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  • 6 Similar Profiles
delta Opioid Receptor Medicine & Life Sciences
Peptides Medicine & Life Sciences
alpha-MSH Medicine & Life Sciences
Melanocyte-Stimulating Hormones Medicine & Life Sciences
Ligands Medicine & Life Sciences
mu Opioid Receptor Medicine & Life Sciences
Oxytocin Medicine & Life Sciences
Enkephalins Medicine & Life Sciences

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Projects 1977 2017

Melanocortins
Melanocyte-Stimulating Hormones
Ligands
Melanocortin Receptors
Peptides

Multimeric Ligands for Targeting of Melanoma

Hruby, V. J., Gillies, R. J. & Morse, D.

National Institutes of Health

7/1/025/31/14

Project: Research projectResearch Project

Melanoma
Ligands
Cell Surface Receptors
Receptor, Melanocortin, Type 2
Membrane Proteins

NOVEL NON-PEPTIDE OPIOID LIGANDS FOR PAIN

Hruby, V. J.

National Institutes of Health

9/1/001/31/16

Project: Research projectResearch Project

Opioid Peptides
Ligands
Pain
Opioid Analgesics
Peptidomimetics

NONPEPTIDIC AND PEPTIDOMIMETIC SELECTIVE DELTA LIGANDS

Hruby, V. J., Porreca, F., Wood, J., Yamamura, H. & Burks, T.

National Institutes of Health

3/1/941/31/00

Project: Research projectResearch Program Projects

delta Opioid Receptor
Peptidomimetics
Ligands
Bioassay
Pharmacology

Research Output 1962 2018

Protection against β-amyloid neurotoxicity by a non-toxic endogenous N-terminal β-amyloid fragment and its active hexapeptide core sequence

Forest, K. H., Alfulaij, N., Arora, K., Taketa, R., Sherrin, T., Todorovic, C., Lawrence, J. L. M., Yoshikawa, G. T., Ng, H. L., Hruby, V. J. & Nichols, R. A. Jan 1 2018 In : Journal of Neurochemistry. 144, 2, p. 201-217 17 p.

Research output: Contribution to journalArticle

Amyloid beta-Peptides
Memory Disorders
Amyloid
Fear
Neurotransmitter Agents

Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH2, leads to hMC1R selectivity and pigmentation

Mowlazadeh Haghighi, S., Zhou, Y., Dai, J., Sawyer, J. R., Hruby, V. J. & Cai, M. May 10 2018 In : European Journal of Medicinal Chemistry. 151, p. 815-823 9 p.

Research output: Contribution to journalArticle

Melanocyte-Stimulating Hormones
Pigmentation
Message passing
Skin Neoplasms
Unsaturated polymers
2 Citations

Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation

Zhou, Y., Mowlazadeh Haghighi, S., Zoi, I., Sawyer, J. R., Hruby, V. J. & Cai, M. Nov 22 2017 In : Journal of Medicinal Chemistry. 60, 22, p. 9320-9329 10 p.

Research output: Contribution to journalArticle

gamma-MSH
Receptor, Melanocortin, Type 1
Pigmentation
Amino Acids
Skin Pigmentation
1 Citations

Fluorescent-labeled bioconjugates of the opioid peptides biphalin and DPDPE incorporating fluorescein-maleimide linkers

Stefanucci, A., Lei, W., Hruby, V. J., Macedonio, G., Luisi, G., Carradori, S., Streicher, J. M. & Mollica, A. Jun 1 2017 In : Future Medicinal Chemistry. 9, 9, p. 859-869 11 p.

Research output: Contribution to journalArticle

D-Penicillamine (2,5)-Enkephalin
Opioid Peptides
delta Opioid Receptor
Enkephalins
mu Opioid Receptor
2 Citations

Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages

Rinne, P., Rami, M., Nuutinen, S., Santovito, D., Van Der Vorst, E. P. C., Guillamat-Prats, R., Lyytikäinen, L. P., Raitoharju, E., Oksala, N., Ring, L., Cai, M., Hruby, V. J., Lehtimäki, T., Weber, C. & Steffens, S. Jul 4 2017 In : Circulation. 136, 1, p. 83-97 15 p.

Research output: Contribution to journalArticle

Receptor, Melanocortin, Type 1
Macrophages
Cholesterol
alpha-MSH
Foam Cells