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  • 7 Similar Profiles
Peptides Medicine & Life Sciences
Ligands Medicine & Life Sciences
delta Opioid Receptor Medicine & Life Sciences
alpha-MSH Medicine & Life Sciences
Amino Acids Chemical Compounds
Melanocyte-Stimulating Hormones Medicine & Life Sciences
Opioid Analgesics Medicine & Life Sciences
mu Opioid Receptor Medicine & Life Sciences

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Projects 1977 2017

Melanocortins
Melanocyte-Stimulating Hormones
Ligands
Peptides
Melanocortin Receptors

Multimeric Ligands for Targeting of Melanoma

Hruby, V. J., Gillies, R. J. & Morse, D.

National Institutes of Health

7/1/025/31/14

Project: Research projectResearch Project

Melanoma
Ligands
Cell Surface Receptors
Membrane Proteins
Therapeutics

NOVEL NON-PEPTIDE OPIOID LIGANDS FOR PAIN

Hruby, V. J.

National Institutes of Health

9/1/001/31/16

Project: Research projectResearch Project

Ligands
Pain
Opioid Peptides
Opioid Analgesics
Pharmacology

NONPEPTIDIC AND PEPTIDOMIMETIC SELECTIVE DELTA LIGANDS

Hruby, V. J., Porreca, F., Wood, J., Yamamura, H. & Burks, T.

National Institutes of Health

3/1/941/31/00

Project: Research projectResearch Program Projects

delta Opioid Receptor
Ligands
Pharmacology
Peptidomimetics
Assays

Research Output 1962 2017

Fluorescent-labeled bioconjugates of the opioid peptides biphalin and DPDPE incorporating fluorescein-maleimide linkers

Stefanucci, A., Lei, W., Hruby, V. J., Macedonio, G., Luisi, G., Carradori, S., Streicher, J. M. & Mollica, A. Jun 1 2017 In : Future Medicinal Chemistry. 9, 9, p. 859-869 11 p.

Research output: Research - peer-reviewArticle

D-Penicillamine (2,5)-Enkephalin
Opioid Peptides
biphalin
fluorescein 5-maleimide
delta Opioid Receptor

Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages

Rinne, P., Rami, M., Nuutinen, S., Santovito, D., Van Der Vorst, E. P. C., Guillamat-Prats, R., Lyytikäinen, L. P., Raitoharju, E., Oksala, N., Ring, L., Cai, M., Hruby, V. J., Lehtimäki, T., Weber, C. & Steffens, S. Jul 4 2017 In : Circulation. 136, 1, p. 83-97 15 p.

Research output: Research - peer-reviewArticle

Receptor, Melanocortin, Type 1
Macrophages
Cholesterol
alpha-MSH
Foam Cells
1 Citations

Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics

Remesic, M., Hruby, V. J., Porreca, F. & Lee, Y. S. Jun 21 2017 In : ACS Chemical Neuroscience. 8, 6, p. 1147-1158 12 p.

Research output: Research - peer-reviewReview article

Opioid Receptors
Opioid Analgesics
Ligands
Therapeutics
Modulators

Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists

Cai, M., Marelli, U. K., Mertz, B., Beck, J. G., Opperer, F., Rechenmacher, F., Kessler, H. & Hruby, V. J. Aug 15 2017 In : Biochemistry. 56, 32, p. 4201-4209 9 p.

Research output: Research - peer-reviewArticle

Receptor, Melanocortin, Type 3
Melanocortin Receptors
Ligands
Peptides
His-His-His-His-His-His

Cyclic non-opioid dynorphin A analogues for the bradykinin receptors

Lee, Y. S., Remesic, M., Ramos-Colon, C., Hall, S. M., Kuzmin, A., Rankin, D., Porreca, F., Lai, J. & Hruby, V. J. 2016 In : Bioorganic and Medicinal Chemistry Letters. 26, 22, p. 5513-5516 4 p.

Research output: Research - peer-reviewArticle

Bradykinin Receptors
Dynorphins
Ligands
Narcotic Antagonists
Hyperalgesia