31 Citations

Biosynthesis of pyrrolopyrimidines

McCarty, R. M. & Bandarian, V. Aug 2012 In : Bioorganic Chemistry. 43, p. 15-25 11 p.

Research output: Contribution to journalArticle

Biosynthesis
Secondary Metabolism
Biosynthetic Pathways
Metabolites
RNA
13 Citations
Biosynthesis
Biological Products
Methionine
Enzymes
Transfer RNA
2011
50 Citations

Comparison of a PreQ1 riboswitch aptamer in metabolite-bound and free states with implications for gene regulation

Jenkins, J. L., Krucinska, J., McCarty, R. M., Bandarian, V. & Wedekind, J. E. Jul 15 2011 In : Journal of Biological Chemistry. 286, 28, p. 24626-24637 12 p.

Research output: Contribution to journalArticle

Riboswitch
Metabolites
Gene expression
Ligands
Genes
40 Citations

Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification

Miles, Z. D., McCarty, R. M., Molnar, G. & Bandarian, V. May 3 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 18, p. 7368-7372 5 p.

Research output: Contribution to journalArticle

Transfer RNA
Oxidoreductases
Biosynthetic Pathways
Nucleoside Q
RNA, Transfer, Asn
20 Citations

Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine

Young, A. P. & Bandarian, V. Dec 13 2011 In : Biochemistry. 50, 49, p. 10573-10575 3 p.

Research output: Contribution to journalArticle

Imidazolines
Pyruvic Acid
Carbon
RNA, Transfer, Phe
Biosynthesis
53 Citations

Revealing the quaternary structure of a heterogeneous noncovalent protein complex through surface-induced dissociation

Blackwell, A. E., Dodds, E. D., Bandarian, V. & Wysocki, V. H. Apr 15 2011 In : Analytical Chemistry. 83, 8, p. 2862-2865 4 p.

Research output: Contribution to journalArticle

Toyocamycin
Mass spectrometry
Proteins
Chemical activation
Topology
2009
30 Citations

Escherichia coli QueD Is a 6-Carboxy-5,6,7,8-tetrahydropterin synthase

McCarty, R. M., Somogyi, Á. & Bandarian, V. Mar 24 2009 In : Biochemistry. 48, 11, p. 2301-2303 3 p.

Research output: Contribution to journalArticle

Biosynthesis
Escherichia coli
Nucleoside Q
Biopterin
Biological Products
48 Citations

The deazapurine biosynthetic pathway revealed: In vitro enzymatic synthesis of PreQ0 from guanosine 5′-triphosphate in four steps

McCarty, R. M., Somogyi, Á., Lin, G., Jacobsen, N. E. & Bandarian, V. May 12 2009 In : Biochemistry. 48, 18, p. 3847-3852 6 p.

Research output: Contribution to journalArticle

Guanosine
Biosynthetic Pathways
Guanosine Triphosphate
Bacillus subtilis
Nucleoside Q
64 Citations

The structural basis for recognition of the preQ0 metabolite by an unusually small riboswitch aptamer domain

Spitale, R. C., Torelli, A. T., Krucinska, J., Bandarian, V. & Wedekind, J. E. Apr 24 2009 In : Journal of Biological Chemistry. 284, 17, p. 11012-11016 5 p.

Research output: Contribution to journalArticle

Riboswitch
Metabolites
Ribosomes
Binding Sites
RNA
2008
8 Citations
Methanocaldococcus
GTP Cyclohydrolase
Guanosine Triphosphate
Metal ions
Crystal structure
48 Citations

Deciphering Deazapurine Biosynthesis: Pathway for Pyrrolopyrimidine Nucleosides Toyocamycin and Sangivamycin

McCarty, R. M. & Bandarian, V. Aug 25 2008 In : Chemistry and Biology. 15, 8, p. 790-798 9 p.

Research output: Contribution to journalArticle

sangivamycin
Toyocamycin
Biosynthesis
Nucleosides
Genes

Delivery of tailor-made cobalamin to methylmalonyl-CoA mutase

Bandarian, V. Mar 2008 In : Nature Chemical Biology. 4, 3, p. 158-159 2 p.

Research output: Contribution to journalArticle

Methylmalonyl-CoA Mutase
Vitamin B 12
Intramolecular Transferases
Enzymes
methylmalonyl-coenzyme A
1 Citations
Pterins
Streptomyces coelicolor
Bioactivity
Metal ions
Zinc
6 Citations

Understanding functional divergence in proteins by studying intragenomic homologues

Spoonamore, J. E. & Bandarian, V. Feb 26 2008 In : Biochemistry. 47, 8, p. 2592-2600 9 p.

Research output: Contribution to journalArticle

Guanosine Triphosphate
Streptomyces coelicolor
Catalytic Domain
Genes
GTP Cyclohydrolase
2007
22 Citations

The copper-inducible cin operon encodes an unusual methionine-rich azurin-like protein and a pre-Q0 reductase in Pseudomonas putida KT2440

Quaranta, D., McCarty, R., Bandarian, V. & Rensing, C. Jul 2007 In : Journal of Bacteriology. 189, 14, p. 5361-5371 11 p.

Research output: Contribution to journalArticle

Azurin
Pseudomonas putida
Operon
Methionine
Copper
2006
15 Citations

Evolution of new function in the GTP cyclohydrolase II proteins of Streptomyces coelicolor

Spoonamore, J. E., Dahlgran, A. L., Jacobsen, N. E. & Bandarian, V. Oct 3 2006 In : Biochemistry. 45, 39, p. 12144-12155 12 p.

Research output: Contribution to journalArticle

Streptomyces coelicolor
Guanosine
Guanosine Triphosphate
GTP Cyclohydrolase
Proteins
11 Citations

Probing nitrogen-sensitive steps in the free-radical-mediated deamination of amino alcohols by ethanolamine ammonia-lyase

Poyner, R. R., Anderson, M. A., Bandarian, V., Cleland, W. W. & Reed, G. H. Jun 7 2006 In : Journal of the American Chemical Society. 128, 22, p. 7120-7121 2 p.

Research output: Contribution to journalArticle

Ethanolamine Ammonia-Lyase
Amino alcohols
Amino Alcohols
Ethanolamines
Deamination
2004
9 Citations

Measurement of Energetics of Conformational Change in Cobalamin-Dependent Methionine Synthase

Bandarian, V. & Matthews, R. G. 2004 In : Methods in Enzymology. 380, p. 152-169 18 p.

Research output: Contribution to journalArticle

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Vitamin B 12
2003
35 Citations

Cobalamin-Dependent and Cobalamin-Independent Methionine Synthases: Are There Two Solutions to the Same Chemical Problem?

Matthews, R. G., Smith, A. E., Zhou, Z. S., Taurog, R. E., Bandarian, V., Evans, J. C. & Ludwig, M. 2003 In : Helvetica Chimica Acta. 86, 12, p. 3939-3954 16 p.

Research output: Contribution to journalArticle

methionine
Vitamin B 12
Folic Acid
Enzymes
Protonation
43 Citations
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Staphylococcal Protein A
Vitamin B 12
Protein Conformation
Enzymes
2002
46 Citations
Ethanolamine Ammonia-Lyase
Electron Spin Resonance Spectroscopy
Paramagnetic resonance
Substrates
Skeleton
69 Citations

Domain alternation switches B12-dependent methionine synthase to the activation conformation

Bandarian, V., Pattridge, K. A., Lennon, B. W., Huddler, D. P., Matthews, R. G. & Ludwig, M. L. 2002 In : Nature Structural Biology. 9, 1, p. 53-56 4 p.

Research output: Contribution to journalArticle

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Vitamin B 12
Conformations
Chemical activation
Switches
2001
45 Citations

5′-deoxyadenosine contacts the substrate radical intermediate in the active site of ethanolamine ammonia-lyase: 2H and 13C electron nuclear double resonance studies

LoBrutto, R., Bandarian, V., Magnusson, O. T., Chen, X., Schramm, V. L. & Reed, G. H. Jan 9 2001 In : Biochemistry. 40, 1, p. 9-14 6 p.

Research output: Contribution to journalArticle

Ethanolamine Ammonia-Lyase
Electron Spin Resonance Spectroscopy
Catalytic Domain
Electrons
Substrates
26 Citations

Inhibition of lysine 2,3-aminomutase by the alternative substrate 4-thialysine and characterization of the 4-thialysyl radical intermediate

Miller, J., Bandarian, V., Reed, G. H. & Frey, P. A. Mar 15 2001 In : Archives of Biochemistry and Biophysics. 387, 2, p. 281-288 8 p.

Research output: Contribution to journalArticle

lysine 2,3-aminomutase
Lysine
Substrates
Catalytic Domain
S-2-aminoethyl cysteine
22 Citations

Quantitation of rate enhancements attained by the binding of cobalamin to methionine synthase

Bandarian, V. & Matthews, R. G. Apr 24 2001 In : Biochemistry. 40, 16, p. 5056-5064 9 p.

Research output: Contribution to journalArticle

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Vitamin B 12
Homocysteine
Methylation
Rate constants