• 34647 Citations
  • 81 h-Index
1962 …2018
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  • 4 Similar Profiles
delta Opioid Receptor Medicine & Life Sciences
Peptides Medicine & Life Sciences
alpha-MSH Medicine & Life Sciences
Melanocyte-Stimulating Hormones Medicine & Life Sciences
Ligands Medicine & Life Sciences
mu Opioid Receptor Medicine & Life Sciences
Oxytocin Medicine & Life Sciences
Melanocortin Receptors Medicine & Life Sciences

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Projects 1977 2017

Melanocortins
Melanocyte-Stimulating Hormones
Ligands
Melanocortin Receptors
Peptides

Multimeric Ligands for Targeting of Melanoma

Hruby, V. J., Gillies, R. J. & Morse, D.

National Institutes of Health

7/1/025/31/14

Project: Research projectResearch Project

Melanoma
Ligands
Cell Surface Receptors
Receptor, Melanocortin, Type 2
Membrane Proteins

NOVEL NON-PEPTIDE OPIOID LIGANDS FOR PAIN

Hruby, V. J.

National Institutes of Health

9/1/001/31/16

Project: Research projectResearch Project

Opioid Peptides
Ligands
Pain
Opioid Analgesics
Peptidomimetics

NONPEPTIDIC AND PEPTIDOMIMETIC SELECTIVE DELTA LIGANDS

Hruby, V. J., Porreca, F., Wood, J., Yamamura, H. & Burks, T.

National Institutes of Health

3/1/941/31/00

Project: Research projectResearch Program Projects

delta Opioid Receptor
Peptidomimetics
Ligands
Bioassay
Pharmacology

Research Output 1962 2018

gamma-MSH
Lizards
Pharmaceutical Chemistry
Pigmentation
Ether

Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors

Remesic, M., Macedonio, G., Mollica, A., Porreca, F., Hruby, V. J. & Lee, Y. S., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

kappa Opioid Receptor
delta Opioid Receptor
mu Opioid Receptor
hydrazine
Opioid Receptors

Development of Macrocyclic Peptidomimetics Containing Constrained α,α-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors

Merlino, F., Zhou, Y., Cai, M., Carotenuto, A., Yousif, A. M., Brancaccio, D., Di Maro, S., Zappavigna, S., Limatola, A., Novellino, E., Grieco, P. & Hruby, V. J., May 10 2018, In : Unknown Journal. 61, 9, p. 4263-4269 7 p.

Research output: Contribution to journalArticle

Melanocortin Receptors
Melanocortins
Peptidomimetics
Human Activities
amino acids

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1

Durek, T., Cromm, P. M., White, A. M., Schroeder, C. I., Kaas, Q., Weidmann, J., Ahmad Fuaad, A., Cheneval, O., Harvey, P. J., Daly, N. L., Zhou, Y., Dellsén, A., Österlund, T., Larsson, N., Knerr, L., Bauer, U., Kessler, H., Cai, M., Hruby, V. J., Plowright, A. T. & 1 othersCraik, D. J., Apr 26 2018, In : Journal of Medicinal Chemistry. 61, 8, p. 3674-3684 11 p.

Research output: Contribution to journalArticle

Melanocortin Receptors
Cyclic Peptides
Methylation
Peptides
Drug Design

Hypothalamic γ-melanocyte stimulating hormone gene delivery reduces fat mass in male mice

Eerola, K., Virtanen, S., Vähätalo, L., Ailanen, L., Cai, M., Hruby, V. J., Savontaus, M. & Savontaus, E., Oct 1 2018, In : Journal of Endocrinology. 239, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

gamma-MSH
Hypothalamic Hormones
Arcuate Nucleus of Hypothalamus
Receptor, Melanocortin, Type 3
Fats