• 34391 Citations
  • 80 h-Index
1962 …2018
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  • 6 Similar Profiles
delta Opioid Receptor Medicine & Life Sciences
Peptides Medicine & Life Sciences
alpha-MSH Medicine & Life Sciences
Melanocyte-Stimulating Hormones Medicine & Life Sciences
Ligands Medicine & Life Sciences
mu Opioid Receptor Medicine & Life Sciences
Oxytocin Medicine & Life Sciences
Enkephalins Medicine & Life Sciences

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Projects 1977 2017

Melanocortins
Melanocyte-Stimulating Hormones
Ligands
Melanocortin Receptors
Peptides

Multimeric Ligands for Targeting of Melanoma

Hruby, V. J., Gillies, R. J. & Morse, D.

National Institutes of Health

7/1/025/31/14

Project: Research projectResearch Project

Melanoma
Ligands
Cell Surface Receptors
Receptor, Melanocortin, Type 2
Membrane Proteins

NOVEL NON-PEPTIDE OPIOID LIGANDS FOR PAIN

Hruby, V. J.

National Institutes of Health

9/1/001/31/16

Project: Research projectResearch Project

Opioid Peptides
Ligands
Pain
Opioid Analgesics
Peptidomimetics

NONPEPTIDIC AND PEPTIDOMIMETIC SELECTIVE DELTA LIGANDS

Hruby, V. J., Porreca, F., Wood, J., Yamamura, H. & Burks, T.

National Institutes of Health

3/1/941/31/00

Project: Research projectResearch Program Projects

delta Opioid Receptor
Peptidomimetics
Ligands
Bioassay
Pharmacology

Research Output 1962 2018

Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors

Remesic, M., Macedonio, G., Mollica, A., Porreca, F., Hruby, V. & Lee, Y. S. Jan 1 2018 (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

Hydrofoil boats
kappa Opioid Receptor
delta Opioid Receptor
mu Opioid Receptor
hydrazine

Development of Macrocyclic Peptidomimetics Containing Constrained α,α-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors

Merlino, F., Zhou, Y., Cai, M., Carotenuto, A., Yousif, A. M., Brancaccio, D., Di Maro, S., Zappavigna, S., Limatola, A., Novellino, E., Grieco, P. & Hruby, V. J. May 10 2018 In : Unknown Journal. 61, 9, p. 4263-4269 7 p.

Research output: Contribution to journalArticle

Melanocortin Receptors
Melanocortins
Peptidomimetics
Human Activities
Amino Acids

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1

Durek, T. , Cromm, P. M. , White, A. M. , Schroeder, C. I. , Kaas, Q. , Weidmann, J. , Ahmad Fuaad, A. , Cheneval, O. , Harvey, P. J. , Daly, N. L. , Zhou, Y. , Dellsén, A. , Österlund, T. , Larsson, N. , Knerr, L. , Bauer, U. , Kessler, H. , Cai, M. , Hruby, V. J. , Plowright, A. T. & 1 others Craik, D. J. Apr 26 2018 In : Journal of Medicinal Chemistry. 61, 8, p. 3674-3684 11 p.

Research output: Contribution to journalArticle

Melanocortin Receptors
Cyclic Peptides
Methylation
Peptides
Drug Design
1 Citations

Protection against β-amyloid neurotoxicity by a non-toxic endogenous N-terminal β-amyloid fragment and its active hexapeptide core sequence

Forest, K. H., Alfulaij, N., Arora, K., Taketa, R., Sherrin, T., Todorovic, C., Lawrence, J. L. M., Yoshikawa, G. T., Ng, H. L., Hruby, V. J. & Nichols, R. A. Jan 1 2018 In : Journal of Neurochemistry. 144, 2, p. 201-217 17 p.

Research output: Contribution to journalArticle

Amyloid beta-Peptides
Memory Disorders
Amyloid
Fear
Neurotransmitter Agents

Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH2, leads to hMC1R selectivity and pigmentation

Mowlazadeh Haghighi, S., Zhou, Y., Dai, J., Sawyer, J. R., Hruby, V. J. & Cai, M. May 10 2018 In : European Journal of Medicinal Chemistry. 151, p. 815-823 9 p.

Research output: Contribution to journalArticle

Melanocyte-Stimulating Hormones
Pigmentation
Message passing
Skin Neoplasms
Unsaturated polymers