Yves A Lussier

  • 3308 Citations
  • 31 h-Index
1988 …2021
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Research Output 1988 2019

  • 3308 Citations
  • 31 h-Index
  • 147 Article
  • 13 Chapter
  • 13 Conference contribution
  • 1 Review article
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Article
2019

A single-subject method to detect pathways enriched with alternatively spliced genes

Schissler, A. G., Aberasturi, D., Kenost, C. & Lussier, Y. A., Jan 1 2019, In : Frontiers in Genetics. 10, MAY, 414.

Research output: Contribution to journalArticle

Open Access
Recombinant DNA
Alternative Splicing
RNA Isoforms
RNA Sequence Analysis
Precision Medicine
1 Citation (Scopus)

Developing a 'personalome' for precision medicine: emerging methods that compute interpretable effect sizes from single-subject transcriptomes

Vitali, F., Li, Q., Schissler, A. G., Berghout, J., Kenost, C. & Lussier, Y. A., May 21 2019, In : Briefings in bioinformatics. 20, 3, p. 789-805 17 p.

Research output: Contribution to journalArticle

Open Access
Precision Medicine
Transcriptome
Medicine
Bioinformatics
Metabolites

Evaluating single-subject study methods for personal transcriptomic interpretations to advance precision medicine

Rachid Zaim, S., Kenost, C., Berghout, J., Vitali, F., Zhang, H. & Lussier, Y. A., Jul 11 2019, In : BMC Medical Genomics. 12, 96.

Research output: Contribution to journalArticle

Open Access
Precision Medicine
Genes
Yeasts
Transcriptome
Gene Expression Profiling

Precision drug repurposing via convergent eQTL-based molecules and pathway targeting independent disease-associated polymorphisms

Vitali, F., Berghout, J., Fan, J., Li, J., Li, Q., Li, H. & Lussier, Y. A., Jan 1 2019, In : Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 24, p. 308-319 12 p.

Research output: Contribution to journalArticle

Drug Repositioning
Single Nucleotide Polymorphism
Genome-Wide Association Study
Drug Delivery Systems
Pharmaceutical Preparations

Translational informatics of population health: How large biomolecular and clinical datasets unite

Lussier, Y. A., Butte, A. J., Li, H., Chen, R. & Moore, J. H., Jan 1 2019, In : Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 24, p. 455-459 5 p.

Research output: Contribution to journalArticle

Informatics
Health
Education
Population
Mathematical Computing

Workshop during the Pacific Symposium of Biocomputing, Jan 3-7, 2019: Reading between the genes: interpreting non-coding DNA in high-throughput

Berghout, J., Lussier, Y. A., Vitali, F., Bulyk, M. L., Kann, M. G. & Moore, J. H., Jan 1 2019, In : Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 24, p. 444-448 5 p.

Research output: Contribution to journalArticle

Reading
Education
DNA
Genes
Chromatin
2018
5 Citations (Scopus)

Genome-wide association study in African Americans with acute respiratory distress syndrome identifies the selectin P ligand gene as a risk factor

Bime, C., Pouladi, N., Sammani, S., Batai, K., Casanova, N., Zhou, T., Kempf, C. L., Sun, X., Camp, S. M., Wang, T., Kittles, R. A., Lussier, Y. A., Jones, T. K., Reilly, J. P., Meyer, N. J., Christie, J. D., Karnes, J. H., Gonzalez-Garay, M., Christiani, D. C., Yates, C. R. & 3 others, Wurfel, M. M., Meduri, G. U. & Garcia, J. GN., Jun 1 2018, In : American Journal of Respiratory and Critical Care Medicine. 197, 11, p. 1421-1432 12 p.

Research output: Contribution to journalArticle

P-Selectin
Genome-Wide Association Study
Adult Respiratory Distress Syndrome
African Americans
Ligands

Novel disease syndromes unveiled by integrative multiscale network analysis of diseases sharing molecular effectors and comorbidities

Li, H., Fan, J., Vitali, F., Berghout, J., Aberasturi, D., Li, J., Wilson, L., Chiu, W., Pumarejo, M., Han, J., Kenost, C., Koripella, P. C., Pouladi, N., Billheimer, D. D., Bedrick, E. J. & Lussier, Y. A., Dec 31 2018, In : BMC Medical Genomics. 11, 112.

Research output: Contribution to journalArticle

Comorbidity
Quantitative Trait Loci
Single Nucleotide Polymorphism
Genome-Wide Association Study
Drug Repositioning
4 Citations (Scopus)

Physician nurse care: A new use of UMLS to measure professional contribution: Are we talking about the same patient a new graph matching algorithm?

Boyd, A. D., Dunn Lopez, K., Lugaresi, C., Macieira, T., Sousa, V., Acharya, S., Balasubramanian, A., Roussi, K., Keenan, G. M., Lussier, Y. A., Li, J. J., Burton, M. & Di Eugenio, B., May 1 2018, In : International Journal of Medical Informatics. 113, p. 63-71 9 p.

Research output: Contribution to journalArticle

Unified Medical Language System
Nurses
Physicians
Documentation
Terminology
2017
8 Citations (Scopus)

A genome-by-environment interaction classifier for precision medicine: Personal transcriptome response to rhinovirus identifies children prone to asthma exacerbations

Gardeux, V., Berghout, J., Achour, I., Schissler, A. G., Li, Q., Kenost, C., Li, J., Shang, Y., Bosco, A., Saner, D., Halonen, M. J., Jackson, D. J., Li, H., Martinez, F. & Lussier, Y. A., Nov 1 2017, In : Journal of the American Medical Informatics Association. 24, 6, p. 1116-1126 11 p.

Research output: Contribution to journalArticle

Rhinovirus
Precision Medicine
Transcriptome
Asthma
Genome
4 Citations (Scopus)

Association of circulating transcriptomic profiles with mortality in sickle cell disease

Desai, A., Lei, Z., Bahroos, N., Maienschein-Cline, M., Saraf, S. L., Zhang, X., Shah, B. N., Nouraie, S. M., Abbasi, T., Patel, A. R., Lang, R. M., Lussier, Y. A., Garcia, J. GN., Gordeuk, V. R. & Machado, R. F., Jun 1 2017, In : Blood. 129, 22, p. 3009-3016 8 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Mortality
Acute Chest Syndrome
Testing
Blood
1 Citation (Scopus)

Exploring wound-healing genomic machinery with a network-based approach

Vitali, F., Marini, S., Balli, M., Grosemans, H., Sampaolesi, M., Lussier, Y. A., Cusella De Angelis, M. G. & Bellazzi, R., Jun 21 2017, In : Pharmaceuticals. 10, 2, 55.

Research output: Contribution to journalArticle

Wound Healing
Computational Biology
Genes
Protein Interaction Maps
Drug Discovery
10 Citations (Scopus)
Sarcoidosis
MicroRNAs
Blood Cells
Genes
Gene Expression
7 Citations (Scopus)

kMEn: Analyzing noisy and bidirectional transcriptional pathway responses in single subjects

Li, Q., Schissler, A. G., Gardeux, V., Berghout, J., Achour, I., Kenost, C., Li, H., Zhang, H. & Lussier, Y. A., Feb 1 2017, In : Journal of Biomedical Informatics. 66, p. 32-41 10 p.

Research output: Contribution to journalArticle

Genes
Noise
Transcriptome
Biomarkers
Medicine
37 Citations (Scopus)

Microbes are associated with host innate immune response in idiopathic pulmonary fibrosis

Huang, Y., Ma, S. F., Espindola, M. S., Vij, R., Oldham, J. M., Huffnagle, G. B., Erb-Downward, J. R., Flaherty, K. R., Moore, B. B., White, E. S., Zhou, T., Li, J., Lussier, Y. A., Han, M. K., Kaminski, N., Garcia, J. GN., Hogaboam, C. M., Martinez, F. J. & Noth, I., Jul 15 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 2, p. 208-219 12 p.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Innate Immunity
Fibroblasts
Disease-Free Survival
Oligodeoxyribonucleotides
8 Citations (Scopus)
Precision Medicine
Gene Expression Profiling
Transcriptome
Point-of-Care Systems
Genes
8 Citations (Scopus)

N-of-1-pathways MixEnrich: advancing precision medicine via single-subject analysis in discovering dynamic changes of transcriptomes

Li, Q., Schissler, A. G., Gardeux, V., Achour, I., Kenost, C., Berghout, J., Li, H., Zhang, H. & Lussier, Y. A., May 24 2017, In : BMC Medical Genomics. 10, 27.

Research output: Contribution to journalArticle

Precision Medicine
Gene Expression Profiling
Transcriptome
Point-of-Care Systems
Genes
2 Citations (Scopus)

Semantic Modeling for Exposomics with Exploratory Evaluation in Clinical Context

Fan, J. W., Li, J. & Lussier, Y. A., 2017, In : Journal of Healthcare Engineering. 2017, 3818302.

Research output: Contribution to journalArticle

Semantics
Microbiological Phenomena
Unified Medical Language System
Iatrogenic Disease
Precision Medicine
4 Citations (Scopus)
Pathway
Gene
Testing
Genes
Triple Negative Breast Neoplasms
Dietary Supplements
Workflow
Drug Repositioning
Databases
Delivery of Health Care
2016
7 Citations (Scopus)

Analysis of aggregated cell-cell statistical distances within pathways unveils therapeutic-resistance mechanisms in circulating tumor cells

Schissler, A. G., Li, Q., Chen, J. L., Kenost, C., Achour, I., Billheimer, D. D., Li, H., Piegorsch, W. W. & Lussier, Y. A., Jun 15 2016, In : Bioinformatics. 32, 12, p. i80-i89

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Tumors
Tumor
Pathway
Genes
6 Citations (Scopus)

Integrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions

Li, H., Achour, I., Bastarache, L., Berghout, J., Gardeux, V., Li, J., Lee, Y., Pesce, L., Yang, X., Ramos, K., Foster, I., Denny, J. C., Moore, J. H. & Lussier, Y. A., Apr 27 2016, In : npj Genomic Medicine. 1, 16006.

Research output: Contribution to journalArticle

Intergenic DNA
Genomics
Single Nucleotide Polymorphism
Genome-Wide Association Study
Entropy
4 Citations (Scopus)

Rethinking the role and impact of health information technology: Informatics as an interventional discipline

Payne, P. R. O., Lussier, Y. A., Foraker, R. E. & Embi, P. J., 2016, In : BMC Medical Informatics and Decision Making. 16, 1, 40.

Research output: Contribution to journalArticle

Medical Informatics
Informatics
Point-of-Care Systems
Health
Costs and Cost Analysis
1 Citation (Scopus)

Simulation of ICD-9 to ICD-10-CM transition for family medicine: Simple or convoluted?

Grief, S. N., Patel, J., Kochendorfer, K. M., Green, L. A., Lussier, Y. A., Li, J., Burton, M. & Boyd, A. D., Jan 1 2016, In : Journal of the American Board of Family Medicine. 29, 1, p. 29-36 8 p.

Research output: Contribution to journalArticle

International Classification of Diseases
Medicine
Family Physicians
Medicaid
2015
17 Citations (Scopus)

A functional genomic model for predicting prognosis in idiopathic pulmonary fibrosis

Huang, Y., Ma, S. F., Vij, R., Oldham, J. M., Herazo-Maya, J., Broderick, S. M., Strek, M. E., White, S. R., Hogarth, D. K., Sandbo, N. K., Lussier, Y. A., Gibson, K. F., Kaminski, N., Garcia, J. GN. & Noth, I., Nov 21 2015, (Accepted/In press) In : BMC Pulmonary Medicine.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Genes
Survival
Regression Analysis
Gene Expression
8 Citations (Scopus)

Challenges and remediation for Patient Safety Indicators in the transition to ICD-10-CM

Boyd, A. D., Yang, Y. M., Li, J., Kenost, C., Burton, M. D., Becker, B. & Lussier, Y. A., 2015, In : Journal of the American Medical Informatics Association. 22, 1, p. 19-28 10 p.

Research output: Contribution to journalArticle

International Classification of Diseases
Patient Safety
Centers for Medicare and Medicaid Services (U.S.)
Safety
Health Services Research
7 Citations (Scopus)
Pulmonary diseases
Inborn Genetic Diseases
Genome-Wide Association Study
Lung Diseases
Genes
14 Citations (Scopus)
RNA Sequence Analysis
Precision Medicine
Mahalanobis Distance
RNA
Breast Cancer
2 Citations (Scopus)

Editorial: Big Data for Health

Atun, R., Lussier, Y. A., Poon, C., Wong, S. T. C. & Yang, G. Z., Jul 1 2015, In : IEEE Journal of Biomedical and Health Informatics. 19, 4, p. 1191-1192 2 p., 7165690.

Research output: Contribution to journalArticle

Informatics
Publications
Health
Big data
4 Citations (Scopus)

eQTL networks unveil enriched mRNA master integrators downstream of complex disease-associated SNPs

Li, H., Pouladi, N., Achour, I., Gardeux, V., Li, J., Li, Q., Zhang, H., Martinez, F., Skip Garcia, J. G. N. & Lussier, Y. A., Dec 1 2015, In : Journal of Biomedical Informatics. 58, p. 226-234 9 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Nucleotides
Polymorphism
Single Nucleotide Polymorphism
Messenger RNA
4 Citations (Scopus)

Erratum: Wnt7a is a novel inducer of β-catenin-independent tumor-suppressive cellular senescence in lung cancer (Oncogene (2015) 34 (5406) DOI:10.1038/onc.2015.165)

Bikkavilli, R. K., Avasarala, S., Van Scoyk, M., Arcaroli, J., Brzezinski, C., Zhang, W., Edwards, M. G., Rathinam, M. K. K., Zhou, T., Tauler, J., Borowicz, S., Lussier, Y. A., Parr, B. A., Cool, C. D. & Winn, R. A., Oct 16 2015, In : Oncogene. 34, 42, p. 5406 1 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Evidence suggesting that discontinuous dosing of ALK Kinase Inhibitors May Prolong Control of ALK+ Tumors

Amin, A. D., Rajan, S. S., Liang, W. S., Pongtornpipat, P., Groysman, M. J., Tapia, E. O., Peters, T. L., Cuyugan, L., Adkins, J., Rimsza, L. M., Lussier, Y. A., Puvvada, S. D. & Schatz, J. H., Jul 15 2015, In : Cancer Research. 75, 14, p. 2916-2927 12 p.

Research output: Contribution to journalArticle

Phosphotransferases
Neoplasms
Anaplastic Large-Cell Lymphoma
Non-Small Cell Lung Carcinoma
Drug Resistance
8 Citations (Scopus)

Metrics and tools for consistent cohort discovery and financial analyses post-transition to ICD-10-CM

Boyd, A. D., Li, J. J., Kenost, C., Joese, B., Yang, Y. M., Kalagidis, O. A., Zenku, I., Saner, D., Bahroos, N. & Lussier, Y. A., 2015, In : Journal of the American Medical Informatics Association. 22, 3, p. 730-737 8 p.

Research output: Contribution to journalArticle

International Classification of Diseases
Delivery of Health Care
Administrative Personnel
Poisoning
Research Personnel
12 Citations (Scopus)
International Classification of Diseases
Physicians
Emergencies
Centers for Medicare and Medicaid Services (U.S.)
Workflow
14 Citations (Scopus)

Towards a PBMC "virogram assay" for precision medicine: Concordance between ex vivo and in vivo viral infection transcriptomes

Gardeux, V., Bosco, A., Li, J., Halonen, M. J., Jackson, D., Martinez, F. & Lussier, Y. A., Jun 1 2015, In : Journal of Biomedical Informatics. 55, p. 94-103 10 p.

Research output: Contribution to journalArticle

Precision Medicine
Virus Diseases
Transcriptome
Rhinovirus
Medicine
17 Citations (Scopus)

Wnt7a is a novel inducer of β-catenin-independent tumor-suppressive cellular senescence in lung cancer

Bikkavilli, R. K., Avasarala, S., Van Scoyk, M., Arcaroli, J., Brzezinski, C., Zhang, W., Edwards, M. G., Rathinam, M. K. K., Zhou, T., Tauler, J., Borowicz, S., Lussier, Y. A., Parr, B. A., Cool, C. D. & Winn, R. A., Mar 2 2015, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Catenins
Cell Aging
Lung Neoplasms
Neoplasms
Iloprost
2014

Accelerating precision biology and medicine with computational biology and bioinformatics

Lussier, Y. A., Li, H., Pouladi, N. & Li, Q., Sep 5 2014, In : Genome Biology. 15, 9, 450.

Research output: Contribution to journalArticle

Precision Medicine
bioinformatics
Systems Biology
artificial intelligence
Computational Biology
1 Citation (Scopus)

ARTS: Automated randomization of multiple traits for study design

Maienschein-Cline, M., Lei, Z., Gardeux, V., Abbasi, T., Machado, R. F., Gordeuk, V., Desai, A., Saraf, S., Bahroos, N. & Lussier, Y. A., Jun 1 2014, In : Bioinformatics. 30, 11, p. 1637-1639 3 p.

Research output: Contribution to journalArticle

Design aids
Microarrays
Random Allocation
Randomisation
Batch
15 Citations (Scopus)

Concordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study

Gardeux, V., Arslan, A. D., Achour, I., Ho, T. T., Beck, W. T. & Lussier, Y. A., May 8 2014, In : BMC Medical Genomics. 7, SUPPL.1, S1.

Research output: Contribution to journalArticle

Transcriptome
RNA Splicing
Precision Medicine
Gene Expression Profiling
Semantics

COPD Hospitalization Risk Increased with Distinct Patterns of Multiple Systems Comorbidities Unveiled by Network Modeling

Lee, Y. J. I., Boyd, A. D., Li, J. J. O., Gardeux, V., Kenost, C., Saner, D., Li, H., Abraham, I. L., Krishnan, J. A. & Lussier, Y. A., 2014, In : AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium. 2014, p. 855-864 10 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Comorbidity
Hospitalization
Mental Disorders
Substance-Related Disorders
9 Citations (Scopus)

Identifying clinically disruptive international classification of diseases 10th revision clinical modification conversions to mitigate financial costs using an online tool

Venepalli, N. K., Qamruzzaman, Y., Li, J., Lussier, Y. A. & Boyd, A. D., 2014, In : Journal of Oncology Practice. 10, 2, p. 97-103 7 p.

Research output: Contribution to journalArticle

International Classification of Diseases
Costs and Cost Analysis
Medicaid
Hematology
Neoplasms
23 Citations (Scopus)

Inflammatory leukocyte phenotypes correlate with disease progression in idiopathic pulmonary fibrosis

The COMET Investigators, Jan 1 2014, In : Frontiers in Medicine. 1, DEC, 56.

Research output: Contribution to journalArticle

Open Access
Idiopathic Pulmonary Fibrosis
Disease Progression
Leukocytes
Phenotype
Biomarkers
2 Citations (Scopus)
Transcriptome
Heterografts
Computer Simulation
Laser Capture Microdissection
Tumor Microenvironment
21 Citations (Scopus)

'N-of-1-pathways' unveils personal deregulated mechanisms from a single pair of RNA-Seq samples: towards precision medicine

Gardeux, V., Achour, I., Li, J., Maienschein-Cline, M., Li, H., Pesce, L., Parinandi, G., Bahroos, N., Winn, R., Foster, I., Garcia, J. GN. & Lussier, Y. A., Nov 1 2014, In : Journal of the American Medical Informatics Association. 21, 6, p. 1015-1025 11 p.

Research output: Contribution to journalArticle

Precision Medicine
RNA
DNA Sequence Analysis
Transcriptome
Epigenomics
6 Citations (Scopus)

Prognostic implication of pulmonary function at the beginning of postoperative radiotherapy in non-small cell lung cancer

Kim, H., Lussier, Y. A., Noh, O. K., Li, H., Oh, Y. T. & Heo, J., Dec 1 2014, In : Radiotherapy and Oncology. 113, 3, p. 374-378 5 p.

Research output: Contribution to journalArticle

Forced Expiratory Volume
Non-Small Cell Lung Carcinoma
Radiotherapy
Lung
Survival
3 Citations (Scopus)

Role of FAM18B in diabetic retinopathy

Wang, A. L., Rao, V. R., Chen, J. J., Lussier, Y. A., Rehman, J., Huang, Y., Jager, R. D. & Grassi, M. A., Aug 4 2014, In : Molecular Vision. 20, p. 1146-1159 14 p.

Research output: Contribution to journalArticle

Diabetic Retinopathy
Endothelial Cells
Hyperglycemia
Down-Regulation
Cell Survival
20 Citations (Scopus)

The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis.

Huang, L. S., Mathew, B., Li, H., Zhao, Y., Ma, S. F., Noth, I., Reddy, S. P., Harijith, A., Usatyuk, P. V., Berdyshev, E. V., Kaminski, N., Zhou, T., Zhang, W., Zhang, Y., Rehman, J., Kotha, S. R., Gurney, T. O., Parinandi, N. L., Lussier, Y. A., Garcia, J. GN. & 1 others, Natarajan, V., 2014, In : American Journal of Respiratory and Critical Care Medicine. 189, 11, p. 1402-1415 14 p.

Research output: Contribution to journalArticle

Acyltransferases
Cardiolipins
Pulmonary Fibrosis
Enzymes
Lung
13 Citations (Scopus)

The transition to ICD-10-CM: Challenges for Pediatric Practice

Caskey, R., Zaman, J., Nam, H., Chae, S. R., Williams, L., Mathew, G., Burton, M., Li, J. J., Lussier, Y. A. & Boyd, A. D., 2014, In : Pediatrics. 134, 1, p. 31-36 6 p.

Research output: Contribution to journalArticle

International Classification of Diseases
Medicaid
Pediatrics
Health Care Quality Assurance
Outcome Assessment (Health Care)
2013
1 Citation (Scopus)

Conquering computational challenges of omics data and post-ENCODE paradigms

Lussier, Y. A., Li, H. & Maienschein-Cline, M., Aug 23 2013, (Accepted/In press) In : Genome Biology. p. 310 1 p.

Research output: Contribution to journalArticle

Systems Biology
artificial intelligence
Berlin
Computational Biology
bioinformatics

Correction: Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs (PLoS ONE)

Lussier, Y. A., Khodarev, N. N., Regan, K., Corbin, K., Li, H., Ganai, S., Khan, S. A., Gnerlich, J. L., Darga, T. E., Fan, H., Karpenko, O., Paty, P. B., Posner, M. C., Chmura, S. J., Hellman, S., Ferguson, M. K. & Weichselbaum, R. R., Jun 7 2013, In : PLoS One. 8, 6

Research output: Contribution to journalArticle

MicroRNAs