Research Output 1992 2017

  • 1372 Citations
  • 22 h-Index
  • 60 Article
  • 1 Chapter
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Article
2017
3 Citations

7-Carboxy-7-deazaguanine synthase: A radical S-adenosyl-L-methionine enzyme with polar tendencies

Bruender, N. A., Grell, T. A. J., Dowling, D. P., McCarty, R. M., Drennan, C. L. & Bandarian, V. Feb 8 2017 In : Journal of the American Chemical Society. 139, 5, p. 1912-1920 9 p.

Research output: Research - peer-reviewArticle

S-Adenosylmethionine
Enzymes
6-carboxypterin
7-deazaguanine
Esters

Human Viperin Causes Radical SAM-Dependent Elongation of Escherichia coli, Hinting at Its Physiological Role

Nelp, M. T., Young, A. P., Stepanski, B. M. & Bandarian, V. Aug 1 2017 In : Biochemistry. 56, 30, p. 3874-3876 3 p.

Research output: Research - peer-reviewArticle

Methionine
Escherichia coli
Elongation
Viruses
Bacteria
2 Citations
creatininase
Biosynthesis
Peptides
Mycobacterium smegmatis
Biological Products
2016
13 Citations

An informatic framework for decoding protein complexes by top-down mass spectrometry

Skinner, O. S., Havugimana, P. C., Haverland, N. A., Fornelli, L., Early, B. P., Greer, J. B., Fellers, R. T., Durbin, K. R., Do Vale, L. H. F., Melani, R. D., Seckler, H. S., Nelp, M. T., Belov, M. E., Horning, S. R., Makarov, A. A., LeDuc, R. D., Bandarian, V., Compton, P. D. & Kelleher, N. L. Feb 25 2016 In : Nature Methods. 13, 3, p. 237-240 4 p.

Research output: Research - peer-reviewArticle

Informatics
Mass Spectrometry
Proteins
Mass spectrometry
Protein Subunits
1 Citations

A protein-derived oxygen is the source of the amide oxygen of nitrile hydratases

Nelp, M. T., Song, Y., Wysocki, V. H. & Bandarian, V. Apr 8 2016 In : Journal of Biological Chemistry. 291, 15, p. 7822-7829 8 p.

Research output: Research - peer-reviewArticle

Amides
Oxygen
Proteins
nitrile hydratase
Nitriles
11 Citations

Biochemical and Spectroscopic Characterization of a Radical S-Adenosyl- l -methionine Enzyme Involved in the Formation of a Peptide Thioether Cross-Link

Bruender, N. A., Wilcoxen, J., Britt, R. D. & Bandarian, V. Apr 26 2016 In : Biochemistry. 55, 14, p. 2122-2134 13 p.

Research output: Research - peer-reviewArticle

Sulfides
Methionine
Peptides
Enzymes
Biological Products
5 Citations

Molecular basis of cobalamin-dependent RNA modification

Dowling, D. P., Miles, Z. D., Köhrer, C., Maiocco, S. J., Elliott, S. J., Bandarian, V. & Drennan, C. L. 2016 In : Nucleic Acids Research. 44, 20, p. 9965-9976 12 p.

Research output: Research - peer-reviewArticle

Vitamin B 12
RNA
Enzymes
Transfer RNA
Nucleoside Q
8 Citations

SkfB Abstracts a Hydrogen Atom from Cα on SkfA to Initiate Thioether Cross-Link Formation

Bruender, N. A. & Bandarian, V. Aug 2 2016 In : Biochemistry. 55, 30, p. 4131-4134 4 p.

Research output: Research - peer-reviewArticle

Sulfides
Methionine
Hydrogen
Atoms
Peptides
9 Citations

The Radical S-Adenosyl- l -methionine Enzyme MftC Catalyzes an Oxidative Decarboxylation of the C-Terminus of the MftA Peptide

Bruender, N. A. & Bandarian, V. May 24 2016 In : Biochemistry. 55, 20, p. 2813-2816 4 p.

Research output: Research - peer-reviewArticle

Methionine
Peptides
Enzymes
Decarboxylation
Accessories
2015
7 Citations

A Single Enzyme Transforms a Carboxylic Acid into a Nitrile through an Amide Intermediate

Nelp, M. T. & Bandarian, V. Sep 1 2015 In : Angewandte Chemie - International Edition. 54, 36, p. 10627-10629 3 p.

Research output: Research - peer-reviewArticle

Carboxylic acids
Amides
Enzymes
Mathematical transformations
Nitriles
10 Citations

Biochemical and Spectroscopic Studies of Epoxyqueuosine Reductase: A Novel Iron-Sulfur Cluster- and Cobalamin-Containing Protein Involved in the Biosynthesis of Queuosine

Miles, Z. D., Myers, W. K., Kincannon, W. M., Britt, R. D. & Bandarian, V. Aug 11 2015 In : Biochemistry. 54, 31, p. 4927-4935 9 p.

Research output: Research - peer-reviewArticle

Nucleoside Q
Biosynthesis
Vitamin B 12
Sulfur
Oxidoreductases
9 Citations

Chemical and biological reduction of the radical SAM enzyme CPH<inf>4</inf> synthase

Bruender, N. A., Young, A. P. & Bandarian, V. May 12 2015 In : Biochemistry. 54, 18, p. 2903-2910 8 p.

Research output: Research - peer-reviewArticle

Flavodoxin
Methionine
Enzymes
Dithionite
Chemical activation
5 Citations
Pyruvic Acid
Methionine
Hydrogen
Atoms
Enzymes
3 Citations

Radical-mediated ring contraction in the biosynthesis of 7-deazapurines

Bandarian, V. & Drennan, C. L. Dec 1 2015 In : Current Opinion in Structural Biology. 35, p. 116-124 9 p.

Research output: Research - peer-reviewArticle

pyrrolopyrimidine
7-deazapurine
Biosynthetic Pathways
Biological Products
11 Citations

Refining the structural model of a heterohexameric protein complex: Surface induced dissociation and ion mobility provide key connectivity and topology information

Song, Y., Nelp, M. T., Bandarian, V. & Wysocki, V. H. Dec 23 2015 In : ACS Central Science. 1, 9, p. 477-487 11 p.

Research output: Research - peer-reviewArticle

Toyocamycin
Refining
Topology
Ions
Proteins
7 Citations

Variable substrate preference among phospholipase D toxins from sicariid spiders

Lajoie, D. M., Roberts, S. A., Zobel-Thropp, P. A., Delahaye, J. L., Bandarian, V., Binford, G. J. & Cordes, M. H. J. Apr 24 2015 In : Journal of Biological Chemistry. 290, 17, p. 10994-11007 14 p.

Research output: Research - peer-reviewArticle

Phospholipase D
Sphingolipids
Spiders
Choline
Ethanolamine
2014
8 Citations
Tunnels
Enzymes
tetrahydropterin
Proteins
dihydroneopterin triphosphate
8 Citations

The alpha subunit of nitrile hydratase is sufficient for catalytic activity and post-translational modification

Nelp, M. T., Astashkin, A. V., Breci, L. A., McCarty, R. M. & Bandarian, V. Jun 24 2014 In : Biochemistry. 53, 24, p. 3990-3994 5 p.

Research output: Research - peer-reviewArticle

Catalyst activity
nitrile hydratase
Post Translational Protein Processing
Toyocamycin
Catalytic Domain
2013
12 Citations

Phospholipase D Toxins of Brown Spider Venom Convert Lysophosphatidylcholine and Sphingomyelin to Cyclic Phosphates

Lajoie, D. M., Zobel-Thropp, P. A., Kumirov, V. K., Bandarian, V., Binford, G. J. & Cordes, M. H. J. Aug 29 2013 In : PLoS One. 8, 8, e72372

Research output: Research - peer-reviewArticle

lysophosphatidylcholine
phospholipase D
sphingomyelins
venoms
Araneae
13 Citations

Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine

Young, A. P. & Bandarian, V. Aug 2013 In : Current Opinion in Chemical Biology. 17, 4, p. 613-618 6 p.

Research output: Research - peer-reviewArticle

RNA, Transfer, Phe
Archaea
Transfer RNA
Eukaryota
Pyruvic Acid
22 Citations
Cyclization
Biosynthesis
Methionine
Kinetics
Enzymes
2012
26 Citations

Biosynthesis of pyrrolopyrimidines

McCarty, R. M. & Bandarian, V. Aug 2012 In : Bioorganic Chemistry. 43, p. 15-25 11 p.

Research output: Research - peer-reviewArticle

Biosynthesis
pyrrolopyrimidine
7-deazapurine
Metabolites
RNA
12 Citations
Biosynthesis
Biological Products
Methionine
Enzymes
purine
2011
46 Citations

Comparison of a PreQ1 riboswitch aptamer in metabolite-bound and free states with implications for gene regulation

Jenkins, J. L., Krucinska, J., McCarty, R. M., Bandarian, V. & Wedekind, J. E. Jul 15 2011 In : Journal of Biological Chemistry. 286, 28, p. 24626-24637 12 p.

Research output: Research - peer-reviewArticle

Riboswitch
Metabolites
Gene expression
Ligands
Genes
35 Citations

Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification

Miles, Z. D., McCarty, R. M., Molnar, G. & Bandarian, V. May 3 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 18, p. 7368-7372 5 p.

Research output: Research - peer-reviewArticle

Transfer RNA
Oxidoreductases
nucleoside oQ
Biosynthetic Pathways
RNA
19 Citations

Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine

Young, A. P. & Bandarian, V. Dec 13 2011 In : Biochemistry. 50, 49, p. 10573-10575 3 p.

Research output: Research - peer-reviewArticle

Imidazolines
Pyruvic Acid
Carbon
4-demethylwyosine
RNA, Transfer, Phe
50 Citations

Revealing the quaternary structure of a heterogeneous noncovalent protein complex through surface-induced dissociation

Blackwell, A. E., Dodds, E. D., Bandarian, V. & Wysocki, V. H. Apr 15 2011 In : Analytical Chemistry. 83, 8, p. 2862-2865 4 p.

Research output: Research - peer-reviewArticle

Proteins
Mass spectrometry
Chemical activation
Toyocamycin
Topology
2009
27 Citations

Escherichia coli QueD Is a 6-Carboxy-5,6,7,8-tetrahydropterin synthase

McCarty, R. M., Somogyi, Á. & Bandarian, V. Mar 24 2009 In : Biochemistry. 48, 11, p. 2301-2303 3 p.

Research output: Research - peer-reviewArticle

Biosynthesis
tetrahydropterin
Escherichia coli
Nucleoside Q
Biopterin
45 Citations

The deazapurine biosynthetic pathway revealed: In vitro enzymatic synthesis of PreQ0 from guanosine 5′-triphosphate in four steps

McCarty, R. M., Somogyi, Á., Lin, G., Jacobsen, N. E. & Bandarian, V. May 12 2009 In : Biochemistry. 48, 18, p. 3847-3852 6 p.

Research output: Research - peer-reviewArticle

Biosynthetic Pathways
Guanosine Triphosphate
Bacillus subtilis
Anti-Bacterial Agents
Enzymes
63 Citations

The structural basis for recognition of the preQ0 metabolite by an unusually small riboswitch aptamer domain

Spitale, R. C., Torelli, A. T., Krucinska, J., Bandarian, V. & Wedekind, J. E. Apr 24 2009 In : Journal of Biological Chemistry. 284, 17, p. 11012-11016 5 p.

Research output: Research - peer-reviewArticle

Riboswitch
Ribosomes
Binding Sites
RNA
Ligands
2008
8 Citations
Methanocaldococcus
GTP Cyclohydrolase
Guanosine Triphosphate
Metals
X-Rays
47 Citations

Deciphering Deazapurine Biosynthesis: Pathway for Pyrrolopyrimidine Nucleosides Toyocamycin and Sangivamycin

McCarty, R. M. & Bandarian, V. Aug 25 2008 In : Chemistry and Biology. 15, 8, p. 790-798 9 p.

Research output: Research - peer-reviewArticle

sangivamycin
Toyocamycin
Biosynthesis
Nucleosides
pyrrolopyrimidine

Delivery of tailor-made cobalamin to methylmalonyl-CoA mutase

Bandarian, V. Mar 2008 In : Nature Chemical Biology. 4, 3, p. 158-159 2 p.

Research output: Research - peer-reviewArticle

Methylmalonyl-CoA Mutase
Vitamin B 12
methylmalonyl-coenzyme A
Intramolecular Transferases
cobamamide
1 Citations
Pterins
Bioactivity
Metal ions
Zinc
Crystal structure
6 Citations

Understanding functional divergence in proteins by studying intragenomic homologues

Spoonamore, J. E. & Bandarian, V. Feb 26 2008 In : Biochemistry. 47, 8, p. 2592-2600 9 p.

Research output: Research - peer-reviewArticle

Guanosine Triphosphate
Proteins
4,6-diamino-5-N-formamidopyrimidine
Streptomyces coelicolor
Catalytic Domain
2007
22 Citations

The copper-inducible cin operon encodes an unusual methionine-rich azurin-like protein and a pre-Q0 reductase in Pseudomonas putida KT2440

Quaranta, D., McCarty, R., Bandarian, V. & Rensing, C. Jul 2007 In : Journal of Bacteriology. 189, 14, p. 5361-5371 11 p.

Research output: Research - peer-reviewArticle

Azurin
Pseudomonas putida
Operon
Methionine
Copper
2006
15 Citations

Evolution of new function in the GTP cyclohydrolase II proteins of Streptomyces coelicolor

Spoonamore, J. E., Dahlgran, A. L., Jacobsen, N. E. & Bandarian, V. Oct 3 2006 In : Biochemistry. 45, 39, p. 12144-12155 12 p.

Research output: Research - peer-reviewArticle

Streptomyces coelicolor
Guanosine Triphosphate
Proteins
Guanosine
triphosphoric acid
10 Citations

Probing nitrogen-sensitive steps in the free-radical-mediated deamination of amino alcohols by ethanolamine ammonia-lyase

Poyner, R. R., Anderson, M. A., Bandarian, V., Cleland, W. W. & Reed, G. H. Jun 7 2006 In : Journal of the American Chemical Society. 128, 22, p. 7120-7121 2 p.

Research output: Research - peer-reviewArticle

Amino alcohols
Ethanolamines
Free radicals
Isotopes
Ammonia
2004
8 Citations

Measurement of Energetics of Conformational Change in Cobalamin-Dependent Methionine Synthase

Bandarian, V. & Matthews, R. G. 2004 In : Methods in Enzymology. 380, p. 152-169 18 p.

Research output: Research - peer-reviewArticle

2003
34 Citations

Cobalamin-Dependent and Cobalamin-Independent Methionine Synthases: Are There Two Solutions to the Same Chemical Problem?

Matthews, R. G., Smith, A. E., Zhou, Z. S., Taurog, R. E., Bandarian, V., Evans, J. C. & Ludwig, M. 2003 In : Helvetica Chimica Acta. 86, 12, p. 3939-3954 16 p.

Research output: Research - peer-reviewArticle

Vitamin B 12
Folic Acid
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase
Enzymes
methionine
42 Citations
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Staphylococcal Protein A
Vitamin B 12
Enzymes
Protein Conformation
2002
45 Citations
Ethanolamine Ammonia-Lyase
Electron Spin Resonance Spectroscopy
2-aminopropanol
7-mercaptoheptanoylthreonine phosphate
Paramagnetic resonance
66 Citations

Domain alternation switches B12-dependent methionine synthase to the activation conformation

Bandarian, V., Pattridge, K. A., Lennon, B. W., Huddler, D. P., Matthews, R. G. & Ludwig, M. L. 2002 In : Nature Structural Biology. 9, 1, p. 53-56 4 p.

Research output: Research - peer-reviewArticle

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Vitamin B 12
Conformations
Chemical activation
Switches
2001
44 Citations

5′-deoxyadenosine contacts the substrate radical intermediate in the active site of ethanolamine ammonia-lyase: 2H and 13C electron nuclear double resonance studies

LoBrutto, R., Bandarian, V., Magnusson, O. T., Chen, X., Schramm, V. L. & Reed, G. H. Jan 9 2001 In : Biochemistry. 40, 1, p. 9-14 6 p.

Research output: Research - peer-reviewArticle

Ethanolamine Ammonia-Lyase
Electron Spin Resonance Spectroscopy
Catalytic Domain
5'-deoxyadenosine
Electrons
26 Citations

Inhibition of lysine 2,3-aminomutase by the alternative substrate 4-thialysine and characterization of the 4-thialysyl radical intermediate

Miller, J., Bandarian, V., Reed, G. H. & Frey, P. A. Mar 15 2001 In : Archives of Biochemistry and Biophysics. 387, 2, p. 281-288 8 p.

Research output: Research - peer-reviewArticle

lysine 2,3-aminomutase
S-2-aminoethyl cysteine
Lysine
Catalytic Domain
Deuterium
22 Citations

Quantitation of rate enhancements attained by the binding of cobalamin to methionine synthase

Bandarian, V. & Matthews, R. G. Apr 24 2001 In : Biochemistry. 40, 16, p. 5056-5064 9 p.

Research output: Research - peer-reviewArticle

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Vitamin B 12
Homocysteine
Proteins
Methylation
2000
19 Citations

Characterization of a unique coenzyme B6 radical in the ascarylose biosynthetic pathway [14]

Chang, C. W. T., Johnson, D. A., Bandarian, V., Zhou, H., LoBrutto, R., Reed, G. H. & Liu, H. W. May 3 2000 In : Journal of the American Chemical Society. 122, 17, p. 4239-4240 2 p.

Research output: Research - peer-reviewArticle

41 Citations

Identification of cis-ethanesemidione as the organic radical derived from glycolaldehyde in the suicide inactivation of dioldehydrase and of ethanolamine ammonia-lyase

Abend, A., Bandarian, V., Reed, G. H. & Frey, P. A. May 23 2000 In : Biochemistry. 39, 20, p. 6250-6257 8 p.

Research output: Research - peer-reviewArticle

Ethanolamine Ammonia-Lyase
Suicide
glycolaldehyde
Hydrates
Electron Spin Resonance Spectroscopy
63 Citations
Ethanolamine Ammonia-Lyase
Coenzymes
Isotopes
Hydrogen
7-mercaptoheptanoylthreonine phosphate