• 5903 Citations
  • 42 h-Index
1985 …2020

Research output per year

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Research Output

2020

Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model

Fan, X., Ding, X. & Zhang, Q. Y., Jan 2020, In : Acta Pharmaceutica Sinica B. 10, 1, p. 123-135 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Proximal tubular vacuolization and hypersensitivity to drug-induced nephrotoxicity in male mice with decreased expression of the NADPH-Cytochrome P450 reductase

Ding, L., Li, L., Liu, S., Bao, X., Dickman, K. G., Sell, S. S., Mei, C., Zhang, Q. Y., Gu, J. & Ding, X., Feb 1 2020, In : Toxicological Sciences. 173, 2, p. 362-372 11 p.

Research output: Contribution to journalArticle

The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene

Leonardi, A., Kovalchuk, N., Yin, L., Endres, L., Evke, S., Nevins, S., Martin, S., Dedon, P. C., Melendez, J. A., Van Winkle, L., Zhang, Q. Y., Ding, X. & Begley, T. J., Jan 1 2020, (Accepted/In press) In : Epigenetics.

Research output: Contribution to journalArticle

Open Access
2019

Characterization of A Bifunctional Synthetic RNA Aptamer and A Truncated Form for Ability to Inhibit Growth of Non-Small Cell Lung Cancer

Wang, H., Qin, M., Liu, R., Ding, X., Chen, I. S. Y. & Jiang, Y., Dec 1 2019, In : Scientific reports. 9, 1, 18836.

Research output: Contribution to journalArticle

Open Access

Metabolism and Lung Toxicity of Inhaled Naphthalene: Effects of Postnatal Age and Sex

Carratt, S. A., Kovalchuk, N., Ding, X. & Van Winkle, L. S., Jun 1 2019, In : Toxicological Sciences. 170, 2, p. 536-548 13 p.

Research output: Contribution to journalArticle

Naphthalene DNA adduct formation and tolerance in the lung

Buchholz, B. A., Carratt, S. A., Kuhn, E. A., Collette, N. M., Ding, X. & Van Winkle, L. S., Jan 1 2019, In : Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms. 438, p. 119-123 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Naphthalene genotoxicity: DNA adducts in primate and mouse airway explants

Carratt, S. A., Hartog, M., Buchholz, B. A., Kuhn, E. A., Collette, N. M., Ding, X. & Van Winkle, L. S., May 1 2019, In : Toxicology letters. 305, p. 103-109 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Role of Mouse Cytochrome P450 Enzymes of the Cyp2abfgs Subfamilies in the Induction of Lung Inflammation by Cigarette Smoke Exposure

Hartog, M., Zhang, Q. Y. & Ding, X., Nov 1 2019, In : Toxicological Sciences. 172, 1, p. 123-131 9 p.

Research output: Contribution to journalArticle

Safety and efficacy of ex vivo expanded CD34+ stem cells in murine and primate models

Zhang, Y., Shen, B., Guan, X., Qin, M., Ren, Z., Ma, Y., Dai, W., Ding, X. & Jiang, Y., Jun 13 2019, In : Stem Cell Research and Therapy. 10, 1, 173.

Research output: Contribution to journalArticle

Open Access
2018

A CYP2B6-humanized mouse model and its potential applications

Li, L., Zhang, Q. Y. & Ding, X., Feb 2018, In : Drug Metabolism and Pharmacokinetics. 33, 1, p. 2-8 7 p.

Research output: Contribution to journalReview article

1 Scopus citations

Biochemical Function of the Respiratory Tract: Metabolism of Xenobiotics

Ding, X., Li, L., Van Winkle, L. S. & Zhang, Q. Y., Jan 1 2018, Respiratory Toxicology. Elsevier Inc., Vol. 15-15. p. 171-193 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Enzyme Regulation

Ding, X. & Zhang, Q. Y., Jan 1 2018, Biotransformation. Elsevier Inc., Vol. 10-15. p. 8-44 37 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

In Vivo SELEX of an Inhibitory NSCLC-Specific RNA Aptamer from PEGylated RNA Library

Wang, H., Zhang, Y., Yang, H., Qin, M., Ding, X., Liu, R. & Jiang, Y., Mar 2 2018, In : Molecular Therapy - Nucleic Acids. 10, p. 187-198 12 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

P450-humanized and human liver chimeric mouse models for studying xenobiotic metabolism and toxicity

Bissig, K. D., Han, W., Barzi, M., Kovalchuk, N., Ding, L., Fan, X., Pankowicz, F. P., Zhang, Q. Y. & Ding, X., Nov 2018, In : Drug Metabolism and Disposition. 46, 11, p. 1734-1744 11 p.

Research output: Contribution to journalReview article

Open Access
9 Scopus citations
2017

An in vitro system for measuring genotoxicity mediated by human CYP3A4 in Saccharomyces cerevisiae

Fasullo, M., Freedland, J., St. John, N., Cera, C., Egner, P., Hartog, M. & Ding, X., May 2017, In : Environmental and Molecular Mutagenesis. 58, 4, p. 217-227 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

A small-molecule/cytokine combination enhances hematopoietic stem cell proliferation via inhibition of cell differentiation

Wang, L., Guan, X., Wang, H., Shen, B., Zhang, Y., Ren, Z., Ma, Y., Ding, X. & Jiang, Y., Jul 18 2017, In : Stem Cell Research and Therapy. 8, 1, 169.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Human CYP2A13 and CYP2F1 mediate naphthalene toxicity in the lung and nasal mucosa of CYP2A13/2F1-humanized mice

Li, L., Carratt, S., Hartog, M., Kovalchuk, N., Jia, K., Wang, Y., Zhang, Q. Y., Edwards, P., Van Winkle, L. & Ding, X., Jun 2017, In : Environmental health perspectives. 125, 6, 067004.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Impact of hepatic P450-mediated biotransformation on the disposition and respiratory tract toxicity of inhaled naphthalene

Kovalchuk, N., Kelty, J., Li, L., Hartog, M., Zhang, Q. Y., Edwards, P., Van Winkle, L. & Ding, X., Aug 15 2017, In : Toxicology and Applied Pharmacology. 329, p. 1-8 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Large-scale ex vivo generation of human neutrophils from cord blood CD34+ cells

Jie, Z., Zhang, Y., Wang, C., Shen, B., Guan, X., Ren, Z., Ding, X., Dai, W. & Jiang, Y., Jul 2017, In : PloS one. 12, 7, e0180832.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Large-scale ex vivo generation of human red blood cells from cord blood CD34+cells

Zhang, Y., Wang, C., Wang, L., Shen, B., Guan, X., Tian, J., Ren, Z., Ding, X., Ma, Y., Dai, W. & Jiang, Y., Aug 2017, In : Stem Cells Translational Medicine. 6, 8, p. 1698-1709 12 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Role of Cyp2b in phenobarbital-induced hepatocyte proliferation in mice

Li, L., Bao, X., Zhang, Q. Y., Negishi, M. & Ding, X., Aug 1 2017, In : Drug Metabolism and Disposition. 45, 8, p. 977-981 5 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Safety and efficacy of megakaryocytes induced from hematopoietic stem cells in murine and nonhuman primate models

Guan, X., Qin, M., Zhang, Y., Wang, Y., Shen, B., Ren, Z., Ding, X., Dai, W. & Jiang, Y., Mar 2017, In : Stem Cells Translational Medicine. 6, 3, p. 897-909 13 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2016

An update on the role of intestinal cytochrome P450 enzymes in drug disposition

Xie, F., Ding, X. & Zhang, Q. Y., Sep 1 2016, In : Acta Pharmaceutica Sinica B. 6, 5, p. 374-383 10 p.

Research output: Contribution to journalReview article

Open Access
42 Scopus citations

Influence of IL-3 functional fragment on cord blood stem cell ex vivo expansion and differentiation

Ren, Z., Zhang, Y., Zhang, Y., Jiang, W., Dai, W., Ding, X. & Jiang, Y., Mar 1 2016, In : Stem Cell Investigation. 2016, 3

Research output: Contribution to journalArticle

3 Scopus citations

Novel Transgenic Mouse Model for Studying Human Serum Albumin as a Biomarker of Carcinogenic Exposure

Sheng, J., Wang, Y., Turesky, R. J., Kluetzman, K., Zhang, Q. Y. & Ding, X., May 16 2016, In : Chemical Research in Toxicology. 29, 5, p. 797-809 13 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Analysis of the AHR gene proximal promoter GGGGC-repeat polymorphism in lung, breast, and colon cancer

Spink, B. C., Bloom, M. S., Wu, S., Sell, S., Schneider, E., Ding, X. & Spink, D. C., Jan 1 2015, In : Toxicology and Applied Pharmacology. 282, 1, p. 30-41 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Characterization of CYP2B6 in a CYP2B6-humanized mouse model: Inducibility in the liver by phenobarbital and dexamethasone and role in nicotine metabolism in vivos

Liu, Z., Li, L., Wu, H., Hu, J., Ma, J., Zhang, Q. Y. & Ding, X., Feb 1 2015, In : Drug Metabolism and Disposition. 43, 2, p. 208-216 9 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Effect of Cytochrome P450 Reductase Deficiency on 2-Amino-9H-pyrido[2,3-b]indole Metabolism and DNA Adduct Formation in Liver and Extrahepatic Tissues of Mice

Turesky, R. J., Konorev, D., Fan, X., Tang, Y., Yao, L., Ding, X., Xie, F., Zhu, Y. & Zhang, Q. Y., Dec 21 2015, In : Chemical Research in Toxicology. 28, 12, p. 2400-2410 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Intestinal epithelium-specific knockout of the cytochrome P450 reductase gene exacerbates dextran sulfate sodium-induced colitis

Zhu, Y., Xie, F., Ding, L., Fan, X., Ding, X. & Zhang, Q. Y., Jul 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 354, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Neuronal cytochrome P450 activity and opioid analgesia: Relevant sites and mechanisms

Hough, L. B., Nalwalk, J. W., Yang, W. & Ding, X., Jan 1 2015, In : Brain Research. 1616, p. 10-18 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Olfactory Mucosa: Composition, Enzymatic Localization, and Metabolism

Ding, X. & Xie, F., Jun 4 2015, Handbook of Olfaction and Gustation: Third Edition. Wiley-Blackwell, p. 63-92 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Opioid Analgesia in P450 gene cluster knockout mice: A search for analgesia-relevant isoforms

Hough, L. B., Nalwalk, J. W., Ding, X. & Scheer, N., Sep 1 2015, In : Drug Metabolism and Disposition. 43, 9, p. 1326-1330 5 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Residues 39-56 of stem cell factor protein sequence are capable of stimulating the expansion of cord blood CD34+ cells

Shen, B., Jiang, W., Fan, J., Dai, W., Ding, X. & Jiang, Y., Oct 27 2015, In : PloS one. 10, 10, e0141485.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Suppression of pulmonary CYP2A13 expression by carcinogen-induced lung tumorigenesis in a CYP2A13-humanized mouse model

Liu, Z., Megaraj, V., Li, L., Sell, S., Hu, J. & Ding, X., May 1 2015, In : Drug Metabolism and Disposition. 43, 5, p. 698-702 5 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2014

A critical role of fas-associated protein with death domain phosphorylation in intracellular reactive oxygen species homeostasis and aging

Cheng, W., Zhang, R., Yao, C., He, L., Jia, K., Yang, B., Du, P., Zhuang, H., Chen, J., Liu, Z., Ding, X. & Hua, Z., Jul 1 2014, In : Antioxidants and Redox Signaling. 21, 1, p. 33-45 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Deficits in neuronal cytochrome P450 activity attenuate opioid analgesia but not opioid side effects

Hough, L. B., Nalwalk, J. W., Cleary, R. A., Phillips, J. G., Fang, C., Yang, W. & Ding, X., Jan 1 2014, In : European Journal of Pharmacology. 740, p. 255-262 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene

Hu, J., Sheng, L., Li, L., Zhou, X., Xie, F., D'Agostino, J., Li, Y. & Ding, X., Jan 1 2014, In : Drug Metabolism and Disposition. 42, 1, p. 23-27 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Generation and characterization of a novel CYP2A13-yransgenic mouse model

Jia, K., Li, L., Liu, Z., Hartog, M., Kluetzman, K., Zhang, Q. Y. & Ding, X., Jan 1 2014, In : Drug Metabolism and Disposition. 42, 8, p. 1341-1348 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
Open Access
19 Scopus citations

Metabolism of styrene to styrene oxide and vinylphenols in cytochrome P450 2F2- and P450 2E1-knockout mouse liver and lung microsomes

Shen, S., Li, L., Ding, X. & Zheng, J., Jan 21 2014, In : Chemical Research in Toxicology. 27, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mice deficient in intestinal epithelium cytochrome P450 reductase are prone to acute toxin-induced mucosal damage

Ahlawat, S., Xie, F., Zhu, Y., D'Hondt, R., Ding, X., Zhang, Q. Y. & Mantis, N. J., Jul 3 2014, In : Scientific reports. 4, 5551.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
8 Scopus citations
Open Access
30 Scopus citations

Role of hepatic and intestinal P450 enzymes in the metabolic activation of the colon carcinogen azoxymethane in mice

Megaraj, V., Ding, X., Fang, C., Kovalchuk, N., Zhu, Y. & Zhang, Q. Y., Apr 21 2014, In : Chemical Research in Toxicology. 27, 4, p. 656-662 7 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Significance of neuronal cytochrome P450 activity in opioid-mediated stress-induced analgesia

Hough, L. B., Nalwalk, J. W., Yang, W. & Ding, X., Jan 1 2014, In : Brain Research. 1578, p. 30-37 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2013
10 Scopus citations

Downregulation of mouse hepatic CYP3A protein by 3-methylcholanthrene does not require cytochrome P450-dependent metabolism

Lee, C., Ding, X. & Riddick, D. S., Oct 1 2013, In : Drug Metabolism and Disposition. 41, 10, p. 1782-1786 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model

Wei, Y., Li, L., Zhou, X., Zhang, Q. Y., Dunbar, A., Liu, F., Kluetzman, K., Yang, W. & Ding, X., Jan 1 2013, In : Drug Metabolism and Disposition. 41, 1, p. 132-140 9 p.

Research output: Contribution to journalArticle

20 Scopus citations